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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046668
UUCD1 version UUC-HoS-00022
Ensembl Protein ID ENSP00000310448.5
UniProt Accession O43290; A6NDN1; Q53GB5; SNUT1_HUMAN
Genbank Protein ID BAA24056.1; AAK49523.1; AAP35283.1; BAD96736.1; AAH01058.1; AAD20223.1
Protein Name U4/U6.U5 tri-snRNP-associated protein 1; SNU66 homolog; Squamous cell carcinoma antigen recognized by T-cells 1; U4/U6.U5 tri-snRNP-associated 110 kDa protein
Genbank Nucleotide ID AB006198; AF353625; BT006637; AK223016; AP006287; AF109680
Gene Name SART1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000175467.14 ENST00000312397.9 ENSP00000310448.5
ENSG00000175467.14 ENST00000530251.1 ENSP00000436218.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 18838541
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/Other 94.29 0.00e+00 1113.00 IUUC-Mmu-064142
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
 Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
Protein Sequence
(Fasta)
MGSSKKHRGE KEAAGTTAAA GTGGATEQPP RHREHKKHKH RSGGSGGSGG ERRKRSRERG 60
GERGSGRRGA EAEARSSTHG RERSQAEPSE RRVKREKRDD GYEAAASSKT SSGDASSLSI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046668|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACACGACAG CGGCTGCCGA GCGACCCGGA AGTATTCCCA TTTTGCGTTG TCTGGGCTCG 60
GCGGCAGCCG GGCTCGGAGT GGACGTGCCA CTATGGGGTC GTCCAAGAAG CATCGCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046668|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0020--Allergen
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0832--Ubl conjugation
Interpro

IPR005011--SNU66/SART1
Pfam

PF03343--SART-1
Gene Ontology

GO:0015030--C:Cajal body
GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0046540--C:U4/U6 x U5 tri-snRNP complex
GO:0003723--F:RNA binding
GO:0007050--P:cell cycle arrest
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0000481--P:maturation of 5S rRNA
GO:0045292--P:mRNA cis splicing, via spliceosome
GO:0000398--P:mRNA splicing, via spliceosome
GO:0045585--P:positive regulation of cytotoxic T cell differentiation
GO:0000387--P:spliceosomal snRNP assembly
KEGG hsa:9092
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000964 Aegilops tauschii 54.55 3.00e-22 100.00
IUUC-Aml-001506 Ailuropoda melanoleuca 94.91 0.00e+00 1115.00
IUUC-Atr-003123 Amborella trichopoda 36.90 3.00e-25 110.00
IUUC-Apl-004159 Anas platyrhynchos 91.11 2.00e-18 83.20
IUUC-Aca-004800 Anolis carolinensis 70.86 2.00e-101 363.00
IUUC-Aly-006240 Arabidopsis lyrata 60.44 4.00e-24 107.00
IUUC-Ath-007175 Arabidopsis thaliana 61.18 8.00e-24 105.00
IUUC-Ago-007952 Ashbya gossypii 28.92 3.00e-05 43.90
IUUC-Acl-008063 Aspergillus clavatus 34.73 2.00e-13 71.20
IUUC-Afl-008404 Aspergillus flavus 35.67 6.00e-15 76.30
IUUC-Afu-008933 Aspergillus fumigatus 35.50 5.00e-15 76.60
IUUC-Ani-009378 Aspergillus nidulans 54.55 2.00e-14 74.70
IUUC-Ang-009865 Aspergillus niger 31.82 9.00e-17 82.40
IUUC-Aor-010214 Aspergillus oryzae 35.67 6.00e-15 76.30
IUUC-Ate-010446 Aspergillus terreus 60.66 3.00e-13 70.90
IUUC-Ame-010802 Astyanax mexicanus 68.79 0.00e+00 770.00
IUUC-Bgr-012139 Blumeria graminis 32.91 3.00e-17 83.60
IUUC-Bta-012547 Bos taurus 94.17 0.00e+00 1168.00
IUUC-Bci-013790 Botrytis cinerea 29.86 1.00e-15 78.60
IUUC-Bdi-014958 Brachypodium distachyon 56.04 2.00e-22 101.00
IUUC-Bol-015305 Brassica oleracea 57.58 3.00e-24 107.00
IUUC-Bra-017189 Brassica rapa 57.58 3.00e-24 107.00
IUUC-Cel-018249 Caenorhabditis elegans 38.21 3.00e-32 134.00
IUUC-Cja-019388 Callithrix jacchus 91.32 0.00e+00 899.00
IUUC-Cfa-020033 Canis familiaris 95.16 0.00e+00 1143.00
IUUC-Cpo-021917 Cavia porcellus 90.71 0.00e+00 1033.00
IUUC-Csa-023428 Chlorocebus sabaeus 99.12 0.00e+00 1169.00
IUUC-Cho-024341 Choloepus hoffmanni 97.06 5.00e-78 285.00
IUUC-Cin-025700 Ciona intestinalis 42.66 2.00e-52 201.00
IUUC-Csv-025826 Ciona savignyi 41.61 3.00e-50 193.00
IUUC-Cgl-026437 Colletotrichum gloeosporioides 28.33 6.00e-16 79.70
IUUC-Cne-026786 Cryptococcus neoformans 51.58 4.00e-22 100.00
IUUC-Dre-027384 Danio rerio 67.03 0.00e+00 717.00
IUUC-Dno-029891 Dasypus novemcinctus 83.95 0.00e+00 832.00
IUUC-Dor-030843 Dipodomys ordii 89.75 0.00e+00 1072.00
IUUC-Dse-031367 Dothistroma septosporum 36.65 2.00e-18 87.40
IUUC-Dme-032008 Drosophila melanogaster 47.13 8.00e-59 222.00
IUUC-Eca-033761 Equus caballus 82.35 0.00e+00 936.00
IUUC-Fca-035723 Felis catus 94.79 0.00e+00 1178.00
IUUC-Fox-037689 Fusarium oxysporum 33.33 1.00e-09 58.20
IUUC-Fso-038345 Fusarium solani 64.71 3.00e-15 77.40
IUUC-Ggr-040049 Gaeumannomyces graminis 58.00 1.00e-12 68.60
IUUC-Gac-042388 Gasterosteus aculeatus 63.96 0.00e+00 741.00
IUUC-Gma-043036 Glycine max 34.52 1.00e-22 102.00
IUUC-Ggo-044803 Gorilla gorilla 99.75 0.00e+00 1139.00
IUUC-Hvu-047161 Hordeum vulgare 54.55 2.00e-22 100.00
IUUC-Itr-049078 Ictidomys tridecemlineatus 94.18 0.00e+00 1121.00
IUUC-Kpa-049385 Komagataella pastoris 51.52 3.00e-06 47.00
IUUC-Lch-049555 Latimeria chalumnae 68.04 1.00e-107 384.00
IUUC-Lpe-051037 Leersia perrieri 59.34 1.00e-23 105.00
IUUC-Loc-051839 Lepisosteus oculatus 85.83 8.00e-124 437.00
IUUC-Lma-053225 Leptosphaeria maculans 59.57 9.00e-13 68.90
IUUC-Laf-054002 Loxodonta africana 93.65 0.00e+00 1102.00
IUUC-Mcc-054874 Macaca mulatta 98.33 9.00e-168 583.00
IUUC-Meu-056111 Macropus eugenii 83.74 0.00e+00 1033.00
IUUC-Mor-056976 Magnaporthe oryzae 55.32 2.00e-11 64.30
IUUC-Mpo-057459 Magnaporthe poae 31.68 2.00e-12 67.80
IUUC-Mtr-058022 Medicago truncatula 54.00 2.00e-23 105.00
IUUC-Mla-058969 Melampsora laricipopulina 55.95 3.00e-13 70.90
IUUC-Mvi-060539 Microbotryum violaceum 38.74 3.00e-16 80.90
IUUC-Mmr-060674 Microcebus murinus 96.00 0.00e+00 1152.00
IUUC-Mdo-063085 Monodelphis domestica 77.70 0.00e+00 865.00
IUUC-Mmu-064142 Mus musculus 94.42 0.00e+00 1156.00
IUUC-Mac-065346 Musa acuminata 56.67 4.00e-23 103.00
IUUC-Mpu-065862 Mustela putorius furo 94.79 0.00e+00 1163.00
IUUC-Mlu-067452 Myotis lucifugus 93.31 0.00e+00 1091.00
IUUC-Nfi-068481 Neosartorya fischeri 34.91 3.00e-14 73.90
IUUC-Ncr-068693 Neurospora crassa 33.11 2.00e-11 64.30
IUUC-Nle-069029 Nomascus leucogenys 97.38 0.00e+00 1151.00
IUUC-Opr-070634 Ochotona princeps 96.47 3.00e-76 280.00
IUUC-Ont-071869 Oreochromis niloticus 67.97 0.00e+00 702.00
IUUC-Ocu-073829 Oryctolagus cuniculus 86.85 6.00e-40 157.00
IUUC-Oba-075629 Oryza barthii 59.34 8.00e-24 105.00
IUUC-Obr-076112 Oryza brachyantha 59.34 1.00e-23 105.00
IUUC-Ogl-077004 Oryza glaberrima 59.34 8.00e-24 105.00
IUUC-Ogu-079015 Oryza glumaepatula 59.34 9.00e-24 105.00
IUUC-Oin-079550 Oryza indica 59.34 9.00e-24 105.00
IUUC-Olo-080458 Oryza longistaminata 58.24 3.00e-23 103.00
IUUC-Ome-081108 Oryza meridionalis 59.34 7.00e-24 106.00
IUUC-Oni-082526 Oryza nivara 59.34 7.00e-24 106.00
IUUC-Opu-084013 Oryza punctata 59.34 8.00e-24 105.00
IUUC-Oru-084776 Oryza rufipogon 59.34 9.00e-24 105.00
IUUC-Osa-085489 Oryza sativa 59.34 3.00e-24 105.00
IUUC-Olu-087878 Ostreococcus lucimarinus 41.67 3.00e-14 74.30
IUUC-Oga-088247 Otolemur garnettii 97.13 0.00e+00 1108.00
IUUC-Oar-089536 Ovis aries 91.56 0.00e+00 1094.00
IUUC-Ptr-091206 Pan troglodytes 98.12 0.00e+00 1115.00
IUUC-Pan-092864 Papio anubis 98.88 0.00e+00 1169.00
IUUC-Psi-093374 Pelodiscus sinensis 76.89 0.00e+00 1000.00
IUUC-Pma-094762 Petromyzon marinus 69.53 2.00e-100 358.00
IUUC-Pno-095018 Phaeosphaeria nodorum 53.12 4.00e-13 70.10
IUUC-Ppa-095669 Physcomitrella patens 34.58 3.00e-17 84.30
IUUC-Pfo-097032 Poecilia formosa 66.99 0.00e+00 675.00
IUUC-Pab-098379 Pongo abelii 97.25 0.00e+00 1097.00
IUUC-Pop-099004 Populus trichocarpa 58.54 2.00e-22 100.00
IUUC-Pca-100431 Procavia capensis 74.39 5.00e-84 305.00
IUUC-Ppe-101183 Prunus persica 58.82 2.00e-22 101.00
IUUC-Pva-102356 Pteropus vampyrus 85.79 0.00e+00 922.00
IUUC-Pgr-103413 Puccinia graminis 31.32 6.00e-17 83.20
IUUC-Ptt-103789 Puccinia triticina 32.14 3.00e-15 77.80
IUUC-Pte-104255 Pyrenophora teres 54.24 7.00e-13 69.30
IUUC-Pyt-104629 Pyrenophora triticirepentis 54.24 6.00e-13 69.70
IUUC-Rno-105629 Rattus norvegicus 92.07 0.00e+00 1142.00
IUUC-Sce-106185 Saccharomyces cerevisiae 54.05 3.00e-07 50.40
IUUC-Sha-107543 Sarcophilus harrisii 89.76 0.00e+00 1037.00
IUUC-Sja-107921 Schizosaccharomyces japonicus 34.65 1.00e-10 61.60
IUUC-Spo-108313 Schizosaccharomyces pombe 26.50 2.00e-10 61.20
IUUC-Smo-109391 Selaginella moellendorffii 50.59 3.00e-14 73.60
IUUC-Sit-109967 Setaria italica 42.86 6.00e-24 106.00
IUUC-Sly-111069 Solanum lycopersicum 54.95 3.00e-22 100.00
IUUC-Stu-112178 Solanum tuberosum 52.13 1.00e-21 99.00
IUUC-Sbi-114103 Sorghum bicolor 42.65 2.00e-23 102.00
IUUC-Sre-115231 Sporisorium reilianum 29.79 3.00e-16 81.30
IUUC-Ssc-116400 Sus scrofa 94.04 0.00e+00 1157.00
IUUC-Tca-121799 Theobroma cacao 56.25 2.00e-16 81.30
IUUC-Tre-121898 Trichoderma reesei 62.00 5.00e-14 72.80
IUUC-Tvi-122645 Trichoderma virens 66.67 2.00e-16 80.90
IUUC-Tae-125176 Triticum aestivum 56.52 2.00e-22 99.80
IUUC-Tur-125962 Triticum urartu 54.55 2.00e-22 101.00
IUUC-Tme-127093 Tuber melanosporum 33.54 6.00e-16 79.30
IUUC-Tbe-127595 Tupaia belangeri 69.52 0.00e+00 803.00
IUUC-Ttr-128741 Tursiops truncatus 90.26 0.00e+00 1025.00
IUUC-Uma-129451 Ustilago maydis 46.43 1.00e-16 82.00
IUUC-Vda-129960 Verticillium dahliae 34.62 2.00e-16 80.90
IUUC-Vvi-131408 Vitis vinifera 34.29 8.00e-24 106.00
IUUC-Xtr-132475 Xenopus tropicalis 68.21 0.00e+00 778.00
IUUC-Xma-133174 Xiphophorus maculatus 67.45 0.00e+00 681.00
IUUC-Yli-134329 Yarrowia lipolytica 48.98 9.00e-10 58.90
IUUC-Zma-134694 Zea mays 43.38 2.00e-23 105.00
Created Date 25-Jun-2017

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