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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105100
UUCD1 version UUC-RaN-01068
Ensembl Protein ID ENSRNOP00000042897.5
UniProt Accession Q5D006; F7FEA4; Q0D2L8; UBP11_RAT
Genbank Protein ID EDL97708.1; AAH90333.1; AAI05614.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11
Genbank Nucleotide ID AC120727; BC090333; BC105613
Gene Name Usp11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009049.7 ENSRNOT00000051956.5 ENSRNOP00000042897.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
HINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 8.20e-112 374.1 257 889
Active Site
Position(s) Description Evidence
266 Nucleophile ECO:0000255|PROSITE-ProRule:PRU01035}
847 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU01035}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS+LQcLsn+p+l+e++l+ ++ e+ln +np ++kgel++++++l+++ w++ ++++ p+ ++++++++a++f gy+
   Q: 257  CGLTNLGNTCFMNSALQCLSNVPQLTEYFLNnRYLEELNFRNPLGMKGELAEAYADLVKQTWSGYHRSIVPNVFKNKVGHFASQFLGYQ 345
           7******************************99******************************************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           q+D+qE+l+flld+l+e+l++ k+k++ e+++ +   + e  +ea++++k++n+s+i+d+F+g +ks+++c++c+nvs++++pf++ls+
   Q: 346  QHDSQELLSFLLDGLHEDLNRVKKKEYVELCNGAgrpDLEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSV 434
           *****************************998761113455666********************************************* PP
   S: 175  pvpgkeetkke.............................................................................. 185
           p+p  + + +e                                                                              
   Q: 435  PLPVCSRRVLEvffvpmdprrkpeqhrvvvpkkgnisdlcvalsthtsvapdkmivadvfshrfyklyqledplsgildrddifvyevt 523
           ****9998888****************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 524  griepvegsrddivvpvylrertpsrdynnsyyglilfghpllvsvprdrfsweglynilmyrlsryvtkptsddddgdekgdeneded 612
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 613  veddssseeekeemsgptdndgtqeseqeqagtssgvtgrcpslldnslhtsqwpprrrrkqlftlqtvnsngtsdrttspeeaqtqpy 701
           ***************************************************************************************** PP
   S: 186  .....................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf 237
                                                +l++c++ ft+ e+le+en +yc++ck++q a+kkl+l+ lPevLi+hLkRf
   Q: 702  iamdwepemkrryydeveaegyvkhdcvgymlkknpvQLKECIKLFTTVETLEKENPWYCSSCKQHQLATKKLDLWMLPEVLIIHLKRF 790
           ***************************************************************************************** PP
   S: 238  sfseeqksrekinkkvefple.Ldlspfctspeekqke.kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevl 323
           sfs+   srek+++ v+fp++ Ld s+f+++p+++++   +kY+Liav +H+G+++ GHY++++ n ++g+W +fdD++V++v+e++++
   Q: 791  SFSK--FSREKLDTLVQFPIRdLDFSEFVIKPKNESAPdLYKYDLIAVSNHYGGMRDGHYTTFACNkDSGQWHYFDDNSVSPVNENQIE 877
           9977..799*********************99988765489*********************988834566****************** PP
   S: 324  eetgstaYvlfYkrr 338
           +   + aYvlfY+r+
   Q: 878  S---KAAYVLFYQRQ 889
           *...*********96 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex.
Protein Sequence
(Fasta)
MAAVAADPAA AAVPASAEDR ETQPEAMPDL DQQWRQIGNG RERPLRAGES WFLVEKHWYK 60
QWEAYVKGGD QDASTFPGSI NNSGLFEDQI SWHLRERLVE GDDYVLLPAP AWNYLVSWYG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105100|DUB,USP|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCGTCTTCC TATCTTCAGT TGCGTCGGCA GTTGGAGGAG GACGGACGGT GATGGCGGCG 60
GTCGCAGCGG ACCCAGCTGC AGCTGCCGTC CCGGCCTCTG CTGAGGACAG AGAGACACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105100|DUB,USP|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
SMART

SM00695--DUSP
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:408217
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001760 Ailuropoda melanoleuca 76.34 0.00e+00 1409.00
IUUC-Aca-004532 Anolis carolinensis 61.59 0.00e+00 1110.00
IUUC-Bta-013284 Bos taurus 75.08 0.00e+00 1390.00
IUUC-Cel-018257 Caenorhabditis elegans 33.04 2.00e-95 344.00
IUUC-Cja-019746 Callithrix jacchus 81.84 0.00e+00 1488.00
IUUC-Cfa-020134 Canis familiaris 77.31 0.00e+00 1434.00
IUUC-Cpo-022535 Cavia porcellus 82.36 0.00e+00 1531.00
IUUC-Csa-023828 Chlorocebus sabaeus 82.41 0.00e+00 1514.00
IUUC-Dre-027398 Danio rerio 60.78 0.00e+00 734.00
IUUC-Dno-028853 Dasypus novemcinctus 77.26 0.00e+00 1224.00
IUUC-Dor-030384 Dipodomys ordii 85.46 0.00e+00 1547.00
IUUC-Eca-033271 Equus caballus 77.84 0.00e+00 1400.00
IUUC-Fca-036012 Felis catus 76.54 0.00e+00 1443.00
IUUC-Gac-042574 Gasterosteus aculeatus 52.47 0.00e+00 865.00
IUUC-Hsa-046551 Homo sapiens 82.52 0.00e+00 1516.00
IUUC-Itr-048915 Ictidomys tridecemlineatus 85.08 0.00e+00 1534.00
IUUC-Laf-054561 Loxodonta africana 74.37 0.00e+00 1402.00
IUUC-Mcc-054881 Macaca mulatta 82.07 0.00e+00 1511.00
IUUC-Meu-056749 Macropus eugenii 75.19 0.00e+00 863.00
IUUC-Mmr-061400 Microcebus murinus 82.61 0.00e+00 1515.00
IUUC-Mmu-063241 Mus musculus 96.35 0.00e+00 1729.00
IUUC-Mpu-066507 Mustela putorius furo 76.81 0.00e+00 1449.00
IUUC-Mlu-066961 Myotis lucifugus 71.65 0.00e+00 1314.00
IUUC-Nle-069284 Nomascus leucogenys 82.52 0.00e+00 1517.00
IUUC-Ont-071847 Oreochromis niloticus 55.96 0.00e+00 959.00
IUUC-Oan-073387 Ornithorhynchus anatinus 67.40 0.00e+00 1150.00
IUUC-Ocu-074066 Oryctolagus cuniculus 82.57 0.00e+00 1497.00
IUUC-Oga-088424 Otolemur garnettii 82.97 0.00e+00 1520.00
IUUC-Oar-089732 Ovis aries 76.22 0.00e+00 1369.00
IUUC-Pan-092292 Papio anubis 81.06 0.00e+00 1515.00
IUUC-Pab-098779 Pongo abelii 74.89 0.00e+00 1299.00
IUUC-Pca-100851 Procavia capensis 77.38 0.00e+00 828.00
IUUC-Pva-103244 Pteropus vampyrus 75.55 0.00e+00 1390.00
IUUC-Ptt-103847 Puccinia triticina 36.22 1.00e-62 235.00
IUUC-Sha-107502 Sarcophilus harrisii 73.97 0.00e+00 853.00
IUUC-Ssc-116345 Sus scrofa 76.78 0.00e+00 1454.00
IUUC-Tsy-119414 Tarsius syrichta 74.65 0.00e+00 1062.00
IUUC-Tbe-128081 Tupaia belangeri 83.43 0.00e+00 948.00
Created Date 25-Jun-2017

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