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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045708
UUCD1 version UUC-HoS-01262
Ensembl Protein ID ENSP00000415327.2
UniProt Accession Q9C0C7; A6XN33; D3DQP8; G3V193; Q86XD6; Q9H8Z0; Q9NXE7; AMRA1_HUMAN
Genbank Protein ID ABI74670.1; BAB21827.1; BAA91067.1; BAB14457.1; EAW67996.1; EAW67999.1; EAW68001.1; AAH45609.1
Protein Name Activating molecule in BECN1-regulated autophagy protein 1
Genbank Nucleotide ID DQ870924; AB051523; AK000301; AK023197; AL834190; CH471064; CH471064; BC045609
Gene Name AMBRA1; KIAA1736
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000110497.14 ENST00000314845.7 ENSP00000318313.3
ENSG00000110497.14 ENST00000533727.5 ENSP00000433372.1
ENSG00000110497.14 ENST00000534300.5 ENSP00000431926.1
ENSG00000110497.14 ENST00000458649.6 ENSP00000415327.2
ENSG00000110497.14 ENST00000526545.5 ENSP00000434895.1
ENSG00000110497.14 ENST00000528950.1 ENSP00000433945.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 20562859
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.30e-07 32.5 93 126
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd..tllvsGsdDgtikvWDlr 31
           gH    +c+ f ++  +l++sG+ Dg +++WDl+
   Q: 93   GHRRTPWCVTFhPTisGLIASGCLDGEVRIWDLH 126
           6777779*****76779***************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
 Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
Protein Sequence
(Fasta)
MKVVPEKNAV RILWGRERGA RAMGAQRLLQ ELVEDKTRWM KWEGKRVELP DSPRSTFLLA 60
FSPDRTLLAS THVNHNIYIT EVKTGKCVHS LIGHRRTPWC VTFHPTISGL IASGCLDGEV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045708|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCTGTTTT TCGGCGCTCG GCTGTGGTTC CTTGAACGAT TGCTTGGGCG TTCCTCCTTT 60
GATGTCTGGG GCGTTCTTGT ATTCGGTGAT CTTTTGCGCC GTCTTCTTGC TTGATGTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045708|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0488--Methylation
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
SMART

