iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.70e-61	206.9	105	477
ULD/UDP/UBQ/UBQ_Other	8.70e-10	39.2	26	73

Active Site

Position(s)	Description	Evidence
113	Nucleophile
430	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.....gyeqqDaqE 94
           Gl NlgNtCYmNS++QcL ++pel+++l + ++ + + ++ ++++  l+ + ++lf el +++ +avsp++++ +l+k+ ++fs       +qqDa+E
   Q: 105  GLVNLGNTCYMNSTVQCLKSVPELKSALSN-YSLAARSNDVDQTSHMLTVATRELFGEL-DRSVNAVSPSQFWMVLRKKYPQFSqlqngMHMQQDAEE 200
           9*****************************.99999999999*****************.99**********************9999889******* PP
   S: 95   flaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLe 192
           ++++ll +l+++l                       +  + +++ + ++ lF++ l+s++ c+e +++ss++e+ ++l+++++ + +     l++ L+
   Q: 201  CWTQLLYTLSQSL-----------------------KAPTSSEGADAVKALFGVNLQSRLHCQESGEESSETESVYSLKCHISHEVN----HLHEGLK 271
           *************.......................357788999**************************************9986....6888887 PP
   S: 193  sftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts....................... 267
           +  k e le      ++   +    +k+  +++lP++L++++ Rf +++e +++ ki +kv++pl Ld+   c++                       
   Q: 272  HGLKGE-LE----KTSPALGRTALYVKESLIDSLPRYLTVQFVRFFWKRESNQKAKILRKVDYPLVLDIFDLCSEdlrkkleaprqklreeegkklgl 364
           776665.44....478999999999**************************************************77777777777777666666666 PP
   S: 268  ..........................peekqke.................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeee 321
                                     +     +                 + +Y+L+av+ H+G s++sGHYva+vk+e+gkW+++dD++ +  +ee+
   Q: 365  qtsaksgskdsdvkmtdaeasangsgE-----SstvnpqegtssekethmTGIYDLVAVLTHKGrSADSGHYVAWVKQESGKWIQYDDDNPSMQREED 457
           666666666666555555555555550.....055555555555566666************************************************ PP
   S: 322  vleetg....staYvlfYkr 337
           + + +g    + aY+ +Yk 
   Q: 458  ITKLSGggdwHMAYITMYKA 477
           ***988************97 PP

ULD/UDP/UBQ/UBQ_Other

   S: 25   eLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           ++K ++++++g+ppe+q++++kG +L+dd ++a+ g+kdg++++++ +
   Q: 26   VFKAQLYDLTGVPPERQKIMVKGGLLKDDGDWAAIGVKDGQKLMMMGT 73
           68*******************************************976 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Interacts with calmodulin (CaM).

Protein Sequence
(Fasta)

MPTVSVKWQK KVLDGIEIDV SLPPYVFKAQ LYDLTGVPPE RQKIMVKGGL LKDDGDWAAI 60
GVKDGQKLMM MGTADEIVKA PEKAIVFAED LPEEALATNL GYSAGLVNLG NTCYMNSTVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTAATCGA TCATATGTGT GTAGACAGAA AAGAGATGAT CTTATGTTAA CCCAAATTTT 60
CAACCGGTTT AATTAGAATT GAAGTGACAT ATAACCGGAG GGAGCTGATA TTTAGAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00240--ubiquitin
PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009506--C:plasmodesma
GO:0005516--F:calmodulin binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G51710

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	51.68	6.00e-83	301.00
IUUC-Aml-002053	Ailuropoda melanoleuca	42.00	2.00e-109	389.00
IUUC-Atr-002725	Amborella trichopoda	74.48	0.00e+00	694.00
IUUC-Aly-006078	Arabidopsis lyrata	96.68	0.00e+00	914.00
IUUC-Ago-007796	Ashbya gossypii	34.12	2.00e-61	229.00
IUUC-Bta-012553	Bos taurus	42.74	7.00e-111	393.00
IUUC-Bci-013606	Botrytis cinerea	37.21	1.00e-83	303.00
IUUC-Bdi-014567	Brachypodium distachyon	69.58	0.00e+00	661.00
IUUC-Bol-015565	Brassica oleracea	91.30	0.00e+00	883.00
IUUC-Bra-017297	Brassica rapa	91.34	0.00e+00	883.00
IUUC-Cel-018140	Caenorhabditis elegans	36.59	8.00e-80	290.00
IUUC-Cja-019516	Callithrix jacchus	42.01	2.00e-110	392.00
IUUC-Cfa-020808	Canis familiaris	42.97	2.00e-111	395.00
IUUC-Cpo-021688	Cavia porcellus	42.00	3.00e-109	388.00
IUUC-Csa-023429	Chlorocebus sabaeus	42.18	8.00e-110	390.00
IUUC-Cho-024347	Choloepus hoffmanni	42.57	2.00e-110	392.00
IUUC-Cin-025198	Ciona intestinalis	37.73	1.00e-82	299.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	41.57	3.00e-66	245.00
IUUC-Cne-026963	Cryptococcus neoformans	36.48	2.00e-77	282.00
IUUC-Cme-027240	Cyanidioschyzon merolae	38.05	4.00e-72	264.00
IUUC-Dre-027647	Danio rerio	42.43	4.00e-113	400.00
IUUC-Dno-029967	Dasypus novemcinctus	42.57	3.00e-109	387.00
IUUC-Dor-030886	Dipodomys ordii	35.78	3.00e-76	278.00
IUUC-Dse-031466	Dothistroma septosporum	33.16	5.00e-74	271.00
IUUC-Ete-032351	Echinops telfairi	40.24	7.00e-101	360.00
IUUC-Eca-033461	Equus caballus	43.11	3.00e-114	404.00
IUUC-Eeu-035220	Erinaceus europaeus	33.14	6.00e-46	177.00
IUUC-Fca-036210	Felis catus	43.17	1.00e-111	396.00
IUUC-Gga-040462	Gallus gallus	41.75	3.00e-109	387.00
IUUC-Gma-043255	Glycine max	74.74	0.00e+00	739.00
IUUC-Hsa-045706	Homo sapiens	42.18	7.00e-110	390.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	42.38	2.00e-111	395.00
IUUC-Lch-050464	Latimeria chalumnae	41.75	4.00e-110	390.00
IUUC-Loc-052732	Lepisosteus oculatus	42.57	1.00e-112	399.00
IUUC-Lma-053177	Leptosphaeria maculans	35.75	1.00e-81	296.00
IUUC-Laf-053822	Loxodonta africana	43.00	5.00e-111	394.00
IUUC-Mcc-055893	Macaca mulatta	42.18	7.00e-110	390.00
IUUC-Meu-056307	Macropus eugenii	38.35	5.00e-100	357.00
IUUC-Mor-057171	Magnaporthe oryzae	36.07	2.00e-78	285.00
IUUC-Mtr-057901	Medicago truncatula	76.67	0.00e+00	749.00
IUUC-Mla-058897	Melampsora laricipopulina	35.69	2.00e-79	289.00
IUUC-Mvi-060562	Microbotryum violaceum	31.34	4.00e-64	238.00
IUUC-Mmr-060624	Microcebus murinus	42.91	4.00e-113	400.00
IUUC-Mdo-061809	Monodelphis domestica	42.41	6.00e-109	387.00
IUUC-Mmu-063869	Mus musculus	43.14	3.00e-110	391.00
IUUC-Mac-064876	Musa acuminata	68.54	5.00e-179	620.00
IUUC-Mpu-066480	Mustela putorius furo	42.97	2.00e-111	395.00
IUUC-Mlu-067866	Myotis lucifugus	43.71	8.00e-112	396.00
IUUC-Nle-070121	Nomascus leucogenys	47.71	8.00e-58	216.00
IUUC-Oan-073635	Ornithorhynchus anatinus	38.94	1.00e-82	299.00
IUUC-Ocu-074926	Oryctolagus cuniculus	41.83	2.00e-108	385.00
IUUC-Oba-075633	Oryza barthii	67.71	0.00e+00	628.00
IUUC-Obr-076423	Oryza brachyantha	69.58	0.00e+00	637.00
IUUC-Ogl-077913	Oryza glaberrima	69.38	0.00e+00	641.00
IUUC-Ogu-078435	Oryza glumaepatula	67.71	0.00e+00	628.00
IUUC-Ome-081309	Oryza meridionalis	67.71	0.00e+00	628.00
IUUC-Oni-083113	Oryza nivara	67.71	0.00e+00	628.00
IUUC-Opu-083168	Oryza punctata	66.04	4.00e-173	600.00
IUUC-Oru-084253	Oryza rufipogon	67.71	0.00e+00	628.00
IUUC-Osa-085554	Oryza sativa	69.58	0.00e+00	644.00
IUUC-Olu-087818	Ostreococcus lucimarinus	40.66	6.00e-91	327.00
IUUC-Oga-088571	Otolemur garnettii	42.26	1.00e-110	392.00
IUUC-Oar-089526	Ovis aries	42.80	2.00e-110	392.00
IUUC-Ptr-091433	Pan troglodytes	42.18	7.00e-110	390.00
IUUC-Pan-091966	Papio anubis	42.18	8.00e-110	390.00
IUUC-Pma-094343	Petromyzon marinus	39.72	1.00e-53	202.00
IUUC-Ppa-095756	Physcomitrella patens	63.20	1.00e-172	598.00
IUUC-Pfo-096514	Poecilia formosa	42.11	1.00e-100	359.00
IUUC-Pab-098477	Pongo abelii	37.42	1.00e-79	289.00
IUUC-Ppe-101812	Prunus persica	79.09	0.00e+00	729.00
IUUC-Pva-102462	Pteropus vampyrus	39.59	3.00e-85	308.00
IUUC-Pgr-103623	Puccinia graminis	43.03	2.00e-72	266.00
IUUC-Ptt-103767	Puccinia triticina	41.74	6.00e-68	251.00
IUUC-Pte-104109	Pyrenophora teres	34.86	2.00e-81	295.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	34.86	3.00e-79	288.00
IUUC-Rno-105351	Rattus norvegicus	42.35	7.00e-109	386.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.99	5.00e-61	228.00
IUUC-Sha-107491	Sarcophilus harrisii	42.69	9.00e-111	393.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	36.56	4.00e-84	305.00
IUUC-Smo-109276	Selaginella moellendorffii	63.77	4.00e-173	600.00
IUUC-Sit-110361	Setaria italica	69.04	0.00e+00	653.00
IUUC-Sly-110965	Solanum lycopersicum	75.16	0.00e+00	724.00
IUUC-Sar-113355	Sorex araneus	39.31	1.00e-61	229.00
IUUC-Ssc-116273	Sus scrofa	42.80	1.00e-108	385.00
IUUC-Tca-121246	Theobroma cacao	78.88	0.00e+00	750.00
IUUC-Tre-121969	Trichoderma reesei	35.42	6.00e-73	267.00
IUUC-Tae-125484	Triticum aestivum	69.17	0.00e+00	652.00
IUUC-Tur-126128	Triticum urartu	52.63	7.00e-79	287.00
IUUC-Ttr-128701	Tursiops truncatus	38.34	9.00e-81	293.00
IUUC-Vda-129723	Verticillium dahliae	34.94	1.00e-73	270.00
IUUC-Vpa-130284	Vicugna pacos	29.71	3.00e-32	132.00
IUUC-Vvi-131037	Vitis vinifera	78.42	0.00e+00	762.00
IUUC-Xtr-132235	Xenopus tropicalis	41.52	2.00e-109	389.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence