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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046562
UUCD1 version UUC-HoS-00146
Ensembl Protein ID ENSP00000361245.4
UniProt Accession Q5T447; B3KPV7; B3KRH4; Q5T448; Q9H783; HECD3_HUMAN
Genbank Protein ID BAB15015.1; BAG51819.1; BAG52386.1; CAI16437.1; CAI16438.1; EAX07010.1; AAH19105.2
Protein Name E3 ubiquitin-protein ligase HECTD3; HECT domain-containing protein 3; HECT-type E3 ubiquitin transferase HECTD3
Genbank Nucleotide ID AK024809; AK056873; AK091583; AL359473; AL359473; CH471059; BC019105
Gene Name HECTD3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000126107.14 ENST00000372168.7 ENSP00000361241.3
ENSG00000126107.14 ENST00000372172.4 ENSP00000361245.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 18194665; 20175895
Classification
Family E-value Score Start End
E3 activity/HECT 6.90e-76 257.5 527 853
Active Site
Position(s) Description Evidence
823 Glycyl thioester intermediate N/A
Domain Profile

   E3 activity/HECT
   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrlldlp 91
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l l 
   Q: 527  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFLVLA 618
           355*****************************9999*99**********************9999999************************ PP
   S: 92   lsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeYvklvve 179
           l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG+ i V + +++++++lv +
   Q: 619  LPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVMEG-----MDKETFEFKFGKELTFttvLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQK 705
           ***********************************5.....56666777777443334449******************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgs 271
           +rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ ++++++ +q+Fwe+l++f++e+r++fL+FvTg+
   Q: 706  ARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGR 795
           ****9.9*************************************************76.********************************* PP
   S: 272  srlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           srlP+        r++++++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 796  SRLPA--------RIYIYPDklgYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAID 853
           ****5........6667777799999**********************************998776 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
 E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).
Protein Sequence
(Fasta)
MAGPGPGAVL ESPRQLLGRV RFLAEAARSL RAGRPLPAAL AFVPREVLYK LYKDPAGPSR 60
VLLPVWEAEG LGLRVGAAGP APGTGSGPLR AARDSIELRR GACVRTTGEE LCNGHGLWVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046562|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCTGTCCG CGGTCGCGCC AGCTGTTCCC CGGGCAGGGT CGCCTCTAGG TGCTCACCTC 60
CGCCACTTCG CCATGGCGGG TCCTGGCCCG GGCGCGGTGC TGGAGTCCCC CCGGCAGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046562|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
PROSITE

PS51284--DOC
PS50237--HECT
Pfam

PF03256--ANAPC10
PF00632--HECT
SMART

SM01337--APC10
SM00119--HECTc
Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
KEGG hsa:79654
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001229 Ailuropoda melanoleuca 97.91 0.00e+00 1672.00
IUUC-Apl-003715 Anas platyrhynchos 85.25 0.00e+00 1317.00
IUUC-Aca-004377 Anolis carolinensis 79.01 0.00e+00 1385.00
IUUC-Ame-011918 Astyanax mexicanus 64.40 0.00e+00 1118.00
IUUC-Bta-012736 Bos taurus 98.61 0.00e+00 1692.00
IUUC-Cja-019926 Callithrix jacchus 98.72 0.00e+00 1684.00
IUUC-Cfa-020753 Canis familiaris 98.61 0.00e+00 1174.00
IUUC-Cpo-021415 Cavia porcellus 97.33 0.00e+00 1664.00
IUUC-Csa-023096 Chlorocebus sabaeus 99.77 0.00e+00 1697.00
IUUC-Dre-028746 Danio rerio 69.28 0.00e+00 1197.00
IUUC-Dno-029293 Dasypus novemcinctus 98.12 0.00e+00 1074.00
IUUC-Dor-031113 Dipodomys ordii 98.52 0.00e+00 1239.00
IUUC-Ete-032601 Echinops telfairi 89.54 0.00e+00 1421.00
IUUC-Eca-034198 Equus caballus 95.82 0.00e+00 1639.00
IUUC-Eeu-034708 Erinaceus europaeus 97.54 0.00e+00 901.00
IUUC-Fca-035478 Felis catus 98.55 0.00e+00 1655.00
IUUC-Fal-037366 Ficedula albicollis 76.99 0.00e+00 1343.00
IUUC-Gmo-039020 Gadus morhua 75.46 0.00e+00 1045.00
IUUC-Gga-040332 Gallus gallus 79.72 0.00e+00 1405.00
IUUC-Gac-042336 Gasterosteus aculeatus 69.86 0.00e+00 1241.00
IUUC-Ggo-045382 Gorilla gorilla 100.00 0.00e+00 1701.00
IUUC-Itr-048208 Ictidomys tridecemlineatus 98.26 0.00e+00 1679.00
IUUC-Lch-049606 Latimeria chalumnae 65.37 0.00e+00 838.00
IUUC-Loc-052448 Lepisosteus oculatus 62.63 0.00e+00 1070.00
IUUC-Laf-054507 Loxodonta africana 97.33 0.00e+00 1697.00
IUUC-Mcc-055690 Macaca mulatta 99.77 0.00e+00 1699.00
IUUC-Meu-055970 Macropus eugenii 85.13 0.00e+00 1438.00
IUUC-Mga-059654 Meleagris gallopavo 85.46 0.00e+00 1303.00
IUUC-Mmr-061069 Microcebus murinus 98.72 0.00e+00 1682.00
IUUC-Mdo-062547 Monodelphis domestica 92.20 0.00e+00 791.00
IUUC-Mmu-063096 Mus musculus 97.79 0.00e+00 1673.00
IUUC-Mpu-065846 Mustela putorius furo 98.03 0.00e+00 1686.00
IUUC-Mlu-067992 Myotis lucifugus 97.16 0.00e+00 1568.00
IUUC-Nle-069565 Nomascus leucogenys 100.00 0.00e+00 1594.00
IUUC-Opr-070853 Ochotona princeps 84.46 0.00e+00 1016.00
IUUC-Ont-071628 Oreochromis niloticus 69.36 0.00e+00 1208.00
IUUC-Ocu-074094 Oryctolagus cuniculus 98.61 0.00e+00 1682.00
IUUC-Ola-087384 Oryzias latipes 69.61 0.00e+00 1256.00
IUUC-Oga-088224 Otolemur garnettii 98.25 0.00e+00 1680.00
IUUC-Oar-090043 Ovis aries 92.45 0.00e+00 1573.00
IUUC-Ptr-090852 Pan troglodytes 99.77 0.00e+00 1692.00
IUUC-Pan-092787 Papio anubis 99.77 0.00e+00 1699.00
IUUC-Psi-092986 Pelodiscus sinensis 72.71 0.00e+00 976.00
IUUC-Pma-094416 Petromyzon marinus 40.56 4.00e-176 611.00
IUUC-Pfo-096720 Poecilia formosa 69.54 0.00e+00 1250.00
IUUC-Pab-098325 Pongo abelii 99.40 0.00e+00 1308.00
IUUC-Pca-100885 Procavia capensis 83.15 0.00e+00 1196.00
IUUC-Pva-102829 Pteropus vampyrus 86.36 0.00e+00 1056.00
IUUC-Rno-104882 Rattus norvegicus 98.03 0.00e+00 1672.00
IUUC-Sha-106811 Sarcophilus harrisii 91.04 7.00e-116 410.00
IUUC-Sar-113020 Sorex araneus 83.37 0.00e+00 707.00
IUUC-Ssc-115436 Sus scrofa 98.52 1.00e-158 552.00
IUUC-Tgu-117042 Taeniopygia guttata 79.42 0.00e+00 1394.00
IUUC-Tru-118419 Takifugu rubripes 67.21 0.00e+00 1171.00
IUUC-Tsy-118829 Tarsius syrichta 97.73 0.00e+00 989.00
IUUC-Tni-120410 Tetraodon nigroviridis 56.43 0.00e+00 926.00
IUUC-Tbe-128113 Tupaia belangeri 98.69 0.00e+00 780.00
IUUC-Ttr-128167 Tursiops truncatus 94.08 0.00e+00 1613.00
IUUC-Xtr-132910 Xenopus tropicalis 64.46 0.00e+00 1079.00
Created Date 25-Jun-2017

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