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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046882
UUCD1 version UUC-HoS-01162
Ensembl Protein ID ENSP00000352676.4
UniProt Accession Q9UGI0; B4DZ98; D3DRF4; Q5SQP6; Q69YK3; ZRAN1_HUMAN
Genbank Protein ID CAB64449.1; BAG64010.1; CAH72159.1; CAH72159.1; CAI16103.1; CAI16103.1; EAW49252.1; EAW49253.1; CAH10620.1
Protein Name Ubiquitin thioesterase ZRANB1; TRAF-binding domain-containing protein; Zinc finger Ran-binding domain-containing protein 1
Genbank Nucleotide ID AJ252060; AK302810; AL731577; AL731571; AL731571; AL731577; CH471066; CH471066; AL832925
Gene Name ZRANB1; TRABID
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000019995.6 ENST00000359653.4 ENSP00000352676.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/OTU OTU 20622874; 20802491
UBD/Other/Other UBD/Other/Other 22157957
Classification
Family E-value Score Start End
DUB/OTU 1.20e-35 124.6 432 592
UBD/ZnF/NZF 4.10e-27 95.0 7 32
Active Site
Position(s) Description Evidence
443 Nucleophile {ECO:0000269|PubMed:22157957}
585 Proton acceptor ECO:0000250}
Domain Profile

   DUB/OTU
   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak.ge 78
           l++l+++++G+CLl++v q+++g++d+ds l++al+++L++ +s+++    +++++++s+++  +        +++++f+ +l+++++   e
   Q: 432  LYALWNRTAGDCLLDSVLQATWGIYDKDSvLRKALHDSLHD-CSHWFytrwKDWESWYSQSFGLHfslreeqwQEDWAFILSLASQPGAsLE 522
           6899*************************************.*****999999999999999999**********************7746* PP
   S: 79   eihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
           ++hif+La+iL+rpiiv+ v++++s         +++g++lpll++++  +k+pi+L+Y++gH++aLva+
   Q: 523  QTHIFVLAHILRRPIIVYGVKYYKSfrgetlgytRFQGVYLPLLWEQSFcWKSPIALGYTRGHFSALVAM 592
           *******************************************************************986 PP
   

   UBD/ZnF/NZF
   S: 4    qWaCsaCTflNePeavkCemCsrpRg 29
           +WaC++CT++N+P+a+kC+mC  +R+
   Q: 7    KWACEYCTYENWPSAIKCTMCRAQRP 32
           7************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
 Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
Protein Sequence
(Fasta)
MSERGIKWAC EYCTYENWPS AIKCTMCRAQ RPSGTIITED PFKSGSSDVG RDWDPSSTEG 60
GSSPLICPDS SARPRVKSSY SMENANKWSC HMCTYLNWPR AIRCTQCLSQ RRTRSPTESP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046882|DUB,OTU;UBD,UBD/Other/Other;UBD,NZF|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGATGGCCT CCCTGAAATT AAACATTTCT ATTAGTGGCT TCCCGTTAAT CTCATCCTTC 60
TTAGATCAAA CCTCGTTATA TCTCCTGCCT ATCTCTTTTG CATTCCAAAG TTCAGTTTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046882|DUB,OTU;UBD,UBD/Other/Other;UBD,NZF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR001876--Znf_RanBP2
PROSITE

PS50802--OTU
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF02338--OTU
PF00641--zf-RanBP
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016477--P:cell migration
GO:0007010--P:cytoskeleton organization
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0016579--P:protein deubiquitination
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0022604--P:regulation of cell morphogenesis
GO:0016055--P:Wnt signaling pathway
KEGG hsa:54764
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002329 Ailuropoda melanoleuca 99.28 0.00e+00 1409.00
IUUC-Apl-003612 Anas platyrhynchos 96.43 0.00e+00 1416.00
IUUC-Aca-004604 Anolis carolinensis 96.56 0.00e+00 1357.00
IUUC-Afu-008779 Aspergillus fumigatus 36.36 4.00e-03 34.70
IUUC-Ame-011865 Astyanax mexicanus 78.09 0.00e+00 1115.00
IUUC-Bta-012482 Bos taurus 99.28 0.00e+00 1410.00
IUUC-Cja-019268 Callithrix jacchus 99.86 0.00e+00 1414.00
IUUC-Cfa-021066 Canis familiaris 99.14 0.00e+00 1408.00
IUUC-Cpo-021479 Cavia porcellus 98.85 0.00e+00 1440.00
IUUC-Cre-022623 Chlamydomonas reinhardtii 29.70 5.00e-03 37.00
IUUC-Csa-023512 Chlorocebus sabaeus 100.00 0.00e+00 1417.00
IUUC-Cho-024615 Choloepus hoffmanni 90.28 0.00e+00 1143.00
IUUC-Cin-025238 Ciona intestinalis 44.17 4.00e-164 571.00
IUUC-Csv-026263 Ciona savignyi 54.55 1.00e-27 115.00
IUUC-Dre-028575 Danio rerio 78.38 0.00e+00 1133.00
IUUC-Dno-029309 Dasypus novemcinctus 97.99 0.00e+00 1391.00
IUUC-Dor-030895 Dipodomys ordii 90.72 1.00e-169 590.00
IUUC-Dse-031270 Dothistroma septosporum 26.13 7.00e-04 38.90
IUUC-Dme-032064 Drosophila melanogaster 42.45 9.00e-144 504.00
IUUC-Ete-032769 Echinops telfairi 96.99 0.00e+00 1383.00
IUUC-Eca-033523 Equus caballus 99.43 0.00e+00 1412.00
IUUC-Eeu-034672 Erinaceus europaeus 95.13 0.00e+00 1145.00
IUUC-Fca-036567 Felis catus 98.42 0.00e+00 1430.00
IUUC-Fal-037545 Ficedula albicollis 96.99 0.00e+00 1422.00
IUUC-Fox-037727 Fusarium oxysporum 34.92 1.60e-02 34.30
IUUC-Gmo-038762 Gadus morhua 82.55 0.00e+00 1178.00
IUUC-Gga-040857 Gallus gallus 96.99 0.00e+00 1424.00
IUUC-Gac-041663 Gasterosteus aculeatus 84.56 0.00e+00 1212.00
IUUC-Ggo-045078 Gorilla gorilla 99.86 0.00e+00 1416.00
IUUC-Itr-048983 Ictidomys tridecemlineatus 99.77 0.00e+00 910.00
IUUC-Lch-050317 Latimeria chalumnae 94.41 0.00e+00 1258.00
IUUC-Loc-052922 Lepisosteus oculatus 91.14 0.00e+00 1310.00
IUUC-Laf-054134 Loxodonta africana 98.71 0.00e+00 1404.00
IUUC-Mcc-054889 Macaca mulatta 100.00 0.00e+00 1407.00
IUUC-Meu-056035 Macropus eugenii 96.70 0.00e+00 1354.00
IUUC-Mga-059653 Meleagris gallopavo 92.98 0.00e+00 1352.00
IUUC-Mmr-061487 Microcebus murinus 99.43 0.00e+00 1413.00
IUUC-Mdo-061945 Monodelphis domestica 97.13 0.00e+00 1383.00
IUUC-Mmu-063923 Mus musculus 99.28 0.00e+00 1409.00
IUUC-Mpu-066044 Mustela putorius furo 99.14 0.00e+00 1410.00
IUUC-Mlu-067031 Myotis lucifugus 97.99 0.00e+00 1312.00
IUUC-Nle-069600 Nomascus leucogenys 99.71 0.00e+00 1412.00
IUUC-Opr-070795 Ochotona princeps 90.82 0.00e+00 1211.00
IUUC-Ont-071422 Oreochromis niloticus 86.04 0.00e+00 1251.00
IUUC-Oan-072942 Ornithorhynchus anatinus 95.17 1.00e-163 569.00
IUUC-Ocu-074481 Oryctolagus cuniculus 94.72 0.00e+00 1367.00
IUUC-Obr-076679 Oryza brachyantha 24.53 3.00e-05 43.50
IUUC-Ola-087151 Oryzias latipes 83.01 0.00e+00 1204.00
IUUC-Olu-087626 Ostreococcus lucimarinus 28.00 4.80e-01 28.90
IUUC-Oga-089035 Otolemur garnettii 99.28 0.00e+00 1407.00
IUUC-Oar-089948 Ovis aries 99.14 0.00e+00 1408.00
IUUC-Ptr-091245 Pan troglodytes 99.86 0.00e+00 1416.00
IUUC-Pan-092797 Papio anubis 100.00 0.00e+00 952.00
IUUC-Psi-093759 Pelodiscus sinensis 96.22 0.00e+00 885.00
IUUC-Pfo-096859 Poecilia formosa 81.93 0.00e+00 1196.00
IUUC-Pab-098015 Pongo abelii 100.00 0.00e+00 1415.00
IUUC-Pca-100282 Procavia capensis 96.38 0.00e+00 1214.00
IUUC-Pva-102680 Pteropus vampyrus 98.90 0.00e+00 1283.00
IUUC-Pgr-103642 Puccinia graminis 22.73 7.00e-03 35.40
IUUC-Rno-105058 Rattus norvegicus 99.28 0.00e+00 1409.00
IUUC-Sha-106846 Sarcophilus harrisii 96.99 0.00e+00 1382.00
IUUC-Sar-113395 Sorex araneus 96.36 3.00e-143 502.00
IUUC-Ssc-116143 Sus scrofa 99.28 0.00e+00 1410.00
IUUC-Tgu-117173 Taeniopygia guttata 97.13 0.00e+00 1425.00
IUUC-Tru-118266 Takifugu rubripes 85.09 0.00e+00 1232.00
IUUC-Tsy-118947 Tarsius syrichta 92.11 0.00e+00 1249.00
IUUC-Tni-120090 Tetraodon nigroviridis 83.78 0.00e+00 1171.00
IUUC-Tbe-127522 Tupaia belangeri 98.12 0.00e+00 851.00
IUUC-Ttr-128170 Tursiops truncatus 99.14 0.00e+00 1409.00
IUUC-Vpa-130143 Vicugna pacos 91.19 0.00e+00 1160.00
IUUC-Xtr-132143 Xenopus tropicalis 89.81 0.00e+00 1266.00
IUUC-Xma-133323 Xiphophorus maculatus 82.51 0.00e+00 1209.00
Created Date 25-Jun-2017

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