iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000161956.12	ENST00000321337.11	ENSP00000314029.8
ENSG00000161956.12	ENST00000580231.5	ENSP00000463358.1
ENSG00000161956.12	ENST00000619785.1	ENSP00000482398.1
ENSG00000161956.12	ENST00000610454.4	ENSP00000479187.1
ENSG00000161956.12	ENST00000582789.5	ENSP00000464172.1
ENSG00000161956.12	ENST00000581093.1	ENSP00000462461.1

Annotation

Cancer Mutation
TCGA	ICGC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/ULP	ULP	21316347

Classification

Family	E-value	Score	Start	End
DUB/ULP	1.60e-51	176.6	387	542

Active Site

Position(s)	Description	Evidence
465	N/A	{ECO:0000250}
482		{ECO:0000250}
532		{ECO:0000250}

Domain Profile

DUB/ULP

   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslavvcf 93
            +t++dl +L  +++lnD+++++y + lv++++     e++h+f+sffy+kl++k+++ vk+wt++vd+f+k+l+++pi+ ++HWsl+ v++
   Q: 387  VLTMDDLGTLYGQNWLNDQVMNMYGD-LVMDTVP----EKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLISVDV 473
           589***********************.******7....99**************************************************** PP
   S: 94   kkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk.vpqQkNssDCGvyvlqyves 163
           ++++i+++DS+ ++ ++++ k++++yl+ e+ kk++ +f++  +kg++++ v++Q+N+sDCG++vlqy+++
   Q: 474  RRRTITYFDSQ-RTLNRRCPKHIAKYLQAEAVKKDRLDFHQ-GWKGYFKMnVARQNNDSDCGAFVLQYCKH 542
           ***********.999*************************9.9***99988******************97 PP

Organism

Homo sapiens

Functional Description
(View)

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Protein Sequence
(Fasta)

MKETIQGTGS WGPEPPGPGI PPAYSSPRRE RLRWPPPPKP RLKSGGGFGP DPGSGTTVPA 60
RRLPVPRPSF DASASEEEEE EEEEEDEDEE EEVAAWRLPP RWSQLGTSQR PRPSRPTHRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGACCGCG CGCTTGGTGG CCGCGCCGGC GCTCTTCGCC GGGTGTGACG TACTAATCGT 60
GCGCCACCGC TGCCGGTGGG CCCGGGGCTC GCGGGAGGGG AAGGAGGAGG GGGGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005737--C:cytoplasm
GO:0071339--C:MLL1 complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0016926--P:protein desumoylation
GO:0006364--P:rRNA processing

KEGG

hsa:26168

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001848	Ailuropoda melanoleuca	96.34	0.00e+00	870.00
IUUC-Bta-013150	Bos taurus	96.17	0.00e+00	871.00
IUUC-Cja-018905	Callithrix jacchus	94.95	0.00e+00	840.00
IUUC-Cfa-020249	Canis familiaris	96.17	0.00e+00	853.00
IUUC-Cpo-021717	Cavia porcellus	96.86	0.00e+00	866.00
IUUC-Csa-023887	Chlorocebus sabaeus	99.61	0.00e+00	924.00
IUUC-Cho-024579	Choloepus hoffmanni	95.64	0.00e+00	845.00
IUUC-Dno-029536	Dasypus novemcinctus	96.34	0.00e+00	874.00
IUUC-Eca-033421	Equus caballus	95.64	0.00e+00	908.00
IUUC-Eeu-035146	Erinaceus europaeus	92.68	0.00e+00	847.00
IUUC-Fca-035634	Felis catus	96.86	0.00e+00	873.00
IUUC-Ggo-045581	Gorilla gorilla	99.61	0.00e+00	924.00
IUUC-Itr-048878	Ictidomys tridecemlineatus	94.95	0.00e+00	879.00
IUUC-Laf-053840	Loxodonta africana	94.56	0.00e+00	875.00
IUUC-Mcc-055153	Macaca mulatta	98.46	0.00e+00	918.00
IUUC-Meu-056597	Macropus eugenii	79.17	0.00e+00	668.00
IUUC-Mmr-060998	Microcebus murinus	98.26	0.00e+00	910.00
IUUC-Mdo-062828	Monodelphis domestica	84.69	0.00e+00	734.00
IUUC-Mmu-063830	Mus musculus	94.25	0.00e+00	893.00
IUUC-Mpu-065895	Mustela putorius furo	96.86	0.00e+00	874.00
IUUC-Mlu-067260	Myotis lucifugus	96.34	0.00e+00	888.00
IUUC-Nle-069377	Nomascus leucogenys	99.23	0.00e+00	922.00
IUUC-Opr-070768	Ochotona princeps	81.74	0.00e+00	707.00
IUUC-Ocu-074443	Oryctolagus cuniculus	96.86	0.00e+00	873.00
IUUC-Oga-088210	Otolemur garnettii	97.21	0.00e+00	890.00
IUUC-Oar-089328	Ovis aries	96.17	0.00e+00	871.00
IUUC-Ptr-091025	Pan troglodytes	99.81	0.00e+00	927.00
IUUC-Pan-092471	Papio anubis	99.48	0.00e+00	937.00
IUUC-Pva-102858	Pteropus vampyrus	96.86	0.00e+00	895.00
IUUC-Rno-105649	Rattus norvegicus	94.60	0.00e+00	897.00
IUUC-Sha-106798	Sarcophilus harrisii	86.51	0.00e+00	718.00
IUUC-Tbe-127410	Tupaia belangeri	84.32	0.00e+00	706.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence