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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063497
UUCD1 version UUC-MuM-00819
Ensembl Protein ID ENSMUSP00000040331.5
UniProt Accession Q9WV71; Q3UZE1; Q3V070; ASB4_MOUSE
Genbank Protein ID AAD38811.1; BAB31183.1; BAE21634.1; BAE21916.1; AAH54745.1; AAH46819.1; AAH56440.1
Protein Name Ankyrin repeat and SOCS box protein 4
Genbank Nucleotide ID AF155355; AK018373; AK133400; AK133894; BC054745; BC046819; BC056440
Gene Name Asb4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042607.15 ENSMUST00000043294.11 ENSMUSP00000040331.5
ENSMUSG00000042607.15 ENSMUST00000183358.1 ENSMUSP00000139245.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.10e-13 52.0 371 421
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           +s ++++++ pr+L+hL+R+aIr++l+++++kai+ L LP  Lk+YLl e+
   Q: 371  HSLFKVCCNTPRTLMHLSRCAIRKALHNRCHKAIPMLSLPLPLKKYLLLEP 421
           57899*******************************************986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism.
Protein Sequence
(Fasta)
MDGITAPISK AGAAKLVKKD FLEALKTNDF GKLKAILIER QIDVDTVFEV EDENMILASY 60
KQGYWLPSYK LKSSWATGLH LSVLLGHVEC LMVLLDHNAT INCRPNGKTP LHVACEIANL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063497|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAAAGTGCT ACCCCAAAAG GTAAAATCAA ATCGATGAAT CTTTGCAACT GGTAAACTGC 60
TTCTTGGTTT CTGTGAACTC TGAGGGCTAA AGGGCATCCT GGGATCTTAG GAAAGAAGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063497|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0379--Hydroxylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019899--F:enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
GO:2001214--P:positive regulation of vasculogenesis
GO:0051865--P:protein autoubiquitination
KEGG mmu:65255
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002121 Ailuropoda melanoleuca 90.61 0.00e+00 793.00
IUUC-Apl-003640 Anas platyrhynchos 72.08 0.00e+00 640.00
IUUC-Aca-004633 Anolis carolinensis 69.90 3.00e-161 561.00
IUUC-Ame-011455 Astyanax mexicanus 54.92 2.00e-137 482.00
IUUC-Bta-012772 Bos taurus 90.61 0.00e+00 787.00
IUUC-Cja-018805 Callithrix jacchus 92.25 0.00e+00 803.00
IUUC-Cfa-021119 Canis familiaris 91.07 0.00e+00 778.00
IUUC-Cpo-022349 Cavia porcellus 91.78 0.00e+00 792.00
IUUC-Csa-023426 Chlorocebus sabaeus 92.02 0.00e+00 801.00
IUUC-Cho-024384 Choloepus hoffmanni 84.51 0.00e+00 703.00
IUUC-Dre-028243 Danio rerio 59.33 5.00e-146 510.00
IUUC-Dno-029462 Dasypus novemcinctus 90.61 0.00e+00 785.00
IUUC-Dor-030208 Dipodomys ordii 92.72 0.00e+00 805.00
IUUC-Eca-033920 Equus caballus 91.08 0.00e+00 780.00
IUUC-Fca-035828 Felis catus 91.08 0.00e+00 796.00
IUUC-Fal-037195 Ficedula albicollis 72.75 1.00e-177 615.00
IUUC-Gmo-039649 Gadus morhua 57.00 1.00e-141 496.00
IUUC-Gga-040225 Gallus gallus 71.76 0.00e+00 646.00
IUUC-Gac-041685 Gasterosteus aculeatus 59.42 3.00e-140 491.00
IUUC-Ggo-044623 Gorilla gorilla 92.49 0.00e+00 806.00
IUUC-Hsa-045812 Homo sapiens 92.49 0.00e+00 806.00
IUUC-Itr-048132 Ictidomys tridecemlineatus 94.84 3.00e-169 587.00
IUUC-Lch-049996 Latimeria chalumnae 67.61 4.00e-169 587.00
IUUC-Loc-052262 Lepisosteus oculatus 62.63 1.00e-152 532.00
IUUC-Laf-054527 Loxodonta africana 89.91 0.00e+00 786.00
IUUC-Mcc-054758 Macaca mulatta 92.02 0.00e+00 801.00
IUUC-Meu-056293 Macropus eugenii 80.38 1.00e-71 263.00
IUUC-Mga-059970 Meleagris gallopavo 71.76 0.00e+00 644.00
IUUC-Mdo-061829 Monodelphis domestica 55.75 7.00e-118 417.00
IUUC-Mpu-066315 Mustela putorius furo 91.55 0.00e+00 795.00
IUUC-Mlu-067796 Myotis lucifugus 90.38 0.00e+00 791.00
IUUC-Nle-069623 Nomascus leucogenys 92.02 0.00e+00 804.00
IUUC-Opr-070668 Ochotona princeps 88.89 2.00e-84 306.00
IUUC-Ont-071845 Oreochromis niloticus 57.49 3.00e-140 491.00
IUUC-Ocu-073775 Oryctolagus cuniculus 92.49 0.00e+00 797.00
IUUC-Ola-087538 Oryzias latipes 57.18 5.00e-144 504.00
IUUC-Oga-088686 Otolemur garnettii 90.85 0.00e+00 790.00
IUUC-Oar-089699 Ovis aries 91.55 0.00e+00 795.00
IUUC-Ptr-091174 Pan troglodytes 92.72 0.00e+00 808.00
IUUC-Pan-091808 Papio anubis 86.65 0.00e+00 737.00
IUUC-Psi-093303 Pelodiscus sinensis 75.18 0.00e+00 645.00
IUUC-Pma-094421 Petromyzon marinus 50.37 1.00e-70 259.00
IUUC-Pfo-097113 Poecilia formosa 59.43 2.00e-119 422.00
IUUC-Pab-097980 Pongo abelii 92.49 0.00e+00 806.00
IUUC-Pca-100774 Procavia capensis 90.11 0.00e+00 694.00
IUUC-Ppe-101537 Prunus persica 38.68 1.00e-11 64.30
IUUC-Pva-102657 Pteropus vampyrus 93.39 0.00e+00 687.00
IUUC-Rno-105621 Rattus norvegicus 97.89 0.00e+00 835.00
IUUC-Sha-107576 Sarcophilus harrisii 71.60 4.00e-175 607.00
IUUC-Sar-113553 Sorex araneus 92.31 0.00e+00 708.00
IUUC-Ssc-115943 Sus scrofa 91.31 0.00e+00 795.00
IUUC-Tgu-116687 Taeniopygia guttata 72.50 1.00e-177 615.00
IUUC-Tru-117879 Takifugu rubripes 55.64 1.00e-134 473.00
IUUC-Tsy-119538 Tarsius syrichta 90.12 9.00e-85 307.00
IUUC-Tni-120849 Tetraodon nigroviridis 57.97 2.00e-123 435.00
IUUC-Tbe-127993 Tupaia belangeri 92.25 0.00e+00 791.00
IUUC-Ttr-128419 Tursiops truncatus 90.61 0.00e+00 792.00
IUUC-Vpa-130445 Vicugna pacos 90.14 0.00e+00 787.00
IUUC-Xtr-132386 Xenopus tropicalis 64.68 4.00e-156 544.00
Created Date 25-Jun-2017

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