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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046778
UUCD1 version UUC-HoS-00149
Ensembl Protein ID ENSP00000306396.8
UniProt Accession Q5TA31; A6NL57; Q6P2J7; Q6PJR0; RN187_HUMAN
Genbank Protein ID CAI23328.1; AAH12758.1; AAH64481.1
Protein Name E3 ubiquitin-protein ligase RNF187; RING domain AP1 coactivator 1; RING finger protein 187; RING-type E3 ubiquitin transferase RNF187
Genbank Nucleotide ID AL139288; BC012758; BC064481
Gene Name RNF187
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168159.10 ENST00000305943.7 ENSP00000306396.8
Annotation
Cancer Mutation
ICGCCOSMICCGAPIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20852630
Classification
Family E-value Score Start End
E3 activity/RING/RING 8.90e-05 24.6 12 52
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           Ca+C+  +++ p+  +CgH f++ C+   w     ++ + f CP C
   Q: 12   CALCQRAPRE-PVRADCGHRFCRACVvRFW----AEEDGPFPCPEC 52
           ****999988.777***********97778....99*********9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
 E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Protein Sequence
(Fasta)
LALPAGPAEA ACALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA 60
VEPGRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD AGPLCAACRM AAGPEPPEWE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046778|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCGCAGGCAG TAGAGTGAAG CGCGCAGCTG CCAGGACTTG CGCGGTGACG TGCGCCGCTG 60
CCAGGACCTT GCAGGTGGAG AGCATAGTTG CCAAAATCAA GGCGGAGGAG CGCACCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046778|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
KEGG hsa:149603
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002191 Ailuropoda melanoleuca 88.68 1.00e-50 190.00
IUUC-Bgr-012065 Blumeria graminis 32.81 6.60e-02 33.10
IUUC-Bta-012513 Bos taurus 92.77 1.00e-93 335.00
IUUC-Cja-019008 Callithrix jacchus 90.98 1.00e-59 221.00
IUUC-Cpo-022460 Cavia porcellus 88.07 4.00e-75 274.00
IUUC-Csa-024164 Chlorocebus sabaeus 100.00 8.00e-62 228.00
IUUC-Dno-029128 Dasypus novemcinctus 86.79 5.00e-35 138.00
IUUC-Ete-033026 Echinops telfairi 82.43 5.00e-16 75.50
IUUC-Eca-034206 Equus caballus 90.48 2.00e-37 146.00
IUUC-Fca-035393 Felis catus 73.38 8.00e-40 155.00
IUUC-Ggo-045548 Gorilla gorilla 100.00 8.00e-62 228.00
IUUC-Itr-047955 Ictidomys tridecemlineatus 92.38 2.00e-52 197.00
IUUC-Laf-054276 Loxodonta africana 90.99 4.00e-43 166.00
IUUC-Mcc-054972 Macaca mulatta 100.00 1.00e-95 342.00
IUUC-Mmu-063109 Mus musculus 94.92 2.00e-97 348.00
IUUC-Mpu-066574 Mustela putorius furo 84.54 2.00e-29 121.00
IUUC-Mlu-067760 Myotis lucifugus 94.55 2.00e-94 338.00
IUUC-Nle-069556 Nomascus leucogenys 97.35 6.00e-60 222.00
IUUC-Ocu-074636 Oryctolagus cuniculus 83.06 7.00e-54 202.00
IUUC-Oga-088384 Otolemur garnettii 95.45 4.00e-91 327.00
IUUC-Oar-090060 Ovis aries 91.39 1.00e-59 222.00
IUUC-Ptr-090496 Pan troglodytes 100.00 1.00e-57 214.00
IUUC-Pan-091825 Papio anubis 100.00 1.00e-95 342.00
IUUC-Pab-098001 Pongo abelii 92.31 4.00e-16 75.50
IUUC-Pca-100168 Procavia capensis 91.89 7.00e-38 149.00
IUUC-Rno-105436 Rattus norvegicus 94.92 2.00e-97 348.00
IUUC-Tbe-127513 Tupaia belangeri 64.00 1.00e-27 114.00
Created Date 25-Jun-2017

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