iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	83.55	6.00e-170	594.00	IUUC-Hsa-046346

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Protein Sequence
(Fasta)

MGEEATAVAA AGVRPELVRE AEVSLLECKV CFERFGHWQQ RRPRNLPCGH VVCLACVAAL 60
AHPRTLGLEC PFCRRACRAC DTSDCLPVLH LLELLGSTLH ASPAALSAAP FAPGTLTCYH 120

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Nucleotide Sequence
(Fasta)

ATGCCCCGCT CCGTGACCGT GACCGTGGCC GTGACTGAGG GCTGCGCGGA GGCAGCGGAG 60
CAGCGGGAGC AATGGGGGAG GAGGCGACGG CGGTGGCAGC GGCTGGGGTG CGGCCCGAGC 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR013017--NHL_repeat_subgr
IPR015943--WD40/YVTN_repeat-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51125--NHL
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0031398--P:positive regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

mmu:105193

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003482	Anas platyrhynchos	49.51	8.00e-57	213.00
IUUC-Aca-004781	Anolis carolinensis	52.85	1.00e-116	413.00
IUUC-Ame-011442	Astyanax mexicanus	43.35	1.00e-75	277.00
IUUC-Bta-013205	Bos taurus	80.75	6.00e-165	573.00
IUUC-Cfa-020810	Canis familiaris	82.68	2.00e-154	538.00
IUUC-Cpo-022053	Cavia porcellus	74.82	2.00e-118	418.00
IUUC-Csa-023522	Chlorocebus sabaeus	83.29	2.00e-161	561.00
IUUC-Dno-029008	Dasypus novemcinctus	77.93	5.00e-158	550.00
IUUC-Ete-032878	Echinops telfairi	79.35	9.00e-44	171.00
IUUC-Eca-034419	Equus caballus	82.78	3.00e-162	564.00
IUUC-Eeu-034990	Erinaceus europaeus	76.65	1.00e-154	539.00
IUUC-Fca-035755	Felis catus	79.10	9.00e-166	576.00
IUUC-Fal-036689	Ficedula albicollis	56.49	3.00e-40	157.00
IUUC-Fox-037671	Fusarium oxysporum	43.86	9.00e-06	43.90
IUUC-Gmo-038749	Gadus morhua	41.84	6.00e-67	247.00
IUUC-Gga-040860	Gallus gallus	53.55	6.00e-99	354.00
IUUC-Gac-041602	Gasterosteus aculeatus	40.61	3.00e-71	262.00
IUUC-Ggo-044705	Gorilla gorilla	80.68	4.00e-160	557.00
IUUC-Hsa-046346	Homo sapiens	83.55	6.00e-162	563.00
IUUC-Itr-048387	Ictidomys tridecemlineatus	82.23	3.00e-164	570.00
IUUC-Lch-049978	Latimeria chalumnae	47.68	6.00e-94	337.00
IUUC-Loc-051893	Lepisosteus oculatus	47.75	4.00e-90	325.00
IUUC-Mcc-054648	Macaca mulatta	83.55	2.00e-162	565.00
IUUC-Meu-056176	Macropus eugenii	64.91	1.00e-127	449.00
IUUC-Mmr-061462	Microcebus murinus	83.42	2.00e-160	558.00
IUUC-Mdo-062329	Monodelphis domestica	64.08	5.00e-137	480.00
IUUC-Mpu-066828	Mustela putorius furo	81.75	2.00e-158	551.00
IUUC-Nle-069194	Nomascus leucogenys	83.29	2.00e-168	584.00
IUUC-Opr-070547	Ochotona princeps	78.61	1.00e-159	556.00
IUUC-Ont-071588	Oreochromis niloticus	40.71	8.00e-70	257.00
IUUC-Oan-073550	Ornithorhynchus anatinus	53.75	5.00e-101	360.00
IUUC-Ocu-074699	Oryctolagus cuniculus	78.40	4.00e-155	540.00
IUUC-Ola-087036	Oryzias latipes	41.27	7.00e-72	264.00
IUUC-Oga-088924	Otolemur garnettii	82.16	3.00e-161	560.00
IUUC-Oar-089939	Ovis aries	75.40	8.00e-106	375.00
IUUC-Ptr-091431	Pan troglodytes	83.55	6.00e-162	563.00
IUUC-Pan-092496	Papio anubis	83.29	9.00e-162	562.00
IUUC-Psi-094079	Pelodiscus sinensis	54.33	5.00e-117	414.00
IUUC-Pab-097605	Pongo abelii	83.03	2.00e-160	558.00
IUUC-Pca-100676	Procavia capensis	74.12	9.00e-159	553.00
IUUC-Pva-102804	Pteropus vampyrus	83.81	1.00e-168	586.00
IUUC-Rno-104999	Rattus norvegicus	94.26	0.00e+00	681.00
IUUC-Sha-107067	Sarcophilus harrisii	64.34	2.00e-132	465.00
IUUC-Tgu-116560	Taeniopygia guttata	49.65	2.00e-37	147.00
IUUC-Tru-117560	Takifugu rubripes	39.02	5.00e-56	211.00
IUUC-Tni-120569	Tetraodon nigroviridis	41.34	2.00e-67	249.00
IUUC-Ttr-129122	Tursiops truncatus	82.41	4.00e-160	557.00
IUUC-Xtr-132226	Xenopus tropicalis	47.40	8.00e-97	347.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence