iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	6.50e-08	33.6	272	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaav 36
           +eta+e+++++FP+l+ys+++v+L++++  +++a+
   Q: 272  VETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQ 306
           89**************************9988887 PP

Organism

Mus musculus

Functional Description
(View)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity (By similarity). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10421573, PubMed:11517342). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11226248). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11226248). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (PubMed:9160754, PubMed:10421573, PubMed:12834865).

Protein Sequence
(Fasta)

MTEIPAPLSY FQNAQMSEDS HSSSAIRSQN DSQERQQQHD RQRLDNPEPI SNGRPQSNSR 60
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGCCGCG AGTATTCGTC GGAAACAAAA CAGCGGCAGC TGAGGCGGAA ACCTAGGCTG 60
CGAGCCGGCC GCCCGGGCGC GGAGAGAGAA GGTGCGTGCC CAGGGTGTGC GGGGCGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0009986--C:cell surface
GO:0005813--C:centrosome
GO:0035253--C:ciliary rootlet
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0043198--C:dendritic shaft
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0000776--C:kinetochore
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0045121--C:membrane raft
GO:0043227--C:membrane-bounded organelle
GO:0005743--C:mitochondrial inner membrane
GO:0005739--C:mitochondrion
GO:0031594--C:neuromuscular junction
GO:0043025--C:neuronal cell body
GO:0031965--C:nuclear membrane
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0098793--C:presynapse
GO:0005791--C:rough endoplasmic reticulum
GO:0005790--C:smooth endoplasmic reticulum
GO:0030018--C:Z disc
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005262--F:calcium channel activity
GO:0004175--F:endopeptidase activity
GO:0030165--F:PDZ domain binding
GO:0000186--P:activation of MAPKK activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0042982--P:amyloid precursor protein metabolic process
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0034205--P:beta-amyloid formation
GO:0050435--P:beta-amyloid metabolic process
GO:0001568--P:blood vessel development
GO:0007420--P:brain development
GO:0048854--P:brain morphogenesis
GO:0021870--P:Cajal-Retzius cell differentiation
GO:0006816--P:calcium ion transport
GO:0060070--P:canonical Wnt signaling pathway
GO:0001708--P:cell fate specification
GO:0006874--P:cellular calcium ion homeostasis
GO:0044267--P:cellular protein metabolic process
GO:0006974--P:cellular response to DNA damage stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0021987--P:cerebral cortex development
GO:0015871--P:choline transport
GO:0021904--P:dorsal/ventral neural tube patterning
GO:0030326--P:embryonic limb morphogenesis
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0050673--P:epithelial cell proliferation
GO:0030900--P:forebrain development
GO:0007507--P:heart development
GO:0001947--P:heart looping
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0015813--P:L-glutamate transport
GO:0007611--P:learning or memory
GO:0040011--P:locomotion
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007613--P:memory
GO:0006839--P:mitochondrial transport
GO:0043011--P:myeloid dendritic cell differentiation
GO:0002573--P:myeloid leukocyte differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0050771--P:negative regulation of axonogenesis
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0006469--P:negative regulation of protein kinase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0003407--P:neural retina development
GO:0022008--P:neurogenesis
GO:0051402--P:neuron apoptotic process
GO:0048666--P:neuron development
GO:0030182--P:neuron differentiation
GO:0001764--P:neuron migration
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0043085--P:positive regulation of catalytic activity
GO:0050820--P:positive regulation of coagulation
GO:0060999--P:positive regulation of dendritic spine development
GO:0043406--P:positive regulation of MAP kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045860--P:positive regulation of protein kinase activity
GO:0001934--P:positive regulation of protein phosphorylation
GO:0001921--P:positive regulation of receptor recycling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0006486--P:protein glycosylation
GO:0051604--P:protein maturation
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0007176--P:regulation of epidermal growth factor-activated receptor activity
GO:0042325--P:regulation of phosphorylation
GO:0043393--P:regulation of protein binding
GO:0060075--P:regulation of resting membrane potential
GO:0048167--P:regulation of synaptic plasticity
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0006979--P:response to oxidative stress
GO:0035282--P:segmentation
GO:0016337--P:single organismal cell-cell adhesion
GO:0048705--P:skeletal system morphogenesis
GO:0043589--P:skin morphogenesis
GO:0051563--P:smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756--P:somitogenesis
GO:0016080--P:synaptic vesicle targeting
GO:0002286--P:T cell activation involved in immune response
GO:0050852--P:T cell receptor signaling pathway
GO:0048538--P:thymus development

KEGG

mmu:19164

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	34.44	7.00e-23	102.00
IUUC-Aml-001648	Ailuropoda melanoleuca	90.68	3.00e-160	557.00
IUUC-Atr-003039	Amborella trichopoda	32.51	1.00e-37	150.00
IUUC-Apl-003727	Anas platyrhynchos	80.34	1.00e-175	609.00
IUUC-Aca-004582	Anolis carolinensis	79.36	0.00e+00	629.00
IUUC-Aly-005455	Arabidopsis lyrata	31.63	9.00e-18	84.70
IUUC-Ath-006730	Arabidopsis thaliana	33.02	2.00e-18	87.00
IUUC-Ame-011500	Astyanax mexicanus	78.89	1.00e-147	516.00
IUUC-Bta-013026	Bos taurus	86.61	0.00e+00	686.00
IUUC-Bdi-014196	Brachypodium distachyon	33.80	5.00e-30	125.00
IUUC-Bol-015841	Brassica oleracea	34.60	5.00e-31	129.00
IUUC-Bra-017580	Brassica rapa	35.05	8.00e-30	124.00
IUUC-Cel-018553	Caenorhabditis elegans	52.06	4.00e-95	341.00
IUUC-Cja-019994	Callithrix jacchus	94.81	0.00e+00	680.00
IUUC-Cfa-020074	Canis familiaris	90.58	0.00e+00	714.00
IUUC-Cpo-022237	Cavia porcellus	93.17	0.00e+00	705.00
IUUC-Csa-023537	Chlorocebus sabaeus	92.72	0.00e+00	755.00
IUUC-Cho-024735	Choloepus hoffmanni	79.74	0.00e+00	651.00
IUUC-Cin-025780	Ciona intestinalis	62.91	5.00e-124	437.00
IUUC-Csv-025967	Ciona savignyi	63.12	1.00e-119	422.00
IUUC-Dre-028689	Danio rerio	78.14	5.00e-144	504.00
IUUC-Dno-029758	Dasypus novemcinctus	89.13	0.00e+00	706.00
IUUC-Dor-030609	Dipodomys ordii	73.23	1.00e-174	605.00
IUUC-Dme-031929	Drosophila melanogaster	54.83	2.00e-108	386.00
IUUC-Ete-032487	Echinops telfairi	80.95	1.00e-80	293.00
IUUC-Eeu-035134	Erinaceus europaeus	89.90	5.00e-141	493.00
IUUC-Fca-036243	Felis catus	90.60	0.00e+00	707.00
IUUC-Fal-036600	Ficedula albicollis	80.64	3.00e-177	614.00
IUUC-Gmo-038550	Gadus morhua	65.40	3.00e-113	401.00
IUUC-Gga-040993	Gallus gallus	81.36	7.00e-179	620.00
IUUC-Gac-042342	Gasterosteus aculeatus	73.50	1.00e-128	452.00
IUUC-Ggo-044859	Gorilla gorilla	91.93	1.00e-164	572.00
IUUC-Hsa-046822	Homo sapiens	92.72	0.00e+00	756.00
IUUC-Hvu-047141	Hordeum vulgare	36.60	2.00e-25	110.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	94.72	9.00e-158	549.00
IUUC-Lch-049946	Latimeria chalumnae	69.18	9.00e-143	499.00
IUUC-Loc-052469	Lepisosteus oculatus	63.41	2.00e-136	479.00
IUUC-Laf-053979	Loxodonta africana	88.06	7.00e-179	619.00
IUUC-Mcc-055682	Macaca mulatta	92.72	0.00e+00	756.00
IUUC-Meu-056004	Macropus eugenii	74.64	2.00e-150	525.00
IUUC-Mtr-058392	Medicago truncatula	34.25	6.00e-33	135.00
IUUC-Mga-059466	Meleagris gallopavo	81.28	3.00e-178	618.00
IUUC-Mmr-061538	Microcebus murinus	75.16	8.00e-159	553.00
IUUC-Mdo-062122	Monodelphis domestica	85.35	0.00e+00	673.00
IUUC-Mpu-065927	Mustela putorius furo	89.51	0.00e+00	705.00
IUUC-Mlu-067079	Myotis lucifugus	89.32	0.00e+00	731.00
IUUC-Nle-070180	Nomascus leucogenys	92.72	0.00e+00	756.00
IUUC-Opr-070847	Ochotona princeps	86.33	0.00e+00	658.00
IUUC-Ont-071846	Oreochromis niloticus	75.25	2.00e-144	505.00
IUUC-Oan-072783	Ornithorhynchus anatinus	81.90	3.00e-131	461.00
IUUC-Ocu-074527	Oryctolagus cuniculus	91.03	0.00e+00	733.00
IUUC-Olo-080484	Oryza longistaminata	61.73	1.00e-16	80.50
IUUC-Oar-090348	Ovis aries	88.68	0.00e+00	718.00
IUUC-Ptr-091060	Pan troglodytes	92.72	0.00e+00	756.00
IUUC-Pan-091855	Papio anubis	84.58	0.00e+00	658.00
IUUC-Psi-093505	Pelodiscus sinensis	81.28	0.00e+00	626.00
IUUC-Pfo-097396	Poecilia formosa	74.51	8.00e-150	523.00
IUUC-Pab-098591	Pongo abelii	91.86	0.00e+00	741.00
IUUC-Pop-099661	Populus trichocarpa	33.33	7.00e-32	131.00
IUUC-Pca-101029	Procavia capensis	84.65	0.00e+00	652.00
IUUC-Ppe-101495	Prunus persica	32.97	4.00e-38	152.00
IUUC-Pva-102244	Pteropus vampyrus	84.19	0.00e+00	661.00
IUUC-Rno-105861	Rattus norvegicus	95.95	0.00e+00	741.00
IUUC-Sha-107045	Sarcophilus harrisii	85.74	0.00e+00	671.00
IUUC-Smo-109325	Selaginella moellendorffii	36.23	3.00e-37	149.00
IUUC-Sit-110624	Setaria italica	32.40	6.00e-26	112.00
IUUC-Stu-112433	Solanum tuberosum	34.83	9.00e-33	134.00
IUUC-Sar-113169	Sorex araneus	86.16	2.00e-140	492.00
IUUC-Ssc-115766	Sus scrofa	88.89	0.00e+00	693.00
IUUC-Tgu-116469	Taeniopygia guttata	86.43	2.00e-138	485.00
IUUC-Tru-117732	Takifugu rubripes	77.22	1.00e-144	506.00
IUUC-Tsy-119624	Tarsius syrichta	81.80	0.00e+00	649.00
IUUC-Tni-119852	Tetraodon nigroviridis	70.63	2.00e-134	472.00
IUUC-Tca-121865	Theobroma cacao	33.67	8.00e-38	151.00
IUUC-Tae-125925	Triticum aestivum	35.53	9.00e-26	111.00
IUUC-Tur-126237	Triticum urartu	35.31	3.00e-23	102.00
IUUC-Tbe-128148	Tupaia belangeri	83.78	2.00e-168	584.00
IUUC-Ttr-128793	Tursiops truncatus	88.25	0.00e+00	680.00
IUUC-Vpa-130625	Vicugna pacos	72.59	6.00e-154	537.00
IUUC-Xtr-131790	Xenopus tropicalis	76.26	1.00e-155	543.00
IUUC-Xma-133377	Xiphophorus maculatus	73.09	6.00e-147	513.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence