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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046752
UUCD1 version UUC-HoS-00307
Ensembl Protein ID ENSP00000341351.5
UniProt Accession Q96JK2; B2RN31; G3V4J7; O60559; Q8N3V3; Q8N3V5; DCAF5_HUMAN
Genbank Protein ID BAB47453.1; CAD38589.1; CAD38537.2; EAW80981.1; EAW80983.1; AAI36633.1; AAC08965.1
Protein Name DDB1- and CUL4-associated factor 5; Breakpoint cluster region protein 2; WD repeat-containing protein 22
Genbank Nucleotide ID AB058727; AL391262; AL831823; CH471061; CH471061; BC136632; AF044774
Gene Name DCAF5; BCRG2; KIAA1824; WDR22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139990.17 ENST00000341516.9 ENSP00000341351.5
ENSG00000139990.17 ENST00000557386.5 ENSP00000451845.1
ENSG00000139990.17 ENST00000556111.1 ENSP00000452077.1
ENSG00000139990.17 ENST00000389997.10 ENSP00000374647.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.40e-27 94.6 141 173
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           H+d v++l+    +d++++s+sdDg + +WD+r
   Q: 141  HEDAVYGLSVspvNDNIFASSSDDGRVLIWDIR 173
           9*******9999999****************87 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
 May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Protein Sequence
(Fasta)
MKRRAGLGGS MRSVVGFLSQ RGLHGDPLLT QDFQRRRLRG CRNLYKKDLL GHFGCVNAIE 60
FSNNGGQWLV SGGDDRRVLL WHMEQAIHSR VKPIQLKGEH HSNIFCLAFN SGNTKVFSGG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046752|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGAAGCCG CGAACGCCGC CGAGTGTCTG CACACCTCGC TCTGCCTGCC ATGGCTGGTT 60
AAAGAACCAT CCGGATCGCA GCGCGGGGGG AGGGCCGGGT GGGGGGAGCA GCGGCCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046752|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005739--C:mitochondrion
GO:0016567--P:protein ubiquitination
KEGG hsa:8816
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001497 Ailuropoda melanoleuca 93.03 0.00e+00 1543.00
IUUC-Apl-003432 Anas platyrhynchos 72.36 0.00e+00 1095.00
IUUC-Aca-005069 Anolis carolinensis 68.65 0.00e+00 1031.00
IUUC-Ame-011063 Astyanax mexicanus 85.81 0.00e+00 748.00
IUUC-Bta-013013 Bos taurus 92.69 0.00e+00 1507.00
IUUC-Cel-018265 Caenorhabditis elegans 30.94 5.00e-33 136.00
IUUC-Cja-018816 Callithrix jacchus 98.20 0.00e+00 1791.00
IUUC-Cfa-020397 Canis familiaris 94.09 0.00e+00 1618.00
IUUC-Cpo-021999 Cavia porcellus 91.79 0.00e+00 1474.00
IUUC-Csa-024256 Chlorocebus sabaeus 98.51 0.00e+00 1791.00
IUUC-Cho-024707 Choloepus hoffmanni 88.44 0.00e+00 1401.00
IUUC-Cin-025728 Ciona intestinalis 46.67 6.00e-53 200.00
IUUC-Dre-027683 Danio rerio 87.50 0.00e+00 761.00
IUUC-Dno-029603 Dasypus novemcinctus 94.83 0.00e+00 1648.00
IUUC-Dme-031660 Drosophila melanogaster 45.34 2.00e-92 333.00
IUUC-Ete-032701 Echinops telfairi 86.73 0.00e+00 1377.00
IUUC-Eca-033345 Equus caballus 94.34 0.00e+00 1533.00
IUUC-Eeu-034973 Erinaceus europaeus 88.07 0.00e+00 904.00
IUUC-Fca-036007 Felis catus 94.40 0.00e+00 1647.00
IUUC-Fal-036759 Ficedula albicollis 71.30 0.00e+00 1075.00
IUUC-Gmo-039095 Gadus morhua 84.88 0.00e+00 761.00
IUUC-Gga-040850 Gallus gallus 96.42 2.00e-159 554.00
IUUC-Ggo-045451 Gorilla gorilla 99.58 0.00e+00 1778.00
IUUC-Itr-048562 Ictidomys tridecemlineatus 92.60 0.00e+00 1065.00
IUUC-Lch-049676 Latimeria chalumnae 59.50 0.00e+00 963.00
IUUC-Loc-052200 Lepisosteus oculatus 76.46 0.00e+00 756.00
IUUC-Laf-053783 Loxodonta africana 93.86 0.00e+00 1510.00
IUUC-Mcc-055495 Macaca mulatta 98.51 0.00e+00 1793.00
IUUC-Meu-056044 Macropus eugenii 79.79 0.00e+00 1221.00
IUUC-Mga-059650 Meleagris gallopavo 71.02 0.00e+00 931.00
IUUC-Mvi-060289 Microbotryum violaceum 26.45 4.00e-13 69.70
IUUC-Mdo-063059 Monodelphis domestica 82.82 0.00e+00 1385.00
IUUC-Mmu-063315 Mus musculus 90.81 0.00e+00 1560.00
IUUC-Mpu-066563 Mustela putorius furo 91.45 0.00e+00 1362.00
IUUC-Mlu-067408 Myotis lucifugus 92.12 0.00e+00 1456.00
IUUC-Nle-069574 Nomascus leucogenys 99.26 0.00e+00 1809.00
IUUC-Opr-070491 Ochotona princeps 81.50 0.00e+00 1392.00
IUUC-Ont-071270 Oreochromis niloticus 84.79 0.00e+00 773.00
IUUC-Oan-073632 Ornithorhynchus anatinus 78.48 0.00e+00 847.00
IUUC-Ocu-074329 Oryctolagus cuniculus 92.60 0.00e+00 1633.00
IUUC-Ola-087017 Oryzias latipes 84.62 3.00e-143 500.00
IUUC-Oga-088295 Otolemur garnettii 91.23 0.00e+00 1633.00
IUUC-Oar-089609 Ovis aries 88.70 0.00e+00 1468.00
IUUC-Ptr-090891 Pan troglodytes 99.79 0.00e+00 1734.00
IUUC-Pan-092220 Papio anubis 98.38 0.00e+00 1755.00
IUUC-Psi-093097 Pelodiscus sinensis 60.34 3.00e-160 559.00
IUUC-Pfo-096844 Poecilia formosa 82.92 0.00e+00 629.00
IUUC-Pab-098512 Pongo abelii 99.47 0.00e+00 1813.00
IUUC-Pca-100999 Procavia capensis 87.57 0.00e+00 1432.00
IUUC-Pva-102524 Pteropus vampyrus 93.88 0.00e+00 1622.00
IUUC-Pgr-103528 Puccinia graminis 24.57 1.00e-29 124.00
IUUC-Rno-104861 Rattus norvegicus 91.66 0.00e+00 1607.00
IUUC-Sha-106554 Sarcophilus harrisii 95.98 2.00e-128 451.00
IUUC-Sar-113644 Sorex araneus 84.51 1.00e-166 580.00
IUUC-Sre-114948 Sporisorium reilianum 27.12 2.00e-22 101.00
IUUC-Ssc-115431 Sus scrofa 100.00 5.00e-79 285.00
IUUC-Tgu-117355 Taeniopygia guttata 74.05 0.00e+00 1187.00
IUUC-Tru-118672 Takifugu rubripes 81.70 0.00e+00 748.00
IUUC-Tni-120215 Tetraodon nigroviridis 74.49 0.00e+00 670.00
IUUC-Ttr-128965 Tursiops truncatus 96.67 0.00e+00 1041.00
IUUC-Vpa-130586 Vicugna pacos 90.17 0.00e+00 1406.00
IUUC-Xtr-132611 Xenopus tropicalis 59.26 0.00e+00 936.00
Created Date 25-Jun-2017

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