iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185104.19	ENST00000396153.6	ENSP00000379457.2
ENSG00000185104.19	ENST00000494400.5	ENSP00000434929.1
ENSG00000185104.19	ENST00000371778.5	ENSP00000360843.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15743842
ULD/UDP/UFD/UBX	UBX	11243799

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	3.00e-07	32.0	5	45
ULD/UDP/UFD/UBX	2.80e-19	71.1	570	647
ULD/UDP/UBQ/UBQ_Other	1.20e-09	39.5	112	170

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 1    sededkleqlve.MGF.dreealqaLraannnleaAveyLl 39
           +++e++l+ +++ +G+ + +ea++ L+++n++l aA++ ++
   Q: 5    MDREMILADFQAcTGIeNIDEAITLLEQNNWDLVAAINGVI 45
           689**********************************9875 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllve 80
           +++ ++l+iR+p+G++l+r+F +s++l+ +++fv+ ++++++d+++L+s+fPrr++++ + +++l e +L+p+++l++e
   Q: 570  AEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVA-SKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLE 647
           56799******************************.****************************************986 PP

ULD/UDP/UBQ/UBQ_Other

   S: 13   ltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL...eddktLadyglkdgstihll 70
            ++ ++ ++tV+e+K+ +e +l ip   +++++kG      ed   L++++l+ ++ +++l
   Q: 112  VDVVLEDTCTVGEIKQILENELQIP--VSKMLLKGWKTgdvEDSTVLKSLHLPKNNSLYVL 170
           455667888****************..55899997776777***************99987 PP

Organism

Homo sapiens

Functional Description
(View)

Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain.

Protein Sequence
(Fasta)

MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSEYGGET 60
IPGPAFNPAS HPASAPTSSS SSAFRPVMPS RQIVERQPRM LDFRVEYRDR NVDVVLEDTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGGCGGAG GCGGCGGCCA GGGAGGAAGC GGAGGAGGCG GAGGCGGCCG CGGCGTTCGC 60
CCGCCCGCTC GCTCGCTCGG TTTCCCCGCC CCCGCCGGGC TTAACGCCGC TGAAGGTATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR033043--FAF1_UBX
IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50033--UBX

Pfam

PF00789--UBX

SMART

SM00594--UAS
SM00166--UBX

Gene Ontology

GO:0031265--C:CD95 death-inducing signaling complex
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031072--F:heat shock protein binding
GO:0051059--F:NF-kappaB binding
GO:0019901--F:protein kinase binding
GO:0019887--F:protein kinase regulator activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0006915--P:apoptotic process
GO:0008219--P:cell death
GO:0007253--P:cytoplasmic sequestering of NF-kappaB
GO:0043065--P:positive regulation of apoptotic process
GO:0010942--P:positive regulation of cell death
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0031334--P:positive regulation of protein complex assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030155--P:regulation of cell adhesion
GO:0042176--P:regulation of protein catabolic process

KEGG

hsa:11124

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002153	Ailuropoda melanoleuca	97.69	0.00e+00	1224.00
IUUC-Apl-004127	Anas platyrhynchos	91.22	0.00e+00	1138.00
IUUC-Aca-005188	Anolis carolinensis	90.42	0.00e+00	1129.00
IUUC-Ame-010696	Astyanax mexicanus	77.76	0.00e+00	870.00
IUUC-Bta-012965	Bos taurus	97.69	0.00e+00	1230.00
IUUC-Cel-018420	Caenorhabditis elegans	29.12	1.00e-29	125.00
IUUC-Cja-019128	Callithrix jacchus	97.86	0.00e+00	1248.00
IUUC-Cfa-021201	Canis familiaris	96.88	0.00e+00	910.00
IUUC-Cpo-021475	Cavia porcellus	96.05	0.00e+00	904.00
IUUC-Csa-024076	Chlorocebus sabaeus	97.69	0.00e+00	1237.00
IUUC-Cho-025067	Choloepus hoffmanni	83.54	0.00e+00	1064.00
IUUC-Cin-025663	Ciona intestinalis	43.79	6.00e-69	254.00
IUUC-Csv-025894	Ciona savignyi	34.56	1.00e-70	260.00
IUUC-Dre-027508	Danio rerio	75.26	0.00e+00	943.00
IUUC-Dno-029336	Dasypus novemcinctus	97.08	0.00e+00	1210.00
IUUC-Dor-030218	Dipodomys ordii	88.77	0.00e+00	1100.00
IUUC-Dme-031581	Drosophila melanogaster	32.63	3.00e-94	339.00
IUUC-Ete-032860	Echinops telfairi	75.98	0.00e+00	679.00
IUUC-Eca-034321	Equus caballus	98.40	0.00e+00	1059.00
IUUC-Eeu-034844	Erinaceus europaeus	75.20	4.00e-146	511.00
IUUC-Fca-036575	Felis catus	98.94	0.00e+00	732.00
IUUC-Fal-037128	Ficedula albicollis	91.55	0.00e+00	1159.00
IUUC-Gmo-038694	Gadus morhua	74.27	0.00e+00	906.00
IUUC-Gga-040826	Gallus gallus	91.86	0.00e+00	1167.00
IUUC-Gac-042125	Gasterosteus aculeatus	75.23	0.00e+00	971.00
IUUC-Ggo-045254	Gorilla gorilla	99.85	0.00e+00	1251.00
IUUC-Itr-048149	Ictidomys tridecemlineatus	98.28	5.00e-103	365.00
IUUC-Lch-050312	Latimeria chalumnae	81.29	0.00e+00	671.00
IUUC-Loc-051990	Lepisosteus oculatus	81.55	0.00e+00	967.00
IUUC-Laf-054375	Loxodonta africana	98.41	0.00e+00	730.00
IUUC-Mcc-054627	Macaca mulatta	99.22	0.00e+00	1212.00
IUUC-Meu-056611	Macropus eugenii	73.18	2.00e-133	469.00
IUUC-Mga-059400	Meleagris gallopavo	89.55	0.00e+00	1142.00
IUUC-Mmr-060882	Microcebus murinus	97.69	0.00e+00	1197.00
IUUC-Mdo-061874	Monodelphis domestica	92.15	0.00e+00	1180.00
IUUC-Mmu-063444	Mus musculus	95.08	0.00e+00	1217.00
IUUC-Mpu-065713	Mustela putorius furo	96.38	0.00e+00	1185.00
IUUC-Mlu-068122	Myotis lucifugus	96.42	0.00e+00	1165.00
IUUC-Nle-069025	Nomascus leucogenys	99.08	0.00e+00	1235.00
IUUC-Opr-071089	Ochotona princeps	86.00	0.00e+00	1096.00
IUUC-Ont-072421	Oreochromis niloticus	74.70	0.00e+00	951.00
IUUC-Oan-073092	Ornithorhynchus anatinus	89.09	0.00e+00	857.00
IUUC-Ola-086497	Oryzias latipes	75.71	0.00e+00	961.00
IUUC-Oga-088854	Otolemur garnettii	96.15	0.00e+00	1217.00
IUUC-Oar-090120	Ovis aries	97.85	0.00e+00	1208.00
IUUC-Ptr-091554	Pan troglodytes	99.85	0.00e+00	1251.00
IUUC-Pan-091985	Papio anubis	99.23	0.00e+00	1218.00
IUUC-Psi-093548	Pelodiscus sinensis	91.51	0.00e+00	1096.00
IUUC-Pma-094123	Petromyzon marinus	52.45	1.00e-51	196.00
IUUC-Pfo-096729	Poecilia formosa	74.18	0.00e+00	951.00
IUUC-Pab-097810	Pongo abelii	99.69	0.00e+00	1249.00
IUUC-Pca-101079	Procavia capensis	89.75	0.00e+00	905.00
IUUC-Pva-102534	Pteropus vampyrus	89.42	0.00e+00	931.00
IUUC-Rno-105127	Rattus norvegicus	94.46	0.00e+00	1099.00
IUUC-Sha-106667	Sarcophilus harrisii	93.10	0.00e+00	1032.00
IUUC-Ssl-108656	Sclerotinia sclerotiorum	24.63	1.40e-02	33.10
IUUC-Sar-113424	Sorex araneus	82.83	0.00e+00	653.00
IUUC-Ssc-115974	Sus scrofa	97.48	0.00e+00	1175.00
IUUC-Tgu-116495	Taeniopygia guttata	91.55	0.00e+00	1161.00
IUUC-Tru-118727	Takifugu rubripes	73.20	0.00e+00	933.00
IUUC-Tsy-118906	Tarsius syrichta	91.54	0.00e+00	1111.00
IUUC-Tni-119717	Tetraodon nigroviridis	76.38	0.00e+00	951.00
IUUC-Tbe-127849	Tupaia belangeri	82.69	0.00e+00	730.00
IUUC-Ttr-128660	Tursiops truncatus	93.25	0.00e+00	1158.00
IUUC-Vpa-130359	Vicugna pacos	97.95	0.00e+00	1205.00
IUUC-Xtr-132212	Xenopus tropicalis	86.87	0.00e+00	722.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence