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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105800
UUCD1 version UUC-RaN-00943
Ensembl Protein ID ENSRNOP00000058869.1
UniProt Accession Q91Z63; TRI63_RAT
Genbank Protein ID AAL16405.1; AAH61824.1
Protein Name E3 ubiquitin-protein ligase TRIM63; Muscle-specific RING finger protein 1; RING-type E3 ubiquitin transferase TRIM63; Tripartite motif-containing protein 63
Genbank Nucleotide ID AY059627; BC061824
Gene Name Trim63; Murf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000016543.7 ENSRNOT00000067524.3 ENSRNOP00000058869.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
miRTarBasemicroRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 5.00e-10 40.1 23 79
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...........pglknssskefrCPlCr 46
           C+iCle+f +++++lpC+H  +++C + +            g+ ++s ++frCP Cr
   Q: 23   CPICLEMFTKPVVILPCQHNLCRKCANDIfqaanpywtnrGGSVSMSGGRFRCPSCR 79
           *************************755556667779***999999**********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
 E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Protein Sequence
(Fasta)
MDYKSGLIPD GNAMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT 60
NRGGSVSMSG GRFRCPSCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105800|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAGAAGCCG GGTGTTCGGG GAGGAAGACA AAGAGGATCC GAGTGGGATC CCTTCCACTC 60
GGTGTGACGC AGGTGGAAGA GACAGTCGCA GTTTCGAAGC AATATGGATT ATAAATCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105800|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0514--Muscle protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017903--COS_domain
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0043292--C:contractile fiber
GO:0031430--C:M band
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006936--P:muscle contraction
GO:0010614--P:negative regulation of cardiac muscle hypertrophy
GO:0014878--P:response to electrical stimulus involved in regulation of muscle adaptation
GO:0051384--P:response to glucocorticoid
GO:0070555--P:response to interleukin-1
GO:0014732--P:skeletal muscle atrophy
KEGG rno:140939
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001472 Ailuropoda melanoleuca 93.88 0.00e+00 639.00
IUUC-Apl-003286 Anas platyrhynchos 65.95 9.00e-126 442.00
IUUC-Aca-004871 Anolis carolinensis 74.01 6.00e-143 500.00
IUUC-Bta-013137 Bos taurus 91.46 2.00e-180 625.00
IUUC-Cja-019635 Callithrix jacchus 91.98 1.00e-170 592.00
IUUC-Cfa-020506 Canis familiaris 92.35 0.00e+00 631.00
IUUC-Cpo-022289 Cavia porcellus 93.23 0.00e+00 633.00
IUUC-Csa-023387 Chlorocebus sabaeus 92.90 2.00e-172 597.00
IUUC-Dno-029227 Dasypus novemcinctus 82.53 5.00e-170 590.00
IUUC-Dor-030999 Dipodomys ordii 84.36 1.00e-159 555.00
IUUC-Ete-033039 Echinops telfairi 93.85 8.00e-178 615.00
IUUC-Eca-033370 Equus caballus 94.10 4.00e-177 613.00
IUUC-Eeu-035345 Erinaceus europaeus 94.17 0.00e+00 642.00
IUUC-Fca-036216 Felis catus 92.92 0.00e+00 631.00
IUUC-Fal-036673 Ficedula albicollis 67.38 1.00e-123 435.00
IUUC-Gga-040807 Gallus gallus 74.84 5.00e-144 503.00
IUUC-Ggo-044440 Gorilla gorilla 92.66 1.00e-172 598.00
IUUC-Hsa-045762 Homo sapiens 92.35 5.00e-173 600.00
IUUC-Itr-048877 Ictidomys tridecemlineatus 91.67 2.00e-180 624.00
IUUC-Lch-049518 Latimeria chalumnae 68.52 3.00e-135 474.00
IUUC-Loc-052735 Lepisosteus oculatus 58.15 4.00e-124 437.00
IUUC-Laf-054300 Loxodonta africana 92.64 0.00e+00 629.00
IUUC-Mcc-055645 Macaca mulatta 92.97 2.00e-174 605.00
IUUC-Meu-056393 Macropus eugenii 74.38 2.00e-136 478.00
IUUC-Mga-059391 Meleagris gallopavo 74.84 4.00e-138 484.00
IUUC-Mmr-061101 Microcebus murinus 90.45 4.00e-170 590.00
IUUC-Mdo-062275 Monodelphis domestica 90.31 2.00e-176 611.00
IUUC-Mmu-063934 Mus musculus 97.83 0.00e+00 649.00
IUUC-Mpu-066782 Mustela putorius furo 93.27 0.00e+00 636.00
IUUC-Mlu-067263 Myotis lucifugus 92.52 6.00e-115 406.00
IUUC-Nle-070021 Nomascus leucogenys 91.44 3.00e-172 597.00
IUUC-Opr-070997 Ochotona princeps 90.40 0.00e+00 640.00
IUUC-Oan-072909 Ornithorhynchus anatinus 86.20 2.00e-169 588.00
IUUC-Ocu-073858 Oryctolagus cuniculus 93.25 0.00e+00 642.00
IUUC-Oga-088334 Otolemur garnettii 85.54 8.00e-163 566.00
IUUC-Oar-090426 Ovis aries 91.13 1.00e-180 625.00
IUUC-Ptr-091030 Pan troglodytes 92.66 1.00e-173 602.00
IUUC-Pan-091789 Papio anubis 92.94 4.00e-174 603.00
IUUC-Psi-093437 Pelodiscus sinensis 76.99 1.00e-153 535.00
IUUC-Pab-098375 Pongo abelii 92.64 6.00e-173 599.00
IUUC-Pva-103090 Pteropus vampyrus 89.91 8.00e-171 592.00
IUUC-Sha-106977 Sarcophilus harrisii 90.74 3.00e-179 620.00
IUUC-Sar-113592 Sorex araneus 95.09 1.00e-177 615.00
IUUC-Ssc-116150 Sus scrofa 92.38 5.00e-173 600.00
IUUC-Tgu-117274 Taeniopygia guttata 75.93 8.00e-146 509.00
Created Date 25-Jun-2017

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