iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRTarBase	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.50e-07	31.1	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Protein Sequence
(Fasta)

MSLLNCENSC ASSQSSSDCC AAMANSCSAA MKDDSVSGCV STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACITKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGCTGGG GCTGAGGCTC CGGCCGTCGG CGGACGCAGT AGCCGCGGCC CAGGAACCGG 60
GAGTTTGGCG TCGGAGACAC TTGATCTCGG AGTGCTGCGT GTATAGGCGG CGCGTGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0551--Lipid droplet
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0987--Osteopetrosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0007254--P:JNK cascade
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

rno:311245

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	85.21	0.00e+00	888.00
IUUC-Apl-004062	Anas platyrhynchos	73.06	0.00e+00	800.00
IUUC-Aca-004636	Anolis carolinensis	72.53	0.00e+00	775.00
IUUC-Ame-011682	Astyanax mexicanus	55.78	4.00e-166	578.00
IUUC-Bta-012692	Bos taurus	81.73	0.00e+00	905.00
IUUC-Bdi-014180	Brachypodium distachyon	25.00	3.00e-08	52.80
IUUC-Bol-016391	Brassica oleracea	26.75	3.00e-07	50.40
IUUC-Cja-019426	Callithrix jacchus	86.23	0.00e+00	910.00
IUUC-Cfa-020948	Canis familiaris	84.05	0.00e+00	789.00
IUUC-Cpo-021378	Cavia porcellus	84.90	0.00e+00	899.00
IUUC-Csa-024045	Chlorocebus sabaeus	86.23	0.00e+00	915.00
IUUC-Cho-024973	Choloepus hoffmanni	70.43	3.00e-92	332.00
IUUC-Csv-026300	Ciona savignyi	37.94	3.00e-44	171.00
IUUC-Dre-027557	Danio rerio	58.37	1.00e-175	609.00
IUUC-Dno-030032	Dasypus novemcinctus	79.14	3.00e-130	457.00
IUUC-Dor-030790	Dipodomys ordii	86.98	0.00e+00	917.00
IUUC-Dme-031921	Drosophila melanogaster	27.19	4.00e-41	162.00
IUUC-Ete-032952	Echinops telfairi	82.32	2.00e-162	565.00
IUUC-Eca-033924	Equus caballus	80.29	0.00e+00	809.00
IUUC-Eeu-034734	Erinaceus europaeus	80.23	0.00e+00	818.00
IUUC-Fca-036222	Felis catus	78.86	0.00e+00	796.00
IUUC-Fal-036834	Ficedula albicollis	73.67	0.00e+00	730.00
IUUC-Fox-037935	Fusarium oxysporum	29.91	8.00e-23	101.00
IUUC-Gmo-039061	Gadus morhua	63.64	4.00e-88	318.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.85	1.00e-14	74.70
IUUC-Gga-040599	Gallus gallus	72.66	0.00e+00	813.00
IUUC-Gac-041977	Gasterosteus aculeatus	54.48	2.00e-167	582.00
IUUC-Ggo-044508	Gorilla gorilla	82.33	0.00e+00	853.00
IUUC-Hsa-046349	Homo sapiens	86.42	0.00e+00	933.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	88.56	0.00e+00	941.00
IUUC-Lch-049821	Latimeria chalumnae	65.83	0.00e+00	724.00
IUUC-Loc-051995	Lepisosteus oculatus	61.49	0.00e+00	640.00
IUUC-Laf-054115	Loxodonta africana	80.78	0.00e+00	879.00
IUUC-Mcc-055298	Macaca mulatta	86.04	0.00e+00	912.00
IUUC-Mor-057263	Magnaporthe oryzae	29.68	3.00e-17	83.60
IUUC-Mpo-057517	Magnaporthe poae	30.77	7.00e-17	82.40
IUUC-Mga-059340	Meleagris gallopavo	74.12	0.00e+00	798.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	1.00e-15	78.20
IUUC-Mmr-061063	Microcebus murinus	87.05	0.00e+00	910.00
IUUC-Mdo-062075	Monodelphis domestica	77.96	0.00e+00	863.00
IUUC-Mmu-063780	Mus musculus	95.85	0.00e+00	991.00
IUUC-Mpu-065748	Mustela putorius furo	85.03	0.00e+00	902.00
IUUC-Mlu-067888	Myotis lucifugus	84.54	0.00e+00	896.00
IUUC-Nle-069234	Nomascus leucogenys	86.42	0.00e+00	916.00
IUUC-Opr-070393	Ochotona princeps	93.90	9.00e-120	423.00
IUUC-Ont-072459	Oreochromis niloticus	55.37	2.00e-175	609.00
IUUC-Oan-073578	Ornithorhynchus anatinus	78.12	0.00e+00	858.00
IUUC-Ocu-074201	Oryctolagus cuniculus	86.67	0.00e+00	919.00
IUUC-Ola-087319	Oryzias latipes	59.13	1.00e-88	320.00
IUUC-Olu-087748	Ostreococcus lucimarinus	25.00	6.00e-11	61.60
IUUC-Oga-087936	Otolemur garnettii	85.23	0.00e+00	905.00
IUUC-Oar-089379	Ovis aries	81.73	0.00e+00	909.00
IUUC-Ptr-090758	Pan troglodytes	86.79	0.00e+00	919.00
IUUC-Pan-092590	Papio anubis	86.23	0.00e+00	913.00
IUUC-Psi-093948	Pelodiscus sinensis	69.75	0.00e+00	794.00
IUUC-Pma-094434	Petromyzon marinus	45.09	4.00e-121	428.00
IUUC-Pfo-096912	Poecilia formosa	54.51	1.00e-165	576.00
IUUC-Pab-097651	Pongo abelii	86.79	0.00e+00	921.00
IUUC-Pca-100958	Procavia capensis	81.89	0.00e+00	672.00
IUUC-Pva-103247	Pteropus vampyrus	86.90	2.00e-119	422.00
IUUC-Pte-104279	Pyrenophora teres	26.48	2.00e-12	68.20
IUUC-Sha-106494	Sarcophilus harrisii	79.62	0.00e+00	877.00
IUUC-Sar-113375	Sorex araneus	84.75	0.00e+00	886.00
IUUC-Sre-115218	Sporisorium reilianum	26.87	1.00e-14	74.70
IUUC-Ssc-115417	Sus scrofa	84.13	0.00e+00	912.00
IUUC-Tgu-117232	Taeniopygia guttata	74.35	0.00e+00	778.00
IUUC-Tru-118321	Takifugu rubripes	54.85	9.00e-171	593.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.97	5.00e-165	574.00
IUUC-Tbe-127719	Tupaia belangeri	75.38	0.00e+00	771.00
IUUC-Ttr-129264	Tursiops truncatus	87.10	1.00e-114	406.00
IUUC-Uma-129620	Ustilago maydis	27.20	9.00e-17	82.00
IUUC-Vpa-130244	Vicugna pacos	84.58	5.00e-119	421.00
IUUC-Xtr-131948	Xenopus tropicalis	64.87	0.00e+00	727.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence