iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063581

UUCD1 version

UUC-MuM-01217

Ensembl Protein ID

ENSMUSP00000051716.7

UniProt Accession

Q7M764; D3YU85; U17PE_MOUSE

Genbank Protein ID

CAD66057.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 17-like protein E; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; Deubiquitinating protein 6; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thioesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2

Genbank Nucleotide ID

AC110621

Gene Name

Usp17le; Dub3; Dub6; Usp17; Usp17l2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000043073.10	ENSMUST00000211384.1	ENSMUSP00000147776.1
ENSMUSG00000043073.10	ENSMUST00000053464.8	ENSMUSP00000051716.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC	RepTar
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	10467179

Classification

Family	E-value	Score	Start	End
DUB/USP	9.40e-81	272.7	85	381

Active Site

Position(s)	Description	Evidence
94	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
341	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsg 86
           +Gl+N gN+CY+N++LQcL+++p+l++++l+ ++++++      +p+g+ +++++  +++ +  +++  +++p+++l++       f++
   Q: 85   CGLQNTGNSCYLNAALQCLTHTPPLADYMLSqEHSQTC-----CSPEGCKMCAMEAHVTQSLlhSHSGDVMKPSQILTSA------FHK 162
           7******************************3333333.....4678888888888777766578888899**9998765......889 PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
            +q+Da+Efl+f l++++e++                  l+ +++++++ + +s+i+d+F+g ++sqikcl+c+ +s +++pfld++l+
   Q: 163  HQQEDAHEFLMFTLETMHESC------------------LQVHRQSDPTPQDTSPIHDIFGGWWRSQIKCLHCQGTSHTFDPFLDVPLD 233
           9********************..................677888999***************************************** PP
   S: 176  vpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +++ +     s++++L +  k eel gen+yyc +c++k  a+k+l ++  P+vL l LkRfs        +k+++kv++p+ Ldl+p+
   Q: 234  ISSAQ-----SVNQALWDTGKSEELLGENAYYCGRCRQKMPASKTLHVHIAPKVLLLVLKRFS----AFTGNKLDRKVSYPEFLDLKPY 313
           *****.....9***************************************************3....37889***************** PP
   S: 265  ctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++p+ +   +  Y L+av+vH G +++sGHY+++vk  +gkW+++dD+kVt ++ ++vl+   ++aYvlfY +
   Q: 314  LSEPTGG---PLPYALYAVLVHDGaTSNSGHYFCCVKAGHGKWYKMDDTKVTRCDVTSVLN---ENAYVLFYVQ 381
           ***9988...89*************************************************...********87 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Protein Sequence
(Fasta)

MVVSLSFPEE TGGENLPSAP LEDSSKFFEE VFGDMVFARS FPEADPALSS PDAPELHQDE 60
AQVVEELTTN GKHSLSWESP QGPGCGLQNT GNSCYLNAAL QCLTHTPPLA DYMLSQEHSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGTTT CTCTTTCCTT CCCAGAAGGT GAGTCTCACT GTGAGGTCTT TATGTCTTGT 60
GTGTCCCCCA GCAGCCTTGT CATCTCTGGC TGCCCTAGAC CTGCATAAGG ATGAACAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006915--P:apoptotic process
GO:0071586--P:CAAX-box protein processing
GO:0000075--P:cell cycle checkpoint
GO:0007093--P:mitotic cell cycle checkpoint
GO:0034260--P:negative regulation of GTPase activity
GO:0031064--P:negative regulation of histone deacetylation
GO:0010955--P:negative regulation of protein processing
GO:0090315--P:negative regulation of protein targeting to membrane
GO:0043547--P:positive regulation of GTPase activity
GO:1900245--P:positive regulation of MDA-5 signaling pathway
GO:1900246--P:positive regulation of RIG-I signaling pathway
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0030334--P:regulation of cell migration
GO:0042127--P:regulation of cell proliferation
GO:0050691--P:regulation of defense response to virus by host
GO:1900027--P:regulation of ruffle assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Opr-070217	Ochotona princeps	51.88	3.00e-98	352.00
IUUC-Rno-105845	Rattus norvegicus	67.11	0.00e+00	685.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence