iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000247746.4	ENST00000500968.3	ENSP00000423333.2
ENSG00000247746.4	ENST00000586165.1	ENSP00000490435.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	1.10e-89	302.7	364	706

Active Site

Position(s)	Description	Evidence
372	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
665	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaq 93
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qqDa+
   Q: 364  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAH 451
           9*****************************.99999875...78************************************************ PP
   S: 94   EflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke 185
           Efl  +ld l+++ k                  s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+  t  +
   Q: 452  EFLIAILDVLHRHSKD----------------DSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDS 527
           **************22................1223456899******************************************99987766 PP
   S: 186  ....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
                               sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+kin+ ++fpl
   Q: 528  qnperadstvsrddhipgipSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRKINTFISFPL 617
           89999*******************************************************************..88889************* PP
   S: 258  eLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           eLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l    s++Y+lfY+++
   Q: 618  ELDMTPFLASTKESRMKegqpptdcvpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY---SEGYLLFYHKQ 706
           ********99665555578888888888**************************************************...********985 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAQVRETSLP SGSGVRWISG GGGGASPEEA VEKAGKMEEA AAGATKASSR REAEEMKLEP 60
LQEREPAPEE NLTWSSSGGD EKVLPSIPLR CHSSSSPVCP RRKPRPRPQP RARSRSQPGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCCCTGGC ATGATCTGAT CGCCTTTGAA GCAGGTAACC GCCTCGGTCT CCCCATCAGC 60
TCCAGGGGCC TCTCAGTTGA GTGGGTGGAG CCGACAGAAG CCGCGGGCTG AGCTCAAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016579--P:protein deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:158880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	93.55	0.00e+00	994.00
IUUC-Cja-019402	Callithrix jacchus	97.44	0.00e+00	762.00
IUUC-Csa-023824	Chlorocebus sabaeus	98.67	0.00e+00	1046.00
IUUC-Eca-033872	Equus caballus	94.32	0.00e+00	1003.00
IUUC-Fca-035534	Felis catus	94.01	0.00e+00	1014.00
IUUC-Ggo-045109	Gorilla gorilla	97.13	0.00e+00	1016.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	95.08	0.00e+00	955.00
IUUC-Mcc-055420	Macaca mulatta	98.53	0.00e+00	1085.00
IUUC-Mmr-061690	Microcebus murinus	95.12	0.00e+00	1037.00
IUUC-Mmu-063435	Mus musculus	80.41	0.00e+00	830.00
IUUC-Mac-065419	Musa acuminata	34.07	2.00e-74	273.00
IUUC-Mpu-065679	Mustela putorius furo	94.31	0.00e+00	985.00
IUUC-Mlu-067084	Myotis lucifugus	92.56	0.00e+00	1008.00
IUUC-Nle-069859	Nomascus leucogenys	99.44	0.00e+00	1140.00
IUUC-Ocu-074365	Oryctolagus cuniculus	93.21	0.00e+00	974.00
IUUC-Ptr-091479	Pan troglodytes	99.58	0.00e+00	1198.00
IUUC-Pan-091707	Papio anubis	98.48	0.00e+00	1043.00
IUUC-Pab-097894	Pongo abelii	99.81	0.00e+00	1070.00
IUUC-Pgr-103657	Puccinia graminis	29.25	6.00e-38	152.00
IUUC-Rno-105644	Rattus norvegicus	79.60	0.00e+00	840.00
IUUC-Sar-113426	Sorex araneus	80.18	0.00e+00	835.00
IUUC-Sre-115195	Sporisorium reilianum	26.03	7.00e-49	189.00
IUUC-Ssc-115500	Sus scrofa	91.49	0.00e+00	981.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence