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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046228
Ensembl Protein ID ENSP00000367299.3
UniProt Accession Q86VN1; A8K125; Q3ZCV7; Q5H9S1; Q5VXB6; Q9H8Z5; Q9Y3E3; VPS36_HUMAN
Genbank Protein ID AAD34140.1; BAB14451.1; BAF82429.1; CAI45953.1; CAH71658.1; EAW55895.1; AAH37279.1; AAH50439.1
Protein Name Vacuolar protein-sorting-associated protein 36; ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36
Genbank Nucleotide ID AF151903; AK023182; AK289740; CR933653; AL359513; CH471274; BC037279; BC050439
Gene Name VPS36; C13orf9; EAP45; CGI-145
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000136100.12 ENST00000378060.8 ENSP00000367299.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/PH/GLUE GLUE 16973552; 17057714; 17057716
Classification
Family E-value Score Start End
UBD/PH/GLUE 9.80e-74 247.6 1 138
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/PH/GLUE
   S: 1    mdrfvytealLeinetlvirqrsvkiydgdekikfdaGellLtthRLiWirdqkneevtlaipLsavvfieeeaaaigksakivvhlhpars 92
           mdrfv+t++lLeinetlvi+qr+v+iydg+ekikfdaG+llL+thRLiW rdqkn+e+++ai+Ls++vfiee+aa+igksakivvhlhpa++
   Q: 1    MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIW-RDQKNHECCMAILLSQIVFIEEQAAGIGKSAKIVVHLHPAPP 91
           9************************************************.****************************************** PP
   S: 93   dkePGpldsskasyiklsfkekgdiefyskLseeltaRaWeelevse 139
           +kePGp++ssk+syiklsfke+g+iefy++Lsee+t+R+We+++vs+
   Q: 92   NKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQ 138
           *********************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two copies of VPS25 (PubMed:14519844). Interacts with VPS25, SNF8, TSG101 and CHMP6 (PubMed:14505570, PubMed:14519844, PubMed:16973552, PubMed:18539118). Interacts (via GLUE domain) with ubiquitin (PubMed:17057716). Interacts with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes (PubMed:17010938). Interacts with ECM29 (PubMed:20682791).
 Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two copies of VPS25 (PubMed:14519844). Interacts with VPS25, SNF8, TSG101 and CHMP6 (PubMed:14505570, PubMed:14519844, PubMed:16973552, PubMed:18539118). Interacts (via GLUE domain) with ubiquitin (PubMed:17057716). Interacts with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes (PubMed:17010938). Interacts with ECM29 (PubMed:20682791).
Protein Sequence
(Fasta)
MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA 60
ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046228|UBD,GLUE|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCTCGGAG GGCCGGGGCT GGGTGGCAGC GGCCATGGAC CGCTTCGTTT GGACCAGCGG 60
CCTCCTGGAG ATCAACGAGA CCCTGGTGAT CCAGCAGCGC GGGGTGCGAA TCTACGATGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046228|UBD,GLUE|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0813--Transport
Interpro

IPR007286--EAP30
IPR021648--GLUE_dom
IPR011993--PH_dom-like
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS51495--GLUE
Pfam

PF04157--EAP30
PF11605--Vps36_ESCRT-II
Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0000814--C:ESCRT II complex
GO:0070062--C:extracellular exosome
GO:0031902--C:late endosome membrane
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0008022--F:protein C-terminus binding
GO:0043130--F:ubiquitin binding
GO:0016197--P:endosomal transport
GO:0016236--P:macroautophagy
GO:0036258--P:multivesicular body assembly
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:51028
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000963 Aegilops tauschii 41.88 7.00e-35 140.00
IUUC-Aml-002313 Ailuropoda melanoleuca 98.19 0.00e+00 754.00
IUUC-Atr-003096 Amborella trichopoda 36.05 2.00e-15 75.90
IUUC-Apl-003218 Anas platyrhynchos 88.45 0.00e+00 681.00
IUUC-Aca-004580 Anolis carolinensis 90.41 0.00e+00 700.00
IUUC-Aly-006398 Arabidopsis lyrata 37.32 1.00e-57 217.00
IUUC-Ath-006907 Arabidopsis thaliana 37.90 3.00e-57 216.00
IUUC-Ago-007840 Ashbya gossypii 22.08 3.00e-04 40.40
IUUC-Acl-008117 Aspergillus clavatus 32.21 3.00e-36 146.00
IUUC-Afl-008595 Aspergillus flavus 32.56 3.00e-36 146.00
IUUC-Afu-008918 Aspergillus fumigatus 31.61 8.00e-36 145.00
IUUC-Ani-009206 Aspergillus nidulans 32.94 4.00e-36 146.00
IUUC-Ang-009784 Aspergillus niger 32.62 5.00e-33 136.00
IUUC-Aor-010126 Aspergillus oryzae 32.56 3.00e-36 146.00
IUUC-Ate-010303 Aspergillus terreus 33.13 3.00e-34 140.00
IUUC-Ame-011190 Astyanax mexicanus 85.08 0.00e+00 663.00
IUUC-Bgr-011979 Blumeria graminis 31.46 3.00e-33 136.00
IUUC-Bta-012661 Bos taurus 98.19 0.00e+00 752.00
IUUC-Bci-013982 Botrytis cinerea 32.97 4.00e-33 136.00
IUUC-Bdi-014753 Brachypodium distachyon 40.21 4.00e-51 195.00
IUUC-Bol-015465 Brassica oleracea 42.25 1.00e-49 190.00
IUUC-Bra-016794 Brassica rapa 42.69 1.00e-50 193.00
IUUC-Cel-018514 Caenorhabditis elegans 42.12 7.00e-82 297.00
IUUC-Cja-019285 Callithrix jacchus 98.31 0.00e+00 687.00
IUUC-Cfa-020746 Canis familiaris 98.96 0.00e+00 759.00
IUUC-Cpo-022005 Cavia porcellus 97.46 0.00e+00 687.00
IUUC-Cre-022686 Chlamydomonas reinhardtii 35.63 6.00e-33 135.00
IUUC-Csa-023520 Chlorocebus sabaeus 99.74 0.00e+00 767.00
IUUC-Cho-024957 Choloepus hoffmanni 93.78 0.00e+00 714.00
IUUC-Cin-025575 Ciona intestinalis 47.62 5.00e-08 48.90
IUUC-Csv-025942 Ciona savignyi 53.11 2.00e-108 385.00
IUUC-Cgl-026558 Colletotrichum gloeosporioides 32.14 1.00e-30 128.00
IUUC-Cne-026915 Cryptococcus neoformans 27.97 1.00e-23 104.00
IUUC-Cme-027099 Cyanidioschyzon merolae 24.68 1.00e-11 65.10
IUUC-Dre-027753 Danio rerio 84.82 0.00e+00 662.00
IUUC-Dno-029922 Dasypus novemcinctus 95.85 0.00e+00 739.00
IUUC-Dor-030643 Dipodomys ordii 90.67 0.00e+00 685.00
IUUC-Dse-031368 Dothistroma septosporum 32.08 2.00e-29 124.00
IUUC-Dme-031977 Drosophila melanogaster 45.11 2.00e-92 332.00
IUUC-Ete-033135 Echinops telfairi 75.07 8.00e-142 496.00
IUUC-Eca-033937 Equus caballus 97.74 0.00e+00 691.00
IUUC-Eeu-034483 Erinaceus europaeus 93.52 0.00e+00 743.00
IUUC-Fca-035496 Felis catus 98.02 0.00e+00 688.00
IUUC-Fal-036743 Ficedula albicollis 89.90 0.00e+00 701.00
IUUC-Fox-037685 Fusarium oxysporum 34.80 9.00e-27 115.00
IUUC-Fso-038421 Fusarium solani 31.19 2.00e-28 121.00
IUUC-Gmo-039456 Gadus morhua 79.11 4.00e-175 607.00
IUUC-Ggr-039763 Gaeumannomyces graminis 31.72 9.00e-36 145.00
IUUC-Gga-040556 Gallus gallus 89.64 0.00e+00 696.00
IUUC-Gac-041481 Gasterosteus aculeatus 80.73 4.00e-160 557.00
IUUC-Gma-044185 Glycine max 44.26 5.00e-53 202.00
IUUC-Ggo-044849 Gorilla gorilla 100.00 0.00e+00 768.00
IUUC-Hvu-047858 Hordeum vulgare 38.68 3.00e-13 68.90
IUUC-Itr-048068 Ictidomys tridecemlineatus 95.36 0.00e+00 730.00
IUUC-Kpa-049240 Komagataella pastoris 26.51 1.00e-05 45.10
IUUC-Lch-050293 Latimeria chalumnae 87.74 1.00e-125 442.00
IUUC-Lpe-051363 Leersia perrieri 45.08 2.00e-51 196.00
IUUC-Loc-052866 Lepisosteus oculatus 84.72 0.00e+00 642.00
IUUC-Lma-053139 Leptosphaeria maculans 29.19 8.00e-32 132.00
IUUC-Laf-053881 Loxodonta africana 91.97 0.00e+00 701.00
IUUC-Mcc-055158 Macaca mulatta 99.48 0.00e+00 766.00
IUUC-Meu-056126 Macropus eugenii 74.58 2.00e-136 478.00
IUUC-Mor-057092 Magnaporthe oryzae 31.25 1.00e-32 135.00
IUUC-Mpo-057629 Magnaporthe poae 31.88 8.00e-28 117.00
IUUC-Mtr-058039 Medicago truncatula 44.86 1.00e-53 203.00
IUUC-Mla-058913 Melampsora laricipopulina 30.87 1.00e-23 104.00
IUUC-Mga-059956 Meleagris gallopavo 89.64 0.00e+00 698.00
IUUC-Mvi-060570 Microbotryum violaceum 23.92 4.00e-17 83.60
IUUC-Mmr-061769 Microcebus murinus 98.59 0.00e+00 691.00
IUUC-Mdo-062751 Monodelphis domestica 91.62 0.00e+00 712.00
IUUC-Mmu-063115 Mus musculus 95.85 0.00e+00 744.00
IUUC-Mac-064979 Musa acuminata 35.58 8.00e-53 201.00
IUUC-Mpu-066904 Mustela putorius furo 98.31 8.00e-139 485.00
IUUC-Mlu-067474 Myotis lucifugus 97.41 0.00e+00 747.00
IUUC-Nfi-068588 Neosartorya fischeri 32.21 1.00e-32 134.00
IUUC-Ncr-068855 Neurospora crassa 29.71 2.00e-27 117.00
IUUC-Nle-069660 Nomascus leucogenys 99.22 0.00e+00 763.00
IUUC-Opr-070695 Ochotona princeps 96.37 0.00e+00 739.00
IUUC-Ont-071837 Oreochromis niloticus 83.51 2.00e-174 605.00
IUUC-Oan-072903 Ornithorhynchus anatinus 93.26 0.00e+00 663.00
IUUC-Ocu-074833 Oryctolagus cuniculus 97.15 0.00e+00 751.00
IUUC-Oba-075899 Oryza barthii 45.42 1.00e-51 196.00
IUUC-Obr-076125 Oryza brachyantha 35.73 3.00e-55 209.00
IUUC-Ogl-077538 Oryza glaberrima 50.00 3.00e-32 133.00
IUUC-Ogu-078272 Oryza glumaepatula 45.08 1.00e-51 197.00
IUUC-Oin-079158 Oryza indica 44.35 4.00e-51 195.00
IUUC-Olo-080496 Oryza longistaminata 44.17 9.00e-48 183.00
IUUC-Ome-081440 Oryza meridionalis 44.77 2.00e-49 189.00
IUUC-Oni-083069 Oryza nivara 44.35 4.00e-51 195.00
IUUC-Opu-083838 Oryza punctata 45.53 5.00e-50 191.00
IUUC-Oru-084377 Oryza rufipogon 45.08 1.00e-51 197.00
IUUC-Osa-085976 Oryza sativa 45.08 1.00e-51 197.00
IUUC-Ola-086431 Oryzias latipes 84.82 3.00e-177 614.00
IUUC-Olu-087789 Ostreococcus lucimarinus 39.30 2.00e-39 155.00
IUUC-Oga-089152 Otolemur garnettii 97.67 0.00e+00 749.00
IUUC-Oar-089198 Ovis aries 98.02 0.00e+00 687.00
IUUC-Ptr-091123 Pan troglodytes 100.00 0.00e+00 768.00
IUUC-Pan-092866 Papio anubis 96.12 0.00e+00 737.00
IUUC-Psi-093384 Pelodiscus sinensis 94.04 0.00e+00 725.00
IUUC-Pno-094773 Phaeosphaeria nodorum 30.79 2.00e-27 117.00
IUUC-Ppa-095753 Physcomitrella patens 36.20 6.00e-56 211.00
IUUC-Pfo-096028 Poecilia formosa 83.51 5.00e-176 610.00
IUUC-Pop-098915 Populus trichocarpa 44.86 2.00e-52 200.00
IUUC-Pca-100422 Procavia capensis 94.63 0.00e+00 660.00
IUUC-Ppe-101564 Prunus persica 44.90 8.00e-54 204.00
IUUC-Pva-103019 Pteropus vampyrus 93.01 0.00e+00 702.00
IUUC-Pgr-103670 Puccinia graminis 28.05 3.00e-20 93.60
IUUC-Ptt-103958 Puccinia triticina 26.77 3.00e-19 89.70
IUUC-Pte-104343 Pyrenophora teres 31.52 1.00e-37 151.00
IUUC-Pyt-104554 Pyrenophora triticirepentis 31.34 2.00e-39 157.00
IUUC-Rno-105775 Rattus norvegicus 96.11 0.00e+00 744.00
IUUC-Sce-106148 Saccharomyces cerevisiae 22.29 1.10e-02 35.00
IUUC-Sha-106468 Sarcophilus harrisii 93.50 0.00e+00 657.00
IUUC-Sja-107850 Schizosaccharomyces japonicus 23.51 2.00e-16 80.90
IUUC-Spo-108225 Schizosaccharomyces pombe 23.37 2.00e-17 83.60
IUUC-Ssl-108412 Sclerotinia sclerotiorum 32.35 2.00e-30 127.00
IUUC-Smo-109001 Selaginella moellendorffii 35.33 9.00e-54 204.00
IUUC-Sit-110126 Setaria italica 34.32 6.00e-49 188.00
IUUC-Sly-110884 Solanum lycopersicum 36.34 4.00e-52 198.00
IUUC-Stu-112573 Solanum tuberosum 35.88 2.00e-52 199.00
IUUC-Sar-113114 Sorex araneus 94.03 1.00e-70 259.00
IUUC-Sbi-114331 Sorghum bicolor 29.86 6.00e-38 151.00
IUUC-Sre-115135 Sporisorium reilianum 22.91 1.00e-09 58.50
IUUC-Ssc-116158 Sus scrofa 98.70 0.00e+00 759.00
IUUC-Tgu-116962 Taeniopygia guttata 89.64 0.00e+00 669.00
IUUC-Tru-117567 Takifugu rubripes 83.25 9.00e-176 609.00
IUUC-Tsy-119357 Tarsius syrichta 81.87 2.00e-167 581.00
IUUC-Tni-120047 Tetraodon nigroviridis 83.09 9.00e-156 542.00
IUUC-Tca-121097 Theobroma cacao 44.86 1.00e-53 204.00
IUUC-Tre-122075 Trichoderma reesei 30.14 3.00e-33 136.00
IUUC-Tvi-122623 Trichoderma virens 32.54 2.00e-39 157.00
IUUC-Tae-123728 Triticum aestivum 43.44 6.00e-51 195.00
IUUC-Tur-125988 Triticum urartu 42.35 1.00e-40 160.00
IUUC-Tme-126936 Tuber melanosporum 31.11 9.00e-34 138.00
IUUC-Tbe-127481 Tupaia belangeri 68.08 1.00e-128 452.00
IUUC-Ttr-128160 Tursiops truncatus 97.41 0.00e+00 739.00
IUUC-Uma-129428 Ustilago maydis 24.83 8.00e-17 82.40
IUUC-Vda-129877 Verticillium dahliae 32.08 5.00e-29 122.00
IUUC-Vpa-130358 Vicugna pacos 98.02 0.00e+00 682.00
IUUC-Vvi-131406 Vitis vinifera 36.70 2.00e-56 213.00
IUUC-Xtr-132548 Xenopus tropicalis 85.01 0.00e+00 651.00
IUUC-Xma-133352 Xiphophorus maculatus 83.77 3.00e-176 610.00
IUUC-Yli-134466 Yarrowia lipolytica 30.77 3.00e-20 93.20
IUUC-Zma-135081 Zea mays 40.14 7.00e-51 194.00
Created Date 25-Jun-2017

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