iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028249.15	ENSMUST00000029912.10	ENSMUSP00000029912.4
ENSMUSG00000028249.15	ENSMUST00000103008.11	ENSMUSP00000100073.5
ENSMUSG00000028249.15	ENSMUST00000108374.7	ENSMUSP00000104011.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	BioGRID	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	90.30	1.00e-159	559.00	IUUC-Hsa-046922

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (By similarity). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (By similarity).

Protein Sequence
(Fasta)

MSLYPSLEDL KVDKVIQAQT AYSANPASQA FVLVDASAAL PPDGNLYPKL YPELSQYMGL 60
SLNEAEICES MPMVSGAPAQ GQLVARPSSV NYMVAPVTGN DAGIRRAEIK QGIREVILCK 120

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Nucleotide Sequence
(Fasta)

TGCGCCTGCG CGGCGGAAGG CGGGGGCGGT GATGACGCGC AGGGCGGGCC CCGAGGTTCG 60
GTTGTGTGGA GCTGGAGCGG GCAGCAGGAG CGGCGCGGTC CTCGGGGCAG GTGAGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted

Interpro

IPR001478--PDZ
IPR030528--SDCBP

PROSITE

PS50106--PDZ

Pfam

PF00595--PDZ

SMART

SM00228--PDZ

Gene Ontology

GO:0072562--C:blood microparticle
GO:0005913--C:cell-cell adherens junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:1903561--C:extracellular vesicle
GO:0005925--C:focal adhesion
GO:0005895--C:interleukin-5 receptor complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0042470--C:melanosome
GO:0045121--C:membrane raft
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0005109--F:frizzled binding
GO:0042802--F:identical protein binding
GO:0005137--F:interleukin-5 receptor binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0046982--F:protein heterodimerization activity
GO:0047485--F:protein N-terminus binding
GO:0045545--F:syndecan binding
GO:0030036--P:actin cytoskeleton organization
GO:0007268--P:chemical synaptic transmission
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0002091--P:negative regulation of receptor internalization
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0010718--P:positive regulation of epithelial to mesenchymal transition
GO:1903543--P:positive regulation of exosomal secretion
GO:1903553--P:positive regulation of extracellular exosome assembly
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042327--P:positive regulation of phosphorylation
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0007265--P:Ras protein signal transduction
GO:0007346--P:regulation of mitotic cell cycle

KEGG

mmu:53378

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001828	Ailuropoda melanoleuca	88.29	2.00e-156	544.00
IUUC-Apl-003873	Anas platyrhynchos	82.61	9.00e-147	512.00
IUUC-Bta-012904	Bos taurus	87.29	7.00e-157	546.00
IUUC-Cja-019757	Callithrix jacchus	89.97	2.00e-160	557.00
IUUC-Cpo-022386	Cavia porcellus	88.29	1.00e-155	542.00
IUUC-Csa-024043	Chlorocebus sabaeus	86.96	2.00e-151	528.00
IUUC-Dor-030235	Dipodomys ordii	89.01	5.00e-148	516.00
IUUC-Ete-033137	Echinops telfairi	86.96	2.00e-157	548.00
IUUC-Eca-033739	Equus caballus	89.74	6.00e-159	553.00
IUUC-Eeu-034833	Erinaceus europaeus	72.58	5.00e-121	427.00
IUUC-Fca-036103	Felis catus	88.63	5.00e-158	550.00
IUUC-Fal-037584	Ficedula albicollis	80.60	3.00e-144	504.00
IUUC-Gga-040373	Gallus gallus	81.94	3.00e-144	504.00
IUUC-Gac-041533	Gasterosteus aculeatus	64.17	7.00e-112	396.00
IUUC-Ggo-044813	Gorilla gorilla	89.97	5.00e-160	556.00
IUUC-Hsa-046922	Homo sapiens	90.30	6.00e-161	559.00
IUUC-Itr-048546	Ictidomys tridecemlineatus	89.63	3.00e-159	554.00
IUUC-Mga-059793	Meleagris gallopavo	79.55	4.00e-141	493.00
IUUC-Mmr-061366	Microcebus murinus	90.64	2.00e-160	558.00
IUUC-Mpu-066678	Mustela putorius furo	89.30	1.00e-158	551.00
IUUC-Mlu-067393	Myotis lucifugus	89.30	8.00e-159	552.00
IUUC-Nle-069522	Nomascus leucogenys	90.30	1.00e-160	558.00
IUUC-Opr-070549	Ochotona princeps	72.58	1.00e-121	429.00
IUUC-Oan-072873	Ornithorhynchus anatinus	73.36	2.00e-124	438.00
IUUC-Ocu-073976	Oryctolagus cuniculus	88.96	1.00e-157	548.00
IUUC-Ola-087243	Oryzias latipes	64.50	1.00e-111	396.00
IUUC-Oga-088683	Otolemur garnettii	90.64	2.00e-160	558.00
IUUC-Pan-091787	Papio anubis	90.64	5.00e-161	560.00
IUUC-Psi-093783	Pelodiscus sinensis	83.28	5.00e-150	523.00
IUUC-Pca-100815	Procavia capensis	88.29	8.00e-155	539.00
IUUC-Pva-102191	Pteropus vampyrus	79.60	4.00e-137	480.00
IUUC-Rno-106107	Rattus norvegicus	95.67	1.00e-169	588.00
IUUC-Sha-107239	Sarcophilus harrisii	87.63	2.00e-156	545.00
IUUC-Sar-113431	Sorex araneus	88.63	2.00e-157	548.00
IUUC-Tgu-117393	Taeniopygia guttata	80.94	8.00e-145	506.00
IUUC-Tru-118034	Takifugu rubripes	28.87	5.00e-09	56.60
IUUC-Tsy-119079	Tarsius syrichta	88.96	1.00e-158	552.00
IUUC-Tbe-127482	Tupaia belangeri	80.60	9.00e-138	482.00
IUUC-Ttr-128987	Tursiops truncatus	70.57	1.00e-118	419.00
IUUC-Vpa-130478	Vicugna pacos	65.55	8.00e-105	373.00
IUUC-Xtr-132378	Xenopus tropicalis	74.92	2.00e-134	471.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence