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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106286
Ensembl Protein ID YIL050W
UniProt Accession P40186; D6VVN1; PCL7_YEAST
Genbank Protein ID CAA86172.1; DAA08497.1
Protein Name PHO85 cyclin-7; PHO85-associated protein 1
Genbank Nucleotide ID Z38060; BK006942
Gene Name PCL7; PAP1; YIL050W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YIL050W YIL050W YIL050W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtPHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 25.62 6.10e-01 32.30 IUUC-Hsa-046914
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL7-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL7-PHO85 also phosphorylates MMR1 and YJL084C.
 Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL7-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL7-PHO85 also phosphorylates MMR1 and YJL084C.
Protein Sequence
(Fasta)
MELSSPSKKT TTSPINIPGG NRDNLIIGPH SHSFKTDPFS SNNSSLLSKI STNPSLESPF 60
SSKSLLDCSP VQAVKKSLES EAKTHSLDEE TNEQTDVKIL NIADFPTDEL ILMISALLNR 120
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Protein Fasta Sequence


>IUUC-Sce-106286|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGGAGCTAA GTTCACCATC AAAAAAAACC ACAACATCGC CAATAAATAT ACCAGGGGGG 60
AATAGAGATA ACCTAATAAT CGGACCACAT TCTCACAGCT TCAAGACCGA TCCATTTTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106286|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0119--Carbohydrate metabolism
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0321--Glycogen metabolism
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR013763--Cyclin-like
IPR013922--Cyclin_PHO80-like
Pfam

PF08613--Cyclin
Gene Ontology

GO:0000307--C:cyclin-dependent protein kinase holoenzyme complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0016538--F:cyclin-dependent protein serine/threonine kinase regulator activity
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0005977--P:glycogen metabolic process
GO:0000079--P:regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0005979--P:regulation of glycogen biosynthetic process
GO:0005981--P:regulation of glycogen catabolic process
GO:0031647--P:regulation of protein stability
KEGG sce:YIL050W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001759 Ailuropoda melanoleuca 28.21 1.50e-02 31.60
IUUC-Bta-012852 Bos taurus 31.58 1.30e-02 32.00
IUUC-Bdi-014999 Brachypodium distachyon 34.21 2.80e+00 25.80
IUUC-Cja-019276 Callithrix jacchus 25.42 9.00e-03 32.30
IUUC-Cfa-020815 Canis familiaris 28.87 7.00e-03 32.70
IUUC-Cpo-022419 Cavia porcellus 26.80 8.00e-03 32.70
IUUC-Csa-023740 Chlorocebus sabaeus 25.42 8.00e-03 32.30
IUUC-Csv-025939 Ciona savignyi 36.84 9.20e-01 26.60
IUUC-Dno-029740 Dasypus novemcinctus 27.84 8.00e-03 32.30
IUUC-Ete-032806 Echinops telfairi 29.17 1.80e-01 28.10
IUUC-Fca-035941 Felis catus 28.87 5.00e-03 33.10
IUUC-Fal-036888 Ficedula albicollis 26.17 4.70e-02 31.20
IUUC-Gga-040226 Gallus gallus 31.82 1.00e-02 32.00
IUUC-Ggo-044928 Gorilla gorilla 25.62 6.00e-03 32.30
IUUC-Hsa-046914 Homo sapiens 25.42 9.00e-03 32.30
IUUC-Laf-053465 Loxodonta africana 26.72 8.00e-03 32.30
IUUC-Mcc-055864 Macaca mulatta 25.42 8.00e-03 32.30
IUUC-Mmr-061137 Microcebus murinus 24.58 6.00e-03 32.70
IUUC-Mmu-064141 Mus musculus 25.68 2.90e-02 30.80
IUUC-Mpu-066805 Mustela putorius furo 29.49 5.00e-03 33.10
IUUC-Mlu-067508 Myotis lucifugus 28.21 1.20e-02 32.00
IUUC-Nle-069103 Nomascus leucogenys 23.36 3.00e-03 33.90
IUUC-Opr-071173 Ochotona princeps 26.80 9.00e-03 32.30
IUUC-Ocu-074789 Oryctolagus cuniculus 25.23 5.00e-03 33.10
IUUC-Oin-079506 Oryza indica 23.53 8.90e-01 27.30
IUUC-Oga-088118 Otolemur garnettii 25.42 3.00e-03 33.90
IUUC-Oar-090015 Ovis aries 31.58 1.00e-02 32.00
IUUC-Ptr-090463 Pan troglodytes 25.42 5.00e-03 33.10
IUUC-Pan-092643 Papio anubis 25.44 2.80e-02 30.80
IUUC-Ppa-095648 Physcomitrella patens 27.27 3.20e-01 26.60
IUUC-Pva-102422 Pteropus vampyrus 27.84 2.70e-02 30.80
IUUC-Rno-105480 Rattus norvegicus 27.03 2.00e-03 34.30
IUUC-Sit-110010 Setaria italica 33.93 5.50e-01 27.70
IUUC-Ssc-115531 Sus scrofa 29.49 4.00e-03 33.50
IUUC-Tsy-119266 Tarsius syrichta 25.42 3.00e-02 30.40
IUUC-Ttr-129049 Tursiops truncatus 32.00 7.00e-03 32.70
IUUC-Vpa-130701 Vicugna pacos 29.90 4.40e-02 30.00
Created Date 25-Jun-2017

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