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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031700
UUCD1 version UUC-DrM-00004
Ensembl Protein ID FBpp0310636
UniProt Accession P21461; A4V214; Q9VVB0; SINA_DROME
Genbank Protein ID AAA28901.1; AAF49403.1; AAN11744.1; AAL25397.1
Protein Name E3 ubiquitin-protein ligase sina; RING-type E3 ubiquitin transferase sina; Seven in absentia protein
Genbank Nucleotide ID M38384; AE014296; AE014296; AY060358
Gene Name sina; CG9949
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003410 FBtr0344230 FBpp0310636
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 9267027; 18701547
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 83.87 2.00e-118 423.00 IUUC-Hsa-046357
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. Also involved in external sensory organ development.
 E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. Also involved in external sensory organ development.
Protein Sequence
(Fasta)
MSNKINPKRR EPTAAAAGAG ATGVATNTST STGSSSAGNT SSANTSSSSS SSLSSAGGGD 60
AGMSADLTSL FECPVCFDYV LPPILQCSSG HLVCVSCRSK LTCCPTCRGP LANIRNLAME 120
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Protein Fasta Sequence


>IUUC-Dme-031700|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
CAATTGGGGT TCCATCTCTG CAACCGACGC GGACATTAGA AGAAACTCAG TATAGTAAAG 60
TAAATTAATT AATTAACCAG CTAAAGGCAG ACATCACGCC CAAAGTACAT GGAGAATGCC 120
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Nucleotide Fasta Sequence


>IUUC-Dme-031700|E3,RING|Drosophila melanogaster
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0716--Sensory transduction
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0844--Vision
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH
PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH
Pfam

PF03145--Sina
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0043621--F:protein self-association
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0010498--P:proteasomal protein catabolic process
GO:0006508--P:proteolysis
GO:0007465--P:R7 cell fate commitment
GO:0045676--P:regulation of R7 cell differentiation
GO:0050896--P:response to stimulus
GO:0007423--P:sensory organ development
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0007601--P:visual perception
KEGG dme:Dmel_CG9949
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000061 Aegilops tauschii 36.15 7.00e-42 163.00
IUUC-Aml-001186 Ailuropoda melanoleuca 81.96 7.00e-127 445.00
IUUC-Atr-002857 Amborella trichopoda 37.01 3.00e-43 167.00
IUUC-Apl-003813 Anas platyrhynchos 81.96 6.00e-127 445.00
IUUC-Aca-005014 Anolis carolinensis 81.96 7.00e-127 445.00
IUUC-Aly-006522 Arabidopsis lyrata 34.25 3.00e-37 147.00
IUUC-Ath-007092 Arabidopsis thaliana 32.94 2.00e-37 148.00
IUUC-Ame-011196 Astyanax mexicanus 81.25 2.00e-127 447.00
IUUC-Bta-012887 Bos taurus 81.96 5.00e-127 446.00
IUUC-Bdi-014200 Brachypodium distachyon 36.54 1.00e-42 165.00
IUUC-Bol-015884 Brassica oleracea 34.65 5.00e-37 147.00
IUUC-Bra-016775 Brassica rapa 34.56 2.00e-37 148.00
IUUC-Cel-018320 Caenorhabditis elegans 69.73 6.00e-111 393.00
IUUC-Cja-019796 Callithrix jacchus 81.96 9.00e-127 445.00
IUUC-Cfa-020642 Canis familiaris 81.96 2.00e-127 447.00
IUUC-Cpo-022348 Cavia porcellus 81.96 8.00e-127 445.00
IUUC-Csa-023974 Chlorocebus sabaeus 81.96 6.00e-127 446.00
IUUC-Cho-024933 Choloepus hoffmanni 82.26 5.00e-122 429.00
IUUC-Cin-025674 Ciona intestinalis 80.63 9.00e-125 438.00
IUUC-Csv-026233 Ciona savignyi 80.24 2.00e-123 434.00
IUUC-Dre-028041 Danio rerio 81.57 3.00e-127 447.00
IUUC-Dno-029764 Dasypus novemcinctus 81.96 6.00e-127 446.00
IUUC-Dor-030489 Dipodomys ordii 84.75 3.00e-90 323.00
IUUC-Ete-032946 Echinops telfairi 82.66 2.00e-122 431.00
IUUC-Eca-033536 Equus caballus 81.96 6.00e-127 445.00
IUUC-Eeu-034861 Erinaceus europaeus 80.24 6.00e-118 416.00
IUUC-Fca-035362 Felis catus 81.96 6.00e-127 446.00
IUUC-Fal-037487 Ficedula albicollis 81.96 9.00e-127 445.00
IUUC-Gmo-039091 Gadus morhua 80.63 4.00e-123 433.00
IUUC-Gga-040269 Gallus gallus 81.96 6.00e-127 445.00
IUUC-Gac-042282 Gasterosteus aculeatus 82.35 8.00e-128 448.00
IUUC-Gma-042926 Glycine max 35.27 1.00e-41 162.00
IUUC-Ggo-045444 Gorilla gorilla 81.96 6.00e-127 446.00
IUUC-Hsa-046357 Homo sapiens 81.96 6.00e-127 446.00
IUUC-Hvu-047574 Hordeum vulgare 36.15 6.00e-42 163.00
IUUC-Itr-048046 Ictidomys tridecemlineatus 81.96 8.00e-127 445.00
IUUC-Lch-049504 Latimeria chalumnae 82.35 2.00e-127 447.00
IUUC-Lpe-050879 Leersia perrieri 38.84 2.00e-41 161.00
IUUC-Loc-052191 Lepisosteus oculatus 82.35 3.00e-127 446.00
IUUC-Laf-053668 Loxodonta africana 81.96 6.00e-127 445.00
IUUC-Mcc-054640 Macaca mulatta 81.96 6.00e-127 446.00
IUUC-Meu-055922 Macropus eugenii 82.26 4.00e-121 426.00
IUUC-Mtr-058422 Medicago truncatula 34.38 2.00e-41 161.00
IUUC-Mga-059503 Meleagris gallopavo 81.96 7.00e-127 445.00
IUUC-Mmr-060794 Microcebus murinus 81.96 8.00e-127 445.00
IUUC-Mdo-061971 Monodelphis domestica 82.26 8.00e-122 428.00
IUUC-Mmu-063876 Mus musculus 84.27 7.00e-127 445.00
IUUC-Mac-065014 Musa acuminata 36.11 1.00e-40 159.00
IUUC-Mpu-066488 Mustela putorius furo 81.96 7.00e-127 445.00
IUUC-Mlu-067207 Myotis lucifugus 81.96 5.00e-127 446.00
IUUC-Nle-069706 Nomascus leucogenys 81.96 6.00e-127 446.00
IUUC-Opr-070341 Ochotona princeps 56.21 2.00e-49 187.00
IUUC-Ont-071849 Oreochromis niloticus 82.35 6.00e-128 449.00
IUUC-Oan-073701 Ornithorhynchus anatinus 52.12 3.00e-50 191.00
IUUC-Ocu-074876 Oryctolagus cuniculus 81.96 1.00e-126 444.00
IUUC-Oba-075789 Oryza barthii 35.27 3.00e-41 160.00
IUUC-Obr-076037 Oryza brachyantha 35.29 9.00e-41 159.00
IUUC-Ogl-077148 Oryza glaberrima 35.27 3.00e-41 160.00
IUUC-Ogu-078042 Oryza glumaepatula 35.27 3.00e-41 161.00
IUUC-Oin-079325 Oryza indica 35.27 3.00e-41 161.00
IUUC-Olo-080244 Oryza longistaminata 35.27 6.00e-41 161.00
IUUC-Ome-081318 Oryza meridionalis 38.43 1.00e-40 159.00
IUUC-Oni-082163 Oryza nivara 35.27 3.00e-41 160.00
IUUC-Opu-084065 Oryza punctata 38.84 6.00e-41 160.00
IUUC-Oru-084833 Oryza rufipogon 35.27 3.00e-41 161.00
IUUC-Osa-085316 Oryza sativa 35.27 3.00e-41 161.00
IUUC-Ola-086814 Oryzias latipes 82.35 8.00e-128 448.00
IUUC-Oga-088399 Otolemur garnettii 81.96 8.00e-127 445.00
IUUC-Oar-089323 Ovis aries 81.96 9.00e-127 445.00
IUUC-Ptr-090692 Pan troglodytes 81.96 8.00e-127 445.00
IUUC-Pan-092012 Papio anubis 81.96 6.00e-127 446.00
IUUC-Psi-093687 Pelodiscus sinensis 81.96 5.00e-127 446.00
IUUC-Pma-094387 Petromyzon marinus 80.08 9.00e-124 435.00
IUUC-Pfo-097134 Poecilia formosa 82.35 8.00e-128 448.00
IUUC-Pab-097555 Pongo abelii 81.96 6.00e-127 446.00
IUUC-Pop-099563 Populus trichocarpa 33.99 1.00e-42 165.00
IUUC-Pca-100328 Procavia capensis 80.65 3.00e-118 417.00
IUUC-Ppe-101760 Prunus persica 35.25 2.00e-41 161.00
IUUC-Pva-102368 Pteropus vampyrus 89.81 9.00e-56 209.00
IUUC-Rno-104866 Rattus norvegicus 82.35 4.00e-127 446.00
IUUC-Sha-106547 Sarcophilus harrisii 81.96 6.00e-127 446.00
IUUC-Sit-110245 Setaria italica 35.18 6.00e-40 157.00
IUUC-Stu-112474 Solanum tuberosum 33.98 8.00e-41 159.00
IUUC-Sbi-114035 Sorghum bicolor 35.57 1.00e-40 159.00
IUUC-Ssc-116441 Sus scrofa 81.85 1.00e-121 428.00
IUUC-Tgu-116579 Taeniopygia guttata 81.96 6.00e-127 445.00
IUUC-Tru-118250 Takifugu rubripes 82.35 4.00e-126 442.00
IUUC-Tsy-119548 Tarsius syrichta 82.31 6.00e-60 222.00
IUUC-Tni-120488 Tetraodon nigroviridis 81.96 2.00e-124 437.00
IUUC-Tca-121228 Theobroma cacao 35.69 3.00e-41 161.00
IUUC-Tae-123647 Triticum aestivum 36.15 7.00e-42 163.00
IUUC-Tur-126049 Triticum urartu 33.99 5.00e-40 157.00
IUUC-Ttr-129166 Tursiops truncatus 80.83 1.00e-115 408.00
IUUC-Vpa-130799 Vicugna pacos 86.39 3.00e-87 312.00
IUUC-Vvi-131365 Vitis vinifera 37.89 2.00e-40 158.00
IUUC-Xtr-132553 Xenopus tropicalis 81.96 7.00e-127 445.00
IUUC-Xma-133670 Xiphophorus maculatus 82.35 8.00e-128 448.00
Created Date 25-Jun-2017

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