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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031793
UUCD1 version UUC-DrM-00151
Ensembl Protein ID FBpp0087924
UniProt Accession Q24311; A4UZ78; Q0E9G0; Q9V312; CUL1_DROME
Genbank Protein ID AAA85085.1; AAD33676.1; AAF59174.1; AAM68871.1; AAM68872.1; AAQ23608.1
Protein Name Cullin homolog 1; Lin-19 homolog protein
Genbank Nucleotide ID L41642; AF136343; AE013599; AE013599; AE013599; BT010290
Gene Name Cul1; cul-1; lin19; CG1877
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0015509 FBtr0088848 FBpp0087924
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 2.00e-184 614.8 25 668
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 4    eavkkilrqesv..kkeyeelytavynlclsk.................vgaklYkklkevleefikqvkkkveesedeq.lLktynreWekfreqlk 81
           e++ ++ ++e++  +++y+  yt+vy++c+s                  vg+klY++l+++l++++ ++  k ++ ++e+ lL  y+++W++++ ++ 
   Q: 25   EGIMQVFEHEKSltRSQYMRFYTHVYDYCTSVsaapsgrssgktggaqlVGKKLYDRLEQFLKSYLSELLTKFKAISGEEvLLSRYTKQWKSYQFSST 122
           5677777766655899*****************************************************999999999999***************** PP
   S: 82   vlrkifayldrtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk.........laiyk 165
           vl+ i+ yl+r++vk+     +k +++++ Lal +w+ ++++ +++ +++++lk ie+eR+g+ ++r+l+++v+e++veLs n+         l++yk
   Q: 123  VLDGICNYLNRNWVKReceegQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEedtdaeqqkLSVYK 220
           ****************999999999**********************************************************9************** PP
   S: 166  esFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraa........ryleestetkLlevvekeliakhlesllaelvallrdkktedl 255
           ++FE kf   t+ fy++es++fl+ n v+eYlk+ve+rl+ee +r++         yl+e+t + L +++e++li+khl+ +++e+++ll+ ++++dl
   Q: 221  QNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRgfnsknglSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDL 318
           *********************************************974444444469***************************************** PP
   S: 256  srmykLlsrvlngleellkeleshikeqgkaalt...aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka...ak 347
           +rmy+L++  ++ l  l   le+hi +qg++a++    + +++dpk+yV+++l++++k++ lv +aFnnd+ F+ aldka+ +f+n n v+ a   +k
   Q: 319  KRMYSLVALSSKNLTDLKSILENHILHQGTEAIAkccTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIAnsaSK 416
           *********************************9898999999*********************************************77766888** PP
   S: 348  spEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSe 445
           spEllA+y+D lL+kssk+++++ele++l++v++vfkyi++kdvF+kyY k+LakRL++ +sas++aE+ +i+kLk+ cg+e+t kL+rMfqd+ vS+
   Q: 417  SPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSK 514
           ************************************************************************************************** PP
   S: 446  dlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkg...kyelqVstfQm 540
           dln  Fk+  ++++   ++++ ++vLs+g+Wp++ + + + LP+ele+++ +f+efY  +hsgRkL+W+++++++el ++++ +   +y+lq+stfQm
   Q: 515  DLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNN-FLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNnssTYTLQASTFQM 611
           **********************************8755.****************************************998877889********** PP
   S: 541  avLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfs 599
            vLL+fn++ +++v++l++ t+ ++e L ++lq L++ k  vl+ ++++++++ e+++ 
   Q: 612  SVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK--VLTSSDNENSLTPESTVE 668
           *************************************98..******999988877765 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (PubMed:20392747).
 Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (PubMed:20392747).
Protein Sequence
(Fasta)
MNRSGNSQTT QKLVNLDDIW SELVEGIMQV FEHEKSLTRS QYMRFYTHVY DYCTSVSAAP 60
SGRSSGKTGG AQLVGKKLYD RLEQFLKSYL SELLTKFKAI SGEEVLLSRY TKQWKSYQFS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031793|E3,Cullin|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTCCCTGAA AAATGAGATC GCCACCAATA GTGGCGCCCA ATAAATAGAT CGCCAACGAT 60
AGCTGGTCTT AAGCGATACC ACCGTCGAGG GCCTTGCAGC GCAATGGCCG AACGGTCACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031793|E3,Cullin|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0043066--P:negative regulation of apoptotic process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0032007--P:negative regulation of TOR signaling
GO:0016322--P:neuron remodeling
GO:0030163--P:protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010906--P:regulation of glucose metabolic process
KEGG dme:Dmel_CG1877
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002277 Ailuropoda melanoleuca 62.10 0.00e+00 939.00
IUUC-Apl-003503 Anas platyrhynchos 60.77 0.00e+00 740.00
IUUC-Aca-005030 Anolis carolinensis 54.61 0.00e+00 709.00
IUUC-Ago-007977 Ashbya gossypii 30.23 8.00e-104 370.00
IUUC-Acl-008190 Aspergillus clavatus 44.13 1.00e-172 599.00
IUUC-Afl-008542 Aspergillus flavus 45.13 3.00e-140 491.00
IUUC-Afu-009007 Aspergillus fumigatus 46.23 2.00e-165 575.00
IUUC-Ani-009290 Aspergillus nidulans 43.81 6.00e-179 620.00
IUUC-Ang-009600 Aspergillus niger 44.84 6.00e-169 587.00
IUUC-Aor-009978 Aspergillus oryzae 45.13 8.00e-156 543.00
IUUC-Ate-010584 Aspergillus terreus 44.52 3.00e-177 614.00
IUUC-Ame-011861 Astyanax mexicanus 62.44 0.00e+00 922.00
IUUC-Bgr-012209 Blumeria graminis 44.99 4.00e-167 580.00
IUUC-Bta-012878 Bos taurus 62.36 0.00e+00 941.00
IUUC-Bci-013941 Botrytis cinerea 43.88 0.00e+00 631.00
IUUC-Cel-018294 Caenorhabditis elegans 42.05 1.00e-175 609.00
IUUC-Cja-018965 Callithrix jacchus 60.64 0.00e+00 899.00
IUUC-Cfa-020671 Canis familiaris 62.36 0.00e+00 941.00
IUUC-Cpo-021762 Cavia porcellus 62.77 0.00e+00 941.00
IUUC-Csa-023873 Chlorocebus sabaeus 62.77 0.00e+00 940.00
IUUC-Cin-025547 Ciona intestinalis 56.64 0.00e+00 841.00
IUUC-Csv-026083 Ciona savignyi 57.12 0.00e+00 880.00
IUUC-Cgl-026452 Colletotrichum gloeosporioides 43.72 1.00e-173 602.00
IUUC-Cne-026919 Cryptococcus neoformans 38.60 2.00e-158 552.00
IUUC-Dre-027875 Danio rerio 61.77 0.00e+00 919.00
IUUC-Dno-028931 Dasypus novemcinctus 62.61 0.00e+00 939.00
IUUC-Dor-030846 Dipodomys ordii 67.87 0.00e+00 682.00
IUUC-Dse-031472 Dothistroma septosporum 42.71 1.00e-166 579.00
IUUC-Ete-033112 Echinops telfairi 60.81 3.00e-109 389.00
IUUC-Eca-034309 Equus caballus 62.36 0.00e+00 941.00
IUUC-Eeu-034450 Erinaceus europaeus 74.04 2.00e-86 312.00
IUUC-Fca-036330 Felis catus 60.76 0.00e+00 895.00
IUUC-Fal-036899 Ficedula albicollis 59.94 0.00e+00 779.00
IUUC-Fox-037705 Fusarium oxysporum 42.94 4.00e-164 571.00
IUUC-Fso-038367 Fusarium solani 44.41 9.00e-172 596.00
IUUC-Gmo-038708 Gadus morhua 61.99 0.00e+00 925.00
IUUC-Ggr-039917 Gaeumannomyces graminis 44.44 9.00e-177 612.00
IUUC-Gga-041038 Gallus gallus 62.48 0.00e+00 942.00
IUUC-Gac-041820 Gasterosteus aculeatus 62.25 0.00e+00 960.00
IUUC-Ggo-045154 Gorilla gorilla 54.79 0.00e+00 664.00
IUUC-Hsa-046034 Homo sapiens 62.77 0.00e+00 940.00
IUUC-Itr-048285 Ictidomys tridecemlineatus 62.48 0.00e+00 943.00
IUUC-Kpa-049231 Komagataella pastoris 34.92 2.00e-123 436.00
IUUC-Lch-049673 Latimeria chalumnae 62.36 0.00e+00 942.00
IUUC-Loc-052490 Lepisosteus oculatus 62.78 0.00e+00 928.00
IUUC-Lma-053191 Leptosphaeria maculans 43.08 5.00e-167 580.00
IUUC-Laf-054582 Loxodonta africana 62.48 0.00e+00 943.00
IUUC-Mcc-055162 Macaca mulatta 62.13 0.00e+00 924.00
IUUC-Meu-055904 Macropus eugenii 62.25 2.00e-108 386.00
IUUC-Mor-057035 Magnaporthe oryzae 45.18 5.00e-170 590.00
IUUC-Mpo-057555 Magnaporthe poae 44.42 2.00e-178 618.00
IUUC-Mla-059021 Melampsora laricipopulina 42.60 1.00e-157 549.00
IUUC-Mga-060078 Meleagris gallopavo 62.48 0.00e+00 942.00
IUUC-Mvi-060519 Microbotryum violaceum 42.47 4.00e-167 581.00
IUUC-Mmr-061312 Microcebus murinus 62.77 0.00e+00 940.00
IUUC-Mdo-062867 Monodelphis domestica 62.36 0.00e+00 941.00
IUUC-Mmu-063336 Mus musculus 62.48 0.00e+00 942.00
IUUC-Mpu-066400 Mustela putorius furo 59.80 0.00e+00 778.00
IUUC-Mlu-067800 Myotis lucifugus 62.10 0.00e+00 939.00
IUUC-Nfi-068384 Neosartorya fischeri 46.23 5.00e-166 577.00
IUUC-Ncr-068965 Neurospora crassa 42.41 3.00e-171 594.00
IUUC-Nle-069729 Nomascus leucogenys 62.77 0.00e+00 940.00
IUUC-Ont-071729 Oreochromis niloticus 62.23 0.00e+00 932.00
IUUC-Oan-073309 Ornithorhynchus anatinus 62.48 0.00e+00 943.00
IUUC-Ocu-074661 Oryctolagus cuniculus 61.85 0.00e+00 926.00
IUUC-Ola-087422 Oryzias latipes 61.69 0.00e+00 926.00
IUUC-Oga-088130 Otolemur garnettii 62.77 0.00e+00 940.00
IUUC-Oar-089510 Ovis aries 60.57 0.00e+00 878.00
IUUC-Ptr-090665 Pan troglodytes 62.77 0.00e+00 940.00
IUUC-Pan-092218 Papio anubis 62.77 0.00e+00 940.00
IUUC-Psi-093175 Pelodiscus sinensis 62.36 0.00e+00 941.00
IUUC-Pma-094502 Petromyzon marinus 62.44 0.00e+00 930.00
IUUC-Pno-095067 Phaeosphaeria nodorum 43.18 1.00e-176 612.00
IUUC-Pfo-096705 Poecilia formosa 62.23 0.00e+00 961.00
IUUC-Pab-097578 Pongo abelii 62.77 0.00e+00 940.00
IUUC-Pca-100242 Procavia capensis 64.88 0.00e+00 658.00
IUUC-Pva-102155 Pteropus vampyrus 63.50 3.00e-155 541.00
IUUC-Pgr-103297 Puccinia graminis 41.36 2.00e-163 568.00
IUUC-Ptt-103706 Puccinia triticina 42.86 2.00e-83 303.00
IUUC-Pte-104257 Pyrenophora teres 43.26 1.00e-172 599.00
IUUC-Pyt-104795 Pyrenophora triticirepentis 43.13 2.00e-172 598.00
IUUC-Rno-105939 Rattus norvegicus 62.48 0.00e+00 942.00
IUUC-Sce-106293 Saccharomyces cerevisiae 29.52 4.00e-102 365.00
IUUC-Sha-106949 Sarcophilus harrisii 62.61 0.00e+00 944.00
IUUC-Sja-107737 Schizosaccharomyces japonicus 40.26 1.00e-145 509.00
IUUC-Spo-108280 Schizosaccharomyces pombe 39.79 4.00e-149 521.00
IUUC-Sre-114984 Sporisorium reilianum 42.84 9.00e-162 563.00
IUUC-Ssc-115829 Sus scrofa 62.20 0.00e+00 929.00
IUUC-Tgu-116950 Taeniopygia guttata 62.48 0.00e+00 942.00
IUUC-Tru-118558 Takifugu rubripes 61.85 0.00e+00 947.00
IUUC-Tsy-118934 Tarsius syrichta 52.12 2.00e-96 345.00
IUUC-Tni-120460 Tetraodon nigroviridis 61.98 0.00e+00 952.00
IUUC-Tre-122223 Trichoderma reesei 43.06 6.00e-159 553.00
IUUC-Tvi-122539 Trichoderma virens 39.74 2.00e-154 538.00
IUUC-Tme-126926 Tuber melanosporum 43.17 9.00e-172 596.00
IUUC-Tbe-127369 Tupaia belangeri 67.44 2.00e-125 442.00
IUUC-Ttr-129022 Tursiops truncatus 60.99 0.00e+00 713.00
IUUC-Uma-129341 Ustilago maydis 43.97 2.00e-154 539.00
IUUC-Vda-129857 Verticillium dahliae 43.04 8.00e-164 570.00
IUUC-Vpa-130166 Vicugna pacos 57.23 0.00e+00 701.00
IUUC-Xtr-131818 Xenopus tropicalis 62.23 0.00e+00 936.00
IUUC-Xma-134206 Xiphophorus maculatus 62.52 0.00e+00 932.00
IUUC-Yli-134486 Yarrowia lipolytica 37.88 2.00e-139 488.00
Created Date 25-Jun-2017

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