iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116750.13	ENST00000367455.8	ENSP00000356425.3
ENSG00000116750.13	ENST00000420791.5	ENSP00000408720.1
ENSG00000116750.13	ENST00000367454.5	ENSP00000356424.1
ENSG00000116750.13	ENST00000449480.5	ENSP00000402847.1
ENSG00000116750.13	ENST00000367450.7	ENSP00000356420.3
ENSG00000116750.13	ENST00000367451.8	ENSP00000356421.4
ENSG00000116750.13	ENST00000367448.5	ENSP00000356418.1
ENSG00000116750.13	ENST00000367449.5	ENSP00000356419.1
ENSG00000116750.13	ENST00000443327.5	ENSP00000391153.1
ENSG00000116750.13	ENST00000416915.1	ENSP00000392416.1
ENSG00000116750.13	ENST00000421683.1	ENSP00000389563.1
ENSG00000116750.13	ENST00000417752.1	ENSP00000412265.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Drug and target
Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	20829789; 21187158; 19489724

Classification

Family	E-value	Score	Start	End
DUB/UCH	3.20e-101	340.8	1	321

Active Site

Position(s)	Description	Evidence
88	Nucleophile	ECO:0000305}
164	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffak 92
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffak
   Q: 1    MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAK 81
           788999************************.****************.********************.........899************ PP
   S: 93   qvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyv 184
           qvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ +++++++    +++afhfvsyv
   Q: 82   QVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAK----EEDAFHFVSYV 169
           **************************************************************************888....79********* PP
   S: 185  ningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlk 267
           ++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +          +  ++l+
   Q: 170  PVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmdtDQGNSMLS 258
           ********************9.78999*********..******************************976666677888888744569*** PP
   S: 268  dieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
           +i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 259  AIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 321
           *******************************************************993...33344 PP

Organism

Homo sapiens

Functional Description
(View)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Protein Sequence
(Fasta)

MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCCTCTC GACGTCGGCC TGTGGGGAGC GATGCCGACA AGCAGGAGCG GTCCCGGCTT 60
CGGAAAGGGC CCACCCTGAG GAATGGTCCG GCCGGGCCTA GCGAGGATGT CCCTACCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031597--C:cytosolic proteasome complex
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004866--F:endopeptidase inhibitor activity
GO:0070628--F:proteasome binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:51377

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.59	6.00e-85	307.00
IUUC-Aml-001866	Ailuropoda melanoleuca	99.36	0.00e+00	650.00
IUUC-Atr-002966	Amborella trichopoda	46.84	5.00e-80	291.00
IUUC-Apl-003306	Anas platyrhynchos	85.47	4.00e-176	610.00
IUUC-Aca-004763	Anolis carolinensis	94.86	9.00e-179	619.00
IUUC-Aly-005581	Arabidopsis lyrata	48.33	6.00e-80	290.00
IUUC-Ath-007283	Arabidopsis thaliana	48.63	5.00e-83	301.00
IUUC-Ago-007999	Ashbya gossypii	33.33	2.00e-33	136.00
IUUC-Acl-008231	Aspergillus clavatus	43.57	7.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	37.91	4.00e-55	207.00
IUUC-Afu-008988	Aspergillus fumigatus	45.00	1.00e-54	206.00
IUUC-Ani-009420	Aspergillus nidulans	37.93	5.00e-53	201.00
IUUC-Ang-009859	Aspergillus niger	40.82	1.00e-49	189.00
IUUC-Aor-010145	Aspergillus oryzae	37.91	4.00e-55	207.00
IUUC-Ate-010347	Aspergillus terreus	42.13	1.00e-53	203.00
IUUC-Ame-010791	Astyanax mexicanus	89.67	0.00e+00	627.00
IUUC-Bgr-012298	Blumeria graminis	37.83	1.00e-49	189.00
IUUC-Bta-013251	Bos taurus	98.40	0.00e+00	640.00
IUUC-Bci-013786	Botrytis cinerea	38.05	4.00e-58	218.00
IUUC-Bdi-014132	Brachypodium distachyon	49.54	3.00e-82	298.00
IUUC-Bol-015611	Brassica oleracea	49.70	1.00e-84	306.00
IUUC-Bra-017769	Brassica rapa	49.70	1.00e-84	306.00
IUUC-Cel-018604	Caenorhabditis elegans	47.13	2.00e-81	295.00
IUUC-Cja-019768	Callithrix jacchus	91.20	0.00e+00	632.00
IUUC-Cfa-020207	Canis familiaris	99.36	0.00e+00	650.00
IUUC-Cpo-021925	Cavia porcellus	95.21	5.00e-179	619.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.21	2.00e-74	272.00
IUUC-Csa-023958	Chlorocebus sabaeus	99.68	0.00e+00	646.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	54.18	8.00e-100	357.00
IUUC-Csv-026149	Ciona savignyi	57.68	1.00e-102	365.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.87	5.00e-52	197.00
IUUC-Cne-026955	Cryptococcus neoformans	37.57	6.00e-55	207.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.06	4.00e-48	185.00
IUUC-Dre-027409	Danio rerio	88.75	7.00e-178	616.00
IUUC-Dno-028921	Dasypus novemcinctus	98.72	0.00e+00	645.00
IUUC-Dse-031170	Dothistroma septosporum	39.68	3.00e-59	222.00
IUUC-Dme-031677	Drosophila melanogaster	59.76	2.00e-115	408.00
IUUC-Ete-032707	Echinops telfairi	68.65	7.00e-119	420.00
IUUC-Eca-033776	Equus caballus	98.96	4.00e-171	593.00
IUUC-Eeu-035305	Erinaceus europaeus	78.72	3.00e-83	301.00
IUUC-Fca-035846	Felis catus	91.47	0.00e+00	632.00
IUUC-Fal-037597	Ficedula albicollis	95.14	2.00e-158	551.00
IUUC-Fox-037670	Fusarium oxysporum	43.18	3.00e-56	211.00
IUUC-Fso-038243	Fusarium solani	43.14	2.00e-55	209.00
IUUC-Gmo-038499	Gadus morhua	83.71	4.00e-161	560.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	2.00e-48	186.00
IUUC-Gga-040904	Gallus gallus	94.19	0.00e+00	644.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.50	2.00e-170	591.00
IUUC-Gma-043030	Glycine max	48.52	4.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	94.14	3.00e-172	597.00
IUUC-Hvu-047359	Hordeum vulgare	46.99	4.00e-83	301.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.83	0.00e+00	628.00
IUUC-Lch-049829	Latimeria chalumnae	92.01	1.00e-174	605.00
IUUC-Lpe-050899	Leersia perrieri	48.90	6.00e-79	287.00
IUUC-Loc-052264	Lepisosteus oculatus	90.13	2.00e-172	598.00
IUUC-Lma-053110	Leptosphaeria maculans	38.74	9.00e-49	187.00
IUUC-Laf-053639	Loxodonta africana	99.36	0.00e+00	650.00
IUUC-Mcc-055506	Macaca mulatta	99.68	0.00e+00	646.00
IUUC-Mor-057001	Magnaporthe oryzae	46.41	3.00e-55	208.00
IUUC-Mpo-057608	Magnaporthe poae	41.18	3.00e-33	134.00
IUUC-Mtr-057731	Medicago truncatula	49.25	2.00e-85	308.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	2.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	94.74	7.00e-173	599.00
IUUC-Mvi-060353	Microbotryum violaceum	38.21	4.00e-54	204.00
IUUC-Mmr-060738	Microcebus murinus	99.36	0.00e+00	650.00
IUUC-Mdo-062266	Monodelphis domestica	97.55	4.00e-120	423.00
IUUC-Mmu-063619	Mus musculus	96.81	0.00e+00	638.00
IUUC-Mac-065301	Musa acuminata	50.16	3.00e-88	318.00
IUUC-Mpu-066058	Mustela putorius furo	99.04	0.00e+00	649.00
IUUC-Mlu-067292	Myotis lucifugus	97.76	0.00e+00	635.00
IUUC-Nfi-068275	Neosartorya fischeri	37.82	1.00e-55	210.00
IUUC-Ncr-068713	Neurospora crassa	38.99	2.00e-58	219.00
IUUC-Nle-069013	Nomascus leucogenys	99.36	0.00e+00	644.00
IUUC-Opr-070628	Ochotona princeps	86.47	2.00e-170	592.00
IUUC-Ont-072688	Oreochromis niloticus	89.21	4.00e-171	593.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.93	2.00e-141	494.00
IUUC-Ocu-074303	Oryctolagus cuniculus	99.04	0.00e+00	649.00
IUUC-Oba-075002	Oryza barthii	48.80	6.00e-82	297.00
IUUC-Obr-076392	Oryza brachyantha	48.90	8.00e-80	290.00
IUUC-Ogl-077271	Oryza glaberrima	48.80	6.00e-82	297.00
IUUC-Ogu-078493	Oryza glumaepatula	48.80	1.00e-82	299.00
IUUC-Oin-080084	Oryza indica	48.80	1.00e-82	299.00
IUUC-Olo-080803	Oryza longistaminata	48.49	3.00e-82	298.00
IUUC-Ome-081146	Oryza meridionalis	47.89	4.00e-81	295.00
IUUC-Oni-082146	Oryza nivara	48.80	1.00e-82	299.00
IUUC-Opu-083633	Oryza punctata	49.53	1.00e-78	286.00
IUUC-Oru-084789	Oryza rufipogon	48.80	1.00e-82	299.00
IUUC-Osa-086196	Oryza sativa	48.80	1.00e-82	299.00
IUUC-Ola-087126	Oryzias latipes	89.46	1.00e-167	582.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.01	2.00e-69	256.00
IUUC-Oga-089140	Otolemur garnettii	91.47	0.00e+00	635.00
IUUC-Oar-090296	Ovis aries	98.08	0.00e+00	641.00
IUUC-Ptr-090566	Pan troglodytes	100.00	0.00e+00	654.00
IUUC-Pan-092052	Papio anubis	99.68	0.00e+00	645.00
IUUC-Psi-093723	Pelodiscus sinensis	94.79	1.00e-164	572.00
IUUC-Pma-094568	Petromyzon marinus	61.46	9.00e-107	379.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.34	2.00e-50	192.00
IUUC-Ppa-095761	Physcomitrella patens	47.37	9.00e-84	303.00
IUUC-Pfo-096210	Poecilia formosa	89.14	6.00e-172	596.00
IUUC-Pab-098463	Pongo abelii	100.00	0.00e+00	653.00
IUUC-Pop-099423	Populus trichocarpa	49.26	6.00e-85	307.00
IUUC-Pca-100108	Procavia capensis	97.15	2.00e-142	498.00
IUUC-Ppe-101176	Prunus persica	51.20	3.00e-86	311.00
IUUC-Pva-102629	Pteropus vampyrus	95.80	7.00e-149	520.00
IUUC-Pgr-103419	Puccinia graminis	39.64	1.00e-56	213.00
IUUC-Pte-104207	Pyrenophora teres	44.97	2.00e-33	134.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.67	2.00e-57	216.00
IUUC-Rno-105579	Rattus norvegicus	87.00	2.00e-163	568.00
IUUC-Sha-106894	Sarcophilus harrisii	93.48	9.00e-155	539.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	38.87	3.00e-59	222.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.91	2.00e-59	222.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.77	5.00e-48	184.00
IUUC-Smo-109396	Selaginella moellendorffii	51.38	2.00e-88	319.00
IUUC-Sit-110630	Setaria italica	49.24	1.00e-85	309.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	6.00e-81	293.00
IUUC-Stu-112185	Solanum tuberosum	50.90	4.00e-89	321.00
IUUC-Sar-113294	Sorex araneus	82.34	2.00e-164	571.00
IUUC-Sbi-113951	Sorghum bicolor	49.54	4.00e-86	311.00
IUUC-Ssc-115501	Sus scrofa	97.64	4.00e-174	603.00
IUUC-Tgu-117152	Taeniopygia guttata	94.79	2.00e-158	551.00
IUUC-Tru-118388	Takifugu rubripes	88.18	1.00e-170	592.00
IUUC-Tsy-119109	Tarsius syrichta	99.68	0.00e+00	651.00
IUUC-Tni-120048	Tetraodon nigroviridis	88.18	3.00e-171	594.00
IUUC-Tca-121750	Theobroma cacao	49.11	2.00e-88	319.00
IUUC-Tre-122130	Trichoderma reesei	39.33	2.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	39.53	6.00e-53	201.00
IUUC-Tae-124082	Triticum aestivum	47.59	2.00e-83	302.00
IUUC-Tur-126366	Triticum urartu	43.25	3.00e-66	246.00
IUUC-Tme-127187	Tuber melanosporum	40.92	2.00e-58	219.00
IUUC-Tbe-127619	Tupaia belangeri	89.90	1.00e-144	505.00
IUUC-Ttr-128867	Tursiops truncatus	87.76	7.00e-124	436.00
IUUC-Vda-129912	Verticillium dahliae	37.16	6.00e-53	201.00
IUUC-Vpa-130552	Vicugna pacos	99.52	4.00e-126	444.00
IUUC-Vvi-130881	Vitis vinifera	50.74	2.00e-84	306.00
IUUC-Xtr-131934	Xenopus tropicalis	85.41	1.00e-173	601.00
IUUC-Xma-133312	Xiphophorus maculatus	89.14	8.00e-172	595.00
IUUC-Yli-134487	Yarrowia lipolytica	40.34	2.00e-48	186.00
IUUC-Zma-135462	Zea mays	43.69	1.00e-71	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence