iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020455.16	ENSMUST00000108809.7	ENSMUSP00000104437.1
ENSMUSG00000020455.16	ENSMUST00000108810.9	ENSMUSP00000104438.3
ENSMUSG00000020455.16	ENSMUST00000093061.6	ENSMUSP00000090749.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	4.40e-06	27.8	12	71
E3 activity/RING/RING	4.20e-08	34.7	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltl 61
           ee  C+I l+ ++dPv++ +G+ + r++I+++    +      cP +r+  ++++l Pn  l
   Q: 12   EEATCAICLDYFTDPVMTDCGHNFCRECIRRCWgqPE--GpyACPECRELSAQRNLRPNRPL 71
           7889***************************995333..346*****************866 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           CaiCl+ f d p+ ++CgH f+++C+  +w     +  +   CP Cr
   Q: 16   CAICLDYFTD-PVMTDCGHNFCRECIrRCW----GQPEGPYACPECR 57
           **********.999************99**....66789999****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Protein Sequence
(Fasta)

MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS 60
AQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCAAHREPLT TFCGDDLSLL CPICERSEHW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGCTTAG TGCCGGATGT ACCCACTACC CAGGAGGCTG AGAGTGCCGC TACCTGCTCC 60
TGGCCCGTTC CCACTGCGCT CTCGCGGCGG AGTTGCCCGA TCCCGGTGCA CCACGAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019904--F:protein domain specific binding
GO:0008134--F:transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0050768--P:negative regulation of neurogenesis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0046598--P:positive regulation of viral entry into host cell

KEGG

mmu:94091

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001800	Ailuropoda melanoleuca	70.73	6.00e-161	560.00
IUUC-Bta-012332	Bos taurus	86.75	0.00e+00	749.00
IUUC-Cja-019969	Callithrix jacchus	77.78	0.00e+00	632.00
IUUC-Cfa-020491	Canis familiaris	87.18	0.00e+00	764.00
IUUC-Cpo-021936	Cavia porcellus	87.39	0.00e+00	741.00
IUUC-Csa-024151	Chlorocebus sabaeus	89.10	0.00e+00	713.00
IUUC-Cho-024990	Choloepus hoffmanni	77.27	4.00e-114	404.00
IUUC-Dno-029580	Dasypus novemcinctus	77.03	2.00e-177	615.00
IUUC-Ete-032556	Echinops telfairi	70.17	6.00e-113	400.00
IUUC-Eca-033612	Equus caballus	74.73	1.00e-135	475.00
IUUC-Fca-035821	Felis catus	86.14	7.00e-146	509.00
IUUC-Ggo-044629	Gorilla gorilla	89.53	0.00e+00	718.00
IUUC-Hsa-046332	Homo sapiens	89.53	0.00e+00	717.00
IUUC-Itr-047946	Ictidomys tridecemlineatus	91.45	0.00e+00	754.00
IUUC-Laf-054350	Loxodonta africana	73.77	3.00e-139	488.00
IUUC-Mcc-055827	Macaca mulatta	87.82	0.00e+00	697.00
IUUC-Meu-056122	Macropus eugenii	71.95	0.00e+00	640.00
IUUC-Mmr-061700	Microcebus murinus	87.15	0.00e+00	738.00
IUUC-Mdo-062921	Monodelphis domestica	62.53	3.00e-161	561.00
IUUC-Mpu-065873	Mustela putorius furo	86.75	0.00e+00	760.00
IUUC-Mlu-067379	Myotis lucifugus	67.61	9.00e-165	573.00
IUUC-Nle-069440	Nomascus leucogenys	88.98	0.00e+00	714.00
IUUC-Opr-070901	Ochotona princeps	78.37	4.00e-173	600.00
IUUC-Oan-073401	Ornithorhynchus anatinus	43.54	2.00e-86	313.00
IUUC-Ocu-074038	Oryctolagus cuniculus	72.84	1.00e-153	535.00
IUUC-Oga-088948	Otolemur garnettii	84.65	0.00e+00	717.00
IUUC-Oar-090242	Ovis aries	79.92	0.00e+00	698.00
IUUC-Ptr-090615	Pan troglodytes	88.94	4.00e-98	351.00
IUUC-Pan-092626	Papio anubis	89.32	0.00e+00	715.00
IUUC-Pab-097895	Pongo abelii	82.91	0.00e+00	719.00
IUUC-Pca-100435	Procavia capensis	86.30	0.00e+00	719.00
IUUC-Pva-102288	Pteropus vampyrus	78.42	0.00e+00	649.00
IUUC-Rno-105938	Rattus norvegicus	98.29	0.00e+00	818.00
IUUC-Sha-107354	Sarcophilus harrisii	74.19	0.00e+00	661.00
IUUC-Smo-108838	Selaginella moellendorffii	44.68	1.00e-07	52.80
IUUC-Tbe-127733	Tupaia belangeri	91.18	0.00e+00	741.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence