iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020184.14	ENSMUST00000020408.14	ENSMUSP00000020408.8
ENSMUSG00000020184.14	ENSMUST00000155285.7	ENSMUSP00000137039.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17468107; 17303558

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0062	18.1	436	477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv.lpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC+ ++k+g +v +  gH++ +++C +k+      ++++  CP+Cr
   Q: 436  CVICQGRPKNGCIVhGKTGHLMsCFTCAKKL------KKRNKPCPVCR 477
           ********998554266***777*****999......**********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219). Permits the nuclear export of p53/TP53 (By similarity). Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity). Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation (By similarity). Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53 (By similarity). Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways (By similarity). Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus (By similarity). Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (By similarity). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (PubMed:25088421).

Protein Sequence
(Fasta)

MCNTNMSVST EGAASTSQIP ASEQETLVRP KPLLLKLLKS VGAQNDTYTM KEIIFYIGQY 60
IMTKRLYDEK QQHIVYCSND LLGDVFGVPS FSVKEHRKIY AMIYRNLVAV SQQDSGTSLS 120

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Nucleotide Sequence
(Fasta)

GTTCTCTCCG CGGACGGTAG GGGGCGCTCG TCACAGAACT CTGCTTTGTT AACGGGGCCT 60
CCGGGGCCAG CGTAGCCTAG GAGCGGCCGG TGAGGAGCCG CCGCCTTCTC GTCGCTCGAG 120

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Sequence Source

Ensembl

Keyword

KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0045202--C:synapse
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0016874--F:ligase activity
GO:0002039--F:p53 binding
GO:0097110--F:scaffold protein binding
GO:0019789--F:SUMO transferase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071312--P:cellular response to alkaloid
GO:0071236--P:cellular response to antibiotic
GO:0071391--P:cellular response to estrogen stimulus
GO:0071363--P:cellular response to growth factor stimulus
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071456--P:cellular response to hypoxia
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0071494--P:cellular response to UV-C
GO:0071301--P:cellular response to vitamin B1
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0007507--P:heart development
GO:0003170--P:heart valve development
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010977--P:negative regulation of neuron projection development
GO:0010955--P:negative regulation of protein processing
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0018205--P:peptidyl-lysine modification
GO:0045787--P:positive regulation of cell cycle
GO:0010628--P:positive regulation of gene expression
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046827--P:positive regulation of protein export from nucleus
GO:1904754--P:positive regulation of vascular associated smooth muscle cell migration
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010468--P:regulation of gene expression
GO:0002027--P:regulation of heart rate
GO:0042176--P:regulation of protein catabolic process
GO:0042220--P:response to cocaine
GO:0042493--P:response to drug
GO:0045472--P:response to ether
GO:1904404--P:response to formaldehyde
GO:0010039--P:response to iron ion
GO:0032026--P:response to magnesium ion
GO:0043278--P:response to morphine
GO:0048545--P:response to steroid hormone
GO:0009636--P:response to toxic substance
GO:1990785--P:response to water-immersion restraint stress
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

KEGG

mmu:17246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	79.84	0.00e+00	667.00
IUUC-Apl-003193	Anas platyrhynchos	59.44	1.00e-132	466.00
IUUC-Aca-004305	Anolis carolinensis	52.72	1.00e-98	353.00
IUUC-Ame-010675	Astyanax mexicanus	44.04	1.00e-50	194.00
IUUC-Bta-013270	Bos taurus	79.07	0.00e+00	645.00
IUUC-Cja-019744	Callithrix jacchus	78.51	0.00e+00	654.00
IUUC-Cfa-020807	Canis familiaris	78.63	7.00e-178	616.00
IUUC-Cpo-022182	Cavia porcellus	78.63	0.00e+00	630.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	1.00e-05	40.80
IUUC-Csa-023541	Chlorocebus sabaeus	80.24	0.00e+00	658.00
IUUC-Cho-024831	Choloepus hoffmanni	90.99	3.00e-51	195.00
IUUC-Cin-025448	Ciona intestinalis	27.40	6.00e-21	94.00
IUUC-Csv-026151	Ciona savignyi	28.04	8.00e-13	67.40
IUUC-Dre-028419	Danio rerio	41.48	4.00e-49	189.00
IUUC-Dno-028950	Dasypus novemcinctus	77.62	0.00e+00	649.00
IUUC-Dor-031048	Dipodomys ordii	73.53	8.00e-93	334.00
IUUC-Ete-032264	Echinops telfairi	69.14	5.00e-93	334.00
IUUC-Eca-033301	Equus caballus	71.57	6.00e-168	583.00
IUUC-Eeu-035005	Erinaceus europaeus	68.28	4.00e-150	524.00
IUUC-Fca-035454	Felis catus	79.44	0.00e+00	660.00
IUUC-Fal-036720	Ficedula albicollis	54.25	8.00e-60	223.00
IUUC-Gmo-039296	Gadus morhua	41.04	2.00e-43	169.00
IUUC-Gga-040251	Gallus gallus	59.64	6.00e-131	461.00
IUUC-Gac-041528	Gasterosteus aculeatus	41.67	2.00e-34	140.00
IUUC-Ggo-044948	Gorilla gorilla	74.19	5.00e-177	613.00
IUUC-Hsa-046376	Homo sapiens	80.24	0.00e+00	660.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	79.32	0.00e+00	640.00
IUUC-Lch-050037	Latimeria chalumnae	49.90	3.00e-94	339.00
IUUC-Loc-051837	Lepisosteus oculatus	47.78	4.00e-101	361.00
IUUC-Laf-053483	Loxodonta africana	75.86	0.00e+00	633.00
IUUC-Mcc-055294	Macaca mulatta	80.44	0.00e+00	662.00
IUUC-Mga-060007	Meleagris gallopavo	58.82	4.00e-125	441.00
IUUC-Mmr-060673	Microcebus murinus	79.84	0.00e+00	665.00
IUUC-Mdo-063057	Monodelphis domestica	64.86	7.00e-154	536.00
IUUC-Mpu-065836	Mustela putorius furo	78.43	0.00e+00	671.00
IUUC-Mlu-068193	Myotis lucifugus	76.95	1.00e-180	625.00
IUUC-Nle-069927	Nomascus leucogenys	80.24	0.00e+00	660.00
IUUC-Opr-070590	Ochotona princeps	73.84	3.00e-171	595.00
IUUC-Ont-071984	Oreochromis niloticus	42.40	3.00e-47	182.00
IUUC-Oan-072744	Ornithorhynchus anatinus	62.97	2.00e-138	485.00
IUUC-Ocu-074071	Oryctolagus cuniculus	79.36	0.00e+00	650.00
IUUC-Ola-087329	Oryzias latipes	40.86	2.00e-46	180.00
IUUC-Oga-088135	Otolemur garnettii	74.15	5.00e-176	610.00
IUUC-Oar-090078	Ovis aries	78.63	0.00e+00	665.00
IUUC-Ptr-091399	Pan troglodytes	80.24	0.00e+00	661.00
IUUC-Pan-092720	Papio anubis	80.44	0.00e+00	662.00
IUUC-Psi-093591	Pelodiscus sinensis	58.08	1.00e-115	409.00
IUUC-Pma-094500	Petromyzon marinus	62.50	5.00e-19	87.40
IUUC-Pfo-096316	Poecilia formosa	42.49	1.00e-48	187.00
IUUC-Pab-097696	Pongo abelii	79.84	0.00e+00	651.00
IUUC-Pca-100974	Procavia capensis	73.24	1.00e-178	619.00
IUUC-Pva-102488	Pteropus vampyrus	74.90	3.00e-164	571.00
IUUC-Rno-105641	Rattus norvegicus	88.75	0.00e+00	713.00
IUUC-Sha-107314	Sarcophilus harrisii	64.20	1.00e-160	559.00
IUUC-Sar-112938	Sorex araneus	73.59	3.00e-175	607.00
IUUC-Ssc-115495	Sus scrofa	79.03	0.00e+00	645.00
IUUC-Tgu-116623	Taeniopygia guttata	59.52	8.00e-128	450.00
IUUC-Tru-117820	Takifugu rubripes	39.26	1.00e-43	170.00
IUUC-Tsy-119162	Tarsius syrichta	55.11	2.00e-54	206.00
IUUC-Tni-119793	Tetraodon nigroviridis	43.92	4.00e-46	178.00
IUUC-Tvi-122445	Trichoderma virens	37.74	4.00e-02	32.70
IUUC-Tbe-127816	Tupaia belangeri	80.18	4.00e-100	358.00
IUUC-Ttr-129194	Tursiops truncatus	69.87	2.00e-153	535.00
IUUC-Vpa-130326	Vicugna pacos	75.00	8.00e-171	593.00
IUUC-Xtr-132216	Xenopus tropicalis	49.61	1.00e-94	340.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence