iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/NEDD8	0	1426.1	761	836
ULD/UDP/UBQ/UBQ_PIM	0	1008.0	761	833

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/NEDD8

   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           m+i+vktLtgk+i++e+e sdtie++k+++++keGiPP+qqrli+aGkqled++t++dyn++k+s+LhLvL+LrGG
   Q: 761  MQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 836
           89*************************************************************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           m+++vktl+gk+++lev+ +dt+e++K+ki+++ g+pp+qq+LI+aGk+L+D +tLs+++i+++s++hlv++ 
   Q: 761  MQIFVKTLTGKTITLEVEASDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL 833
           99********************************************************************986 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).

Protein Sequence
(Fasta)

MQIFVKTLTG KTITLEVEAS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 60
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEASDTIE NVKAKIQDKE GIPPDQQRLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAATAGGCG ACTTCTTGCT AACAGAAAGT GAGCATAGCA ACATTTTTTA CTTTGTGGCC 60
TTCAATAATA CGTGCGTCGT TTAATTAGAA TGTTTGAGTA AAGTTCAACG TGTAGATTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus

KEGG

cel:CELE_F25B5.4

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000772	Aegilops tauschii	46.77	3.00e-48	186.00
IUUC-Aml-001483	Ailuropoda melanoleuca	98.25	3.00e-127	446.00
IUUC-Atr-003143	Amborella trichopoda	96.05	7.00e-39	151.00
IUUC-Apl-003614	Anas platyrhynchos	98.55	1.00e-155	540.00
IUUC-Aca-004901	Anolis carolinensis	98.68	0.00e+00	740.00
IUUC-Aly-006562	Arabidopsis lyrata	92.29	0.00e+00	978.00
IUUC-Ath-006600	Arabidopsis thaliana	95.83	0.00e+00	876.00
IUUC-Ago-007937	Ashbya gossypii	96.05	0.00e+00	733.00
IUUC-Acl-008108	Aspergillus clavatus	95.74	7.00e-170	588.00
IUUC-Afl-008740	Aspergillus flavus	95.74	7.00e-170	588.00
IUUC-Afu-009031	Aspergillus fumigatus	92.97	3.00e-167	579.00
IUUC-Ani-009444	Aspergillus nidulans	96.05	6.00e-169	585.00
IUUC-Ang-009646	Aspergillus niger	95.74	9.00e-169	584.00
IUUC-Aor-009964	Aspergillus oryzae	95.74	7.00e-170	588.00
IUUC-Ate-010298	Aspergillus terreus	95.74	7.00e-170	588.00
IUUC-Ame-011696	Astyanax mexicanus	96.32	0.00e+00	718.00
IUUC-Bta-012771	Bos taurus	98.68	2.00e-171	593.00
IUUC-Bci-013832	Botrytis cinerea	97.37	3.00e-171	592.00
IUUC-Bdi-015013	Brachypodium distachyon	96.05	0.00e+00	733.00
IUUC-Bol-015598	Brassica oleracea	95.83	0.00e+00	876.00
IUUC-Bra-017586	Brassica rapa	96.05	5.00e-126	441.00
IUUC-Cja-019812	Callithrix jacchus	98.43	0.00e+00	741.00
IUUC-Cfa-020579	Canis familiaris	98.43	0.00e+00	740.00
IUUC-Cre-022556	Chlamydomonas reinhardtii	97.37	2.00e-83	299.00
IUUC-Csa-024086	Chlorocebus sabaeus	98.68	3.00e-127	445.00
IUUC-Cin-025600	Ciona intestinalis	97.38	0.00e+00	742.00
IUUC-Csv-026265	Ciona savignyi	95.87	0.00e+00	1389.00
IUUC-Cgl-026543	Colletotrichum gloeosporioides	96.05	6.00e-126	441.00
IUUC-Cne-026938	Cryptococcus neoformans	97.15	0.00e+00	882.00
IUUC-Dre-028641	Danio rerio	98.52	0.00e+00	1178.00
IUUC-Dno-029812	Dasypus novemcinctus	98.43	0.00e+00	740.00
IUUC-Dor-031044	Dipodomys ordii	98.55	2.00e-75	272.00
IUUC-Dse-031434	Dothistroma septosporum	96.05	6.00e-126	441.00
IUUC-Dme-031690	Drosophila melanogaster	98.43	0.00e+00	1476.00
IUUC-Eca-033850	Equus caballus	98.25	3.00e-127	446.00
IUUC-Fca-036501	Felis catus	98.25	3.00e-127	446.00
IUUC-Fal-036678	Ficedula albicollis	98.68	2.00e-171	593.00
IUUC-Fox-037730	Fusarium oxysporum	95.61	1.00e-125	440.00
IUUC-Fso-038454	Fusarium solani	95.72	2.00e-169	586.00
IUUC-Ggr-040118	Gaeumannomyces graminis	96.05	1.00e-169	587.00
IUUC-Gga-041058	Gallus gallus	98.68	2.00e-171	593.00
IUUC-Gac-042568	Gasterosteus aculeatus	97.87	0.00e+00	1170.00
IUUC-Gma-043881	Glycine max	95.68	0.00e+00	1022.00
IUUC-Ggo-044799	Gorilla gorilla	98.42	0.00e+00	738.00
IUUC-Hsa-046405	Homo sapiens	98.54	0.00e+00	1326.00
IUUC-Hvu-047805	Hordeum vulgare	34.64	2.00e-40	157.00
IUUC-Itr-048563	Ictidomys tridecemlineatus	94.51	2.00e-44	168.00
IUUC-Kpa-049199	Komagataella pastoris	95.42	5.00e-170	588.00
IUUC-Lpe-050731	Leersia perrieri	34.73	5.00e-44	170.00
IUUC-Lma-053015	Leptosphaeria maculans	94.84	3.00e-170	590.00
IUUC-Laf-053548	Loxodonta africana	98.43	0.00e+00	740.00
IUUC-Mcc-055561	Macaca mulatta	98.52	0.00e+00	1180.00
IUUC-Mor-056991	Magnaporthe oryzae	96.05	1.00e-169	587.00
IUUC-Mpo-057384	Magnaporthe poae	96.05	1.00e-169	587.00
IUUC-Mtr-058240	Medicago truncatula	95.81	0.00e+00	1600.00
IUUC-Mla-058957	Melampsora laricipopulina	95.68	0.00e+00	1019.00
IUUC-Mga-059240	Meleagris gallopavo	96.89	9.00e-87	310.00
IUUC-Mmr-061259	Microcebus murinus	93.42	6.00e-117	411.00
IUUC-Mdo-062630	Monodelphis domestica	98.31	0.00e+00	1033.00
IUUC-Mmu-063593	Mus musculus	97.75	0.00e+00	1366.00
IUUC-Mac-065145	Musa acuminata	86.18	3.00e-70	255.00
IUUC-Mpu-066106	Mustela putorius furo	82.89	6.00e-137	478.00
IUUC-Mlu-068100	Myotis lucifugus	98.68	2.00e-171	593.00
IUUC-Nfi-068475	Neosartorya fischeri	95.74	7.00e-170	588.00
IUUC-Ncr-068770	Neurospora crassa	96.05	5.00e-168	581.00
IUUC-Nle-069526	Nomascus leucogenys	98.68	2.00e-171	593.00
IUUC-Opr-070947	Ochotona princeps	98.68	4.00e-127	445.00
IUUC-Oan-073470	Ornithorhynchus anatinus	98.68	0.00e+00	740.00
IUUC-Ocu-074508	Oryctolagus cuniculus	98.25	3.00e-127	446.00
IUUC-Oba-075152	Oryza barthii	34.31	3.00e-42	164.00
IUUC-Obr-076236	Oryza brachyantha	95.83	0.00e+00	875.00
IUUC-Ogl-077274	Oryza glaberrima	90.53	0.00e+00	678.00
IUUC-Ogu-078628	Oryza glumaepatula	93.42	2.00e-37	149.00
IUUC-Oin-079920	Oryza indica	95.86	0.00e+00	1021.00
IUUC-Olo-080418	Oryza longistaminata	34.78	1.00e-31	128.00
IUUC-Ome-081397	Oryza meridionalis	33.99	8.00e-42	162.00
IUUC-Oni-082299	Oryza nivara	33.66	4.00e-41	160.00
IUUC-Opu-083917	Oryza punctata	35.22	2.00e-30	125.00
IUUC-Oru-084544	Oryza rufipogon	78.29	7.00e-61	224.00
IUUC-Osa-085789	Oryza sativa	95.86	0.00e+00	1023.00
IUUC-Ola-087192	Oryzias latipes	93.94	0.00e+00	1157.00
IUUC-Olu-087888	Ostreococcus lucimarinus	96.05	0.00e+00	733.00
IUUC-Oga-089171	Otolemur garnettii	98.04	2.00e-83	299.00
IUUC-Oar-089386	Ovis aries	93.51	0.00e+00	954.00
IUUC-Ptr-091261	Pan troglodytes	98.43	0.00e+00	740.00
IUUC-Pan-092134	Papio anubis	98.46	0.00e+00	885.00
IUUC-Psi-093239	Pelodiscus sinensis	76.32	0.00e+00	633.00
IUUC-Pma-094556	Petromyzon marinus	97.52	0.00e+00	778.00
IUUC-Pno-095087	Phaeosphaeria nodorum	96.05	1.00e-125	440.00
IUUC-Ppa-095548	Physcomitrella patens	94.55	0.00e+00	1007.00
IUUC-Pfo-096371	Poecilia formosa	94.19	1.00e-128	450.00
IUUC-Pab-097884	Pongo abelii	98.52	0.00e+00	1178.00
IUUC-Pop-099396	Populus trichocarpa	96.05	0.00e+00	733.00
IUUC-Pca-100992	Procavia capensis	98.56	0.00e+00	675.00
IUUC-Ppe-102064	Prunus persica	95.62	0.00e+00	877.00
IUUC-Pva-102696	Pteropus vampyrus	98.25	3.00e-127	446.00
IUUC-Pgr-103301	Puccinia graminis	95.73	0.00e+00	1167.00
IUUC-Ptt-103710	Puccinia triticina	96.05	8.00e-170	587.00
IUUC-Pte-104277	Pyrenophora teres	96.05	6.00e-126	441.00
IUUC-Pyt-104779	Pyrenophora triticirepentis	96.05	6.00e-126	441.00
IUUC-Rno-105199	Rattus norvegicus	97.71	0.00e+00	1512.00
IUUC-Sce-106142	Saccharomyces cerevisiae	96.05	0.00e+00	733.00
IUUC-Sha-106780	Sarcophilus harrisii	97.38	2.00e-168	583.00
IUUC-Sja-107825	Schizosaccharomyces japonicus	96.05	0.00e+00	732.00
IUUC-Spo-108219	Schizosaccharomyces pombe	95.80	0.00e+00	733.00
IUUC-Ssl-108565	Sclerotinia sclerotiorum	97.04	3.00e-170	588.00
IUUC-Smo-109259	Selaginella moellendorffii	94.60	0.00e+00	1297.00
IUUC-Sit-109965	Setaria italica	95.86	0.00e+00	1021.00
IUUC-Sly-111224	Solanum lycopersicum	95.69	0.00e+00	1025.00
IUUC-Stu-112256	Solanum tuberosum	95.86	0.00e+00	1021.00
IUUC-Sbi-114776	Sorghum bicolor	95.76	0.00e+00	860.00
IUUC-Ssc-115672	Sus scrofa	98.12	0.00e+00	1028.00
IUUC-Tgu-116620	Taeniopygia guttata	94.83	1.00e-153	534.00
IUUC-Tsy-119558	Tarsius syrichta	88.89	1.00e-73	266.00
IUUC-Tni-120338	Tetraodon nigroviridis	98.68	3.00e-83	298.00
IUUC-Tca-120959	Theobroma cacao	95.61	0.00e+00	874.00
IUUC-Tre-122012	Trichoderma reesei	96.05	1.00e-169	587.00
IUUC-Tvi-122369	Trichoderma virens	96.05	1.00e-169	587.00
IUUC-Tae-123654	Triticum aestivum	95.83	0.00e+00	875.00
IUUC-Tur-126025	Triticum urartu	95.86	0.00e+00	1026.00
IUUC-Tme-127032	Tuber melanosporum	96.05	1.00e-169	587.00
IUUC-Ttr-128311	Tursiops truncatus	97.81	0.00e+00	882.00
IUUC-Uma-129417	Ustilago maydis	97.15	0.00e+00	882.00
IUUC-Vda-129663	Verticillium dahliae	96.05	6.00e-126	441.00
IUUC-Vvi-130874	Vitis vinifera	88.33	0.00e+00	1450.00
IUUC-Xtr-132052	Xenopus tropicalis	97.99	0.00e+00	1236.00
IUUC-Yli-134420	Yarrowia lipolytica	95.83	0.00e+00	876.00
IUUC-Zma-135881	Zea mays	95.86	0.00e+00	1022.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence