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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018522
UUCD1 version UUC-CaE-00436
Ensembl Protein ID ZK856.1
UniProt Accession Q23639; CUL5_CAEEL
Genbank Protein ID CAA94852.2
Protein Name Cullin-5
Genbank Nucleotide ID Z70783
Gene Name cul-5; ZK856.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000840 ZK856.1 ZK856.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 1.30e-161 539.7 12 657
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 4    eavkkilrqesv.kkeyeelytavynlclsk..vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlkvlrkifayldrtyvkk...s 98
            +v+++l+q+sv  + +++l+ +vy++ ++   +  k+ + l   +++++++++k++ + + +  lL  y++eW++f +q+++l+ +f+ +d +  ++   +
   Q: 12   PIVHALLHQKSVtPAAWQDLFYHVYKITSWVddGPLKIRDILTRCINDYVHEANKRIRSLQTDGsLLIGYIKEWNRFYQQANILPLPFKKIDESSRRRsvpE 113
           689**************************988899******************999999876666*****************************99885544 PP
   S: 99   kkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk....laiykesFEakfleatqefykaesaeflqenevdeY 196
           +  +++r+++l++w++ i+ +i+++ll  +l+l+++eR+g+++d++ + g++es+v L   +    l +y++sFE +f e+t e+yk+   ++l+e +v eY
   Q: 114  TPEESIRTVMLEKWNEIIFMNISEQLLVEALRLVKEERDGNIIDAQNVIGIRESFVALNDRAgedpLLVYRQSFERQFIEQTTEYYKKICGNLLNELGVLEY 215
           555*******************************************************76669999************************************ PP
   S: 197  lkkvearlneeeeraaryleestetk..LlevvekeliakhlesllaelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeeke 294
           + +++++l+ee++ra+ryle  + t+   +e+ + +l++++ +++lae+ +l+ +k  e+l+r+y+L++r + g++++lk++ +hi+++g++++   ae+ +
   Q: 216  MVYADKKLEEEQQRAKRYLEMNSPTSgkHMEKAVIALVESFEDTILAECSKLIASKDVERLQRLYRLIRRTRSGIDTVLKCIDTHIRTEGLNDMRnnAENLS 317
           *******************988766544888889999**********************************************************8778889 PP
   S: 295  kdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka.............akspEllAryiDqlLrks..skglteeeleaqldkvll 381
           +dp+ yV++ll +++k+++lv+e F +da+ l+a+dkaf+++vn+ s++k+             +k++EllA+y+D lLrk+  sk+lt+ee++++l++vll
   Q: 318  TDPERYVQQLLLMFDKFSSLVREGFCDDARLLTARDKAFRAVVNDSSIFKTemmnkkgrtlsveSKCAELLANYCDLLLRKTqlSKKLTSEEIDEKLNQVLL 419
           9***************************************************************************************************** PP
   S: 382  vfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeec.gaeftskLerMfqdlkvSedlnrqFkeeke..nteesesvelsvlvLsagaWpta. 479
           v+ky+++kdvF+++++ hL++RL++++sa++e+Ee +++kL+e + + + ++kL+rM+qd+++ +d+n  Fk+  +  n+++s +++++++vL+ gaW +  
   Q: 420  VLKYVENKDVFMRFHRAHLSRRLILEMSADQEKEEMMVTKLRECGmPSDAVNKLSRMLQDIELNKDMNSSFKKALTgtNNNKSIADSINMKVLNGGAWGRGg 521
           *****************************************9988999************************876511555667789**************9 PP
   S: 480  setekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkg.kyelqVstfQmavLLafnns..ekvsveelkkatelpeeeLrrtlqsLvs. 577
           se+ ++sLP ele+ +++ e+fY+++h+gRkL W h+ +++++ +  ++g +++l+ +tfQmavL+ fn++  +k+s+e+l+ atelp++eL+rtl sLv+ 
   Q: 522  SERIRFSLPRELEDFVPEMEAFYKKQHNGRKLCWMHHWSSGTMVFGTANGgRFDLECTTFQMAVLFCFNDRahDKISLETLRLATELPDAELNRTLLSLVAy 623
           99999****************************************887766********************99****************************9 PP
   S: 578  sk..kqvlkkepeske.....ieeedlfsvNqef 604
           +k   q+l  +  s+      +++ ++f +N++f
   Q: 624  PKmrYQILLCDVPSTTvtardFTDSTKFLINHDF 657
           999977777766554445566**********998 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline.
 Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline.
Protein Sequence
(Fasta)
MQFDEEWSKA DPIVHALLHQ KSVTPAAWQD LFYHVYKITS WVDDGPLKIR DILTRCINDY 60
VHEANKRIRS LQTDGSLLIG YIKEWNRFYQ QANILPLPFK KIDESSRRRS VPETPEESIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018522|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAGGTCTCG GAGAGAGAGA CCATCAGAAT ATGCAATTCG ACGAAGAATG GAGCAAAGCC 60
GATCCAATTG TACATGCACT TCTGCATCAG AAAGTTAGTT TCATTCGTCT CAACGTAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018522|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG cel:CELE_ZK856.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002082 Ailuropoda melanoleuca 51.48 0.00e+00 726.00
IUUC-Apl-003564 Anas platyrhynchos 51.61 0.00e+00 729.00
IUUC-Aca-004319 Anolis carolinensis 51.61 0.00e+00 729.00
IUUC-Ame-011742 Astyanax mexicanus 51.29 0.00e+00 726.00
IUUC-Bta-012515 Bos taurus 51.70 0.00e+00 717.00
IUUC-Cja-018785 Callithrix jacchus 51.29 0.00e+00 726.00
IUUC-Cfa-020932 Canis familiaris 52.02 0.00e+00 719.00
IUUC-Cpo-022317 Cavia porcellus 51.22 0.00e+00 726.00
IUUC-Csa-023949 Chlorocebus sabaeus 51.35 0.00e+00 726.00
IUUC-Cin-025540 Ciona intestinalis 57.80 5.00e-111 392.00
IUUC-Csv-025978 Ciona savignyi 48.83 0.00e+00 691.00
IUUC-Dre-027958 Danio rerio 51.48 0.00e+00 741.00
IUUC-Dno-029195 Dasypus novemcinctus 51.35 0.00e+00 725.00
IUUC-Dor-030573 Dipodomys ordii 50.43 1.00e-90 326.00
IUUC-Dme-032083 Drosophila melanogaster 52.20 0.00e+00 669.00
IUUC-Ete-032428 Echinops telfairi 47.23 2.00e-150 525.00
IUUC-Eca-033232 Equus caballus 51.22 0.00e+00 724.00
IUUC-Eeu-035348 Erinaceus europaeus 59.44 4.00e-122 431.00
IUUC-Fca-035401 Felis catus 51.61 0.00e+00 714.00
IUUC-Fal-037514 Ficedula albicollis 51.61 0.00e+00 729.00
IUUC-Gmo-038577 Gadus morhua 50.13 0.00e+00 712.00
IUUC-Gga-041096 Gallus gallus 51.61 0.00e+00 728.00
IUUC-Gac-042108 Gasterosteus aculeatus 50.77 0.00e+00 716.00
IUUC-Ggo-045313 Gorilla gorilla 51.35 0.00e+00 726.00
IUUC-Hsa-045974 Homo sapiens 51.35 0.00e+00 726.00
IUUC-Itr-049009 Ictidomys tridecemlineatus 51.35 0.00e+00 725.00
IUUC-Lch-050615 Latimeria chalumnae 51.70 0.00e+00 715.00
IUUC-Loc-051807 Lepisosteus oculatus 51.55 0.00e+00 729.00
IUUC-Laf-053601 Loxodonta africana 51.35 0.00e+00 725.00
IUUC-Mcc-055260 Macaca mulatta 51.35 0.00e+00 724.00
IUUC-Meu-056632 Macropus eugenii 48.94 2.00e-111 394.00
IUUC-Mga-059658 Meleagris gallopavo 51.35 0.00e+00 728.00
IUUC-Mmr-061424 Microcebus murinus 47.23 0.00e+00 635.00
IUUC-Mdo-061836 Monodelphis domestica 51.35 0.00e+00 729.00
IUUC-Mmu-063757 Mus musculus 51.35 0.00e+00 723.00
IUUC-Mpu-065823 Mustela putorius furo 51.67 0.00e+00 728.00
IUUC-Mlu-066969 Myotis lucifugus 51.22 0.00e+00 723.00
IUUC-Nle-069943 Nomascus leucogenys 51.35 0.00e+00 726.00
IUUC-Opr-070820 Ochotona princeps 48.86 2.00e-101 362.00
IUUC-Ont-072527 Oreochromis niloticus 51.16 0.00e+00 726.00
IUUC-Oan-072743 Ornithorhynchus anatinus 51.96 0.00e+00 721.00
IUUC-Ocu-074586 Oryctolagus cuniculus 51.35 0.00e+00 726.00
IUUC-Ola-087526 Oryzias latipes 51.03 0.00e+00 724.00
IUUC-Oga-088425 Otolemur garnettii 48.59 0.00e+00 704.00
IUUC-Oar-089785 Ovis aries 51.35 0.00e+00 726.00
IUUC-Ptr-091242 Pan troglodytes 51.35 0.00e+00 726.00
IUUC-Pan-092246 Papio anubis 51.35 0.00e+00 726.00
IUUC-Psi-094081 Pelodiscus sinensis 51.61 0.00e+00 729.00
IUUC-Pma-094735 Petromyzon marinus 46.05 1.00e-100 358.00
IUUC-Pfo-096357 Poecilia formosa 51.29 0.00e+00 727.00
IUUC-Pab-098248 Pongo abelii 48.64 0.00e+00 664.00
IUUC-Pca-100756 Procavia capensis 50.67 6.00e-131 460.00
IUUC-Pva-102990 Pteropus vampyrus 39.62 2.00e-98 352.00
IUUC-Rno-105887 Rattus norvegicus 51.61 0.00e+00 724.00
IUUC-Sha-107016 Sarcophilus harrisii 51.35 0.00e+00 729.00
IUUC-Sar-113558 Sorex araneus 47.23 0.00e+00 679.00
IUUC-Ssc-115414 Sus scrofa 51.35 0.00e+00 726.00
IUUC-Tgu-116801 Taeniopygia guttata 51.29 0.00e+00 717.00
IUUC-Tru-117565 Takifugu rubripes 51.03 0.00e+00 722.00
IUUC-Tsy-119292 Tarsius syrichta 49.13 0.00e+00 649.00
IUUC-Tni-120471 Tetraodon nigroviridis 50.90 0.00e+00 721.00
IUUC-Tbe-127838 Tupaia belangeri 47.36 0.00e+00 682.00
IUUC-Ttr-128345 Tursiops truncatus 51.35 0.00e+00 725.00
IUUC-Vpa-130191 Vicugna pacos 45.55 1.00e-96 346.00
IUUC-Xtr-132810 Xenopus tropicalis 51.61 0.00e+00 731.00
Created Date 25-Jun-2017

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