SM00320--WD40
Gene Ontology

GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0045335--C:phagocytic vesicle
GO:0031625--F:ubiquitin protein ligase binding
GO:0030154--P:cell differentiation
GO:0009267--P:cellular response to starvation
GO:0016236--P:macroautophagy
GO:0010667--P:negative regulation of cardiac muscle cell apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0021915--P:neural tube development
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:1903599--P:positive regulation of mitophagy
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000785--P:regulation of autophagosome assembly
KEGG hsa:55626
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001917 Ailuropoda melanoleuca 97.81 0.00e+00 1813.00
IUUC-Atr-002557 Amborella trichopoda 37.74 3.00e-30 127.00
IUUC-Apl-004186 Anas platyrhynchos 81.80 0.00e+00 1944.00
IUUC-Aca-004419 Anolis carolinensis 77.59 0.00e+00 1837.00
IUUC-Aly-006308 Arabidopsis lyrata 37.85 1.00e-28 122.00
IUUC-Ath-007656 Arabidopsis thaliana 36.92 3.00e-28 120.00
IUUC-Ame-011354 Astyanax mexicanus 59.17 0.00e+00 1312.00
IUUC-Bta-012455 Bos taurus 94.46 0.00e+00 2237.00
IUUC-Bdi-014580 Brachypodium distachyon 42.33 4.00e-30 126.00
IUUC-Bol-016094 Brassica oleracea 40.22 1.00e-28 122.00
IUUC-Bra-017308 Brassica rapa 40.76 1.00e-29 125.00
IUUC-Cja-019073 Callithrix jacchus 98.82 3.00e-169 588.00
IUUC-Cfa-020994 Canis familiaris 95.01 0.00e+00 1528.00
IUUC-Cpo-022101 Cavia porcellus 94.85 0.00e+00 2208.00
IUUC-Csa-023273 Chlorocebus sabaeus 98.12 0.00e+00 1635.00
IUUC-Cin-025567 Ciona intestinalis 54.64 6.00e-56 212.00
IUUC-Csv-026005 Ciona savignyi 51.26 5.00e-56 210.00
IUUC-Dre-028282 Danio rerio 58.72 0.00e+00 1298.00
IUUC-Dno-029948 Dasypus novemcinctus 96.23 0.00e+00 2226.00
IUUC-Dor-030568 Dipodomys ordii 96.78 0.00e+00 1258.00
IUUC-Ete-032864 Echinops telfairi 94.31 0.00e+00 1182.00
IUUC-Eca-034392 Equus caballus 96.87 0.00e+00 1641.00
IUUC-Eeu-034440 Erinaceus europaeus 87.98 0.00e+00 1248.00
IUUC-Fca-035359 Felis catus 94.18 0.00e+00 2186.00
IUUC-Fal-037483 Ficedula albicollis 82.17 0.00e+00 1983.00
IUUC-Gmo-039343 Gadus morhua 75.72 0.00e+00 780.00
IUUC-Gga-040787 Gallus gallus 82.79 0.00e+00 1246.00
IUUC-Gac-041321 Gasterosteus aculeatus 62.43 0.00e+00 1369.00
IUUC-Gma-044022 Glycine max 36.63 4.00e-29 123.00
IUUC-Ggo-044775 Gorilla gorilla 99.66 0.00e+00 1112.00
IUUC-Hvu-047536 Hordeum vulgare 41.57 1.00e-29 124.00
IUUC-Itr-048376 Ictidomys tridecemlineatus 98.27 0.00e+00 1266.00
IUUC-Lch-050255 Latimeria chalumnae 70.32 0.00e+00 1425.00
IUUC-Lpe-050684 Leersia perrieri 41.76 2.00e-30 128.00
IUUC-Loc-052881 Lepisosteus oculatus 67.86 0.00e+00 1506.00
IUUC-Laf-053342 Loxodonta africana 73.27 0.00e+00 988.00
IUUC-Mcc-055848 Macaca mulatta 96.69 0.00e+00 2292.00
IUUC-Meu-056320 Macropus eugenii 85.44 0.00e+00 1102.00
IUUC-Mtr-058484 Medicago truncatula 38.54 2.00e-29 124.00
IUUC-Mga-059401 Meleagris gallopavo 85.62 0.00e+00 1681.00
IUUC-Mmr-061037 Microcebus murinus 96.47 0.00e+00 2220.00
IUUC-Mdo-062484 Monodelphis domestica 75.32 0.00e+00 1698.00
IUUC-Mmu-064090 Mus musculus 95.69 0.00e+00 2229.00
IUUC-Mac-065675 Musa acuminata 34.89 2.00e-29 124.00
IUUC-Mpu-066165 Mustela putorius furo 95.62 0.00e+00 1541.00
IUUC-Mlu-068038 Myotis lucifugus 95.23 0.00e+00 2306.00
IUUC-Nle-069361 Nomascus leucogenys 99.26 0.00e+00 1981.00
IUUC-Opr-070360 Ochotona princeps 93.45 0.00e+00 875.00
IUUC-Ont-071277 Oreochromis niloticus 63.67 0.00e+00 1372.00
IUUC-Oan-073623 Ornithorhynchus anatinus 83.19 0.00e+00 1038.00
IUUC-Ocu-074600 Oryctolagus cuniculus 97.57 0.00e+00 1420.00
IUUC-Oba-075024 Oryza barthii 38.19 6.00e-32 133.00
IUUC-Obr-076172 Oryza brachyantha 34.71 1.00e-32 135.00
IUUC-Ogl-077411 Oryza glaberrima 34.30 8.00e-32 132.00
IUUC-Ogu-078025 Oryza glumaepatula 38.19 8.00e-32 132.00
IUUC-Oni-082463 Oryza nivara 38.19 5.00e-32 133.00
IUUC-Opu-084041 Oryza punctata 38.19 1.00e-31 131.00
IUUC-Oru-085075 Oryza rufipogon 38.19 2.00e-31 131.00
IUUC-Osa-085781 Oryza sativa 38.19 7.00e-32 132.00
IUUC-Ola-086729 Oryzias latipes 63.72 0.00e+00 1400.00
IUUC-Olu-087735 Ostreococcus lucimarinus 40.32 8.00e-24 105.00
IUUC-Oga-089113 Otolemur garnettii 95.54 0.00e+00 2169.00
IUUC-Oar-090171 Ovis aries 95.71 0.00e+00 2082.00
IUUC-Ptr-090970 Pan troglodytes 99.92 0.00e+00 2343.00
IUUC-Pan-092778 Papio anubis 98.22 0.00e+00 1662.00
IUUC-Psi-093571 Pelodiscus sinensis 81.73 0.00e+00 1971.00
IUUC-Pma-094563 Petromyzon marinus 74.58 2.00e-106 378.00
IUUC-Ppa-095832 Physcomitrella patens 36.70 1.00e-30 128.00
IUUC-Pfo-097365 Poecilia formosa 61.26 0.00e+00 1282.00
IUUC-Pab-098647 Pongo abelii 99.31 0.00e+00 1278.00
IUUC-Pop-099742 Populus trichocarpa 40.32 1.00e-29 125.00
IUUC-Pca-101035 Procavia capensis 92.78 0.00e+00 1194.00
IUUC-Ppe-101783 Prunus persica 42.22 3.00e-29 124.00
IUUC-Pva-103187 Pteropus vampyrus 99.01 0.00e+00 942.00
IUUC-Rno-105701 Rattus norvegicus 95.69 0.00e+00 2211.00
IUUC-Sha-107612 Sarcophilus harrisii 85.68 0.00e+00 2007.00
IUUC-Smo-109107 Selaginella moellendorffii 39.66 6.00e-27 116.00
IUUC-Sit-110786 Setaria italica 38.12 2.00e-32 134.00
IUUC-Sly-110859 Solanum lycopersicum 38.10 7.00e-32 132.00
IUUC-Stu-112031 Solanum tuberosum 38.57 7.00e-32 132.00
IUUC-Sar-113242 Sorex araneus 95.86 0.00e+00 1090.00
IUUC-Ssc-116094 Sus scrofa 96.62 0.00e+00 2274.00
IUUC-Tru-118308 Takifugu rubripes 62.19 0.00e+00 1331.00
IUUC-Tsy-119552 Tarsius syrichta 94.86 0.00e+00 1247.00
IUUC-Tca-121616 Theobroma cacao 38.10 1.00e-30 128.00
IUUC-Tae-124768 Triticum aestivum 42.17 5.00e-30 126.00
IUUC-Tur-126480 Triticum urartu 42.17 2.00e-30 127.00
IUUC-Tbe-127902 Tupaia belangeri 95.65 0.00e+00 983.00
IUUC-Ttr-129278 Tursiops truncatus 94.72 0.00e+00 1207.00
IUUC-Vpa-130741 Vicugna pacos 90.17 0.00e+00 838.00
IUUC-Vvi-131437 Vitis vinifera 40.30 2.00e-29 124.00
IUUC-Xtr-132247 Xenopus tropicalis 65.12 0.00e+00 1325.00
IUUC-Xma-134277 Xiphophorus maculatus 61.63 0.00e+00 1393.00
Created Date 25-Jun-2017

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