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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106188
UUCD1 version UUC-SaC-00032
Ensembl Protein ID YNL311C
UniProt Accession P42843; D6W0N4; Q6B2L9; SKP2_YEAST
Genbank Protein ID CAA86384.1; CAA96240.1; AAT92730.1; DAA10250.1
Protein Name F-box protein SKP2
Genbank Nucleotide ID Z46259; Z71587; AY692711; BK006947
Gene Name SKP2; YNL311C; N0376
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YNL311C YNL311C YNL311C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 14747994
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis.
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis.
Protein Sequence
(Fasta)
MKRLQLFGRS KYFSLVSSAA KEEEEEEEGC ADAKSLLHST SHDIKSRSLR FNDKSSLMCL 60
PTKVLLLILR TLDFNTLVTL CQVNSRFYNL ITNEFLFQNV ILDSKLSLLK FNALIHSEFH 120
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Protein Fasta Sequence



>IUUC-Sce-106188|E3,F-box|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAAACGGT TGCAATTGTT TGGTAGATCA AAATATTTCT CGCTGGTCTC CAGTGCTGCG 60
AAGGAGGAAG AAGAAGAGGA AGAGGGCTGT GCTGATGCCA AAAGCCTTCT ACATAGTACG 120
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Nucleotide Fasta Sequence



>IUUC-Sce-106188|E3,F-box|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0044257--P:cellular protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0031335--P:regulation of sulfur amino acid metabolic process

KEGG sce:YNL311C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001476 Ailuropoda melanoleuca 25.19 2.00e-03 37.00
IUUC-Apl-004061 Anas platyrhynchos 24.30 1.60e-01 31.20
IUUC-Ath-007364 Arabidopsis thaliana 45.71 1.90e+00 26.20
IUUC-Ago-007764 Ashbya gossypii 32.97 1.00e-94 338.00
IUUC-Ani-009205 Aspergillus nidulans 35.29 6.60e-02 32.30
IUUC-Cel-018348 Caenorhabditis elegans 35.38 5.90e-02 29.60
IUUC-Cja-019252 Callithrix jacchus 23.70 8.00e-03 35.00
IUUC-Cfa-020574 Canis familiaris 25.19 4.00e-03 36.60
IUUC-Cpo-021734 Cavia porcellus 23.70 7.10e-02 32.30
IUUC-Cre-022844 Chlamydomonas reinhardtii 23.71 2.00e-03 34.30
IUUC-Csa-023992 Chlorocebus sabaeus 23.81 1.20e-02 34.70
IUUC-Cho-024336 Choloepus hoffmanni 31.82 2.40e-02 30.80
IUUC-Eeu-035241 Erinaceus europaeus 36.59 4.00e-03 33.10
IUUC-Fal-036950 Ficedula albicollis 27.10 2.20e-02 33.90
IUUC-Fox-038071 Fusarium oxysporum 25.24 2.40e-01 28.10
IUUC-Gga-040562 Gallus gallus 30.77 3.70e-02 32.00
IUUC-Ggo-045640 Gorilla gorilla 23.81 1.10e-02 34.70
IUUC-Hsa-046368 Homo sapiens 23.81 1.00e-02 35.00
IUUC-Itr-048444 Ictidomys tridecemlineatus 25.85 1.30e-02 34.70
IUUC-Kpa-049358 Komagataella pastoris 34.06 2.00e-08 52.00
IUUC-Mcc-054783 Macaca mulatta 23.81 1.10e-02 35.00
IUUC-Mor-057046 Magnaporthe oryzae 27.69 4.30e-02 32.00
IUUC-Mmu-064164 Mus musculus 22.63 2.70e-02 33.50
IUUC-Mpu-066051 Mustela putorius furo 25.19 2.00e-03 37.40
IUUC-Nle-069462 Nomascus leucogenys 23.81 1.10e-02 34.70
IUUC-Ont-071378 Oreochromis niloticus 52.38 2.70e-02 32.70
IUUC-Oan-072894 Ornithorhynchus anatinus 25.68 2.80e-02 31.20
IUUC-Oin-080200 Oryza indica 43.24 2.90e-02 32.30
IUUC-Olu-087816 Ostreococcus lucimarinus 27.16 1.90e-02 31.60
IUUC-Ptr-091115 Pan troglodytes 23.81 1.00e-02 35.00
IUUC-Pan-092731 Papio anubis 23.40 2.00e-03 35.40
IUUC-Psi-093690 Pelodiscus sinensis 33.33 4.70e-02 31.60
IUUC-Pfo-096953 Poecilia formosa 25.58 9.00e-03 33.50
IUUC-Pab-097831 Pongo abelii 23.81 1.00e-02 35.00
IUUC-Pgr-103500 Puccinia graminis 32.05 1.70e-02 32.00
IUUC-Rno-105571 Rattus norvegicus 22.76 2.20e-02 33.90
IUUC-Sha-107394 Sarcophilus harrisii 30.77 3.00e-03 34.30
IUUC-Smo-108987 Selaginella moellendorffii 36.54 4.00e-03 33.50
IUUC-Ssc-115961 Sus scrofa 34.78 2.00e-05 41.20
IUUC-Tgu-116880 Taeniopygia guttata 27.10 2.70e-02 33.50
IUUC-Tsy-119044 Tarsius syrichta 42.50 2.30e-02 32.30
IUUC-Tre-122032 Trichoderma reesei 28.95 1.00e-02 32.30
IUUC-Tvi-122463 Trichoderma virens 26.74 6.00e-03 34.30
IUUC-Tae-125038 Triticum aestivum 28.38 2.00e-04 38.10
IUUC-Tur-126172 Triticum urartu 30.23 6.00e-03 33.50
IUUC-Tbe-127817 Tupaia belangeri 22.96 4.50e-02 32.70
IUUC-Vpa-130476 Vicugna pacos 22.83 6.60e-02 30.40
IUUC-Vvi-131196 Vitis vinifera 30.85 5.00e-03 32.70
IUUC-Xtr-132493 Xenopus tropicalis 31.88 2.40e-02 35.00
IUUC-Xma-133785 Xiphophorus maculatus 26.74 6.00e-03 33.90
Created Date 25-Jun-2017

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