iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045769

UUCD1 version

UUC-HoS-00113

Ensembl Protein ID

ENSP00000227758.2

UniProt Accession

Q13490; B4E026; Q16516; Q4TTG0; BIRC2_HUMAN

Genbank Protein ID

AAC41942.1; AAC50372.1; AAC50508.1; BAG64288.1; AAY46158.1; AAH16174.1; AAH28578.1

Protein Name

Baculoviral IAP repeat-containing protein 2; Cellular inhibitor of apoptosis 1; IAP homolog B; Inhibitor of apoptosis protein 2; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2

Genbank Nucleotide ID

L49431; U45879; U37547; AK303197; AP000942; BC016174; BC028578

Gene Name

BIRC2; API1; MIHB; RNF48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000110330.8	ENST00000532832.5	ENSP00000432410.1
ENSG00000110330.8	ENST00000227758.6	ENSP00000227758.2
ENSG00000110330.8	ENST00000528344.1	ENSP00000434557.1
ENSG00000110330.8	ENST00000621637.1	ENSP00000484838.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19592251; 11907583; 19584093; 19506082; 19258326; 19223549; 17220297; 16282325; 21113135; 19854138; 18997792; 18082613; 16235027

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.0035	19.1	390	428

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 1    sededkleqlveMGFdreealqaLra.......annnle 32
           +++++++  + eMGF+r++++q  ++       ++++++
   Q: 390  MMNTPVVKSALEMGFNRDLVKQTVQSkilttgeNYKTVN 428
           789**********************99997443344444 PP

Organism

Homo sapiens

Functional Description
(View)

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Protein Sequence
(Fasta)

MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV 60
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCATCGTGC GTCAGAGTGA GCCCGGATGG GGCGGCGGGC TTCGGGAGCG CCCGGGCTGA 60
TCCGAGCCGA GCGGGCCGTA TCTCCTTGTC GGCGCCGCTG ATTCCCGGCT CTGCGGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR028795--C-IAP1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50209--CARD
PS50089--ZF_RING_2

Pfam

PF00653--BIR
PF00619--CARD

SMART

SM00238--BIR
SM00114--CARD
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0001741--C:XY body
GO:0051087--F:chaperone binding
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0098770--F:FBXO family protein binding
GO:0047485--F:protein N-terminus binding
GO:0003713--F:transcription coactivator activity
GO:0016740--F:transferase activity
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0097194--P:execution phase of apoptosis
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070266--P:necroptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0060546--P:negative regulation of necroptotic process
GO:1902443--P:negative regulation of ripoptosome assembly involved in necroptotic process
GO:0038061--P:NIK/NF-kappaB signaling
GO:0001890--P:placenta development
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902524--P:positive regulation of protein K48-linked ubiquitination
GO:1902523--P:positive regulation of protein K63-linked ubiquitination
GO:1902527--P:positive regulation of protein monoubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0051291--P:protein heterooligomerization
GO:0000209--P:protein polyubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:0045595--P:regulation of cell differentiation
GO:0042127--P:regulation of cell proliferation
GO:2000116--P:regulation of cysteine-type endopeptidase activity
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0060544--P:regulation of necroptotic process
GO:1901222--P:regulation of NIK/NF-kappaB signaling
GO:0070424--P:regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0039535--P:regulation of RIG-I signaling pathway
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0051591--P:response to cAMP
GO:0045471--P:response to ethanol
GO:0001666--P:response to hypoxia
GO:0006351--P:transcription, DNA-templated
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

KEGG

hsa:329

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002369	Ailuropoda melanoleuca	88.24	0.00e+00	1078.00
IUUC-Aca-004515	Anolis carolinensis	69.61	0.00e+00	775.00
IUUC-Aly-006460	Arabidopsis lyrata	38.89	2.00e-09	56.60
IUUC-Afl-008648	Aspergillus flavus	31.03	1.00e-14	75.50
IUUC-Ang-009667	Aspergillus niger	30.67	2.00e-12	68.20
IUUC-Ame-011877	Astyanax mexicanus	55.33	0.00e+00	656.00
IUUC-Bgr-012051	Blumeria graminis	33.76	2.00e-12	68.20
IUUC-Bta-012450	Bos taurus	88.61	0.00e+00	960.00
IUUC-Bci-013905	Botrytis cinerea	35.00	1.00e-16	81.60
IUUC-Cja-018895	Callithrix jacchus	95.80	0.00e+00	1130.00
IUUC-Cfa-020419	Canis familiaris	88.05	0.00e+00	1079.00
IUUC-Cpo-022048	Cavia porcellus	88.35	0.00e+00	1073.00
IUUC-Cho-024277	Choloepus hoffmanni	86.75	0.00e+00	1029.00
IUUC-Cin-025521	Ciona intestinalis	30.85	6.00e-76	278.00
IUUC-Dre-028647	Danio rerio	55.10	0.00e+00	644.00
IUUC-Dno-029509	Dasypus novemcinctus	82.39	0.00e+00	959.00
IUUC-Dor-030796	Dipodomys ordii	74.48	5.00e-99	355.00
IUUC-Dme-031819	Drosophila melanogaster	29.30	8.00e-67	248.00
IUUC-Ete-032768	Echinops telfairi	69.01	0.00e+00	731.00
IUUC-Eca-033393	Equus caballus	93.16	0.00e+00	1089.00
IUUC-Eeu-035114	Erinaceus europaeus	85.60	0.00e+00	1018.00
IUUC-Fca-036034	Felis catus	87.24	0.00e+00	1050.00
IUUC-Gmo-038477	Gadus morhua	55.74	1.00e-178	619.00
IUUC-Gga-040601	Gallus gallus	71.48	0.00e+00	847.00
IUUC-Gac-041467	Gasterosteus aculeatus	56.44	0.00e+00	630.00
IUUC-Ggo-044857	Gorilla gorilla	99.68	0.00e+00	1176.00
IUUC-Itr-048441	Ictidomys tridecemlineatus	91.53	0.00e+00	1098.00
IUUC-Lch-050259	Latimeria chalumnae	61.30	0.00e+00	724.00
IUUC-Loc-052169	Lepisosteus oculatus	54.80	3.00e-172	598.00
IUUC-Laf-053449	Loxodonta africana	86.75	0.00e+00	1045.00
IUUC-Meu-056241	Macropus eugenii	69.78	0.00e+00	711.00
IUUC-Mga-059947	Meleagris gallopavo	71.50	0.00e+00	850.00
IUUC-Mdo-062352	Monodelphis domestica	77.69	0.00e+00	929.00
IUUC-Mmu-064340	Mus musculus	83.23	0.00e+00	1006.00
IUUC-Mpu-065890	Mustela putorius furo	88.60	0.00e+00	979.00
IUUC-Mlu-068077	Myotis lucifugus	90.55	0.00e+00	1080.00
IUUC-Nfi-068591	Neosartorya fischeri	31.06	2.00e-13	71.20
IUUC-Nle-070081	Nomascus leucogenys	97.57	0.00e+00	1168.00
IUUC-Opr-070561	Ochotona princeps	84.14	0.00e+00	993.00
IUUC-Ont-071776	Oreochromis niloticus	54.85	0.00e+00	643.00
IUUC-Oan-073604	Ornithorhynchus anatinus	76.57	0.00e+00	897.00
IUUC-Ocu-073963	Oryctolagus cuniculus	91.12	0.00e+00	1061.00
IUUC-Ogu-078452	Oryza glumaepatula	47.73	4.00e-07	49.30
IUUC-Ome-081435	Oryza meridionalis	45.65	1.00e-06	47.40
IUUC-Oni-082044	Oryza nivara	43.64	2.00e-09	57.40
IUUC-Opu-084085	Oryza punctata	41.67	2.00e-06	47.00
IUUC-Oru-085060	Oryza rufipogon	46.51	1.00e-06	48.10
IUUC-Ola-086446	Oryzias latipes	52.72	3.00e-174	605.00
IUUC-Oga-087976	Otolemur garnettii	92.88	0.00e+00	1110.00
IUUC-Oar-090097	Ovis aries	88.62	0.00e+00	1085.00
IUUC-Ptr-091137	Pan troglodytes	99.84	0.00e+00	1179.00
IUUC-Pan-092673	Papio anubis	98.54	0.00e+00	1174.00
IUUC-Psi-092992	Pelodiscus sinensis	71.15	0.00e+00	837.00
IUUC-Pma-094277	Petromyzon marinus	37.96	3.00e-112	399.00
IUUC-Pfo-096790	Poecilia formosa	53.96	2.00e-178	619.00
IUUC-Pab-098734	Pongo abelii	99.66	0.00e+00	1134.00
IUUC-Pop-098944	Populus trichocarpa	42.59	6.00e-10	58.20
IUUC-Pca-100708	Procavia capensis	73.58	3.00e-178	617.00
IUUC-Pva-102788	Pteropus vampyrus	91.92	0.00e+00	1098.00
IUUC-Rno-105026	Rattus norvegicus	81.57	0.00e+00	969.00
IUUC-Sha-107229	Sarcophilus harrisii	71.77	0.00e+00	852.00
IUUC-Sja-107720	Schizosaccharomyces japonicus	33.56	1.00e-15	79.00
IUUC-Ssc-115804	Sus scrofa	88.10	0.00e+00	1048.00
IUUC-Tru-117620	Takifugu rubripes	53.71	0.00e+00	628.00
IUUC-Tni-119683	Tetraodon nigroviridis	54.28	0.00e+00	627.00
IUUC-Tbe-127523	Tupaia belangeri	92.07	0.00e+00	1118.00
IUUC-Ttr-128954	Tursiops truncatus	88.39	0.00e+00	1059.00
IUUC-Vpa-130441	Vicugna pacos	90.29	0.00e+00	1087.00
IUUC-Xtr-132031	Xenopus tropicalis	57.96	0.00e+00	655.00
IUUC-Xma-132984	Xiphophorus maculatus	54.56	0.00e+00	627.00
IUUC-Yli-134629	Yarrowia lipolytica	32.79	5.00e-16	79.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence