iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000017677.11	ENSMUST00000017821.11	ENSMUSP00000017821.5
ENSMUSG00000017677.11	ENSMUST00000131818.7	ENSMUSP00000131290.1
ENSMUSG00000017677.11	ENSMUST00000145772.7	ENSMUSP00000137999.1
ENSMUSG00000017677.11	ENSMUST00000131848.7	ENSMUSP00000128181.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.40e-14	54.1	375	420
E3 adaptor/Cullin RING/DCX/DWD	1.40e-30	105.1	173	203
UBD/Beta-Prp	1.80e-45	156.5	135	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++++SLqh+CR++Irr + +q++   +kLP P+++  +L+y+
   Q: 375  VYFWATPRQVPSLQHICRMSIRRVMSTQEV---QKLPVPSKILAFLSYR 420
           689************************999...**************96 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           v++l f +d   llvs+s+D+t++vWDl+++
   Q: 173  VRDLTFaPDgsLLLVSASRDKTLRVWDLKDD 203
           89999**7766779*************9887 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
            f +d+ llatg  +g+ik+wdv tgkll  l +h + v++++f pdg+ +lv++s+D+t++vwdl+ +g +v +l++h++ v+s++fs
   Q: 135  RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSlLLVSASRDKTLRVWDLKdDGNMVKVLRAHQNWVYSCAFS 223
           5678999******************************************999**************989******************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgght 180
           p+ + l s ++ + + +w++++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd  +g+ll ++             g+++
   Q: 224  PDCSMLCSVGASKAVFLWNMDKYTMIR-KLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEFghlfpsptpifaGGAND 311
           *99************************.9******************************************************98889* PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           + v+ +sf+++g +++s ++d+ v++w + +      + +  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 312  RWVRAVSFSHDGLHVASLADDKMVRFWRIDED--CPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           *****************************777..67789999*************************** PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity).

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGGENWTV AFAPDGSYFA WSQGYRIVKL 60
VPWSQCRKNF LLHGSKNVTN SSCLKLARQN SNGGQKNKPP EHVIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTCTGGTT TGGCGGCGGA AGCATTGGCG GGCTGTGTGA GTCTGTGAGT GGAAGGCGCG 60
CCGGCTCTTT TGTCTGAGTG TGACCCGGTG GCTTTGTTCC AGGCATTCCG GTGATTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction

KEGG

mmu:78889

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	92.38	0.00e+00	796.00
IUUC-Apl-003903	Anas platyrhynchos	85.47	0.00e+00	739.00
IUUC-Aca-005214	Anolis carolinensis	76.00	0.00e+00	674.00
IUUC-Ame-011740	Astyanax mexicanus	73.16	0.00e+00	657.00
IUUC-Bta-013475	Bos taurus	92.86	0.00e+00	799.00
IUUC-Cja-019053	Callithrix jacchus	92.84	0.00e+00	819.00
IUUC-Cfa-020103	Canis familiaris	93.10	0.00e+00	803.00
IUUC-Cpo-022438	Cavia porcellus	90.95	0.00e+00	807.00
IUUC-Csa-024062	Chlorocebus sabaeus	93.10	0.00e+00	823.00
IUUC-Cho-024334	Choloepus hoffmanni	80.48	0.00e+00	674.00
IUUC-Cin-025590	Ciona intestinalis	38.64	3.00e-75	275.00
IUUC-Csv-026023	Ciona savignyi	38.22	3.00e-74	272.00
IUUC-Dre-028089	Danio rerio	72.68	0.00e+00	655.00
IUUC-Dno-029436	Dasypus novemcinctus	88.40	0.00e+00	654.00
IUUC-Dor-031107	Dipodomys ordii	85.95	0.00e+00	728.00
IUUC-Ete-032326	Echinops telfairi	91.11	0.00e+00	756.00
IUUC-Eca-033401	Equus caballus	91.67	0.00e+00	790.00
IUUC-Eeu-034520	Erinaceus europaeus	90.00	0.00e+00	804.00
IUUC-Fca-036386	Felis catus	92.86	0.00e+00	798.00
IUUC-Fal-036616	Ficedula albicollis	82.76	0.00e+00	713.00
IUUC-Gmo-039335	Gadus morhua	70.44	7.00e-174	603.00
IUUC-Gga-040856	Gallus gallus	84.29	0.00e+00	752.00
IUUC-Gac-042140	Gasterosteus aculeatus	72.71	0.00e+00	650.00
IUUC-Ggo-044619	Gorilla gorilla	93.10	0.00e+00	822.00
IUUC-Hsa-046300	Homo sapiens	92.86	0.00e+00	821.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	92.14	0.00e+00	816.00
IUUC-Lch-049550	Latimeria chalumnae	77.39	3.00e-164	571.00
IUUC-Loc-051769	Lepisosteus oculatus	74.17	0.00e+00	664.00
IUUC-Laf-054576	Loxodonta africana	92.14	0.00e+00	797.00
IUUC-Mcc-054666	Macaca mulatta	93.49	1.00e-147	515.00
IUUC-Meu-055989	Macropus eugenii	85.71	0.00e+00	628.00
IUUC-Mga-059722	Meleagris gallopavo	83.33	0.00e+00	743.00
IUUC-Mmr-060970	Microcebus murinus	92.14	0.00e+00	796.00
IUUC-Mdo-062249	Monodelphis domestica	77.14	0.00e+00	630.00
IUUC-Mpu-066518	Mustela putorius furo	92.38	0.00e+00	819.00
IUUC-Mlu-068063	Myotis lucifugus	91.43	0.00e+00	790.00
IUUC-Nle-069561	Nomascus leucogenys	92.62	0.00e+00	820.00
IUUC-Opr-071158	Ochotona princeps	87.38	0.00e+00	779.00
IUUC-Ont-072542	Oreochromis niloticus	71.53	0.00e+00	645.00
IUUC-Oan-073217	Ornithorhynchus anatinus	88.84	0.00e+00	780.00
IUUC-Ocu-074251	Oryctolagus cuniculus	90.69	0.00e+00	772.00
IUUC-Ola-086549	Oryzias latipes	70.12	0.00e+00	644.00
IUUC-Oga-088382	Otolemur garnettii	92.38	0.00e+00	802.00
IUUC-Oar-090263	Ovis aries	91.67	0.00e+00	806.00
IUUC-Ptr-090922	Pan troglodytes	92.62	0.00e+00	820.00
IUUC-Pan-092518	Papio anubis	93.10	0.00e+00	823.00
IUUC-Psi-093512	Pelodiscus sinensis	85.95	0.00e+00	764.00
IUUC-Pma-094324	Petromyzon marinus	58.10	6.00e-135	474.00
IUUC-Pfo-096264	Poecilia formosa	70.59	0.00e+00	642.00
IUUC-Pab-098018	Pongo abelii	91.43	0.00e+00	807.00
IUUC-Pca-101034	Procavia capensis	89.90	0.00e+00	741.00
IUUC-Pva-102862	Pteropus vampyrus	87.62	0.00e+00	730.00
IUUC-Rno-106116	Rattus norvegicus	95.95	0.00e+00	838.00
IUUC-Sha-106952	Sarcophilus harrisii	88.73	0.00e+00	737.00
IUUC-Sar-113211	Sorex araneus	81.76	2.00e-146	511.00
IUUC-Ssc-116440	Sus scrofa	92.62	0.00e+00	799.00
IUUC-Tgu-116675	Taeniopygia guttata	83.00	0.00e+00	714.00
IUUC-Tru-118295	Takifugu rubripes	71.06	0.00e+00	628.00
IUUC-Tsy-118916	Tarsius syrichta	81.19	0.00e+00	678.00
IUUC-Tni-120302	Tetraodon nigroviridis	70.12	2.00e-180	624.00
IUUC-Tbe-127416	Tupaia belangeri	80.05	0.00e+00	645.00
IUUC-Ttr-128185	Tursiops truncatus	92.86	0.00e+00	800.00
IUUC-Xtr-132465	Xenopus tropicalis	79.76	0.00e+00	716.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence