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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064059
Ensembl Protein ID ENSMUSP00000025377.6
UniProt Accession Q6ZWR4; Q3UF60; Q8K413; Q9D3B7; Q9D6I1; 2ABB_MOUSE
Genbank Protein ID AAM46987.1; AAN05641.1; BAB28921.1; BAB31079.1; BAC30395.1; BAE28701.1; EDL10024.1; EDL10025.1; AAH26686.1; AAH88979.1
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta
Genbank Nucleotide ID AF512670; AF536771; AK013600; AK018119; AK039592; AK148956; CH466528; CH466528; BC026686; BC088979
Gene Name Ppp2r2b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024500.18 ENSMUST00000117687.7 ENSMUSP00000113731.1
ENSMUSG00000024500.18 ENSMUST00000025377.13 ENSMUSP00000025377.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-11 45.7 94 123
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf...sd.tllvsGsdDgtikvWDl 30
           +++ +++   ++  +++ +++D+t+k+W +
   Q: 94   KINKIRWlpqQNaAYFLLSTNDKTVKLWKV 123
           79999***986678899999********97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.
Protein Sequence
(Fasta)
MKCFSRYLPY IFRPPNTILS SSCHTEADII STVEFNHTGE LLATGDKGGR VVIFQREQES 60
KNQVHRRGEY NVYSTFQSHE PEFDYLKSLE IEEKINKIRW LPQQNAAYFL LSTNDKTVKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064059|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGGGGGCT TCTGAGTTTG AGCTGCCTGC AGAAATGTAA GGCATTGCTT CCTGGCGCTG 60
ATGGCAAAAT GGGACCCATC TCCAGTGATT CCTTGGGCTT CCCAGCTCTG CAGATCTGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064059|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PS00678--WD_REPEATS_1
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0006915--P:apoptotic process
GO:0032502--P:developmental process
GO:0000278--P:mitotic cell cycle
GO:0070262--P:peptidyl-serine dephosphorylation
KEGG mmu:72930
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001169 Aegilops tauschii 50.96 5.00e-125 441.00
IUUC-Aml-001777 Ailuropoda melanoleuca 99.52 0.00e+00 850.00
IUUC-Apl-004114 Anas platyrhynchos 98.57 0.00e+00 842.00
IUUC-Aca-004308 Anolis carolinensis 98.82 0.00e+00 849.00
IUUC-Aly-006304 Arabidopsis lyrata 52.46 2.00e-134 472.00
IUUC-Ago-007825 Ashbya gossypii 54.46 6.00e-132 464.00
IUUC-Ame-011491 Astyanax mexicanus 93.50 0.00e+00 864.00
IUUC-Bgr-012221 Blumeria graminis 54.63 2.00e-138 485.00
IUUC-Bta-012662 Bos taurus 100.00 0.00e+00 857.00
IUUC-Bol-016140 Brassica oleracea 52.67 5.00e-135 474.00
IUUC-Bra-018100 Brassica rapa 52.25 7.00e-135 474.00
IUUC-Cja-018822 Callithrix jacchus 99.76 0.00e+00 853.00
IUUC-Cfa-020968 Canis familiaris 99.53 0.00e+00 853.00
IUUC-Cpo-022045 Cavia porcellus 100.00 0.00e+00 854.00
IUUC-Cho-024810 Choloepus hoffmanni 100.00 0.00e+00 851.00
IUUC-Cne-026887 Cryptococcus neoformans 62.98 2.00e-149 522.00
IUUC-Cme-027332 Cyanidioschyzon merolae 47.64 6.00e-116 411.00
IUUC-Dre-027721 Danio rerio 93.60 0.00e+00 815.00
IUUC-Dno-029502 Dasypus novemcinctus 100.00 0.00e+00 857.00
IUUC-Ete-032410 Echinops telfairi 77.57 1.00e-174 605.00
IUUC-Eca-033882 Equus caballus 100.00 0.00e+00 857.00
IUUC-Fca-035978 Felis catus 99.76 0.00e+00 856.00
IUUC-Fal-037489 Ficedula albicollis 98.10 0.00e+00 840.00
IUUC-Gmo-039536 Gadus morhua 90.05 0.00e+00 788.00
IUUC-Gga-041033 Gallus gallus 97.98 0.00e+00 892.00
IUUC-Gac-041573 Gasterosteus aculeatus 89.81 0.00e+00 786.00
IUUC-Hsa-046527 Homo sapiens 100.00 0.00e+00 854.00
IUUC-Hvu-047813 Hordeum vulgare 51.84 5.00e-130 457.00
IUUC-Kpa-049100 Komagataella pastoris 54.09 4.00e-133 468.00
IUUC-Lch-050157 Latimeria chalumnae 96.67 0.00e+00 836.00
IUUC-Lpe-050866 Leersia perrieri 53.61 9.00e-133 466.00
IUUC-Loc-052619 Lepisosteus oculatus 94.08 0.00e+00 822.00
IUUC-Laf-053989 Loxodonta africana 99.76 0.00e+00 853.00
IUUC-Mcc-055718 Macaca mulatta 100.00 0.00e+00 853.00
IUUC-Meu-056450 Macropus eugenii 86.73 0.00e+00 717.00
IUUC-Mmr-061080 Microcebus murinus 100.00 0.00e+00 855.00
IUUC-Mdo-062231 Monodelphis domestica 99.29 0.00e+00 847.00
IUUC-Mpu-066201 Mustela putorius furo 99.53 0.00e+00 850.00
IUUC-Mlu-067042 Myotis lucifugus 93.16 0.00e+00 786.00
IUUC-Nle-069840 Nomascus leucogenys 100.00 0.00e+00 854.00
IUUC-Opr-070857 Ochotona princeps 99.52 0.00e+00 845.00
IUUC-Ont-071958 Oreochromis niloticus 90.28 0.00e+00 789.00
IUUC-Ocu-074693 Oryctolagus cuniculus 96.36 0.00e+00 858.00
IUUC-Oba-075019 Oryza barthii 52.70 2.00e-132 466.00
IUUC-Ogl-077077 Oryza glaberrima 52.63 1.00e-130 460.00
IUUC-Ogu-078671 Oryza glumaepatula 52.70 8.00e-133 467.00
IUUC-Oin-079114 Oryza indica 52.74 5.00e-132 464.00
IUUC-Olo-080800 Oryza longistaminata 52.93 1.00e-132 466.00
IUUC-Ome-081334 Oryza meridionalis 52.70 9.00e-133 467.00
IUUC-Oni-082387 Oryza nivara 51.78 3.00e-132 465.00
IUUC-Opu-084074 Oryza punctata 52.38 7.00e-134 470.00
IUUC-Osa-085954 Oryza sativa 52.70 1.00e-132 466.00
IUUC-Oga-088363 Otolemur garnettii 100.00 0.00e+00 857.00
IUUC-Oar-090213 Ovis aries 99.53 0.00e+00 850.00
IUUC-Ptr-090700 Pan troglodytes 99.78 0.00e+00 907.00
IUUC-Pan-092915 Papio anubis 99.76 0.00e+00 853.00
IUUC-Psi-093137 Pelodiscus sinensis 98.34 0.00e+00 845.00
IUUC-Pfo-096432 Poecilia formosa 90.13 0.00e+00 836.00
IUUC-Pab-097563 Pongo abelii 100.00 0.00e+00 854.00
IUUC-Pop-099639 Populus trichocarpa 50.10 2.00e-127 449.00
IUUC-Ppe-102006 Prunus persica 50.94 2.00e-126 446.00
IUUC-Pva-102279 Pteropus vampyrus 100.00 0.00e+00 854.00
IUUC-Pgr-103671 Puccinia graminis 52.38 6.00e-118 417.00
IUUC-Ptt-103844 Puccinia triticina 57.76 1.00e-142 499.00
IUUC-Rno-106071 Rattus norvegicus 93.30 0.00e+00 838.00
IUUC-Sha-106616 Sarcophilus harrisii 98.82 0.00e+00 850.00
IUUC-Sit-110793 Setaria italica 51.84 1.00e-132 466.00
IUUC-Stu-111973 Solanum tuberosum 49.58 2.00e-122 432.00
IUUC-Sre-115166 Sporisorium reilianum 61.33 4.00e-146 511.00
IUUC-Ssc-115334 Sus scrofa 93.19 0.00e+00 788.00
IUUC-Tgu-116646 Taeniopygia guttata 98.10 0.00e+00 839.00
IUUC-Tru-118603 Takifugu rubripes 89.34 0.00e+00 782.00
IUUC-Tni-120319 Tetraodon nigroviridis 89.34 0.00e+00 784.00
IUUC-Tca-121708 Theobroma cacao 51.36 2.00e-129 455.00
IUUC-Tur-126274 Triticum urartu 51.84 8.00e-126 444.00
IUUC-Tme-127130 Tuber melanosporum 60.66 4.00e-140 491.00
IUUC-Tbe-128016 Tupaia belangeri 93.29 0.00e+00 831.00
IUUC-Uma-129346 Ustilago maydis 61.33 4.00e-146 511.00
IUUC-Xtr-132662 Xenopus tropicalis 95.28 0.00e+00 819.00
Created Date 25-Jun-2017

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