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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046297
UUCD1 version UUC-HoS-00181
Ensembl Protein ID ENSP00000451653.1
UniProt Accession Q7L622; Q9BVR2; Q9H9E9; Q9NXC0; Q9P2L3; G2E3_HUMAN
Genbank Protein ID BAA92571.1; BAA91095.1; BAB14280.1; AAH00973.2
Protein Name G2/M phase-specific E3 ubiquitin-protein ligase; G2/M phase-specific HECT-type E3 ubiquitin transferase
Genbank Nucleotide ID AB037754; AK000340; AK022867; BC000973
Gene Name G2E3; KIAA1333
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000092140.14 ENST00000553504.5 ENSP00000451653.1
ENSG00000092140.14 ENST00000552515.5 ENSP00000448515.1
ENSG00000092140.14 ENST00000548934.1 ENSP00000446535.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 18511420; 20175895
Classification
Family E-value Score Start End
E3 activity/HECT 1.80e-42 147.6 418 726
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/HECT
   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsks 95
           + +ev +v E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++sk+
   Q: 418  YAIEVAYVIENdnfGSEHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFFSKT 500
           56788898887777***********************..45..677788888888885.....689************************** PP
   S: 96   fyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           ++++l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      ++e++++  + g+ +   t ++k++ vk+++ y++ +++
   Q: 501  LFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATTVADLKSI-----INECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRV 582
           ********8...*************988888774..555555788765.....88999**99****************************** PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq....FvTgssr 273
           ++ +e+f++G++++  le+++++ e  +++l+++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + ++ ++    F+Tg+s+
   Q: 583  HTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSE--LFTVHTLPDVKAL-GFWNSYlQAVEDGKSTTTMEdiliFATGCSS 671
           *********************************************..888899******8.899876578877777766666666******* PP
   S: 274  lPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +P++Gf++ + ++ +++      ++P  n+C n+L +P  +++++++e++ ++i++t ++e
   Q: 672  IPPAGFKPTP-SIECLHV-----DFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLE 726
           *********9.99****9.....********************************987665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
Protein Sequence
(Fasta)
MLIPALQISD SESVGLEDGI EQSAYLTESK MNESKPGDSQ NLACVFCRKH DDCPNKYGEK 60
KTKEKWNLTV HYYCLLMSSG IWQRGKEEEG VYGFLIEDIR KEVNRASKLK CCVCKKNGAS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046297|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACCGCTCTT TCCGGGTTTG CGAGCGGAAG TGGACGAATT TGAATCCTGT GGGCCGTTGA 60
ATGTGGCTGC TCGCGGTCGG CGTGCCCCGA CGTACAGCGG GCCGGGAAAA GTGGCACTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046297|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1
Pfam

PF00632--HECT
SMART

SM00119--HECTc
SM00249--PHD
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007275--P:multicellular organism development
KEGG hsa:55632
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001501 Ailuropoda melanoleuca 91.64 0.00e+00 1366.00
IUUC-Apl-003763 Anas platyrhynchos 60.60 0.00e+00 859.00
IUUC-Aca-004328 Anolis carolinensis 61.10 0.00e+00 872.00
IUUC-Ame-011288 Astyanax mexicanus 40.08 8.00e-162 564.00
IUUC-Bta-012496 Bos taurus 86.65 0.00e+00 1294.00
IUUC-Cja-019756 Callithrix jacchus 94.74 0.00e+00 1392.00
IUUC-Cfa-020806 Canis familiaris 89.39 0.00e+00 1345.00
IUUC-Cpo-022519 Cavia porcellus 85.98 0.00e+00 1267.00
IUUC-Csa-023957 Chlorocebus sabaeus 98.02 0.00e+00 1446.00
IUUC-Cho-024375 Choloepus hoffmanni 83.26 0.00e+00 1191.00
IUUC-Cin-025325 Ciona intestinalis 40.88 3.00e-65 241.00
IUUC-Csv-026262 Ciona savignyi 42.66 1.00e-66 247.00
IUUC-Dre-027829 Danio rerio 40.48 5.00e-154 538.00
IUUC-Dno-029362 Dasypus novemcinctus 89.42 0.00e+00 1321.00
IUUC-Dor-030710 Dipodomys ordii 83.29 0.00e+00 1256.00
IUUC-Dse-031248 Dothistroma septosporum 40.38 3.00e-03 37.40
IUUC-Dme-031692 Drosophila melanogaster 34.83 7.00e-42 165.00
IUUC-Ete-032282 Echinops telfairi 80.99 0.00e+00 1166.00
IUUC-Eca-033963 Equus caballus 89.80 0.00e+00 1355.00
IUUC-Eeu-035029 Erinaceus europaeus 86.24 0.00e+00 1292.00
IUUC-Fca-036229 Felis catus 90.65 0.00e+00 1365.00
IUUC-Fal-037015 Ficedula albicollis 58.33 0.00e+00 875.00
IUUC-Gmo-039715 Gadus morhua 38.71 2.00e-75 276.00
IUUC-Gga-040298 Gallus gallus 59.03 0.00e+00 904.00
IUUC-Gac-041444 Gasterosteus aculeatus 39.43 2.00e-143 502.00
IUUC-Ggo-045456 Gorilla gorilla 99.29 0.00e+00 1459.00
IUUC-Itr-047897 Ictidomys tridecemlineatus 88.67 0.00e+00 936.00
IUUC-Lch-050287 Latimeria chalumnae 67.32 5.00e-106 378.00
IUUC-Loc-052839 Lepisosteus oculatus 57.58 1.00e-31 128.00
IUUC-Laf-053581 Loxodonta africana 88.44 0.00e+00 1306.00
IUUC-Mcc-055615 Macaca mulatta 97.15 0.00e+00 1461.00
IUUC-Meu-056753 Macropus eugenii 49.49 5.00e-130 458.00
IUUC-Mga-059902 Meleagris gallopavo 59.24 0.00e+00 910.00
IUUC-Mmr-061522 Microcebus murinus 92.52 0.00e+00 1416.00
IUUC-Mdo-063022 Monodelphis domestica 66.32 0.00e+00 911.00
IUUC-Mmu-063609 Mus musculus 77.17 0.00e+00 1175.00
IUUC-Mpu-066656 Mustela putorius furo 89.96 0.00e+00 1358.00
IUUC-Mlu-067011 Myotis lucifugus 88.26 0.00e+00 1317.00
IUUC-Nle-069949 Nomascus leucogenys 99.01 0.00e+00 1454.00
IUUC-Opr-071224 Ochotona princeps 83.46 5.00e-133 468.00
IUUC-Ont-072174 Oreochromis niloticus 37.77 5.00e-139 488.00
IUUC-Oan-072712 Ornithorhynchus anatinus 68.72 0.00e+00 987.00
IUUC-Ocu-073776 Oryctolagus cuniculus 91.08 0.00e+00 1353.00
IUUC-Ola-087247 Oryzias latipes 36.83 3.00e-129 456.00
IUUC-Oga-088094 Otolemur garnettii 88.18 0.00e+00 1238.00
IUUC-Oar-090248 Ovis aries 86.38 0.00e+00 1286.00
IUUC-Ptr-090634 Pan troglodytes 99.58 0.00e+00 1465.00
IUUC-Pan-092876 Papio anubis 98.16 0.00e+00 1446.00
IUUC-Psi-093580 Pelodiscus sinensis 61.84 0.00e+00 889.00
IUUC-Pma-094295 Petromyzon marinus 53.97 4.00e-74 270.00
IUUC-Pfo-096351 Poecilia formosa 36.99 2.00e-144 506.00
IUUC-Pab-097596 Pongo abelii 99.15 0.00e+00 1457.00
IUUC-Pca-100309 Procavia capensis 82.15 0.00e+00 1221.00
IUUC-Pva-102526 Pteropus vampyrus 92.01 0.00e+00 859.00
IUUC-Rno-105432 Rattus norvegicus 82.24 0.00e+00 1230.00
IUUC-Sha-107089 Sarcophilus harrisii 65.64 0.00e+00 1015.00
IUUC-Sar-113667 Sorex araneus 69.03 0.00e+00 979.00
IUUC-Ssc-116200 Sus scrofa 89.52 0.00e+00 1340.00
IUUC-Tgu-116467 Taeniopygia guttata 58.10 0.00e+00 855.00
IUUC-Tru-117690 Takifugu rubripes 38.26 2.00e-153 536.00
IUUC-Tsy-119481 Tarsius syrichta 88.00 0.00e+00 922.00
IUUC-Tni-119669 Tetraodon nigroviridis 37.54 4.00e-135 475.00
IUUC-Tbe-127241 Tupaia belangeri 82.39 0.00e+00 1169.00
IUUC-Ttr-129057 Tursiops truncatus 81.30 0.00e+00 1163.00
IUUC-Vpa-130685 Vicugna pacos 87.62 0.00e+00 1271.00
IUUC-Xtr-132555 Xenopus tropicalis 53.25 0.00e+00 755.00
IUUC-Xma-133723 Xiphophorus maculatus 49.65 7.00e-82 296.00
Created Date 25-Jun-2017

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