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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064282
Ensembl Protein ID ENSMUSP00000130487.1
UniProt Accession Q8BHB0; Q8BUT6; NOD1_MOUSE
Genbank Protein ID BAC38566.1; BAC40940.1; AAH42670.1; AAH43670.1
Protein Name Nucleotide-binding oligomerization domain-containing protein 1; Caspase recruitment domain-containing protein 4
Genbank Nucleotide ID AK082663; AK089662; BC042670; BC043670
Gene Name Nod1; Card4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038058.14 ENSMUST00000168172.3 ENSMUSP00000130487.1
ENSMUSG00000038058.14 ENSMUST00000203076.1 ENSMUSP00000145123.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/CARD 81.63 0.00e+00 1496.00 IUUC-Hsa-046886
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity).
 Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity).
Protein Sequence
(Fasta)
MEEHGHHEME GTPLGCHSHI KLLKINREHL VTNIRNTQCL VDNLLENGYF SAEDAEIVCA 60
CPTKPDKVRK ILDLVQSKGE EVSEFFLYVL QQLEDAYVDL RLWLSEIGFS PSQLIRTKTI 120
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Protein Fasta Sequence


>IUUC-Mmu-064282|UBD,CARD|Mus musculus
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Nucleotide Sequence
(Fasta)
GGTGTCACCC CTGGGCGAAC TGCGAGGCCT GCCCACTCCC ACTGCGCAGT GGCCGCTCGT 60
CCGATGCAGT GTGCGGCGGC TCCTTCCCGG GAAACGAGAC AGGGGGGCAG CGCTACGGAT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064282|UBD,CARD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
PROSITE

PS50209--CARD
PS50837--NACHT
Pfam

PF00619--CARD
PF13516--LRR_6
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0050700--F:CARD domain binding
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:0071225--P:cellular response to muramyl dipeptide
GO:0042742--P:defense response to bacterium
GO:0050830--P:defense response to Gram-positive bacterium
GO:0016045--P:detection of bacterium
GO:0045087--P:innate immune response
GO:0042228--P:interleukin-8 biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002606--P:positive regulation of dendritic cell antigen processing and presentation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:1904417--P:positive regulation of xenophagy
KEGG mmu:107607
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001299 Ailuropoda melanoleuca 77.59 0.00e+00 1298.00
IUUC-Apl-003908 Anas platyrhynchos 60.34 0.00e+00 1120.00
IUUC-Aca-005144 Anolis carolinensis 59.45 0.00e+00 1100.00
IUUC-Ame-010829 Astyanax mexicanus 51.47 0.00e+00 896.00
IUUC-Bta-013358 Bos taurus 78.43 0.00e+00 1384.00
IUUC-Cja-019392 Callithrix jacchus 80.82 0.00e+00 1434.00
IUUC-Cfa-020776 Canis familiaris 78.85 0.00e+00 1375.00
IUUC-Cpo-021393 Cavia porcellus 79.87 0.00e+00 1439.00
IUUC-Csa-023872 Chlorocebus sabaeus 81.76 0.00e+00 1482.00
IUUC-Cho-024569 Choloepus hoffmanni 69.32 4.00e-168 585.00
IUUC-Dre-027478 Danio rerio 50.21 0.00e+00 866.00
IUUC-Dno-029231 Dasypus novemcinctus 78.09 0.00e+00 1403.00
IUUC-Dor-030251 Dipodomys ordii 58.56 1.00e-158 553.00
IUUC-Ete-032484 Echinops telfairi 68.72 0.00e+00 702.00
IUUC-Eca-033564 Equus caballus 79.73 0.00e+00 1423.00
IUUC-Eeu-034456 Erinaceus europaeus 67.49 2.00e-138 486.00
IUUC-Fca-036372 Felis catus 77.80 0.00e+00 1375.00
IUUC-Fal-037418 Ficedula albicollis 60.26 0.00e+00 1115.00
IUUC-Gmo-038740 Gadus morhua 50.32 0.00e+00 886.00
IUUC-Gga-040775 Gallus gallus 60.55 0.00e+00 1151.00
IUUC-Gac-041612 Gasterosteus aculeatus 49.58 0.00e+00 885.00
IUUC-Ggo-045161 Gorilla gorilla 81.20 0.00e+00 1233.00
IUUC-Hsa-046886 Homo sapiens 81.45 0.00e+00 1469.00
IUUC-Itr-048414 Ictidomys tridecemlineatus 83.49 0.00e+00 1561.00
IUUC-Lch-049764 Latimeria chalumnae 57.52 0.00e+00 994.00
IUUC-Loc-052143 Lepisosteus oculatus 54.55 0.00e+00 988.00
IUUC-Laf-053503 Loxodonta africana 77.78 0.00e+00 1407.00
IUUC-Mcc-054992 Macaca mulatta 81.55 0.00e+00 1474.00
IUUC-Meu-056406 Macropus eugenii 61.51 0.00e+00 1054.00
IUUC-Mga-059351 Meleagris gallopavo 59.41 0.00e+00 1140.00
IUUC-Mmr-061537 Microcebus murinus 80.71 0.00e+00 1368.00
IUUC-Mdo-061832 Monodelphis domestica 64.48 0.00e+00 1060.00
IUUC-Mpu-066399 Mustela putorius furo 78.53 0.00e+00 1391.00
IUUC-Mlu-067265 Myotis lucifugus 77.75 0.00e+00 1349.00
IUUC-Nle-069078 Nomascus leucogenys 80.92 0.00e+00 1464.00
IUUC-Opr-070946 Ochotona princeps 72.37 0.00e+00 1299.00
IUUC-Ont-071355 Oreochromis niloticus 48.66 0.00e+00 877.00
IUUC-Oan-072937 Ornithorhynchus anatinus 70.76 0.00e+00 1295.00
IUUC-Ocu-073815 Oryctolagus cuniculus 79.04 0.00e+00 1460.00
IUUC-Ola-087381 Oryzias latipes 49.46 0.00e+00 869.00
IUUC-Oga-088725 Otolemur garnettii 79.66 0.00e+00 1432.00
IUUC-Oar-090401 Ovis aries 76.65 0.00e+00 1399.00
IUUC-Ptr-090590 Pan troglodytes 81.34 0.00e+00 1468.00
IUUC-Pan-091765 Papio anubis 81.55 0.00e+00 1475.00
IUUC-Psi-093182 Pelodiscus sinensis 60.85 0.00e+00 1133.00
IUUC-Pfo-097422 Poecilia formosa 48.25 0.00e+00 863.00
IUUC-Pab-098289 Pongo abelii 81.13 0.00e+00 1457.00
IUUC-Pca-100165 Procavia capensis 69.61 0.00e+00 951.00
IUUC-Pva-102943 Pteropus vampyrus 79.04 0.00e+00 1420.00
IUUC-Rno-104930 Rattus norvegicus 95.28 0.00e+00 1739.00
IUUC-Sha-106800 Sarcophilus harrisii 46.93 0.00e+00 636.00
IUUC-Sar-113205 Sorex araneus 70.06 0.00e+00 953.00
IUUC-Ssc-115910 Sus scrofa 79.55 0.00e+00 1243.00
IUUC-Tgu-117179 Taeniopygia guttata 61.30 0.00e+00 1134.00
IUUC-Tru-118220 Takifugu rubripes 48.88 0.00e+00 855.00
IUUC-Tsy-119418 Tarsius syrichta 73.38 0.00e+00 1184.00
IUUC-Tni-120033 Tetraodon nigroviridis 52.71 5.00e-71 260.00
IUUC-Tbe-127308 Tupaia belangeri 82.29 6.00e-176 611.00
IUUC-Ttr-129233 Tursiops truncatus 78.72 0.00e+00 1405.00
IUUC-Vpa-130620 Vicugna pacos 77.38 6.00e-105 375.00
IUUC-Xtr-132075 Xenopus tropicalis 53.26 0.00e+00 993.00
Created Date 25-Jun-2017

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