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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063710
UUCD1 version UUC-MuM-01193
Ensembl Protein ID ENSMUSP00000034508.7
UniProt Accession O88623; Q6X4T9; Q6X4U1; Q8VD74; Q9JJ87; UBP2_MOUSE
Genbank Protein ID AAQ83301.1; AAQ83302.1; AAQ83303.1; AAQ83304.1; BAA95110.1; BAE23782.1; AAH17517.1; AAC28393.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2
Genbank Nucleotide ID AY255637; AY255638; AY255639; AY255640; AB041799; AK138799; BC017517; AF079565
Gene Name Usp2; Ubp41; MNCb-0190
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032010.15 ENSMUST00000034508.13 ENSMUSP00000034508.7
ENSMUSG00000032010.15 ENSMUST00000065461.8 ENSMUSP00000070264.7
ENSMUSG00000032010.15 ENSMUST00000176416.7 ENSMUSP00000135482.1
ENSMUSG00000032010.15 ENSMUST00000175816.1 ENSMUSP00000135788.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.20e-97 328.2 282 611
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           Gl+NlgNtC+mNS+LQcLsn++elr+++l+  + ++l ++  ++ +++l+++++kl++ +w +s + +vsp+e++++++++a++f gy+
   Q: 282  GLRNLGNTCFMNSILQCLSNTRELRDYCLQrLYMRDLGHT--SSAHTALMEEFAKLIQTIWtSSPNDVVSPSEFKTQIQRYAPRFMGYN 368
           9*****************************7788888877..7899***************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk...eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           qqDaqEfl+flld+l++e+++   + + + e++ +  ++e+ ++ ++k  ++++s i dlF gqlks+++c +c+  s+ ++pf+dlsl
   Q: 369  QQDAQEFLRFLLDGLHNEVNRvaaRPKASPETLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL 457
           *******************99444222333333333344455559******************************************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls 262
           p+ ++    + +l dc++ ftke+ l+g++k  c +c++++++ kk++++++P++L+lhLkRf  se++ + +k+++ v+fpl+ Ldl+
   Q: 458  PIAKRGYP-EVTLMDCMRLFTKEDILDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRF--SESRIRTSKLTTFVNFPLRdLDLR 543
           ****9976.779***************************************************..88899******************* PP
   S: 263  pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +f +++++    +  Y+L+av +HsG++ +GHY+ay+++  +g+W +f+Ds+Vt+++ ++v +   s+aY+lfY+
   Q: 544  EFASENTN----HAVYNLYAVSNHSGTTMGGHYTAYCRSpVTGEWHTFNDSSVTPMSSSQVRT---SDAYLLFYE 611
           ****9553....78*************************44666*******************...********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (PubMed:25238854).
 Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (PubMed:25238854).
Protein Sequence
(Fasta)
MSQLSSTLKR YTESSRYTDA PYAKPGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL 60
PRPRTYGPSS ILDCDRGRPL LRSDIIGSSK RSESQTRGNE RPSGSGLNGG SGFSYGVSSN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063710|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGGGTGGC GCCGATTTCC CGGGGAGGTC CTTTCTGGGC CCCCGGCGGA GGTGGGGGAG 60
AGGCGGGCAG GCACCGAGCG AGGCCAGGGA GCCCTCTGCG TCAGCCACTG CTCGCTGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063710|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0517--Myogenesis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030332--F:cyclin binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0007049--P:cell cycle
GO:0048512--P:circadian behavior
GO:0032922--P:circadian regulation of gene expression
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0007517--P:muscle organ development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:53376
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001988 Ailuropoda melanoleuca 90.95 0.00e+00 1067.00
IUUC-Aca-005132 Anolis carolinensis 60.51 0.00e+00 675.00
IUUC-Ame-011102 Astyanax mexicanus 74.49 6.00e-144 503.00
IUUC-Bta-012529 Bos taurus 88.37 0.00e+00 982.00
IUUC-Bra-016678 Brassica rapa 36.26 1.00e-46 180.00
IUUC-Cja-019016 Callithrix jacchus 86.84 0.00e+00 985.00
IUUC-Cfa-020714 Canis familiaris 90.63 0.00e+00 1073.00
IUUC-Cpo-021727 Cavia porcellus 88.05 0.00e+00 1022.00
IUUC-Csa-023071 Chlorocebus sabaeus 95.97 0.00e+00 673.00
IUUC-Cin-025797 Ciona intestinalis 50.72 1.00e-95 342.00
IUUC-Csv-026132 Ciona savignyi 52.07 3.00e-99 355.00
IUUC-Dre-027872 Danio rerio 80.94 1.00e-161 562.00
IUUC-Dno-029329 Dasypus novemcinctus 89.50 0.00e+00 1045.00
IUUC-Dor-030574 Dipodomys ordii 90.95 0.00e+00 1026.00
IUUC-Dme-032208 Drosophila melanogaster 47.21 2.00e-82 301.00
IUUC-Ete-032725 Echinops telfairi 78.64 5.00e-171 594.00
IUUC-Eca-033361 Equus caballus 91.11 0.00e+00 1070.00
IUUC-Eeu-035272 Erinaceus europaeus 76.36 0.00e+00 689.00
IUUC-Fca-036497 Felis catus 91.60 0.00e+00 1076.00
IUUC-Fal-036766 Ficedula albicollis 63.46 0.00e+00 678.00
IUUC-Gmo-039129 Gadus morhua 65.20 6.00e-122 430.00
IUUC-Gga-040889 Gallus gallus 82.84 8.00e-147 513.00
IUUC-Gac-042475 Gasterosteus aculeatus 68.39 4.00e-135 474.00
IUUC-Ggo-044814 Gorilla gorilla 90.23 6.00e-174 603.00
IUUC-Hsa-045937 Homo sapiens 87.40 0.00e+00 998.00
IUUC-Itr-048171 Ictidomys tridecemlineatus 92.57 0.00e+00 1092.00
IUUC-Lch-050527 Latimeria chalumnae 60.45 0.00e+00 632.00
IUUC-Loc-052697 Lepisosteus oculatus 78.00 3.00e-160 558.00
IUUC-Laf-054167 Loxodonta africana 84.08 0.00e+00 987.00
IUUC-Mcc-055584 Macaca mulatta 89.01 0.00e+00 1040.00
IUUC-Meu-056542 Macropus eugenii 83.71 0.00e+00 938.00
IUUC-Mga-060020 Meleagris gallopavo 59.78 0.00e+00 639.00
IUUC-Mmr-060989 Microcebus murinus 90.15 0.00e+00 1056.00
IUUC-Mdo-062761 Monodelphis domestica 82.61 0.00e+00 935.00
IUUC-Mpu-066573 Mustela putorius furo 91.11 0.00e+00 1071.00
IUUC-Nle-070013 Nomascus leucogenys 87.97 0.00e+00 972.00
IUUC-Opr-070907 Ochotona princeps 89.01 0.00e+00 1014.00
IUUC-Ont-071944 Oreochromis niloticus 80.98 1.00e-163 568.00
IUUC-Oan-073105 Ornithorhynchus anatinus 81.13 8.00e-145 506.00
IUUC-Ocu-073941 Oryctolagus cuniculus 90.63 0.00e+00 1064.00
IUUC-Ola-087412 Oryzias latipes 70.77 1.00e-151 529.00
IUUC-Oga-088973 Otolemur garnettii 90.79 0.00e+00 1065.00
IUUC-Oar-089916 Ovis aries 89.01 0.00e+00 1026.00
IUUC-Ptr-090998 Pan troglodytes 87.72 0.00e+00 1006.00
IUUC-Pan-092686 Papio anubis 89.18 0.00e+00 1042.00
IUUC-Psi-093284 Pelodiscus sinensis 69.50 2.00e-121 428.00
IUUC-Pma-094462 Petromyzon marinus 64.71 7.00e-74 269.00
IUUC-Pno-094986 Phaeosphaeria nodorum 32.11 6.00e-39 156.00
IUUC-Pfo-097352 Poecilia formosa 78.86 5.00e-166 577.00
IUUC-Pab-098688 Pongo abelii 81.42 0.00e+00 894.00
IUUC-Pca-100205 Procavia capensis 91.64 0.00e+00 636.00
IUUC-Pva-103188 Pteropus vampyrus 89.82 0.00e+00 1028.00
IUUC-Rno-105853 Rattus norvegicus 97.42 0.00e+00 1153.00
IUUC-Sha-107237 Sarcophilus harrisii 83.23 0.00e+00 934.00
IUUC-Sar-113103 Sorex araneus 90.49 0.00e+00 625.00
IUUC-Ssc-115955 Sus scrofa 91.11 0.00e+00 1040.00
IUUC-Tgu-116894 Taeniopygia guttata 67.77 3.00e-180 624.00
IUUC-Tru-117703 Takifugu rubripes 65.50 6.00e-134 470.00
IUUC-Tsy-118879 Tarsius syrichta 94.63 0.00e+00 821.00
IUUC-Tni-119866 Tetraodon nigroviridis 78.62 5.00e-153 533.00
IUUC-Tbe-127367 Tupaia belangeri 81.69 0.00e+00 652.00
IUUC-Ttr-128773 Tursiops truncatus 87.40 0.00e+00 1027.00
IUUC-Vpa-130402 Vicugna pacos 79.45 0.00e+00 761.00
IUUC-Xtr-132658 Xenopus tropicalis 57.33 2.00e-179 622.00
Created Date 25-Jun-2017

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