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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063944
Ensembl Protein ID ENSMUSP00000038138.7
UniProt Accession Q80Y84; Q5DTR9; Q8BLU1; Q8JZL8; KDM5B_MOUSE
Genbank Protein ID AAL92848.1; AAL92849.1; BAD90482.1; AAH48180.1; AAH57318.1; BAC30898.1
Protein Name Lysine-specific demethylase 5B; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1
Genbank Nucleotide ID AY082429; AY082430; AK220451; BC048180; BC057318; AK041304
Gene Name Kdm5b; Jarid1b; Kiaa4034; Plu1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042207.17 ENSMUST00000047714.13 ENSMUSP00000038138.7
ENSMUSG00000042207.17 ENSMUST00000112198.2 ENSMUSP00000107817.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.60e-21 76.2 311 357
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           vCl+Cg+g +++  l+ C+ C++ +H  Cl ++   ++p+ + w CpkC 
   Q: 311  VCLLCGSGNDED-RLLLCDGCDDSYHTFCLVPP-LHDVPKGD-WRCPKCL 357
           8********988.6*******************.*******7.******5 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
 Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Protein Sequence
(Fasta)
MEPATTLPPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH KIRPIAEQTG 60
ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK LNFLDQIAKY WELQGSTLKI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063944|E3,PHD|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCAAGACGT CGTCGGAGGA AGGCTGAAAA AGCCCTAGGT GTTGCCGTTG CTAGTAGAAG 60
TCGGACCTGT CGCCCGAGCT GTGCGTCTGC ACGGGTTTCG GACGGAGCGG AGCTCGCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063944|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0034648--F:histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034647--F:histone demethylase activity (H3-trimethyl-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0044344--P:cellular response to fibroblast growth factor stimulus
GO:0034720--P:histone H3-K4 demethylation
GO:0070306--P:lens fiber cell differentiation
GO:0060763--P:mammary duct terminal end bud growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010628--P:positive regulation of gene expression
GO:0033601--P:positive regulation of mammary gland epithelial cell proliferation
GO:0009791--P:post-embryonic development
GO:0042752--P:regulation of circadian rhythm
GO:2000864--P:regulation of estradiol secretion
GO:0060992--P:response to fungicide
GO:0048511--P:rhythmic process
GO:0007338--P:single fertilization
GO:0006351--P:transcription, DNA-templated
GO:0061038--P:uterus morphogenesis
KEGG mmu:75605
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000552 Aegilops tauschii 32.20 1.00e-101 365.00
IUUC-Aml-001963 Ailuropoda melanoleuca 93.43 0.00e+00 2685.00
IUUC-Apl-003770 Anas platyrhynchos 84.79 0.00e+00 2122.00
IUUC-Aca-004867 Anolis carolinensis 81.33 0.00e+00 2481.00
IUUC-Ath-007218 Arabidopsis thaliana 35.56 3.00e-09 58.90
IUUC-Ame-010620 Astyanax mexicanus 63.15 0.00e+00 1919.00
IUUC-Bta-012733 Bos taurus 89.82 0.00e+00 2617.00
IUUC-Bdi-014050 Brachypodium distachyon 29.64 1.00e-121 432.00
IUUC-Bol-015336 Brassica oleracea 36.45 2.00e-14 76.30
IUUC-Cja-019050 Callithrix jacchus 93.71 0.00e+00 2799.00
IUUC-Cfa-021015 Canis familiaris 93.50 0.00e+00 2681.00
IUUC-Cpo-022340 Cavia porcellus 93.70 0.00e+00 2654.00
IUUC-Csa-023441 Chlorocebus sabaeus 94.12 0.00e+00 2762.00
IUUC-Cho-024823 Choloepus hoffmanni 97.48 0.00e+00 1694.00
IUUC-Cgl-026613 Colletotrichum gloeosporioides 29.77 2.00e-105 378.00
IUUC-Dre-027707 Danio rerio 61.17 0.00e+00 1828.00
IUUC-Dno-028978 Dasypus novemcinctus 93.78 0.00e+00 2753.00
IUUC-Dor-030854 Dipodomys ordii 84.64 0.00e+00 1868.00
IUUC-Ete-032760 Echinops telfairi 88.23 0.00e+00 1773.00
IUUC-Eca-034370 Equus caballus 93.77 0.00e+00 2617.00
IUUC-Eeu-035012 Erinaceus europaeus 74.92 0.00e+00 1826.00
IUUC-Fca-035494 Felis catus 93.97 0.00e+00 2690.00
IUUC-Fal-037631 Ficedula albicollis 81.96 0.00e+00 2370.00
IUUC-Gmo-039522 Gadus morhua 58.63 0.00e+00 1726.00
IUUC-Gga-040802 Gallus gallus 82.49 0.00e+00 2407.00
IUUC-Gac-041563 Gasterosteus aculeatus 61.94 0.00e+00 1854.00
IUUC-Gma-042675 Glycine max 32.71 1.00e-100 362.00
IUUC-Ggo-044856 Gorilla gorilla 76.56 0.00e+00 2095.00
IUUC-Hsa-045888 Homo sapiens 92.06 0.00e+00 2774.00
IUUC-Hvu-047583 Hordeum vulgare 37.61 8.00e-16 79.30
IUUC-Itr-048297 Ictidomys tridecemlineatus 94.37 0.00e+00 2753.00
IUUC-Lch-050483 Latimeria chalumnae 66.81 0.00e+00 2015.00
IUUC-Lpe-051537 Leersia perrieri 31.62 2.00e-92 334.00
IUUC-Loc-052550 Lepisosteus oculatus 70.61 0.00e+00 2103.00
IUUC-Laf-053761 Loxodonta africana 92.14 0.00e+00 2625.00
IUUC-Mcc-055505 Macaca mulatta 92.06 0.00e+00 2773.00
IUUC-Mga-059358 Meleagris gallopavo 81.54 0.00e+00 2386.00
IUUC-Mmr-060863 Microcebus murinus 93.93 0.00e+00 2753.00
IUUC-Mdo-061957 Monodelphis domestica 87.71 0.00e+00 2630.00
IUUC-Mac-065069 Musa acuminata 35.14 6.00e-08 54.70
IUUC-Mpu-066719 Mustela putorius furo 91.61 0.00e+00 2727.00
IUUC-Mlu-067366 Myotis lucifugus 85.40 0.00e+00 2520.00
IUUC-Nle-069256 Nomascus leucogenys 91.14 0.00e+00 2730.00
IUUC-Ont-071756 Oreochromis niloticus 61.84 0.00e+00 1877.00
IUUC-Oan-073568 Ornithorhynchus anatinus 87.80 0.00e+00 2640.00
IUUC-Ocu-073961 Oryctolagus cuniculus 91.26 0.00e+00 2689.00
IUUC-Ogl-077886 Oryza glaberrima 38.83 2.00e-16 81.60
IUUC-Olo-080668 Oryza longistaminata 38.83 5.00e-16 81.30
IUUC-Opu-083164 Oryza punctata 31.27 2.00e-88 321.00
IUUC-Osa-085487 Oryza sativa 38.83 2.00e-16 82.00
IUUC-Ola-086448 Oryzias latipes 61.34 0.00e+00 1853.00
IUUC-Oga-088501 Otolemur garnettii 89.27 0.00e+00 2292.00
IUUC-Oar-090162 Ovis aries 89.02 0.00e+00 2590.00
IUUC-Ptr-090816 Pan troglodytes 92.26 0.00e+00 2788.00
IUUC-Pan-092764 Papio anubis 94.25 0.00e+00 2768.00
IUUC-Psi-093918 Pelodiscus sinensis 81.42 0.00e+00 2180.00
IUUC-Ppa-095839 Physcomitrella patens 38.60 8.00e-16 80.50
IUUC-Pfo-096672 Poecilia formosa 61.67 0.00e+00 1816.00
IUUC-Pab-097854 Pongo abelii 91.77 0.00e+00 2135.00
IUUC-Pca-100241 Procavia capensis 88.36 0.00e+00 1738.00
IUUC-Pva-103035 Pteropus vampyrus 83.76 0.00e+00 2153.00
IUUC-Rno-105574 Rattus norvegicus 95.97 0.00e+00 2813.00
IUUC-Sce-106207 Saccharomyces cerevisiae 35.59 4.00e-74 272.00
IUUC-Sar-113477 Sorex araneus 88.49 0.00e+00 2357.00
IUUC-Ssc-116132 Sus scrofa 93.16 0.00e+00 2365.00
IUUC-Tgu-117452 Taeniopygia guttata 82.54 0.00e+00 2376.00
IUUC-Tru-117561 Takifugu rubripes 59.95 0.00e+00 1788.00
IUUC-Tsy-119271 Tarsius syrichta 92.32 0.00e+00 2112.00
IUUC-Tni-119650 Tetraodon nigroviridis 61.36 0.00e+00 1820.00
IUUC-Tur-126632 Triticum urartu 32.32 4.00e-101 363.00
IUUC-Tbe-127890 Tupaia belangeri 87.31 0.00e+00 1471.00
IUUC-Ttr-128546 Tursiops truncatus 89.43 0.00e+00 1977.00
IUUC-Vpa-130432 Vicugna pacos 87.91 0.00e+00 1531.00
IUUC-Xtr-132008 Xenopus tropicalis 70.61 0.00e+00 2112.00
Created Date 25-Jun-2017

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