iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	9.60e-16	58.9	44	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla...skksllrll 80
           +vr+k++++ge r+  +++++p+ +ed++++v+t   ++++ ++l+Y++++ +++ lk+++dldka+++l+   s+ksl r+l
   Q: 44   DVRIKFEHNGERRI--IAFSRPVRYEDVEHKVTT---VFGQPLDLHYMNNELSIL-LKNQDDLDKAIDILDrssSMKSL-RIL 119
           59**********77..******************...******************.***************77444444.444 PP

Organism

Mus musculus

Functional Description
(View)

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Protein Sequence
(Fasta)

MDEQEALDSI MKDLVALQMS RRTRLSGYET MKNKDTGHPN RQSDVRIKFE HNGERRIIAF 60
SRPVRYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL DKAIDILDRS SSMKSLRILL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACAGTGGC CGGTCGGAGC GTCTTCTGGA CTTCAGGACT CGCAGGCGGC CCGGTCGAGT 60
GGCGCCGCCG AGGCCGGGTT GGGCCGAGCC TGGGAGCGCC GGGGATGTAG CGGGCCAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR000719--Prot_kinase_dom

PROSITE

PS51745--PB1
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00564--PB1
PF00069--Pkinase

SMART

SM00666--PB1
SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0004702--F:signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0030036--P:actin cytoskeleton organization
GO:0001568--P:blood vessel development
GO:0035556--P:intracellular signal transduction
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1900745--P:positive regulation of p38MAPK cascade
GO:0046777--P:protein autophosphorylation

KEGG

mmu:26406

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001464	Ailuropoda melanoleuca	92.68	0.00e+00	1250.00
IUUC-Ame-011807	Astyanax mexicanus	76.95	0.00e+00	963.00
IUUC-Bta-012717	Bos taurus	96.48	0.00e+00	1254.00
IUUC-Cja-019548	Callithrix jacchus	96.27	0.00e+00	1137.00
IUUC-Cfa-020785	Canis familiaris	96.96	0.00e+00	1264.00
IUUC-Cpo-021444	Cavia porcellus	96.80	0.00e+00	1258.00
IUUC-Csa-023898	Chlorocebus sabaeus	92.09	0.00e+00	1251.00
IUUC-Cin-025443	Ciona intestinalis	45.02	1.00e-133	470.00
IUUC-Dre-027587	Danio rerio	76.95	0.00e+00	992.00
IUUC-Dno-028984	Dasypus novemcinctus	91.17	0.00e+00	1234.00
IUUC-Eca-034089	Equus caballus	97.12	0.00e+00	1266.00
IUUC-Fca-035656	Felis catus	97.08	0.00e+00	1245.00
IUUC-Ggo-045339	Gorilla gorilla	92.09	0.00e+00	1251.00
IUUC-Hsa-046137	Homo sapiens	96.65	0.00e+00	1263.00
IUUC-Itr-048091	Ictidomys tridecemlineatus	97.44	0.00e+00	1270.00
IUUC-Loc-052751	Lepisosteus oculatus	76.44	0.00e+00	1027.00
IUUC-Laf-054342	Loxodonta africana	96.18	0.00e+00	1248.00
IUUC-Mcc-055631	Macaca mulatta	91.93	0.00e+00	1246.00
IUUC-Mga-059565	Meleagris gallopavo	85.94	0.00e+00	1102.00
IUUC-Mmr-060745	Microcebus murinus	91.92	0.00e+00	1243.00
IUUC-Mpu-066544	Mustela putorius furo	92.27	0.00e+00	1230.00
IUUC-Mlu-067655	Myotis lucifugus	96.01	0.00e+00	1253.00
IUUC-Nle-070048	Nomascus leucogenys	85.67	0.00e+00	1126.00
IUUC-Ont-071889	Oreochromis niloticus	77.16	0.00e+00	995.00
IUUC-Oan-073137	Ornithorhynchus anatinus	77.63	0.00e+00	710.00
IUUC-Ola-087055	Oryzias latipes	72.93	0.00e+00	931.00
IUUC-Oga-088913	Otolemur garnettii	92.20	0.00e+00	1191.00
IUUC-Oar-090321	Ovis aries	91.77	0.00e+00	1241.00
IUUC-Ptr-091046	Pan troglodytes	91.93	0.00e+00	1248.00
IUUC-Pan-092280	Papio anubis	91.79	0.00e+00	1247.00
IUUC-Pfo-096365	Poecilia formosa	76.28	0.00e+00	984.00
IUUC-Pab-097785	Pongo abelii	92.09	0.00e+00	1251.00
IUUC-Pva-102740	Pteropus vampyrus	92.06	0.00e+00	1240.00
IUUC-Rno-104946	Rattus norvegicus	98.88	0.00e+00	1293.00
IUUC-Ssc-115554	Sus scrofa	96.27	0.00e+00	1233.00
IUUC-Tgu-117312	Taeniopygia guttata	89.44	0.00e+00	1169.00
IUUC-Tni-120426	Tetraodon nigroviridis	76.00	0.00e+00	965.00
IUUC-Ttr-128646	Tursiops truncatus	92.54	0.00e+00	1252.00
IUUC-Xtr-132121	Xenopus tropicalis	83.07	0.00e+00	1070.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence