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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063278
UUCD1 version UUC-MuM-00434
Ensembl Protein ID ENSMUSP00000029989.4
UniProt Accession Q5DTM8; A2AIR3; Q3UT10; Q3V350; Q7TT11; Q8BKA8; Q8BKN8; Q8BUF7; Q8BVU4; BRE1A_MOUSE
Genbank Protein ID BAD90290.1; CAM14732.1; AAH52482.1; BAE43337.1; BAC34590.2; BAC35521.1; BAC36367.1; BAC39446.1; BAE24170.1
Protein Name E3 ubiquitin-protein ligase BRE1A; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A
Genbank Nucleotide ID AK220492; AL732521; BC052482; AK048862; AK051278; AK053783; AK076501; AK085436; AK139883
Gene Name Rnf20; Bre1a; Kiaa4116
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028309.14 ENSMUST00000029989.10 ENSMUSP00000029989.4
ENSMUSG00000028309.14 ENSMUST00000146547.1 ENSMUSP00000120668.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 97.42 0.00e+00 1020.00 IUUC-Hsa-046462
E3 activity/RING/RING 43.08 3.00e-14 75.50 IUUC-Spo-108304
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation.
 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation.
Protein Sequence
(Fasta)
MSGIGNKRAA GEPGTSMPPE KKTAVEDSGT TVETIKLGGV SSTEELDIRT LQSKNRKLAE 60
MLDQRQAIED ELREHIEKLE RRQATDDASL LIVNRYWSQF DENIRIILKR YDLDQGLGDL 120
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Protein Fasta Sequence


>IUUC-Mmu-063278|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CTTCCGCCCT CTCCTCGCCG TGCCTCGGGT AAAGTTGAAG CAACTTCCTT TTCCTTTTCC 60
CTACTTCCTC TCCGTGCCTC CGCCTCCGTG GAGCTCAGTC CCTCTCGCAG CGGATCCCAA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063278|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015422--PyrdxlP-dep_Trfase_sub2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0033503--C:HULC complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0002039--F:p53 binding
GO:0003713--F:transcription coactivator activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0030336--P:negative regulation of cell migration
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:0031062--P:positive regulation of histone methylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:109331
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000858 Aegilops tauschii 45.45 1.00e-09 57.00
IUUC-Aml-001976 Ailuropoda melanoleuca 97.23 0.00e+00 1651.00
IUUC-Apl-003407 Anas platyrhynchos 87.01 0.00e+00 940.00
IUUC-Aca-004246 Anolis carolinensis 86.81 0.00e+00 934.00
IUUC-Ago-007988 Ashbya gossypii 31.15 4.00e-15 76.60
IUUC-Acl-008319 Aspergillus clavatus 26.19 2.00e-14 74.70
IUUC-Aor-010142 Aspergillus oryzae 28.62 2.00e-15 78.20
IUUC-Ate-010547 Aspergillus terreus 26.54 1.00e-14 74.70
IUUC-Ame-011916 Astyanax mexicanus 77.93 2.00e-143 503.00
IUUC-Bgr-012245 Blumeria graminis 41.51 6.00e-10 59.70
IUUC-Bta-012357 Bos taurus 97.44 0.00e+00 1622.00
IUUC-Cel-018659 Caenorhabditis elegans 34.41 8.00e-40 159.00
IUUC-Cja-019244 Callithrix jacchus 97.21 0.00e+00 1006.00
IUUC-Cfa-020320 Canis familiaris 97.44 0.00e+00 1639.00
IUUC-Cpo-021617 Cavia porcellus 94.88 0.00e+00 1674.00
IUUC-Csa-023509 Chlorocebus sabaeus 97.58 0.00e+00 1010.00
IUUC-Cho-024616 Choloepus hoffmanni 80.31 0.00e+00 974.00
IUUC-Cme-027134 Cyanidioschyzon merolae 39.06 1.00e-13 71.60
IUUC-Dno-029537 Dasypus novemcinctus 97.42 0.00e+00 1024.00
IUUC-Dor-030250 Dipodomys ordii 95.28 0.00e+00 1552.00
IUUC-Dse-031300 Dothistroma septosporum 38.46 3.00e-15 77.40
IUUC-Ete-033164 Echinops telfairi 93.73 0.00e+00 1223.00
IUUC-Eca-033347 Equus caballus 97.34 0.00e+00 1615.00
IUUC-Eeu-034801 Erinaceus europaeus 94.88 2.00e-170 592.00
IUUC-Fca-036024 Felis catus 97.64 0.00e+00 1670.00
IUUC-Fal-037622 Ficedula albicollis 88.49 0.00e+00 949.00
IUUC-Gmo-039446 Gadus morhua 77.55 6.00e-132 465.00
IUUC-Ggr-040117 Gaeumannomyces graminis 45.28 3.00e-11 64.30
IUUC-Gga-040412 Gallus gallus 88.81 0.00e+00 901.00
IUUC-Gac-042205 Gasterosteus aculeatus 61.03 3.00e-142 499.00
IUUC-Ggo-044703 Gorilla gorilla 97.39 0.00e+00 1009.00
IUUC-Hsa-046462 Homo sapiens 97.58 0.00e+00 1010.00
IUUC-Itr-048298 Ictidomys tridecemlineatus 97.71 0.00e+00 1599.00
IUUC-Lch-049505 Latimeria chalumnae 74.42 0.00e+00 704.00
IUUC-Loc-051951 Lepisosteus oculatus 63.47 6.00e-112 399.00
IUUC-Lma-053312 Leptosphaeria maculans 28.71 6.00e-15 76.30
IUUC-Laf-054122 Loxodonta africana 96.01 0.00e+00 1595.00
IUUC-Mcc-054647 Macaca mulatta 97.58 0.00e+00 1010.00
IUUC-Meu-056559 Macropus eugenii 91.61 0.00e+00 1451.00
IUUC-Mpo-057568 Magnaporthe poae 45.28 3.00e-11 63.90
IUUC-Mga-059731 Meleagris gallopavo 94.90 6.00e-173 601.00
IUUC-Mmr-061495 Microcebus murinus 97.64 0.00e+00 1659.00
IUUC-Mdo-062599 Monodelphis domestica 93.17 0.00e+00 972.00
IUUC-Mpu-065910 Mustela putorius furo 97.44 0.00e+00 1656.00
IUUC-Mlu-067040 Myotis lucifugus 96.49 0.00e+00 1014.00
IUUC-Ncr-068695 Neurospora crassa 27.31 5.00e-12 66.60
IUUC-Nle-069058 Nomascus leucogenys 97.39 0.00e+00 1007.00
IUUC-Opr-071149 Ochotona princeps 96.88 0.00e+00 1008.00
IUUC-Oan-072996 Ornithorhynchus anatinus 97.25 0.00e+00 646.00
IUUC-Ocu-074773 Oryctolagus cuniculus 97.77 0.00e+00 1017.00
IUUC-Ola-087287 Oryzias latipes 62.79 0.00e+00 891.00
IUUC-Olu-087683 Ostreococcus lucimarinus 36.36 9.00e-14 68.90
IUUC-Oga-088961 Otolemur garnettii 97.44 0.00e+00 1629.00
IUUC-Oar-089755 Ovis aries 97.44 0.00e+00 1605.00
IUUC-Ptr-091602 Pan troglodytes 97.58 0.00e+00 1010.00
IUUC-Pan-092263 Papio anubis 97.58 0.00e+00 1010.00
IUUC-Psi-093554 Pelodiscus sinensis 88.67 0.00e+00 950.00
IUUC-Pab-098598 Pongo abelii 97.21 0.00e+00 1008.00
IUUC-Pca-100157 Procavia capensis 95.42 0.00e+00 993.00
IUUC-Pva-102720 Pteropus vampyrus 96.92 0.00e+00 1582.00
IUUC-Rno-104996 Rattus norvegicus 99.18 0.00e+00 1650.00
IUUC-Sha-107000 Sarcophilus harrisii 94.10 0.00e+00 958.00
IUUC-Sja-107993 Schizosaccharomyces japonicus 45.00 2.00e-12 68.20
IUUC-Spo-108304 Schizosaccharomyces pombe 43.08 9.00e-15 75.50
IUUC-Sar-113349 Sorex araneus 96.29 0.00e+00 939.00
IUUC-Ssc-115723 Sus scrofa 97.23 0.00e+00 1609.00
IUUC-Tgu-116549 Taeniopygia guttata 87.93 0.00e+00 876.00
IUUC-Tsy-118808 Tarsius syrichta 95.03 0.00e+00 1171.00
IUUC-Tni-120790 Tetraodon nigroviridis 61.67 0.00e+00 938.00
IUUC-Ttr-128266 Tursiops truncatus 97.03 0.00e+00 1603.00
IUUC-Vpa-130237 Vicugna pacos 97.24 0.00e+00 1650.00
IUUC-Xtr-132589 Xenopus tropicalis 73.49 0.00e+00 1227.00
Created Date 25-Jun-2017

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