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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046482
UUCD1 version UUC-HoS-00728
Ensembl Protein ID ENSP00000348842.6
UniProt Accession Q6ZMW3; A8MUB5; B6ZDG7; EMAL6_HUMAN
Genbank Protein ID BAD18612.1
Protein Name Echinoderm microtubule-associated protein-like 6; Echinoderm microtubule-associated protein-like 5-like
Genbank Nucleotide ID AC013414
Gene Name EML6; EML5L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000214595.11 ENST00000356458.6 ENSP00000348842.6
Annotation
Cancer Mutation
ICGCCOSMICCGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
InWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.40e-59 197.0 105 144
UBD/Beta-Prp 2.30e-132 442.4 725 943
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdD..gtikvWDlrtgvllk 37
           Ht +v claf sd  +l+s + D  +t+ +WD+r+g+ll 
   Q: 105  HTHGVACLAFdSDgQRLASVGLDakNTVCIWDWRKGKLLA 144
           99*********999*******9999***********9875 PP
   

   UBD/Beta-Prp
   S: 7    ghhksvitcvkfspdksllatg..srdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkgh 93
           gh+++ ++ ++++p k+++atg  +rd+ i vwd++t k+l+ l  +h+ +v a++fs dgk lv+++ D  + i  wd ++g+ + t +gh
   Q: 725  GHDDDILS-LTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLkGQHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGH 815
           45555555.9999*******995569999***********99997779999***************999977778889************** PP
   S: 94   edsvlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           +d++  ++ +p   dklv+ +  + i+ w+   g   ++       g+ ++ +cv++   ++l++sG++ + + +W  k   ll+t +  h+
   Q: 816  KDKIFVVKCNPHHvDKLVTVG-IKHIKFWQQAGGGFTSKrgtfGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDILLLKTVKA-HD 903
           ***********7769998887.9999**988888877778977677889999999999999***************..78999999998.99 PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght 222
           ++v  +   +  k +v+g++dg v+lwd   ++c++t+   +
   Q: 904  GPVFAMYALD--KGFVTGGKDGIVELWDDMFERCLKTYAIKR 943
           9999999888..579*************99999999997655 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Protein Sequence
(Fasta)
MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHSQKFFLGH 60
NDDIISLALH PDKTLVATGQ VGKEPYICIW DSYNVQTVSL LKDVHTHGVA CLAFDSDGQR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046482|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGACAGGCA GAGGGAGGGG GCGGCCCCAG TCCTCCGGGG CGTCGCTGTT TCCAAGCGGC 60
GAGATCTCGC CTAGTAACCG GCAGCTGAGG TTCACTAGCG CGGCGTTGTG GCCCCGCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046482|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR011048--Haem_d1
IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF03451--HELP
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0008017--F:microtubule binding
KEGG hsa:400954
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001387 Ailuropoda melanoleuca 98.11 0.00e+00 3865.00
IUUC-Apl-003604 Anas platyrhynchos 94.00 0.00e+00 3694.00
IUUC-Aca-004572 Anolis carolinensis 90.11 0.00e+00 3596.00
IUUC-Ame-010713 Astyanax mexicanus 80.64 0.00e+00 3231.00
IUUC-Bta-012812 Bos taurus 97.96 0.00e+00 3857.00
IUUC-Cja-019191 Callithrix jacchus 98.61 0.00e+00 3845.00
IUUC-Cfa-020041 Canis familiaris 98.20 0.00e+00 3588.00
IUUC-Cre-022931 Chlamydomonas reinhardtii 35.12 2.00e-101 366.00
IUUC-Csa-023689 Chlorocebus sabaeus 98.27 0.00e+00 3760.00
IUUC-Cho-025038 Choloepus hoffmanni 97.13 0.00e+00 1494.00
IUUC-Cin-025205 Ciona intestinalis 62.42 0.00e+00 2589.00
IUUC-Csv-026014 Ciona savignyi 63.65 0.00e+00 2607.00
IUUC-Dno-029982 Dasypus novemcinctus 95.60 0.00e+00 3660.00
IUUC-Eca-034161 Equus caballus 96.53 0.00e+00 3683.00
IUUC-Fca-036307 Felis catus 98.31 0.00e+00 3862.00
IUUC-Fal-037332 Ficedula albicollis 92.84 0.00e+00 3621.00
IUUC-Gmo-039057 Gadus morhua 75.09 0.00e+00 2998.00
IUUC-Gac-042555 Gasterosteus aculeatus 80.35 0.00e+00 3235.00
IUUC-Ggo-045107 Gorilla gorilla 99.54 0.00e+00 3896.00
IUUC-Itr-049023 Ictidomys tridecemlineatus 96.16 0.00e+00 3727.00
IUUC-Loc-052642 Lepisosteus oculatus 88.44 0.00e+00 3487.00
IUUC-Laf-053649 Loxodonta africana 95.71 0.00e+00 3736.00
IUUC-Mcc-055361 Macaca mulatta 99.18 0.00e+00 3412.00
IUUC-Meu-056618 Macropus eugenii 79.05 0.00e+00 1809.00
IUUC-Mga-059202 Meleagris gallopavo 92.94 0.00e+00 3576.00
IUUC-Mmr-060729 Microcebus murinus 96.21 0.00e+00 3839.00
IUUC-Mdo-062462 Monodelphis domestica 95.62 0.00e+00 3680.00
IUUC-Mmu-063865 Mus musculus 97.09 0.00e+00 3845.00
IUUC-Mpu-066724 Mustela putorius furo 98.47 0.00e+00 3868.00
IUUC-Mlu-067816 Myotis lucifugus 97.61 0.00e+00 3854.00
IUUC-Opr-070213 Ochotona princeps 95.13 0.00e+00 2009.00
IUUC-Ont-071928 Oreochromis niloticus 79.84 0.00e+00 3248.00
IUUC-Oan-073563 Ornithorhynchus anatinus 95.32 0.00e+00 3766.00
IUUC-Ocu-074531 Oryctolagus cuniculus 97.91 0.00e+00 3856.00
IUUC-Ola-086943 Oryzias latipes 78.91 0.00e+00 3138.00
IUUC-Olu-087860 Ostreococcus lucimarinus 39.17 9.00e-118 417.00
IUUC-Oga-088665 Otolemur garnettii 97.37 0.00e+00 3717.00
IUUC-Oar-090429 Ovis aries 98.11 0.00e+00 3864.00
IUUC-Ptr-091168 Pan troglodytes 90.21 0.00e+00 3471.00
IUUC-Pan-092788 Papio anubis 99.17 0.00e+00 3093.00
IUUC-Psi-093281 Pelodiscus sinensis 92.37 0.00e+00 3653.00
IUUC-Pma-094424 Petromyzon marinus 73.19 6.00e-125 440.00
IUUC-Pab-098561 Pongo abelii 98.23 0.00e+00 3370.00
IUUC-Pca-100177 Procavia capensis 86.08 0.00e+00 1536.00
IUUC-Rno-105002 Rattus norvegicus 96.27 0.00e+00 3832.00
IUUC-Sha-107105 Sarcophilus harrisii 93.00 0.00e+00 3559.00
IUUC-Ssc-116282 Sus scrofa 98.10 0.00e+00 3754.00
IUUC-Tgu-116807 Taeniopygia guttata 94.08 0.00e+00 3694.00
IUUC-Tru-118040 Takifugu rubripes 78.98 0.00e+00 3179.00
IUUC-Tni-120118 Tetraodon nigroviridis 76.55 0.00e+00 3152.00
Created Date 25-Jun-2017

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