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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046514
UUCD1 version UUC-HoS-00541
Ensembl Protein ID ENSP00000354775.2
UniProt Accession O43164; A8K6U4; D3DSZ5; Q68D49; Q8N1G5; PJA2_HUMAN
Genbank Protein ID BAA23710.2; BAF84448.1; EAW49050.1; EAW49051.1; AAH30826.1; CAH18371.1
Protein Name E3 ubiquitin-protein ligase Praja-2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2
Genbank Nucleotide ID AB007898; AK291759; AC008467; CH471086; BC030826; CR749579
Gene Name PJA2; KIAA0438; RNF131
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198961.9 ENST00000361189.6 ENSP00000354775.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 12036302
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.30e-06 28.3 634 675
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++  +d    lpC H+fh+ C+  w       +k+ +CP+Cr
   Q: 634  CPICCSEYikDDIATELPCHHFFHKPCVSIW------LQKSGTCPVCR 675
           ******99753324449**************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
 Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
Protein Sequence
(Fasta)
MSQYTEKEPA AMDQESGKAV WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG 60
DDYEVLELDD VPKENSSGSS PLDQVDSSLP SEPIFEKSET EIPTCGSALN QTTESSQSFV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046514|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTCTGCTTC CGCCGCCGCC ACCGCCGCCG CCGCCGCCAC AGCCGCCAGC CGCTTCGCGT 60
TCGGCGGGGG AGGAGTTGGA GGCGGAGAAG AAGGCGGTGG TGGCGGGTGG AGGTTCGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046514|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR030639--Praja-2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0045111--C:intermediate filament cytoskeleton
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0034236--F:protein kinase A catalytic subunit binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0035329--P:hippo signaling
GO:0007616--P:long-term memory
GO:0016567--P:protein ubiquitination
GO:0010738--P:regulation of protein kinase A signaling
KEGG hsa:9867
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001388 Ailuropoda melanoleuca 86.66 0.00e+00 1214.00
IUUC-Aca-004858 Anolis carolinensis 47.64 9.00e-151 527.00
IUUC-Ago-007872 Ashbya gossypii 41.54 5.00e-09 53.50
IUUC-Ame-010842 Astyanax mexicanus 59.61 6.00e-62 232.00
IUUC-Bta-013122 Bos taurus 84.93 0.00e+00 1196.00
IUUC-Cja-019345 Callithrix jacchus 93.81 0.00e+00 1021.00
IUUC-Cfa-021193 Canis familiaris 89.13 0.00e+00 1205.00
IUUC-Cpo-021991 Cavia porcellus 82.44 0.00e+00 1123.00
IUUC-Csa-024052 Chlorocebus sabaeus 96.55 0.00e+00 1295.00
IUUC-Cho-024680 Choloepus hoffmanni 85.63 0.00e+00 1190.00
IUUC-Dre-027662 Danio rerio 44.91 2.00e-62 233.00
IUUC-Dno-028851 Dasypus novemcinctus 87.14 0.00e+00 1204.00
IUUC-Dor-031005 Dipodomys ordii 83.20 0.00e+00 947.00
IUUC-Ete-032637 Echinops telfairi 71.77 5.00e-138 485.00
IUUC-Eca-034011 Equus caballus 89.85 0.00e+00 1036.00
IUUC-Eeu-034596 Erinaceus europaeus 82.60 0.00e+00 1083.00
IUUC-Fca-036523 Felis catus 89.27 0.00e+00 1185.00
IUUC-Fal-037255 Ficedula albicollis 42.18 3.00e-116 412.00
IUUC-Gga-040434 Gallus gallus 47.65 2.00e-135 476.00
IUUC-Itr-047883 Ictidomys tridecemlineatus 87.67 0.00e+00 1169.00
IUUC-Lch-050133 Latimeria chalumnae 34.00 1.00e-51 197.00
IUUC-Loc-051901 Lepisosteus oculatus 41.14 1.00e-113 404.00
IUUC-Laf-054289 Loxodonta africana 86.90 0.00e+00 1171.00
IUUC-Mcc-055552 Macaca mulatta 96.90 0.00e+00 1319.00
IUUC-Meu-056394 Macropus eugenii 76.92 1.00e-107 384.00
IUUC-Mga-059679 Meleagris gallopavo 34.60 4.00e-20 91.70
IUUC-Mmr-060712 Microcebus murinus 88.66 0.00e+00 1167.00
IUUC-Mdo-062457 Monodelphis domestica 57.00 0.00e+00 724.00
IUUC-Mmu-063933 Mus musculus 83.26 0.00e+00 1106.00
IUUC-Mpu-065994 Mustela putorius furo 89.64 0.00e+00 1233.00
IUUC-Mlu-067843 Myotis lucifugus 85.34 0.00e+00 1160.00
IUUC-Nle-069787 Nomascus leucogenys 97.64 0.00e+00 1329.00
IUUC-Opr-071190 Ochotona princeps 71.68 5.00e-135 474.00
IUUC-Oan-072728 Ornithorhynchus anatinus 32.86 7.00e-65 241.00
IUUC-Ocu-074152 Oryctolagus cuniculus 87.91 0.00e+00 1150.00
IUUC-Oga-088608 Otolemur garnettii 88.31 0.00e+00 1182.00
IUUC-Oar-090415 Ovis aries 82.24 0.00e+00 1115.00
IUUC-Ptr-091211 Pan troglodytes 99.12 0.00e+00 1345.00
IUUC-Pan-091698 Papio anubis 89.38 0.00e+00 1191.00
IUUC-Psi-093139 Pelodiscus sinensis 51.85 2.00e-151 530.00
IUUC-Pab-097745 Pongo abelii 97.94 0.00e+00 1333.00
IUUC-Pca-100681 Procavia capensis 80.00 0.00e+00 1042.00
IUUC-Pva-102525 Pteropus vampyrus 88.43 0.00e+00 1229.00
IUUC-Rno-105620 Rattus norvegicus 81.58 0.00e+00 1111.00
IUUC-Sce-106223 Saccharomyces cerevisiae 48.89 9.00e-09 53.10
IUUC-Sha-106812 Sarcophilus harrisii 53.36 4.00e-135 475.00
IUUC-Sar-113270 Sorex araneus 88.18 9.00e-167 580.00
IUUC-Ssc-115913 Sus scrofa 82.75 0.00e+00 732.00
IUUC-Tgu-117101 Taeniopygia guttata 52.61 1.00e-66 246.00
IUUC-Tsy-119078 Tarsius syrichta 88.64 0.00e+00 1014.00
IUUC-Tbe-127715 Tupaia belangeri 81.55 0.00e+00 1091.00
IUUC-Ttr-129003 Tursiops truncatus 89.30 0.00e+00 1260.00
IUUC-Vpa-130373 Vicugna pacos 90.54 0.00e+00 1234.00
IUUC-Vvi-131189 Vitis vinifera 46.05 3.00e-13 68.60
Created Date 25-Jun-2017

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