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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046394
UUCD1 version UUC-HoS-00510
Ensembl Protein ID ENSP00000388723.2
UniProt Accession C9JR72; KBTBD_HUMAN
Genbank Protein ID EAW77711.1
Protein Name Kelch repeat and BTB domain-containing protein 13
Genbank Nucleotide ID AC013553
Gene Name KBTBD13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000234438.3 ENST00000432196.3 ENSP00000388723.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
miRTarBaseTRANSFACTargetScanmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexInWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 22542517
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.60e-07 33.2 9 69
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 0.00054 19.4 103 131
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 3    vilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgk 64
           v++ vgg+ f+a ++ L  ++ +F+ lf ++++e++   +v +  ++++ fra l+ l+ ++
   Q: 9    VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETR-AAEVRLGVLSAGGFRATLQVLRGDR 69
           8889*******************************9.99999999***********998766 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilk 29
           ++Nc+ ++++A +++++d+ ++a  fi++
   Q: 103  SDNCALLCDAAAAFGLRDVFHSAALFICD 131
           69**************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.
Protein Sequence
(Fasta)
MARGPQTLVQ VWVGGQLFQA DRALLVEHCG FFRGLFRSGM RETRAAEVRL GVLSAGGFRA 60
TLQVLRGDRP ALAAEDELLQ AVECAAFLQA PALARFLEHN LTSDNCALLC DAAAAFGLRD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046394|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCACGGG GTCCACAGAC CCTGGTGCAG GTGTGGGTGG GCGGCCAGCT CTTCCAAGCC 60
GACCGCGCCC TGCTGGTGGA GCACTGTGGC TTCTTCCGAG GCCTCTTCCG CTCCGGCATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046394|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-1057--Nemaline myopathy
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF00651--BTB
PF01344--Kelch_1
SMART

SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination
KEGG hsa:390594
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003699 Anas platyrhynchos 63.37 1.00e-144 506.00
IUUC-Aca-004959 Anolis carolinensis 57.76 2.00e-155 542.00
IUUC-Ame-011920 Astyanax mexicanus 53.72 1.00e-135 476.00
IUUC-Bta-012380 Bos taurus 89.52 0.00e+00 782.00
IUUC-Cja-019736 Callithrix jacchus 93.89 0.00e+00 806.00
IUUC-Cpo-022236 Cavia porcellus 90.25 0.00e+00 712.00
IUUC-Csa-023908 Chlorocebus sabaeus 95.63 0.00e+00 835.00
IUUC-Dre-027361 Danio rerio 52.62 4.00e-133 468.00
IUUC-Dno-030079 Dasypus novemcinctus 92.36 0.00e+00 823.00
IUUC-Ete-032377 Echinops telfairi 86.40 0.00e+00 674.00
IUUC-Eca-034407 Equus caballus 95.22 3.00e-142 497.00
IUUC-Fca-035574 Felis catus 88.81 0.00e+00 751.00
IUUC-Fal-036769 Ficedula albicollis 63.24 1.00e-162 566.00
IUUC-Gmo-038753 Gadus morhua 53.95 3.00e-107 382.00
IUUC-Gga-040678 Gallus gallus 63.66 9.00e-151 526.00
IUUC-Gac-041669 Gasterosteus aculeatus 52.28 5.00e-109 387.00
IUUC-Ggo-044613 Gorilla gorilla 99.17 8.00e-143 499.00
IUUC-Itr-048535 Ictidomys tridecemlineatus 89.08 0.00e+00 796.00
IUUC-Lch-049523 Latimeria chalumnae 54.34 7.00e-140 490.00
IUUC-Loc-052394 Lepisosteus oculatus 56.62 1.00e-139 489.00
IUUC-Laf-053945 Loxodonta africana 81.56 0.00e+00 689.00
IUUC-Mcc-055194 Macaca mulatta 95.63 0.00e+00 830.00
IUUC-Mga-059920 Meleagris gallopavo 58.69 1.00e-140 493.00
IUUC-Mdo-062291 Monodelphis domestica 76.01 0.00e+00 684.00
IUUC-Mmu-063371 Mus musculus 86.24 0.00e+00 780.00
IUUC-Mpu-066900 Mustela putorius furo 90.99 0.00e+00 759.00
IUUC-Mlu-067679 Myotis lucifugus 85.71 1.00e-111 396.00
IUUC-Ont-071874 Oreochromis niloticus 48.89 6.00e-121 427.00
IUUC-Oan-073257 Ornithorhynchus anatinus 72.81 6.00e-43 165.00
IUUC-Ocu-074692 Oryctolagus cuniculus 80.13 9.00e-180 622.00
IUUC-Ola-086638 Oryzias latipes 52.04 7.00e-117 414.00
IUUC-Oga-088679 Otolemur garnettii 91.10 0.00e+00 760.00
IUUC-Oar-089583 Ovis aries 90.00 8.00e-137 479.00
IUUC-Ptr-091441 Pan troglodytes 94.76 0.00e+00 802.00
IUUC-Pan-092522 Papio anubis 95.20 0.00e+00 828.00
IUUC-Psi-093222 Pelodiscus sinensis 60.76 3.00e-163 567.00
IUUC-Pfo-097348 Poecilia formosa 51.59 8.00e-128 450.00
IUUC-Pab-097889 Pongo abelii 97.83 0.00e+00 758.00
IUUC-Tru-117584 Takifugu rubripes 50.69 4.00e-123 434.00
IUUC-Tni-119886 Tetraodon nigroviridis 49.53 3.00e-107 381.00
IUUC-Xtr-131981 Xenopus tropicalis 54.81 5.00e-134 471.00
Created Date 25-Jun-2017

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