iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0029903	FBtr0070964	FBpp0070925
FBgn0029903	FBtr0112956	FBpp0111869
FBgn0029903	FBtr0308228	FBpp0300548

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-27	94.6	77	111
UBD/Beta-Prp	3.30e-43	148.0	68	296

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           gHtd vt+l+f   +d+ll+++s D+ +k+W + +
   Q: 77   GHTDTVTDLKFspfHDGLLATASQDCLVKIWHIPE 111
           8************988***************8655 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllr 173
           ++k++  l+gh+d+v++l+fsp  +  l+++s+d  +++w+++++   ++      ++s +++ v +v +hp+++ l+ +++ ++v l+dl+t+k + 
   Q: 68   KSKTMPLLHGHTDTVTDLKFSPfHDGLLATASQDCLVKIWHIPEKGLEQSlsdpeaIFSHKQRRVETVGFHPTADGLMYSTAAGCVALFDLSTQKEIF 165
           6789999***************888*******************988888999********************************************* PP
   S: 174  tltgghtdsvyslsfdsngkelvsgsldgtvklwdlq.tgecvr.tlnghtdnvksvrfs.pnderlvsgs....sDgsiriWdlrs.gdllktlqlh 263
              + h + ++s s++++g  l++  +d+ v+++d + +g+ ++ t + h++   s  ++  n++r+++++      +++ i d+r+ +++ ktl+l 
   Q: 166  SNNE-HPEVIQSASWREDGSVLATSCKDKNVRIFDPRaAGSPIQlTAESHQSIKDSRVVWlGNQHRILTTGfdaaRLRQVIIRDVRNfNTPEKTLELD 262
           **99.********************************9777665266777777777777799*********544444778888*99946689****** PP
   S: 264  nssvisvavlsfgdnvlvlgse.dskvniwklkk 296
            s+ i + +++++ n+l+l+++ d ++n+++ + 
   Q: 263  CSTGILMPLFDPDTNMLFLAGKgDTTINYLEITD 296
           ******************99999*****999875 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAWRFKASKY KNAAPIVPKA EACVREICVG SYQTYGNNIA ASGAFMAFNW EHTGSSVAVL 60
PLDDCGRKSK TMPLLHGHTD TVTDLKFSPF HDGLLATASQ DCLVKIWHIP EKGLEQSLSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGATGGA AACTATCGAT AGACGATGAC AAAACGTTTG AAAAAAAGTT GAAGATCTCT 60
CGCGTAGTTT ATTGATTGCA TTGGTAATTT AATTGCAATA TTTGTAATTA CAAGCGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR027331--CORO7
IPR015505--Coronin
IPR015048--DUF1899
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF08953--DUF1899
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0031594--C:neuromuscular junction
GO:0005886--C:plasma membrane
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0008017--F:microtubule binding
GO:0030674--F:protein binding, bridging
GO:0031532--P:actin cytoskeleton reorganization
GO:0097113--P:AMPA glutamate receptor clustering
GO:0007411--P:axon guidance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002235	Ailuropoda melanoleuca	43.90	1.00e-108	386.00
IUUC-Aca-005201	Anolis carolinensis	45.73	7.00e-115	407.00
IUUC-Bta-012843	Bos taurus	44.28	1.00e-116	413.00
IUUC-Cel-018204	Caenorhabditis elegans	36.52	6.00e-73	268.00
IUUC-Cja-019024	Callithrix jacchus	43.75	5.00e-115	408.00
IUUC-Cfa-020626	Canis familiaris	43.97	8.00e-109	387.00
IUUC-Cpo-022429	Cavia porcellus	44.35	1.00e-112	400.00
IUUC-Csa-023919	Chlorocebus sabaeus	42.76	1.00e-105	377.00
IUUC-Cin-025202	Ciona intestinalis	44.20	2.00e-115	409.00
IUUC-Csv-026236	Ciona savignyi	43.87	3.00e-115	408.00
IUUC-Dre-028759	Danio rerio	46.92	5.00e-122	431.00
IUUC-Dno-029234	Dasypus novemcinctus	37.41	1.00e-73	270.00
IUUC-Dor-030242	Dipodomys ordii	43.88	6.00e-114	404.00
IUUC-Ete-032862	Echinops telfairi	46.84	2.00e-106	379.00
IUUC-Eca-033902	Equus caballus	40.64	4.00e-99	355.00
IUUC-Fca-036335	Felis catus	43.25	2.00e-112	399.00
IUUC-Fal-037278	Ficedula albicollis	45.97	3.00e-122	432.00
IUUC-Gmo-038846	Gadus morhua	48.14	2.00e-121	429.00
IUUC-Gga-041144	Gallus gallus	42.86	8.00e-106	377.00
IUUC-Gac-041680	Gasterosteus aculeatus	46.14	6.00e-120	424.00
IUUC-Ggo-045469	Gorilla gorilla	37.98	2.00e-82	300.00
IUUC-Hsa-046873	Homo sapiens	43.20	2.00e-105	376.00
IUUC-Itr-048351	Ictidomys tridecemlineatus	44.54	2.00e-114	406.00
IUUC-Loc-052682	Lepisosteus oculatus	46.71	3.00e-126	445.00
IUUC-Laf-053869	Loxodonta africana	41.84	4.00e-62	232.00
IUUC-Mcc-054896	Macaca mulatta	42.55	2.00e-105	376.00
IUUC-Meu-056428	Macropus eugenii	42.55	4.00e-109	388.00
IUUC-Mga-059389	Meleagris gallopavo	45.26	1.00e-115	410.00
IUUC-Mmr-060935	Microcebus murinus	44.19	1.00e-111	397.00
IUUC-Mdo-062707	Monodelphis domestica	42.12	5.00e-109	388.00
IUUC-Mmu-063976	Mus musculus	45.26	4.00e-120	424.00
IUUC-Mpu-066441	Mustela putorius furo	44.28	2.00e-106	379.00
IUUC-Mlu-067524	Myotis lucifugus	44.30	4.00e-116	412.00
IUUC-Opr-071099	Ochotona princeps	43.04	5.00e-110	391.00
IUUC-Ont-071673	Oreochromis niloticus	44.16	5.00e-119	421.00
IUUC-Oan-072860	Ornithorhynchus anatinus	42.17	5.00e-101	361.00
IUUC-Ocu-074794	Oryctolagus cuniculus	43.94	2.00e-106	379.00
IUUC-Ola-086479	Oryzias latipes	44.78	6.00e-127	447.00
IUUC-Oga-088030	Otolemur garnettii	43.76	2.00e-104	372.00
IUUC-Oar-090379	Ovis aries	43.20	2.00e-109	389.00
IUUC-Ptr-091006	Pan troglodytes	40.17	5.00e-90	325.00
IUUC-Pan-092428	Papio anubis	42.76	2.00e-105	376.00
IUUC-Pfo-096558	Poecilia formosa	44.89	1.00e-126	446.00
IUUC-Pab-098298	Pongo abelii	43.49	5.00e-74	272.00
IUUC-Pca-100305	Procavia capensis	51.82	3.00e-73	269.00
IUUC-Pva-102702	Pteropus vampyrus	44.75	1.00e-115	410.00
IUUC-Rno-105934	Rattus norvegicus	44.87	1.00e-125	443.00
IUUC-Sha-106795	Sarcophilus harrisii	41.34	3.00e-105	375.00
IUUC-Sar-112987	Sorex araneus	51.70	2.00e-68	252.00
IUUC-Ssc-116071	Sus scrofa	44.92	2.00e-117	416.00
IUUC-Tgu-116813	Taeniopygia guttata	50.15	6.00e-93	333.00
IUUC-Tru-118359	Takifugu rubripes	45.73	3.00e-127	448.00
IUUC-Tni-119997	Tetraodon nigroviridis	47.11	1.00e-129	456.00
IUUC-Ttr-129020	Tursiops truncatus	43.41	8.00e-114	404.00
IUUC-Xtr-132552	Xenopus tropicalis	45.18	5.00e-89	320.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence