iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046197

Ensembl Protein ID

ENSP00000005587.2

UniProt Accession

O75563; A4D173; Q53GP6; Q75MK6; Q75MZ4; Q9UBZ3; Q9UED8; SKAP2_HUMAN

Genbank Protein ID

BAA36194.1; CAA06193.1; AAC39924.1; AAC99296.1; BAG36025.1; BAD96605.1; AAS02033.1; AAS07536.1; EAL24231.1; EAW93859.1; AAH02893.1; AAH36044.1

Protein Name

Src kinase-associated phosphoprotein 2; Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP55 homolog; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains

Genbank Nucleotide ID

AB014486; AJ004886; AF072166; AF051323; AK313209; AK222885; AC003999; AC011299; CH236948; CH471073; BC002893; BC036044

Gene Name

SKAP2; PRAP; RA70; SAPS; SCAP2; SKAP55R

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000005020.12	ENST00000345317.6	ENSP00000005587.2
ENSG00000005020.12	ENST00000432747.1	ENSP00000408163.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-11	45.3	302	355

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            q l+d +++ +deL++k+Gdv+++++ke +  gW++g  e +g  Gl+P+ ++ +
   Q: 302  YQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVG--EMKGAIGLVPKAYIME 355
           57789999999***************************..9************987 PP

Organism

Homo sapiens

Functional Description
(View)

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.

Protein Sequence
(Fasta)

MPNPSSTSSP YPLPEEIRNL LADVETFVAD ILKGENLSKK AKEKRESLIK KIKDVKSIYL 60
QEFQDKGDAE DGEEYDDPFA GPPDTISLAS ERYDKDDEAP SDGAQFPPIA AQDLPFVLKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTTTTCTC TGCTTGTTGG ACATGAAGAG AGGGAGACAA AGGCTCTCAG AAAGAGAAAG 60
ACGGGCTGGT GAAGGACAAA CTAAGGTGAG TGAGATGCTG AGTTCCTTAT TTCTAGTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0075--B-cell activation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005070--F:SH3/SH2 adaptor activity
GO:0042113--P:B cell activation
GO:0002757--P:immune response-activating signal transduction
GO:0008285--P:negative regulation of cell proliferation
GO:0006461--P:protein complex assembly
GO:0007165--P:signal transduction

KEGG

hsa:8935

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001212	Ailuropoda melanoleuca	92.48	0.00e+00	647.00
IUUC-Apl-003565	Anas platyrhynchos	72.76	2.00e-101	361.00
IUUC-Aca-005159	Anolis carolinensis	68.25	5.00e-126	444.00
IUUC-Ame-011510	Astyanax mexicanus	61.21	1.00e-108	386.00
IUUC-Bta-013222	Bos taurus	91.64	0.00e+00	629.00
IUUC-Cja-019091	Callithrix jacchus	93.89	0.00e+00	677.00
IUUC-Cfa-020492	Canis familiaris	93.59	0.00e+00	636.00
IUUC-Cpo-021974	Cavia porcellus	89.57	5.00e-169	587.00
IUUC-Csa-023195	Chlorocebus sabaeus	98.83	1.00e-138	485.00
IUUC-Cho-024462	Choloepus hoffmanni	84.17	2.00e-171	595.00
IUUC-Dno-029759	Dasypus novemcinctus	93.61	0.00e+00	631.00
IUUC-Dor-030116	Dipodomys ordii	80.22	7.00e-153	533.00
IUUC-Eca-034293	Equus caballus	92.20	1.00e-178	619.00
IUUC-Fca-036423	Felis catus	92.20	0.00e+00	639.00
IUUC-Fal-037146	Ficedula albicollis	69.16	2.00e-111	395.00
IUUC-Gmo-039059	Gadus morhua	56.85	3.00e-85	308.00
IUUC-Gga-040385	Gallus gallus	70.03	5.00e-116	410.00
IUUC-Gac-042122	Gasterosteus aculeatus	58.38	4.00e-94	338.00
IUUC-Ggo-044961	Gorilla gorilla	99.16	0.00e+00	692.00
IUUC-Lch-049485	Latimeria chalumnae	72.24	2.00e-111	395.00
IUUC-Loc-052335	Lepisosteus oculatus	63.43	2.00e-109	389.00
IUUC-Laf-053622	Loxodonta africana	92.24	0.00e+00	643.00
IUUC-Mcc-055725	Macaca mulatta	98.33	0.00e+00	689.00
IUUC-Meu-056098	Macropus eugenii	81.55	1.00e-157	548.00
IUUC-Mga-059932	Meleagris gallopavo	76.65	5.00e-111	393.00
IUUC-Mmr-061781	Microcebus murinus	91.36	3.00e-170	590.00
IUUC-Mdo-062502	Monodelphis domestica	76.67	1.00e-147	516.00
IUUC-Mmu-063978	Mus musculus	90.53	0.00e+00	630.00
IUUC-Mpu-065930	Mustela putorius furo	91.92	0.00e+00	644.00
IUUC-Mlu-067603	Myotis lucifugus	89.88	6.00e-117	413.00
IUUC-Nle-069223	Nomascus leucogenys	98.89	0.00e+00	688.00
IUUC-Opr-070422	Ochotona princeps	68.80	4.00e-115	407.00
IUUC-Ont-072351	Oreochromis niloticus	57.93	2.00e-104	372.00
IUUC-Oan-073125	Ornithorhynchus anatinus	89.11	2.00e-126	445.00
IUUC-Ocu-074410	Oryctolagus cuniculus	89.97	1.00e-170	592.00
IUUC-Ola-087314	Oryzias latipes	54.42	8.00e-91	327.00
IUUC-Oga-087912	Otolemur garnettii	92.20	0.00e+00	637.00
IUUC-Oar-089480	Ovis aries	92.48	0.00e+00	631.00
IUUC-Ptr-091579	Pan troglodytes	99.72	0.00e+00	695.00
IUUC-Pan-092200	Papio anubis	91.36	6.00e-178	616.00
IUUC-Psi-093510	Pelodiscus sinensis	76.08	2.00e-102	364.00
IUUC-Pfo-096925	Poecilia formosa	57.23	1.00e-98	353.00
IUUC-Pab-097723	Pongo abelii	98.33	0.00e+00	684.00
IUUC-Pca-100318	Procavia capensis	90.56	0.00e+00	643.00
IUUC-Pva-102860	Pteropus vampyrus	90.25	0.00e+00	635.00
IUUC-Rno-105825	Rattus norvegicus	86.63	3.00e-171	594.00
IUUC-Sha-107224	Sarcophilus harrisii	78.95	5.00e-132	464.00
IUUC-Sar-112982	Sorex araneus	82.44	9.00e-147	513.00
IUUC-Ssc-115926	Sus scrofa	91.64	0.00e+00	642.00
IUUC-Tgu-116935	Taeniopygia guttata	70.82	4.00e-102	363.00
IUUC-Tru-118152	Takifugu rubripes	51.42	2.00e-92	332.00
IUUC-Tsy-119643	Tarsius syrichta	86.63	2.00e-166	578.00
IUUC-Tni-120040	Tetraodon nigroviridis	56.98	4.00e-101	361.00
IUUC-Tbe-127242	Tupaia belangeri	92.76	1.00e-160	559.00
IUUC-Ttr-128482	Tursiops truncatus	82.73	1.00e-150	525.00
IUUC-Xtr-132597	Xenopus tropicalis	57.18	3.00e-98	351.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence