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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106291
UUCD1 version UUC-SaC-00097
Ensembl Protein ID YBL008W
UniProt Accession P32479; D6VPZ2; HIR1_YEAST
Genbank Protein ID AAB23989.1; CAA84827.1; DAA07112.2
Protein Name Protein HIR1; Histone transcription regulator 1
Genbank Nucleotide ID L03838; Z35769; BK006936
Gene Name HIR1; YBL008W; YBL0318
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBL008W YBL008W YBL008W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-26 88.8 78 109
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           Ht+s+tc++f +d ++l+sGsdD  + +W l+
   Q: 78   HTGSITCVKFsPDgKYLASGSDDRILLIWALD 109
           9**********999***************986 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
 Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
Protein Sequence
(Fasta)
MKVVKFPWLA HREESRKYEI YTVDVSHDGK RLATGGLDGK IRIWSIDSIL RCMELESLTP 60
EIPLPQDLQM PLCSMSRHTG SITCVKFSPD GKYLASGSDD RILLIWALDE EQSSQPAFGS 120
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Protein Fasta Sequence


>IUUC-Sce-106291|E3,WD_repeat|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAAAGTGG TAAAGTTTCC ATGGTTGGCT CACCGTGAAG AATCGCGAAA ATATGAAATA 60
TACACAGTCG ATGTTAGCCA CGATGGGAAA AGGTTGGCCA CAGGCGGCCT AGATGGCAAG 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106291|E3,WD_repeat|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR011659--PD40
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07569--Hira
PF09453--HIRA_B
PF07676--PD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0000417--C:HIR complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031935--P:regulation of chromatin silencing
GO:0006368--P:transcription elongation from RNA polymerase II promoter
KEGG sce:YBL008W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001039 Aegilops tauschii 32.17 2.00e-59 221.00
IUUC-Aml-001723 Ailuropoda melanoleuca 32.04 5.00e-55 207.00
IUUC-Atr-003132 Amborella trichopoda 30.77 6.00e-63 233.00
IUUC-Apl-003197 Anas platyrhynchos 32.04 5.00e-56 211.00
IUUC-Aca-004733 Anolis carolinensis 31.36 3.00e-57 215.00
IUUC-Aly-005446 Arabidopsis lyrata 29.98 1.00e-58 219.00
IUUC-Ath-007627 Arabidopsis thaliana 30.53 4.00e-63 234.00
IUUC-Ago-007766 Ashbya gossypii 54.31 0.00e+00 876.00
IUUC-Acl-008104 Aspergillus clavatus 33.26 7.00e-127 446.00
IUUC-Afl-008591 Aspergillus flavus 32.55 8.00e-125 439.00
IUUC-Afu-008781 Aspergillus fumigatus 33.25 6.00e-119 420.00
IUUC-Ani-009272 Aspergillus nidulans 32.34 2.00e-112 398.00
IUUC-Ang-009655 Aspergillus niger 32.75 3.00e-125 441.00
IUUC-Aor-010119 Aspergillus oryzae 32.78 7.00e-125 439.00
IUUC-Ate-010530 Aspergillus terreus 37.36 8.00e-109 386.00
IUUC-Bgr-012237 Blumeria graminis 46.19 3.00e-114 404.00
IUUC-Bta-013320 Bos taurus 31.61 2.00e-54 205.00
IUUC-Bci-013795 Botrytis cinerea 33.73 4.00e-123 433.00
IUUC-Bdi-014075 Brachypodium distachyon 27.07 9.00e-65 239.00
IUUC-Bol-016440 Brassica oleracea 32.33 8.00e-65 240.00
IUUC-Bra-016651 Brassica rapa 32.60 6.00e-66 243.00
IUUC-Cel-018692 Caenorhabditis elegans 23.10 5.00e-27 114.00
IUUC-Cja-018987 Callithrix jacchus 31.72 1.00e-49 189.00
IUUC-Cfa-020132 Canis familiaris 32.04 4.00e-55 207.00
IUUC-Cpo-021484 Cavia porcellus 31.77 1.00e-56 213.00
IUUC-Cre-022846 Chlamydomonas reinhardtii 29.70 4.00e-51 194.00
IUUC-Csa-023081 Chlorocebus sabaeus 31.77 1.00e-56 212.00
IUUC-Cin-025182 Ciona intestinalis 30.07 9.00e-53 200.00
IUUC-Csv-026154 Ciona savignyi 29.89 7.00e-53 200.00
IUUC-Cgl-026655 Colletotrichum gloeosporioides 33.01 3.00e-121 427.00
IUUC-Cne-026891 Cryptococcus neoformans 34.46 4.00e-81 293.00
IUUC-Cme-027349 Cyanidioschyzon merolae 27.07 5.00e-35 141.00
IUUC-Dre-027655 Danio rerio 31.73 3.00e-56 211.00
IUUC-Dno-029557 Dasypus novemcinctus 30.97 1.00e-47 182.00
IUUC-Dor-030687 Dipodomys ordii 29.32 3.00e-44 171.00
IUUC-Dse-031334 Dothistroma septosporum 35.52 3.00e-127 447.00
IUUC-Dme-031746 Drosophila melanogaster 32.02 4.00e-62 231.00
IUUC-Ete-032384 Echinops telfairi 27.39 2.00e-36 145.00
IUUC-Eca-033430 Equus caballus 31.78 1.00e-54 206.00
IUUC-Fca-036121 Felis catus 32.04 5.00e-55 207.00
IUUC-Fal-036817 Ficedula albicollis 32.04 6.00e-56 210.00
IUUC-Fox-037906 Fusarium oxysporum 43.21 9.00e-117 412.00
IUUC-Fso-038409 Fusarium solani 34.93 1.00e-123 435.00
IUUC-Gmo-039151 Gadus morhua 32.17 8.00e-60 223.00
IUUC-Ggr-040016 Gaeumannomyces graminis 34.12 5.00e-123 433.00
IUUC-Gga-040936 Gallus gallus 31.77 2.00e-57 215.00
IUUC-Gac-041405 Gasterosteus aculeatus 28.60 2.00e-54 205.00
IUUC-Gma-044252 Glycine max 31.14 2.00e-65 241.00
IUUC-Ggo-045430 Gorilla gorilla 31.77 4.00e-56 211.00
IUUC-Hsa-046442 Homo sapiens 31.77 3.00e-56 211.00
IUUC-Hvu-047587 Hordeum vulgare 34.40 3.00e-56 211.00
IUUC-Itr-048910 Ictidomys tridecemlineatus 34.72 4.00e-44 169.00
IUUC-Kpa-049145 Komagataella pastoris 55.02 3.00e-152 530.00
IUUC-Lch-050474 Latimeria chalumnae 30.84 7.00e-57 213.00
IUUC-Lpe-051209 Leersia perrieri 30.08 6.00e-56 210.00
IUUC-Loc-052119 Lepisosteus oculatus 31.08 5.00e-56 211.00
IUUC-Lma-053237 Leptosphaeria maculans 35.49 3.00e-120 424.00
IUUC-Laf-053718 Loxodonta africana 31.53 2.00e-56 212.00
IUUC-Mcc-055621 Macaca mulatta 31.93 6.00e-50 190.00
IUUC-Meu-055914 Macropus eugenii 33.74 1.00e-37 150.00
IUUC-Mor-057090 Magnaporthe oryzae 48.30 2.00e-114 405.00
IUUC-Mpo-057364 Magnaporthe poae 34.28 1.00e-123 435.00
IUUC-Mtr-058691 Medicago truncatula 33.83 4.00e-65 241.00
IUUC-Mla-058914 Melampsora laricipopulina 38.46 2.00e-71 262.00
IUUC-Mga-060181 Meleagris gallopavo 31.89 3.00e-56 211.00
IUUC-Mvi-060432 Microbotryum violaceum 34.65 4.00e-69 254.00
IUUC-Mmr-060871 Microcebus murinus 31.77 4.00e-56 211.00
IUUC-Mdo-062301 Monodelphis domestica 29.49 2.00e-57 215.00
IUUC-Mmu-063888 Mus musculus 31.77 2.00e-56 212.00
IUUC-Mac-065137 Musa acuminata 32.68 3.00e-58 218.00
IUUC-Mpu-066732 Mustela putorius furo 32.04 6.00e-55 207.00
IUUC-Mlu-067542 Myotis lucifugus 32.04 6.00e-55 207.00
IUUC-Nfi-068396 Neosartorya fischeri 33.33 1.00e-119 422.00
IUUC-Ncr-068842 Neurospora crassa 35.72 6.00e-124 436.00
IUUC-Nle-070156 Nomascus leucogenys 31.77 4.00e-56 211.00
IUUC-Opr-070808 Ochotona princeps 31.42 9.00e-36 143.00
IUUC-Ont-072105 Oreochromis niloticus 32.05 1.00e-55 209.00
IUUC-Ocu-074962 Oryctolagus cuniculus 32.04 4.00e-55 208.00
IUUC-Oba-075178 Oryza barthii 32.79 5.00e-60 224.00
IUUC-Obr-076399 Oryza brachyantha 33.72 2.00e-62 232.00
IUUC-Ogu-078797 Oryza glumaepatula 32.79 5.00e-60 224.00
IUUC-Oin-080085 Oryza indica 33.43 2.00e-52 199.00
IUUC-Olo-081048 Oryza longistaminata 33.12 5.00e-44 171.00
IUUC-Ome-081324 Oryza meridionalis 32.79 6.00e-60 224.00
IUUC-Oni-082548 Oryza nivara 32.79 5.00e-60 224.00
IUUC-Opu-084008 Oryza punctata 33.02 1.00e-61 229.00
IUUC-Oru-084339 Oryza rufipogon 32.79 6.00e-60 224.00
IUUC-Osa-085782 Oryza sativa 32.79 6.00e-60 224.00
IUUC-Ola-087302 Oryzias latipes 27.33 6.00e-51 194.00
IUUC-Olu-087611 Ostreococcus lucimarinus 34.48 6.00e-65 240.00
IUUC-Oga-087935 Otolemur garnettii 32.04 8.00e-55 206.00
IUUC-Oar-089229 Ovis aries 28.46 1.00e-43 170.00
IUUC-Ptr-090715 Pan troglodytes 31.77 4.00e-56 211.00
IUUC-Pan-092318 Papio anubis 32.04 4.00e-55 207.00
IUUC-Psi-094053 Pelodiscus sinensis 31.20 5.00e-56 211.00
IUUC-Pno-094985 Phaeosphaeria nodorum 45.89 4.00e-102 364.00
IUUC-Ppa-095819 Physcomitrella patens 32.26 5.00e-60 224.00
IUUC-Pfo-096857 Poecilia formosa 31.97 2.00e-54 206.00
IUUC-Pab-098047 Pongo abelii 31.77 4.00e-56 211.00
IUUC-Pop-099865 Populus trichocarpa 34.71 2.00e-64 239.00
IUUC-Pca-100558 Procavia capensis 34.26 1.00e-32 133.00
IUUC-Ppe-101261 Prunus persica 32.49 3.00e-66 244.00
IUUC-Pva-102683 Pteropus vampyrus 32.04 4.00e-55 207.00
IUUC-Pgr-103660 Puccinia graminis 38.05 2.00e-68 251.00
IUUC-Ptt-103900 Puccinia triticina 38.56 2.00e-69 254.00
IUUC-Pte-104209 Pyrenophora teres 32.85 7.00e-120 423.00
IUUC-Pyt-104802 Pyrenophora triticirepentis 33.73 3.00e-120 424.00
IUUC-Rno-105566 Rattus norvegicus 31.77 2.00e-56 212.00
IUUC-Sha-107514 Sarcophilus harrisii 27.82 4.00e-44 171.00
IUUC-Sja-107833 Schizosaccharomyces japonicus 33.33 5.00e-123 433.00
IUUC-Spo-108162 Schizosaccharomyces pombe 42.62 1.00e-116 412.00
IUUC-Ssl-108629 Sclerotinia sclerotiorum 64.29 2.00e-31 129.00
IUUC-Smo-109186 Selaginella moellendorffii 33.49 8.00e-62 230.00
IUUC-Sit-109980 Setaria italica 34.46 3.00e-64 238.00
IUUC-Sly-111547 Solanum lycopersicum 25.69 1.00e-65 243.00
IUUC-Stu-112705 Solanum tuberosum 33.41 6.00e-62 230.00
IUUC-Sar-113222 Sorex araneus 29.97 1.00e-47 183.00
IUUC-Sbi-114528 Sorghum bicolor 33.56 4.00e-64 238.00
IUUC-Sre-115061 Sporisorium reilianum 34.12 2.00e-78 285.00
IUUC-Ssc-116364 Sus scrofa 31.52 5.00e-54 204.00
IUUC-Tgu-116645 Taeniopygia guttata 32.04 7.00e-56 210.00
IUUC-Tru-117590 Takifugu rubripes 31.11 3.00e-55 208.00
IUUC-Tsy-119212 Tarsius syrichta 31.82 3.00e-47 181.00
IUUC-Tni-119915 Tetraodon nigroviridis 31.57 2.00e-55 209.00
IUUC-Tca-121765 Theobroma cacao 31.77 2.00e-67 248.00
IUUC-Tre-121887 Trichoderma reesei 33.49 1.00e-119 422.00
IUUC-Tvi-122262 Trichoderma virens 34.21 1.00e-119 422.00
IUUC-Tur-126483 Triticum urartu 33.49 3.00e-63 234.00
IUUC-Tme-127202 Tuber melanosporum 33.66 3.00e-109 387.00
IUUC-Tbe-127350 Tupaia belangeri 27.54 7.00e-28 117.00
IUUC-Ttr-129077 Tursiops truncatus 34.34 2.00e-43 169.00
IUUC-Uma-129465 Ustilago maydis 34.31 8.00e-76 276.00
IUUC-Vda-129844 Verticillium dahliae 36.04 6.00e-118 416.00
IUUC-Vvi-131397 Vitis vinifera 31.66 1.00e-65 243.00
IUUC-Xtr-132057 Xenopus tropicalis 29.10 2.00e-56 212.00
IUUC-Xma-134139 Xiphophorus maculatus 31.96 6.00e-48 183.00
IUUC-Yli-134424 Yarrowia lipolytica 52.56 4.00e-130 457.00
IUUC-Zma-135506 Zea mays 34.33 7.00e-64 236.00
Created Date 25-Jun-2017

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