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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104872
UUCD1 version UUC-RaN-00859
Ensembl Protein ID ENSRNOP00000010961.5
UniProt Accession Q5U2X1; FBX9_RAT
Genbank Protein ID AAH85831.1
Protein Name F-box only protein 9
Genbank Nucleotide ID BC085831
Gene Name Fbxo9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000008214.5 ENSRNOT00000010961.5 ENSRNOP00000010961.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 23.16 6.00e-15 76.60 IUUC-Sce-106426
E3 adaptor/Cullin RING/SCF/F-box 30.16 1.00e-18 89.00 IUUC-Spo-108193
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).
Protein Sequence
(Fasta)
MAEAEEDCHS DAVRVGDEGH ESPAERDLQA QLQMFRAQWM FELTPGVGSS NVESRPCRAG 60
RSSILKAAAD KGRQELAKEE KARELFLKAV EEEQNGALYE AIKFYRRAMQ LVPDIEFKIT 120
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Protein Fasta Sequence


>IUUC-Rno-104872|E3,F-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCGCAGCAG AGCCGGCAGC TCCGCCGCTG CGTCCAGACG TCTCCTGCTG GGCCGACGCT 60
CGGGTCTTCC CTCCGTGCTC GGCCTCCGCG GACGACCGGC GACCCCTCCG CAGCTCGAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104872|E3,F-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR007330--MIT
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0016567--P:protein ubiquitination
GO:0032006--P:regulation of TOR signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG rno:300849
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000378 Aegilops tauschii 34.71 5.00e-15 74.30
IUUC-Aml-001660 Ailuropoda melanoleuca 91.03 0.00e+00 838.00
IUUC-Atr-003042 Amborella trichopoda 35.59 1.00e-23 103.00
IUUC-Apl-004118 Anas platyrhynchos 82.61 0.00e+00 710.00
IUUC-Aca-005282 Anolis carolinensis 81.65 0.00e+00 724.00
IUUC-Aly-005616 Arabidopsis lyrata 31.82 9.00e-19 87.40
IUUC-Ath-007590 Arabidopsis thaliana 32.39 6.00e-19 88.20
IUUC-Acl-008135 Aspergillus clavatus 27.76 3.00e-17 83.60
IUUC-Afl-008699 Aspergillus flavus 27.84 3.00e-18 86.70
IUUC-Afu-008824 Aspergillus fumigatus 26.62 2.00e-17 84.00
IUUC-Ani-009388 Aspergillus nidulans 26.30 2.00e-18 87.00
IUUC-Ang-009815 Aspergillus niger 25.86 3.00e-17 83.60
IUUC-Aor-010113 Aspergillus oryzae 48.57 5.00e-05 41.60
IUUC-Ate-010365 Aspergillus terreus 32.00 3.00e-15 76.60
IUUC-Ame-011406 Astyanax mexicanus 72.37 1.00e-179 622.00
IUUC-Bgr-012145 Blumeria graminis 28.06 2.00e-18 87.40
IUUC-Bta-012354 Bos taurus 90.16 0.00e+00 831.00
IUUC-Bci-013686 Botrytis cinerea 25.19 2.00e-19 90.10
IUUC-Bdi-014609 Brachypodium distachyon 36.42 1.00e-24 107.00
IUUC-Bol-016149 Brassica oleracea 31.82 1.00e-19 90.50
IUUC-Bra-017126 Brassica rapa 31.82 9.00e-20 90.90
IUUC-Cfa-020387 Canis familiaris 91.03 0.00e+00 840.00
IUUC-Cpo-021298 Cavia porcellus 89.45 0.00e+00 794.00
IUUC-Cre-022803 Chlamydomonas reinhardtii 33.92 1.00e-19 90.90
IUUC-Csa-024074 Chlorocebus sabaeus 92.22 0.00e+00 821.00
IUUC-Cho-024705 Choloepus hoffmanni 92.61 6.00e-142 497.00
IUUC-Cin-025508 Ciona intestinalis 36.73 2.00e-65 243.00
IUUC-Csv-026173 Ciona savignyi 35.02 2.00e-61 229.00
IUUC-Cgl-026681 Colletotrichum gloeosporioides 25.98 4.00e-18 86.30
IUUC-Cne-026854 Cryptococcus neoformans 26.70 4.00e-23 102.00
IUUC-Cme-027201 Cyanidioschyzon merolae 35.50 2.00e-22 100.00
IUUC-Dre-027811 Danio rerio 67.43 2.00e-172 598.00
IUUC-Dno-029907 Dasypus novemcinctus 91.99 0.00e+00 840.00
IUUC-Dor-030126 Dipodomys ordii 88.02 0.00e+00 801.00
IUUC-Dse-031460 Dothistroma septosporum 43.21 3.00e-13 69.70
IUUC-Dme-031882 Drosophila melanogaster 35.79 9.00e-68 250.00
IUUC-Ete-032852 Echinops telfairi 79.27 0.00e+00 677.00
IUUC-Eca-033835 Equus caballus 91.08 0.00e+00 832.00
IUUC-Eeu-034960 Erinaceus europaeus 79.86 0.00e+00 695.00
IUUC-Fca-035547 Felis catus 90.55 0.00e+00 830.00
IUUC-Fal-037181 Ficedula albicollis 80.55 0.00e+00 672.00
IUUC-Fox-038043 Fusarium oxysporum 22.75 3.00e-14 73.20
IUUC-Fso-038242 Fusarium solani 27.54 2.00e-17 84.30
IUUC-Gmo-039658 Gadus morhua 62.72 5.00e-149 520.00
IUUC-Ggr-040039 Gaeumannomyces graminis 44.44 1.00e-13 71.60
IUUC-Gga-040387 Gallus gallus 82.61 0.00e+00 712.00
IUUC-Gac-042247 Gasterosteus aculeatus 65.29 4.00e-173 600.00
IUUC-Gma-043457 Glycine max 34.48 3.00e-22 99.40
IUUC-Ggo-045216 Gorilla gorilla 92.01 0.00e+00 818.00
IUUC-Hsa-046445 Homo sapiens 91.97 0.00e+00 818.00
IUUC-Hvu-047506 Hordeum vulgare 35.19 5.00e-24 104.00
IUUC-Itr-048990 Ictidomys tridecemlineatus 89.91 1.00e-111 395.00
IUUC-Kpa-049180 Komagataella pastoris 25.26 7.00e-18 84.70
IUUC-Lch-049659 Latimeria chalumnae 72.54 0.00e+00 677.00
IUUC-Lpe-051160 Leersia perrieri 34.62 6.00e-09 54.70
IUUC-Loc-051734 Lepisosteus oculatus 72.71 0.00e+00 642.00
IUUC-Lma-053018 Leptosphaeria maculans 24.24 3.00e-14 73.20
IUUC-Laf-053937 Loxodonta africana 90.60 0.00e+00 821.00
IUUC-Mcc-055178 Macaca mulatta 92.45 0.00e+00 826.00
IUUC-Mor-056938 Magnaporthe oryzae 44.74 1.00e-12 68.20
IUUC-Mpo-057448 Magnaporthe poae 44.44 4.00e-14 72.40
IUUC-Mtr-058008 Medicago truncatula 35.63 5.00e-24 105.00
IUUC-Mla-058994 Melampsora laricipopulina 29.02 6.00e-14 72.40
IUUC-Mga-059979 Meleagris gallopavo 81.88 0.00e+00 705.00
IUUC-Mvi-060524 Microbotryum violaceum 30.36 1.00e-20 95.10
IUUC-Mmr-061163 Microcebus murinus 72.18 1.00e-166 578.00
IUUC-Mdo-062767 Monodelphis domestica 85.81 0.00e+00 771.00
IUUC-Mmu-064355 Mus musculus 95.64 0.00e+00 874.00
IUUC-Mac-064946 Musa acuminata 33.54 4.00e-21 95.50
IUUC-Mpu-066278 Mustela putorius furo 89.71 0.00e+00 769.00
IUUC-Mlu-068028 Myotis lucifugus 90.55 0.00e+00 835.00
IUUC-Nfi-068607 Neosartorya fischeri 26.25 6.00e-19 89.00
IUUC-Ncr-068733 Neurospora crassa 30.22 1.00e-14 74.30
IUUC-Nle-070061 Nomascus leucogenys 92.22 0.00e+00 823.00
IUUC-Opr-071040 Ochotona princeps 55.28 2.00e-122 432.00
IUUC-Ont-071715 Oreochromis niloticus 69.80 2.00e-176 611.00
IUUC-Oan-073385 Ornithorhynchus anatinus 84.86 0.00e+00 777.00
IUUC-Ocu-074608 Oryctolagus cuniculus 91.06 0.00e+00 816.00
IUUC-Oba-075531 Oryza barthii 31.33 6.00e-09 54.30
IUUC-Obr-076891 Oryza brachyantha 35.80 6.00e-24 104.00
IUUC-Ogl-077925 Oryza glaberrima 35.80 3.00e-24 105.00
IUUC-Ogu-078352 Oryza glumaepatula 31.33 6.00e-09 54.30
IUUC-Oin-080025 Oryza indica 35.80 3.00e-24 105.00
IUUC-Olo-080624 Oryza longistaminata 29.68 1.00e-15 76.60
IUUC-Ome-081745 Oryza meridionalis 35.80 3.00e-24 105.00
IUUC-Oni-082992 Oryza nivara 36.42 2.00e-24 106.00
IUUC-Opu-083594 Oryza punctata 30.72 2.00e-15 76.60
IUUC-Oru-084792 Oryza rufipogon 31.33 6.00e-09 54.70
IUUC-Osa-086272 Oryza sativa 38.37 1.00e-10 58.50
IUUC-Ola-086443 Oryzias latipes 67.56 3.00e-172 597.00
IUUC-Olu-087849 Ostreococcus lucimarinus 27.38 2.00e-14 72.80
IUUC-Oga-087973 Otolemur garnettii 82.92 0.00e+00 738.00
IUUC-Oar-089479 Ovis aries 89.93 0.00e+00 830.00
IUUC-Ptr-091217 Pan troglodytes 92.22 0.00e+00 825.00
IUUC-Pan-092809 Papio anubis 92.45 0.00e+00 826.00
IUUC-Psi-093838 Pelodiscus sinensis 82.57 0.00e+00 760.00
IUUC-Pma-094194 Petromyzon marinus 49.42 1.00e-110 392.00
IUUC-Pno-094974 Phaeosphaeria nodorum 21.49 2.00e-15 77.40
IUUC-Ppa-095612 Physcomitrella patens 36.63 2.00e-21 96.30
IUUC-Pfo-097152 Poecilia formosa 64.65 2.00e-169 588.00
IUUC-Pab-098181 Pongo abelii 92.22 0.00e+00 824.00
IUUC-Pop-098903 Populus trichocarpa 37.27 2.00e-21 96.30
IUUC-Pca-100097 Procavia capensis 85.09 0.00e+00 756.00
IUUC-Ppe-101770 Prunus persica 35.40 8.00e-22 97.40
IUUC-Pva-103016 Pteropus vampyrus 91.49 0.00e+00 840.00
IUUC-Pgr-103565 Puccinia graminis 47.06 1.00e-12 68.60
IUUC-Ptt-103963 Puccinia triticina 28.09 6.40e-02 32.30
IUUC-Pte-104397 Pyrenophora teres 28.16 2.00e-13 70.50
IUUC-Pyt-104618 Pyrenophora triticirepentis 51.85 2.50e-02 33.50
IUUC-Sce-106426 Saccharomyces cerevisiae 25.84 2.00e-14 73.60
IUUC-Sha-106487 Sarcophilus harrisii 85.92 1.00e-175 608.00
IUUC-Sja-107695 Schizosaccharomyces japonicus 30.80 3.00e-20 92.40
IUUC-Spo-108193 Schizosaccharomyces pombe 30.16 4.00e-19 89.00
IUUC-Ssl-108468 Sclerotinia sclerotiorum 26.58 1.00e-20 94.70
IUUC-Smo-109062 Selaginella moellendorffii 36.26 4.00e-21 95.10
IUUC-Sit-110175 Setaria italica 37.65 1.00e-25 110.00
IUUC-Sly-111632 Solanum lycopersicum 31.75 4.00e-22 98.60
IUUC-Stu-112393 Solanum tuberosum 33.18 2.00e-22 99.40
IUUC-Sar-113758 Sorex araneus 87.76 0.00e+00 758.00
IUUC-Sbi-114191 Sorghum bicolor 36.42 1.00e-24 107.00
IUUC-Sre-115169 Sporisorium reilianum 29.76 3.00e-16 80.50
IUUC-Ssc-116249 Sus scrofa 89.73 0.00e+00 815.00
IUUC-Tgu-117421 Taeniopygia guttata 79.82 0.00e+00 667.00
IUUC-Tru-118114 Takifugu rubripes 65.48 1.00e-162 565.00
IUUC-Tsy-119305 Tarsius syrichta 78.90 0.00e+00 681.00
IUUC-Tni-120491 Tetraodon nigroviridis 63.22 3.00e-161 560.00
IUUC-Tca-120948 Theobroma cacao 37.27 6.00e-22 98.20
IUUC-Tre-121934 Trichoderma reesei 28.35 5.00e-18 85.90
IUUC-Tvi-122432 Trichoderma virens 26.23 2.00e-18 87.00
IUUC-Tae-123129 Triticum aestivum 35.19 7.00e-24 104.00
IUUC-Tur-126459 Triticum urartu 34.62 3.00e-09 55.10
IUUC-Tme-127190 Tuber melanosporum 29.51 3.00e-16 80.10
IUUC-Tbe-127313 Tupaia belangeri 67.30 1.00e-120 426.00
IUUC-Ttr-128471 Tursiops truncatus 91.03 0.00e+00 825.00
IUUC-Uma-129486 Ustilago maydis 29.94 8.00e-14 72.80
IUUC-Vda-129897 Verticillium dahliae 25.62 1.00e-20 94.70
IUUC-Vpa-130277 Vicugna pacos 65.70 2.00e-122 432.00
IUUC-Vvi-130912 Vitis vinifera 35.63 1.00e-22 100.00
IUUC-Xtr-132405 Xenopus tropicalis 76.20 0.00e+00 663.00
IUUC-Xma-133338 Xiphophorus maculatus 65.12 4.00e-171 593.00
IUUC-Yli-134647 Yarrowia lipolytica 48.65 3.00e-14 73.20
IUUC-Zma-135447 Zea mays 37.04 4.00e-25 108.00
Created Date 25-Jun-2017

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