iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000031770.16	ENSMUST00000161576.7	ENSMUSP00000124201.1
ENSMUSG00000031770.16	ENSMUST00000034220.7	ENSMUSP00000034220.7
ENSMUSG00000031770.16	ENSMUST00000161085.7	ENSMUSP00000148426.1
ENSMUSG00000031770.16	ENSMUST00000159450.1	ENSMUSP00000148775.1
ENSMUSG00000031770.16	ENSMUST00000211982.1	ENSMUSP00000148581.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10922362; 26616647

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	9.40e-14	52.2	10	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgke..felevseddtveelKekiakesgvp....peqqkLIyaGkiLkDdttLselgikdg..svvhlv 70
           ++l vk +++++  +el+++++++v++lK++++++  +p    pe+q+LIy+Gk L D+++L++l  k++  +v+hlv
   Q: 10   VTLLVKSPNQRHrdLELSGDRSWSVSRLKAHLSRV--YPerprPEDQRLIYSGKLLLDHQCLQDLLPKQEkrHVLHLV 85
           6899********999********************..777778*********************95544322566666 PP

Organism

Mus musculus

Functional Description
(View)

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.

Protein Sequence
(Fasta)

MEPEPQPEPV TLLVKSPNQR HRDLELSGDR SWSVSRLKAH LSRVYPERPR PEDQRLIYSG 60
KLLLDHQCLQ DLLPKQEKRH VLHLVCNVKN PSKMPETSTK GAESTEQPDN SNQTQHPGDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATCTGCGGA GCCCTGGCAC GGGGCGCCCA TAAAAGGTAC CCGAGACGGG GGCGCGTGTC 60
CCAAAGACGC CAAGTGTCGT TGTGTGGTCT CAGACGGCTG CGTCGCCGCC CGTTCGGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0834--Unfolded protein response

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0034704--C:calcium channel complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990037--C:Lewy body core
GO:0016020--C:membrane
GO:0044325--F:ion channel binding
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902235--P:regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903069--P:regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0031396--P:regulation of protein ubiquitination
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:64209

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001104	Aegilops tauschii	48.15	3.10e-01	29.60
IUUC-Aml-001647	Ailuropoda melanoleuca	88.98	3.00e-160	558.00
IUUC-Atr-002574	Amborella trichopoda	27.66	2.60e-01	28.10
IUUC-Apl-004142	Anas platyrhynchos	56.00	2.00e-79	289.00
IUUC-Acl-008367	Aspergillus clavatus	36.47	2.00e-04	40.80
IUUC-Afl-008623	Aspergillus flavus	43.86	2.00e-04	40.80
IUUC-Ani-009402	Aspergillus nidulans	33.02	6.00e-06	45.80
IUUC-Ang-009511	Aspergillus niger	38.36	3.00e-05	43.50
IUUC-Aor-010022	Aspergillus oryzae	43.86	2.00e-04	41.20
IUUC-Ate-010527	Aspergillus terreus	47.37	5.00e-06	46.20
IUUC-Ame-011187	Astyanax mexicanus	32.02	9.00e-48	184.00
IUUC-Bta-013339	Bos taurus	87.89	8.00e-156	543.00
IUUC-Cja-018806	Callithrix jacchus	87.50	4.00e-147	514.00
IUUC-Cfa-020141	Canis familiaris	88.71	2.00e-144	505.00
IUUC-Cpo-021802	Cavia porcellus	87.47	4.00e-166	577.00
IUUC-Csa-023973	Chlorocebus sabaeus	88.24	1.00e-159	555.00
IUUC-Cho-024463	Choloepus hoffmanni	82.72	3.00e-139	488.00
IUUC-Cin-025601	Ciona intestinalis	35.67	6.00e-14	71.60
IUUC-Csv-025997	Ciona savignyi	37.50	7.00e-11	58.90
IUUC-Cme-027117	Cyanidioschyzon merolae	30.10	3.00e-05	43.50
IUUC-Dno-029118	Dasypus novemcinctus	83.64	3.00e-160	558.00
IUUC-Dor-030815	Dipodomys ordii	83.25	2.00e-153	535.00
IUUC-Ete-033054	Echinops telfairi	67.89	3.00e-100	358.00
IUUC-Eca-033245	Equus caballus	85.56	2.00e-153	535.00
IUUC-Eeu-034795	Erinaceus europaeus	88.52	4.00e-164	570.00
IUUC-Fca-036200	Felis catus	90.03	6.00e-162	563.00
IUUC-Fal-036890	Ficedula albicollis	51.80	2.00e-76	279.00
IUUC-Fox-037920	Fusarium oxysporum	48.00	2.30e-01	29.60
IUUC-Gmo-038670	Gadus morhua	43.58	1.00e-32	134.00
IUUC-Gga-040151	Gallus gallus	52.77	1.00e-70	259.00
IUUC-Gac-041925	Gasterosteus aculeatus	36.48	8.00e-54	204.00
IUUC-Gma-043968	Glycine max	28.00	7.40e-02	32.70
IUUC-Ggo-045103	Gorilla gorilla	88.68	2.00e-149	521.00
IUUC-Hsa-046226	Homo sapiens	88.75	6.00e-162	563.00
IUUC-Itr-048589	Ictidomys tridecemlineatus	90.05	1.00e-168	585.00
IUUC-Lch-050254	Latimeria chalumnae	50.13	4.00e-64	238.00
IUUC-Loc-052154	Lepisosteus oculatus	51.63	1.00e-41	164.00
IUUC-Laf-053533	Loxodonta africana	87.12	2.00e-168	585.00
IUUC-Mcc-055840	Macaca mulatta	89.00	1.00e-161	562.00
IUUC-Meu-056691	Macropus eugenii	82.49	9.00e-109	386.00
IUUC-Mga-060042	Meleagris gallopavo	54.39	2.00e-74	272.00
IUUC-Mmr-060875	Microcebus murinus	90.58	3.00e-175	608.00
IUUC-Mdo-062924	Monodelphis domestica	77.81	4.00e-129	454.00
IUUC-Mpu-066883	Mustela putorius furo	89.24	8.00e-160	556.00
IUUC-Mlu-067932	Myotis lucifugus	82.14	2.00e-138	485.00
IUUC-Nfi-068353	Neosartorya fischeri	35.09	6.00e-06	46.20
IUUC-Nle-069005	Nomascus leucogenys	88.24	2.00e-160	558.00
IUUC-Opr-070231	Ochotona princeps	86.13	1.00e-160	559.00
IUUC-Ont-072578	Oreochromis niloticus	34.69	2.00e-39	156.00
IUUC-Oan-073354	Ornithorhynchus anatinus	70.57	2.00e-121	428.00
IUUC-Ocu-074495	Oryctolagus cuniculus	89.27	1.00e-160	559.00
IUUC-Ome-081116	Oryza meridionalis	42.55	2.20e+00	26.60
IUUC-Ola-087167	Oryzias latipes	35.28	3.00e-56	212.00
IUUC-Oga-088825	Otolemur garnettii	90.28	4.00e-162	564.00
IUUC-Oar-089616	Ovis aries	87.43	1.00e-151	529.00
IUUC-Ptr-090458	Pan troglodytes	88.49	5.00e-160	556.00
IUUC-Pan-091940	Papio anubis	88.55	6.00e-160	556.00
IUUC-Psi-093972	Pelodiscus sinensis	55.96	3.00e-55	208.00
IUUC-Pfo-096041	Poecilia formosa	40.61	3.00e-44	172.00
IUUC-Pab-097734	Pongo abelii	88.24	8.00e-170	589.00
IUUC-Pca-100301	Procavia capensis	78.88	4.00e-85	307.00
IUUC-Pva-102349	Pteropus vampyrus	88.86	2.00e-170	592.00
IUUC-Rno-105129	Rattus norvegicus	94.88	0.00e+00	630.00
IUUC-Sha-107280	Sarcophilus harrisii	78.18	3.00e-140	491.00
IUUC-Sar-113496	Sorex araneus	79.90	4.00e-144	504.00
IUUC-Ssc-115558	Sus scrofa	88.83	3.00e-93	333.00
IUUC-Tgu-117337	Taeniopygia guttata	50.91	4.00e-85	308.00
IUUC-Tru-117847	Takifugu rubripes	39.02	5.00e-40	158.00
IUUC-Tsy-119527	Tarsius syrichta	90.34	9.00e-128	449.00
IUUC-Tni-119885	Tetraodon nigroviridis	34.38	2.00e-50	192.00
IUUC-Tre-121967	Trichoderma reesei	37.29	4.00e-03	37.00
IUUC-Tur-126441	Triticum urartu	48.15	2.10e-01	30.40
IUUC-Tbe-127599	Tupaia belangeri	87.13	9.00e-88	317.00
IUUC-Ttr-128320	Tursiops truncatus	81.35	2.00e-137	481.00
IUUC-Vpa-130608	Vicugna pacos	89.46	2.00e-163	568.00
IUUC-Xtr-131896	Xenopus tropicalis	48.84	9.00e-54	204.00
IUUC-Xma-133006	Xiphophorus maculatus	43.28	2.00e-65	243.00
IUUC-Zma-135954	Zea mays	31.34	3.90e-01	29.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence