iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	2.90e-16	59.8	16	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqk 83
           v+vk+++++e+r+fal + ++ +f+++ +++  ++++++ +v l+Y+D++GDl++l++D+ l+ a+    s  + lrll+qk
   Q: 16   VEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALA---SGPPPLRLLVQK 94
           79*****************************************************************...**********98 PP

Organism

Rattus norvegicus

Functional Description
(View)

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization.

Protein Sequence
(Fasta)

MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRTSVRGFQ EFSRLLCVVH QIPGLDVLLG 60
YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKREGDSS GLAFASNSLQ RRKKGLLLRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAACCTCGCT GCTGGCTCAT GACAGCTTAT CCTTACTGTA CCATCTCTCT GAACCTGTGA 60
GCTGTTCCAC AGTACTACTC TAGAACCGGA AAAGAAAAGT CAAGGACTAC CCTGGATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction

Interpro

IPR000270--PB1_dom
IPR001478--PDZ

PROSITE

PS51745--PB1
PS50106--PDZ

Pfam

PF00564--PB1
PF00595--PDZ

SMART

SM00666--PB1
SM00228--PDZ

Gene Ontology

GO:0044295--C:axonal growth cone
GO:0005923--C:bicellular tight junction
GO:0034451--C:centriolar satellite
GO:0005813--C:centrosome
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0051297--P:centrosome organization
GO:1904781--P:positive regulation of protein localization to centrosome
GO:0060341--P:regulation of cellular localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001436	Ailuropoda melanoleuca	91.91	2.00e-175	607.00
IUUC-Apl-004064	Anas platyrhynchos	71.09	1.00e-101	362.00
IUUC-Bta-012518	Bos taurus	89.60	7.00e-158	549.00
IUUC-Cja-019906	Callithrix jacchus	87.86	2.00e-163	568.00
IUUC-Cfa-020182	Canis familiaris	92.46	3.00e-177	614.00
IUUC-Cpo-021341	Cavia porcellus	91.33	2.00e-166	578.00
IUUC-Csa-023165	Chlorocebus sabaeus	91.91	9.00e-167	579.00
IUUC-Dre-027395	Danio rerio	66.67	5.00e-88	317.00
IUUC-Dno-028998	Dasypus novemcinctus	89.60	7.00e-161	559.00
IUUC-Dor-030206	Dipodomys ordii	91.04	7.00e-165	572.00
IUUC-Ete-032644	Echinops telfairi	74.01	1.00e-112	399.00
IUUC-Eca-033390	Equus caballus	92.17	1.00e-170	592.00
IUUC-Fca-035382	Felis catus	91.91	5.00e-162	563.00
IUUC-Gga-040804	Gallus gallus	75.39	7.00e-111	393.00
IUUC-Ggo-044974	Gorilla gorilla	91.91	4.00e-168	583.00
IUUC-Hsa-045815	Homo sapiens	91.91	4.00e-168	583.00
IUUC-Itr-047959	Ictidomys tridecemlineatus	91.35	7.00e-171	592.00
IUUC-Laf-054157	Loxodonta africana	87.86	2.00e-163	568.00
IUUC-Mcc-054932	Macaca mulatta	91.59	3.00e-167	580.00
IUUC-Meu-056725	Macropus eugenii	90.13	5.00e-118	417.00
IUUC-Mpo-057356	Magnaporthe poae	47.37	2.10e-02	35.80
IUUC-Mvi-060532	Microbotryum violaceum	31.25	2.50e-01	30.40
IUUC-Mmr-061600	Microcebus murinus	92.73	1.00e-166	579.00
IUUC-Mdo-062981	Monodelphis domestica	74.58	1.00e-134	472.00
IUUC-Mmu-063824	Mus musculus	98.84	5.00e-171	593.00
IUUC-Mpu-066720	Mustela putorius furo	91.33	1.00e-173	602.00
IUUC-Mlu-067104	Myotis lucifugus	90.57	1.00e-165	575.00
IUUC-Nle-070003	Nomascus leucogenys	91.59	7.00e-174	602.00
IUUC-Opr-070932	Ochotona princeps	81.56	9.00e-142	496.00
IUUC-Ont-072310	Oreochromis niloticus	66.67	4.00e-94	338.00
IUUC-Oan-073018	Ornithorhynchus anatinus	78.16	6.00e-115	407.00
IUUC-Ocu-074524	Oryctolagus cuniculus	91.79	1.00e-154	538.00
IUUC-Oga-089103	Otolemur garnettii	89.31	2.00e-165	575.00
IUUC-Oar-090055	Ovis aries	90.46	4.00e-161	560.00
IUUC-Ptr-090840	Pan troglodytes	91.59	1.00e-167	582.00
IUUC-Pan-092904	Papio anubis	91.62	3.00e-166	577.00
IUUC-Psi-093762	Pelodiscus sinensis	71.88	1.00e-84	305.00
IUUC-Pfo-096234	Poecilia formosa	65.00	3.00e-91	328.00
IUUC-Pab-097709	Pongo abelii	91.33	2.00e-167	581.00
IUUC-Pca-100345	Procavia capensis	88.75	1.00e-153	535.00
IUUC-Pva-102267	Pteropus vampyrus	90.75	2.00e-162	564.00
IUUC-Smo-109040	Selaginella moellendorffii	27.50	3.00e-03	37.00
IUUC-Sar-113091	Sorex araneus	78.03	1.00e-133	469.00
IUUC-Tni-120748	Tetraodon nigroviridis	61.51	9.00e-91	326.00
IUUC-Tre-121982	Trichoderma reesei	33.33	1.20e+00	28.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence