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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046004
Ensembl Protein ID ENSP00000321537.4
UniProt Accession Q15334; A7MBM7; O00188; Q58F11; Q86UK6; L2GL1_HUMAN
Genbank Protein ID CAA60130.1; BAA19516.1; AAH28037.1; AAI51839.1
Protein Name Lethal(2) giant larvae protein homolog 1; DLG4; Hugl-1; Human homolog to the D-lgl gene protein
Genbank Nucleotide ID X86371; D50550; BC028037; BC151838
Gene Name LLGL1; DLG4; HUGL; HUGL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000131899.10 ENST00000316843.8 ENSP00000321537.4
ENSG00000131899.10 ENST00000621229.1 ENSP00000480006.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.60e-07 32.4 428 461
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 9    laf............sd.tllvsGsdDgtikvWD 29
           l++            s  +ll++G  Dgt++ WD
   Q: 428  LSWpitggrnlaqepSQrGLLLTGHEDGTVRFWD 461
           67777777777777544789************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
 Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
Protein Sequence
(Fasta)
MMKFRFRRQG ADPQREKLKQ ELFAFNKTVE HGFPNQPSAL AFDPELRIMA IGTRSGAVKI 60
YGAPGVEFTG LHRDAATVTQ MHFLTGQGRL LSLLDDSSLH LWEIVHHNGC AHLEEALSFQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046004|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCTGGCGC CCCGCCCGCG CCTTAGGACC CGCGGGGCCG CGCGGCGCAT CCTGCGGGCG 60
GCGGCGGCGG GCGAGGCGCC TGCAGCCGGG CGCAAGATGA TGAAGTTTCG GTTCCGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046004|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0268--Exocytosis
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013577--LLGL2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
Pfam

PF08366--LLGL
PF00400--WD40
PRINTS

PR00962--LETHAL2GIANT
SMART

SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0030864--C:cortical actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0031901--C:early endosome membrane
GO:0000137--C:Golgi cis cisterna
GO:0005886--C:plasma membrane
GO:0032588--C:trans-Golgi network membrane
GO:0005096--F:GTPase activator activity
GO:0019901--F:protein kinase binding
GO:0017137--F:Rab GTPase binding
GO:0005198--F:structural molecule activity
GO:0007409--P:axonogenesis
GO:0030866--P:cortical actin cytoskeleton organization
GO:0006887--P:exocytosis
GO:0006893--P:Golgi to plasma membrane transport
GO:0006461--P:protein complex assembly
GO:0017157--P:regulation of exocytosis
GO:0050708--P:regulation of protein secretion
KEGG hsa:3996
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001841 Ailuropoda melanoleuca 92.78 0.00e+00 1790.00
IUUC-Aca-005314 Anolis carolinensis 73.44 0.00e+00 1511.00
IUUC-Ame-011869 Astyanax mexicanus 68.29 0.00e+00 1441.00
IUUC-Bta-013086 Bos taurus 88.36 0.00e+00 1830.00
IUUC-Cja-019964 Callithrix jacchus 97.37 0.00e+00 1911.00
IUUC-Cfa-021081 Canis familiaris 93.70 0.00e+00 1893.00
IUUC-Cpo-022226 Cavia porcellus 92.58 0.00e+00 1740.00
IUUC-Csa-023680 Chlorocebus sabaeus 98.97 0.00e+00 1983.00
IUUC-Csv-025981 Ciona savignyi 47.09 0.00e+00 835.00
IUUC-Dre-027684 Danio rerio 68.70 0.00e+00 1422.00
IUUC-Dor-030545 Dipodomys ordii 91.73 0.00e+00 1870.00
IUUC-Ete-033043 Echinops telfairi 85.49 0.00e+00 731.00
IUUC-Eca-034305 Equus caballus 93.64 0.00e+00 1844.00
IUUC-Fca-035636 Felis catus 93.14 0.00e+00 1812.00
IUUC-Fal-037109 Ficedula albicollis 73.70 0.00e+00 1518.00
IUUC-Gmo-039657 Gadus morhua 66.71 0.00e+00 961.00
IUUC-Gga-040497 Gallus gallus 73.22 0.00e+00 1553.00
IUUC-Gac-041546 Gasterosteus aculeatus 64.46 0.00e+00 1337.00
IUUC-Ggo-045291 Gorilla gorilla 99.53 0.00e+00 1964.00
IUUC-Itr-048031 Ictidomys tridecemlineatus 93.16 0.00e+00 1852.00
IUUC-Lch-049832 Latimeria chalumnae 67.62 0.00e+00 1337.00
IUUC-Loc-052641 Lepisosteus oculatus 70.10 0.00e+00 1495.00
IUUC-Laf-054218 Loxodonta africana 89.85 0.00e+00 1695.00
IUUC-Mcc-055013 Macaca mulatta 98.50 0.00e+00 1972.00
IUUC-Mga-060026 Meleagris gallopavo 70.15 0.00e+00 1389.00
IUUC-Mdo-062135 Monodelphis domestica 77.10 0.00e+00 1623.00
IUUC-Mmu-063168 Mus musculus 89.95 0.00e+00 1822.00
IUUC-Mpu-066685 Mustela putorius furo 93.83 0.00e+00 1838.00
IUUC-Mlu-067389 Myotis lucifugus 91.64 0.00e+00 1907.00
IUUC-Opr-070896 Ochotona princeps 88.56 0.00e+00 1772.00
IUUC-Ont-071498 Oreochromis niloticus 64.48 0.00e+00 1286.00
IUUC-Oan-073365 Ornithorhynchus anatinus 75.30 0.00e+00 1519.00
IUUC-Ocu-074237 Oryctolagus cuniculus 88.76 0.00e+00 1276.00
IUUC-Ola-086914 Oryzias latipes 62.41 0.00e+00 1291.00
IUUC-Oga-088401 Otolemur garnettii 93.11 0.00e+00 1832.00
IUUC-Oar-089232 Ovis aries 87.03 0.00e+00 1788.00
IUUC-Ptr-090647 Pan troglodytes 99.61 0.00e+00 1911.00
IUUC-Pan-092339 Papio anubis 98.50 0.00e+00 1974.00
IUUC-Psi-093016 Pelodiscus sinensis 66.67 0.00e+00 1237.00
IUUC-Pfo-096941 Poecilia formosa 64.36 0.00e+00 1338.00
IUUC-Pab-098102 Pongo abelii 99.33 0.00e+00 1948.00
IUUC-Pva-102768 Pteropus vampyrus 91.35 0.00e+00 1938.00
IUUC-Rno-105033 Rattus norvegicus 89.23 0.00e+00 1875.00
IUUC-Sar-113145 Sorex araneus 87.24 0.00e+00 1085.00
IUUC-Tru-118539 Takifugu rubripes 67.08 0.00e+00 1264.00
IUUC-Tsy-119013 Tarsius syrichta 90.00 0.00e+00 949.00
IUUC-Ttr-128232 Tursiops truncatus 87.69 0.00e+00 1761.00
IUUC-Xtr-132060 Xenopus tropicalis 70.70 0.00e+00 1508.00
Created Date 25-Jun-2017

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