iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.73	1.00e-17	87.80	IUUC-Hsa-046908

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Protein Sequence
(Fasta)

MEYPNPPPPV TSNYQGEPEK IAQATDMMIK RVTDAKKIIE ELLQMLDLQE KCPWPLMLEK 60
FSTLASFMSS LQSSVRKSGM PHGHEDYGQF LRSHVLVTQR LQYEPDETLQ RATQGRVMSW 120

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Nucleotide Sequence
(Fasta)

ATGGAGTATC CAAATCCACC TCCTCCGGTG ACTTCGAATT ACCAAGGCGA GCCTGAGAAA 60
ATCGCACAAG CTACGGATAT GATGATCAAA AGAGTGACGG ACGCCAAGAA AATCATCGAA 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR019364--Mediatior_Med8_fun/met

Pfam

PF10232--Med8

Gene Ontology

GO:0016592--C:mediator complex
GO:0001104--F:RNA polymerase II transcription cofactor activity
GO:0006351--P:transcription, DNA-templated

KEGG

cel:CELE_Y62F5A.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001562	Ailuropoda melanoleuca	26.60	5.00e-17	79.70
IUUC-Apl-004218	Anas platyrhynchos	26.50	2.00e-16	77.80
IUUC-Aca-005363	Anolis carolinensis	28.19	7.00e-23	99.80
IUUC-Ame-011384	Astyanax mexicanus	28.12	7.00e-20	89.40
IUUC-Bta-012751	Bos taurus	26.73	5.00e-17	80.10
IUUC-Cja-019318	Callithrix jacchus	26.60	3.00e-17	81.30
IUUC-Cfa-020106	Canis familiaris	26.27	3.00e-09	53.90
IUUC-Cpo-022416	Cavia porcellus	28.31	3.00e-15	74.30
IUUC-Csa-023695	Chlorocebus sabaeus	26.73	5.00e-17	80.10
IUUC-Cin-025570	Ciona intestinalis	26.50	3.00e-17	80.90
IUUC-Csv-025808	Ciona savignyi	27.18	9.00e-16	75.50
IUUC-Dre-027606	Danio rerio	26.38	3.00e-14	70.10
IUUC-Dno-029924	Dasypus novemcinctus	28.05	5.00e-16	76.60
IUUC-Dor-030115	Dipodomys ordii	26.73	2.00e-17	81.30
IUUC-Dme-031887	Drosophila melanogaster	28.43	2.00e-16	77.40
IUUC-Eca-034101	Equus caballus	26.73	4.00e-17	80.10
IUUC-Eeu-034655	Erinaceus europaeus	25.37	2.00e-14	71.60
IUUC-Fca-036172	Felis catus	26.73	2.00e-17	81.30
IUUC-Fal-036877	Ficedula albicollis	26.67	2.00e-16	77.80
IUUC-Gmo-039244	Gadus morhua	27.45	5.00e-19	86.70
IUUC-Gga-040751	Gallus gallus	26.73	4.00e-16	77.00
IUUC-Gac-041885	Gasterosteus aculeatus	28.81	1.00e-21	95.50
IUUC-Ggo-045201	Gorilla gorilla	26.73	2.00e-16	78.20
IUUC-Hsa-046908	Homo sapiens	26.73	2.00e-16	78.20
IUUC-Itr-048814	Ictidomys tridecemlineatus	26.60	4.00e-17	80.50
IUUC-Lch-049994	Latimeria chalumnae	34.68	1.00e-15	75.50
IUUC-Loc-051765	Lepisosteus oculatus	29.24	1.00e-20	91.70
IUUC-Laf-053336	Loxodonta africana	28.92	1.00e-18	85.50
IUUC-Mcc-055259	Macaca mulatta	26.73	3.00e-16	77.40
IUUC-Meu-056166	Macropus eugenii	26.37	2.00e-16	78.20
IUUC-Mga-059317	Meleagris gallopavo	26.50	8.00e-16	76.30
IUUC-Mmr-061501	Microcebus murinus	26.73	2.00e-17	81.30
IUUC-Mdo-062026	Monodelphis domestica	26.73	7.00e-17	79.30
IUUC-Mmu-063469	Mus musculus	26.73	2.00e-17	81.30
IUUC-Mpu-065945	Mustela putorius furo	26.60	6.00e-17	79.70
IUUC-Mlu-067414	Myotis lucifugus	26.73	3.00e-17	80.90
IUUC-Nle-069411	Nomascus leucogenys	26.73	2.00e-16	78.60
IUUC-Opr-070733	Ochotona princeps	27.09	2.00e-17	81.60
IUUC-Ont-071344	Oreochromis niloticus	28.92	1.00e-20	92.00
IUUC-Oan-073366	Ornithorhynchus anatinus	27.23	7.00e-17	79.70
IUUC-Ocu-074762	Oryctolagus cuniculus	26.73	5.00e-17	80.10
IUUC-Ola-086874	Oryzias latipes	28.88	1.00e-20	92.40
IUUC-Oga-088187	Otolemur garnettii	26.60	2.00e-17	81.60
IUUC-Oar-089832	Ovis aries	26.73	5.00e-17	80.10
IUUC-Ptr-091178	Pan troglodytes	26.73	1.00e-16	78.60
IUUC-Pan-092520	Papio anubis	26.73	2.00e-16	78.60
IUUC-Psi-093517	Pelodiscus sinensis	25.19	1.00e-17	81.60
IUUC-Pma-094752	Petromyzon marinus	27.75	4.00e-20	90.10
IUUC-Pfo-096659	Poecilia formosa	29.73	2.00e-23	101.00
IUUC-Pca-101064	Procavia capensis	25.74	1.00e-10	58.50
IUUC-Pva-102173	Pteropus vampyrus	26.24	3.00e-17	80.90
IUUC-Sar-113363	Sorex araneus	27.23	2.00e-16	78.20
IUUC-Ssc-115563	Sus scrofa	26.73	7.00e-20	89.70
IUUC-Tgu-116686	Taeniopygia guttata	26.67	2.00e-16	77.80
IUUC-Tru-118003	Takifugu rubripes	26.47	2.00e-17	81.60
IUUC-Tsy-118875	Tarsius syrichta	29.01	5.00e-13	67.00
IUUC-Tni-120624	Tetraodon nigroviridis	26.83	1.00e-16	79.00
IUUC-Tbe-127611	Tupaia belangeri	27.95	3.00e-15	74.30
IUUC-Ttr-129198	Tursiops truncatus	26.73	1.00e-19	89.00
IUUC-Vpa-130245	Vicugna pacos	28.40	4.50e+00	23.50
IUUC-Xtr-132397	Xenopus tropicalis	25.74	6.00e-20	89.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence