iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-33	112.3	151	184
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.50e-15	54.9	356	402
UBD/Beta-Prp	2.80e-46	158.4	125	279

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  ++  +lvs+s+D+t+++WDl 
   Q: 151  GHQDVVRDLSFtpNGsLILVSASRDKTLRIWDLN 184
           8***********5446778*************85 PP

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           ++++w++++   SL+hLCR+a rr+l+++++    +LP+Pk++kd+L y+
   Q: 356  HVQFWTAPRVLSSLKHLCRKALRRFLTTYQV---LALPIPKKMKDFLTYR 402
           689****************************...**************97 PP

UBD/Beta-Prp

   S: 66   ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllv 153
           il+tg +D+ ik+w+++tg  +  l+gh+d v++lsf p+g   lvs+s+d+t+r+wdl++  +  ++lsgh ++v c +++pd+++l 
   Q: 125  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGsLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLC 213
           899************************************9967789************987666666********************** PP
   S: 154  sGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           s++  + v lW++++ +l+r+l+g h++sv s +f++++  lv++s+d++v++wd  tge +r+l+ 
   Q: 214  SAAGEKSVFLWSMRSYTLIRKLEG-HQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHH 279
           **********************99.**********************************99999875 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MEAGEEPLLL AELKPGRPHQ FDWKSSCETW SVAFSPDGSW FAWSQGHCVV KLVPWPLEEQ 60
FIPKGFEAKS RSSKNDSKGR GSLKEKTLDC GQIVWGLAFS PWPSPPSRKL WLRHHPQVPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGGGGCT GAGGCGCCCG CCGCCTGGGG CGGGCCGCGC GTCCTCATGG AGGCCGGAGG 60
TGAGTGCGGG GCGGCGACCG GGGCGGGAGC GCAGCTTTGT TTCACTTTCG CTGACAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

rno:288692

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	95.25	0.00e+00	793.00
IUUC-Apl-004107	Anas platyrhynchos	68.77	1.00e-131	462.00
IUUC-Aca-004354	Anolis carolinensis	73.07	5.00e-167	580.00
IUUC-Bta-012627	Bos taurus	95.40	0.00e+00	756.00
IUUC-Cja-018897	Callithrix jacchus	93.32	0.00e+00	754.00
IUUC-Cfa-020122	Canis familiaris	95.50	0.00e+00	793.00
IUUC-Cpo-022540	Cavia porcellus	95.14	0.00e+00	773.00
IUUC-Csa-023719	Chlorocebus sabaeus	94.59	0.00e+00	766.00
IUUC-Cho-024367	Choloepus hoffmanni	94.97	3.00e-168	583.00
IUUC-Dno-029021	Dasypus novemcinctus	96.16	0.00e+00	780.00
IUUC-Dor-030321	Dipodomys ordii	95.10	0.00e+00	766.00
IUUC-Ete-032955	Echinops telfairi	95.49	0.00e+00	765.00
IUUC-Eca-033485	Equus caballus	95.91	0.00e+00	748.00
IUUC-Fca-035389	Felis catus	95.12	0.00e+00	771.00
IUUC-Fal-037184	Ficedula albicollis	84.45	1.00e-142	498.00
IUUC-Gga-041014	Gallus gallus	77.08	6.00e-176	610.00
IUUC-Ggo-045585	Gorilla gorilla	94.88	0.00e+00	775.00
IUUC-Hsa-046344	Homo sapiens	94.88	0.00e+00	775.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	96.40	0.00e+00	778.00
IUUC-Lch-050131	Latimeria chalumnae	69.29	2.00e-165	574.00
IUUC-Loc-052807	Lepisosteus oculatus	54.68	8.00e-118	417.00
IUUC-Laf-053528	Loxodonta africana	95.40	0.00e+00	752.00
IUUC-Mcc-055665	Macaca mulatta	94.88	0.00e+00	775.00
IUUC-Meu-056054	Macropus eugenii	86.47	0.00e+00	690.00
IUUC-Mga-059326	Meleagris gallopavo	76.81	0.00e+00	628.00
IUUC-Mmr-060815	Microcebus murinus	92.58	0.00e+00	758.00
IUUC-Mdo-062000	Monodelphis domestica	90.10	0.00e+00	745.00
IUUC-Mmu-063927	Mus musculus	97.17	0.00e+00	779.00
IUUC-Mpu-065726	Mustela putorius furo	94.34	0.00e+00	762.00
IUUC-Mlu-067527	Myotis lucifugus	95.24	1.00e-117	415.00
IUUC-Nle-069680	Nomascus leucogenys	94.37	0.00e+00	766.00
IUUC-Opr-070356	Ochotona princeps	95.49	0.00e+00	785.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.64	5.00e-135	474.00
IUUC-Ocu-073973	Oryctolagus cuniculus	95.40	0.00e+00	770.00
IUUC-Oga-088797	Otolemur garnettii	94.39	0.00e+00	765.00
IUUC-Oar-089187	Ovis aries	95.40	0.00e+00	756.00
IUUC-Ptr-091317	Pan troglodytes	94.88	0.00e+00	773.00
IUUC-Pan-092694	Papio anubis	87.27	0.00e+00	658.00
IUUC-Psi-093392	Pelodiscus sinensis	79.15	0.00e+00	637.00
IUUC-Pab-098145	Pongo abelii	94.59	0.00e+00	765.00
IUUC-Pca-100454	Procavia capensis	86.97	0.00e+00	704.00
IUUC-Pva-102986	Pteropus vampyrus	86.97	0.00e+00	706.00
IUUC-Sha-106476	Sarcophilus harrisii	90.52	0.00e+00	735.00
IUUC-Ssc-115643	Sus scrofa	95.88	0.00e+00	772.00
IUUC-Tgu-117522	Taeniopygia guttata	64.04	3.00e-135	474.00
IUUC-Tsy-119301	Tarsius syrichta	94.99	0.00e+00	788.00
IUUC-Ttr-128683	Tursiops truncatus	95.88	0.00e+00	772.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence