iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.70e-14	53.8	400	450

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           +s ++++++ pr+L+hL+R+aIr++l+++++kai+ L LP sLk+YLl e+
   Q: 400  HSLFKVCCNTPRTLMHLSRCAIRKALHNRCHKAIPMLSLPLSLKKYLLLEP 450
           57899*******************************************986 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MQKTQDSTEW RKVLSNLNCP PALRGRARRM DGITASMSRA GAAKLVKKEF LEALKTNDFE 60
KLKAILIERQ IDVDTVFEVE DENMILASYK QGYWLPSYKL KSSWATGLHL SVLLGHVECL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTGGGGGA TGACTAAGAT AGGAACCAAA GGAAAACAGC CAAGCACTGA AGCACCGGTT 60
ATGTATATTG ATCTCTATGA AGCTTAGGAT TGTTTTTTAT TTTTCCATTT AATTTTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF12796--Ank_2
PF07525--SOCS_box

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
GO:2001214--P:positive regulation of vasculogenesis
GO:0051865--P:protein autoubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002121	Ailuropoda melanoleuca	90.14	0.00e+00	786.00
IUUC-Apl-003640	Anas platyrhynchos	73.27	0.00e+00	671.00
IUUC-Aca-004633	Anolis carolinensis	70.23	6.00e-163	566.00
IUUC-Ame-011455	Astyanax mexicanus	54.68	1.00e-142	499.00
IUUC-Bta-012772	Bos taurus	89.91	0.00e+00	781.00
IUUC-Cja-018805	Callithrix jacchus	91.78	0.00e+00	796.00
IUUC-Cfa-021119	Canis familiaris	90.07	0.00e+00	773.00
IUUC-Cpo-022349	Cavia porcellus	91.08	0.00e+00	785.00
IUUC-Csa-023426	Chlorocebus sabaeus	91.55	0.00e+00	796.00
IUUC-Cho-024384	Choloepus hoffmanni	84.27	0.00e+00	700.00
IUUC-Dre-028243	Danio rerio	59.57	3.00e-152	531.00
IUUC-Dno-029462	Dasypus novemcinctus	90.14	0.00e+00	780.00
IUUC-Dor-030208	Dipodomys ordii	91.55	0.00e+00	796.00
IUUC-Eca-033920	Equus caballus	90.61	0.00e+00	779.00
IUUC-Fca-035828	Felis catus	90.61	0.00e+00	790.00
IUUC-Fal-037195	Ficedula albicollis	72.43	0.00e+00	645.00
IUUC-Gmo-039649	Gadus morhua	57.00	4.00e-147	514.00
IUUC-Gga-040225	Gallus gallus	72.43	0.00e+00	674.00
IUUC-Gac-041685	Gasterosteus aculeatus	58.94	1.00e-140	493.00
IUUC-Ggo-044623	Gorilla gorilla	92.02	0.00e+00	800.00
IUUC-Hsa-045812	Homo sapiens	92.02	0.00e+00	800.00
IUUC-Itr-048132	Ictidomys tridecemlineatus	95.16	6.00e-170	589.00
IUUC-Lch-049996	Latimeria chalumnae	67.84	2.00e-170	592.00
IUUC-Loc-052262	Lepisosteus oculatus	63.13	2.00e-154	538.00
IUUC-Laf-054527	Loxodonta africana	89.44	0.00e+00	780.00
IUUC-Mcc-054758	Macaca mulatta	91.55	0.00e+00	795.00
IUUC-Meu-056293	Macropus eugenii	79.75	3.00e-70	258.00
IUUC-Mga-059970	Meleagris gallopavo	72.43	0.00e+00	675.00
IUUC-Mdo-061829	Monodelphis domestica	55.50	2.00e-120	426.00
IUUC-Mmu-063497	Mus musculus	97.89	0.00e+00	830.00
IUUC-Mpu-066315	Mustela putorius furo	90.85	0.00e+00	788.00
IUUC-Mlu-067796	Myotis lucifugus	90.14	0.00e+00	784.00
IUUC-Nle-069623	Nomascus leucogenys	91.55	0.00e+00	798.00
IUUC-Opr-070668	Ochotona princeps	86.42	1.00e-81	296.00
IUUC-Ont-071845	Oreochromis niloticus	57.31	1.00e-147	516.00
IUUC-Ocu-073775	Oryctolagus cuniculus	91.55	0.00e+00	787.00
IUUC-Ola-087538	Oryzias latipes	56.94	4.00e-150	524.00
IUUC-Oga-088686	Otolemur garnettii	90.14	0.00e+00	783.00
IUUC-Oar-089699	Ovis aries	90.85	0.00e+00	788.00
IUUC-Ptr-091174	Pan troglodytes	92.25	0.00e+00	801.00
IUUC-Pan-091808	Papio anubis	86.18	0.00e+00	731.00
IUUC-Psi-093303	Pelodiscus sinensis	74.35	0.00e+00	650.00
IUUC-Pma-094421	Petromyzon marinus	50.37	4.00e-76	277.00
IUUC-Pfo-097113	Poecilia formosa	59.14	2.00e-125	441.00
IUUC-Pab-097980	Pongo abelii	92.02	0.00e+00	800.00
IUUC-Pca-100774	Procavia capensis	89.84	0.00e+00	692.00
IUUC-Ppe-101537	Prunus persica	38.68	7.00e-12	65.50
IUUC-Pva-102657	Pteropus vampyrus	93.66	0.00e+00	690.00
IUUC-Sha-107576	Sarcophilus harrisii	72.07	2.00e-180	624.00
IUUC-Sar-113553	Sorex araneus	90.93	0.00e+00	700.00
IUUC-Ssc-115943	Sus scrofa	90.85	0.00e+00	789.00
IUUC-Tgu-116687	Taeniopygia guttata	73.25	0.00e+00	643.00
IUUC-Tru-117879	Takifugu rubripes	55.88	3.00e-142	498.00
IUUC-Tsy-119538	Tarsius syrichta	88.27	2.00e-82	299.00
IUUC-Tni-120849	Tetraodon nigroviridis	57.69	4.00e-129	454.00
IUUC-Tbe-127993	Tupaia belangeri	91.78	0.00e+00	786.00
IUUC-Ttr-128419	Tursiops truncatus	89.91	0.00e+00	785.00
IUUC-Vpa-130445	Vicugna pacos	89.67	0.00e+00	781.00
IUUC-Xtr-132386	Xenopus tropicalis	65.16	3.00e-163	568.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence